Patents by Inventor Lawrence J. Heinz

Lawrence J. Heinz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NMDA receptor selective antagonists
    Patent number: 5880138
    Abstract: This invention discloses novel piperidine tetrazole compounds which are selective antagonists of EAA receptors particularly the NMDA receptors. The invention also provides formulations of the preferred compounds and for methods of using the compounds to treat various disorders associated with neuronal excitotoxicity.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: March 9, 1999
    Assignee: Eli Lilly and Company
    Inventors: Lawrence J. Heinz, William H. W. Lunn, Paul L. Ornstein
  • Excitatory amino acid receptor antagonists
    Patent number: 5843997
    Abstract: The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods for the preparation of the novel compounds.
    Type: Grant
    Filed: April 2, 1996
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventors: Lawrence J. Heinz, William H.W. Lunn, Darryle Darwin Schoepp
  • Inhibitors of amyloid beta-protein production
    Patent number: 5814646
    Abstract: A method of protecting a warm-blooded mammal from the progression of Alzheimer's disease, which comprises administering an effective amount of a compound of general formula. ##STR1## in which: R.sup.1 represents an optionally substituted aromatic or heteroaromatic group;L.sup.1 and L.sup.2 each independently represents a bond or an unbranched (1-4C) alkylene group, which alkylene group may optionally bear a (1-4C) alkyl, phenyl or phenyl (1-2C) alkyl substituent;one of Y.sup.1 and Y.sup.2 represents NR.sup.3 and the other represents O, S or NR.sup.3, in which R.sup.3 represent hydrogen, hydroxyl, (1-4C) alkoxy, (1-4C) alkyl or di (1-4C) alkylamino;Z represents O or S; andR.sup.2 represents (3-8C) cycloalkyl, heterocyclyl, and optionally substituted aromatic or heteroaromatic group, or together with L.sup.2, (1-10C) alkyl;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: September 29, 1998
    Assignee: Eli Lilly and Company
    Inventors: Lawrence J. Heinz, Jill A. Panetta, Michael L. Phillips, Jon K. Reel, John K. Shadle, Richard L. Simon, Celia A. Whitesitt
  • Excitatory amino acid receptor antagonists
    Patent number: 5576323
    Abstract: The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods for the preparation of the novel compounds.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: November 19, 1996
    Assignee: Eli Lilly and Company
    Inventors: Lawrence J. Heinz, William H. W. Lunn, Darryle D. Schoepp