Abstract: The present invention provides for methods of treating and preventing muscle atrophy, cardiac hypertrophy, heart failure and/or primary pulmonary hypertension linked to a family of serotonin receptors called 5-HT2 receptors. The present invention further demonstrates that modulators of 5-HT2 receptors can inhibit or treat muscle atrophy, heart failure, cardiac hypertrophy, and/or primary pulmonary hypertension.

Abstract: Complex layout features, especially two-dimensional (2D) features such as jogs and corners, are more susceptible to photo-resist pinching and bridging, even with the use of optical proximity correction. These problems may arise due to unrealistic targets, e.g. square corners, thereby resulting in excessively aggressive correction in the vicinity of these 2D features. To provide a more realistic target, an aerial image can be sampled and its gradient computed at evaluation points on the 2D feature. The aerial image contains spatial information about the local pattern and the interaction of the pattern with the manufacturing process. This information can be used to predict a feasible shape or curvature for the 2D feature. The predicted shape can then be used to retarget the 2D feature based on realistic process capabilities.

Abstract: One embodiment of the invention provides a system that dissects edges of a layout of an integrated circuit to produce a segmentation of the layout for a subsequent optical proximity correction (OPC) operation. In order to perform the dissection, the system first performs a model-based simulation on the layout to generate intensity gradients along edges of features in the layout. Next, the system generates a segmentation for edges in the layout based upon the intensity gradients. This segmentation is used during a subsequent optical proximity correction (OPC) process to generate corrections for the layout so that the layout prints more accurately on a semiconductor chip.

Abstract: A foundation component (1) is disclosed which is suitable for forming part of a modular foundation for a building structure. The foundation component (1), defines at least one receptacle (2) which, in use, may be filled with a suitable particulate material. A plurality of protrusions (5) extending generally downwards from the base (6) of the foundation component (1) engage a foundation surface on which the foundation component is located. In a preferred embodiment the foundation component may include tongue in groove interengagement of adjacent foundation components (1), and may also include provision for service channels and reinforcing rods.

Abstract: Compounds having the formula ##STR1## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.