Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: This document describes apparatuses and techniques enabling a scale down capture preview for a panorama capture user interface. This scale down preview enables users to more-easily and more-accurately capture images for a panorama.

Abstract: A computing device includes: a housing supporting a transparent panel to define an enclosure; a camera supported within the enclosure, the camera having a field of view extending through the transparent panel; and a privacy shutter supported within the enclosure, between the transparent panel and the camera, the privacy shutter having a shutter magnet, and being movable via magnetic activation between (i) an enabled position obstructing the field of view, and (ii) a disabled position clearing the field of view.

Abstract: A dock for a computing device includes: a cradle configured to receive a first edge of the computing device; a body extending from the cradle, the body having: (i) a first mounting surface configured to removably support a first accessory module in a first volume adjacent to the computing device, and (ii) a second mounting surface configured to removably support, independently of the first accessory module, a second accessory module in a second volume disjoint from the first volume.

Abstract: A portable device may include a housing sized and shaped to enclose: a power source, a wireless communication module including an antenna and associated transceiver circuitry coupled with the antenna to receive and transmit wireless signals, a human-interaction interface, a memory storing computer-readable instructions; and a processor in communication with the power source, the wireless communication module, and the memory. The housing may be sized and shaped to self-stand when placed at a location. The computer-readable instructions, when executed by the processor, may cause the portable device to: scan, using the wireless communication module, for ones of the plurality of wireless nodes within operating range of the wireless communication module, receive, in response to the scan, wireless-node data from responding ones of the plurality of wireless nodes, generate a user-interpretable signal based on the wireless-node data; and output, using the human-interaction interface, the user-interpretable signal.

Abstract: An additive manufacturing apparatus includes a support plate and a foil supporting an uncured layer of a resin. A stage is configured to hold a component of one or more cured layers of the resin. One or more actuators is operable to move the stage away from the support plate in a Z-axis direction. A radiant energy device is positioned opposite the stage such that the support plate is positioned between the radiant energy device and the stage. A foil interaction device includes a first pneumatic actuation zone and a second pneumatic actuation zone. Each of the first and second pneumatic actuation zones is configured to apply a force on a surface of the foil. The first and second pneumatic actuation zones are fluidly separable and configured to apply varied pressures relative to one another to the surface of the foil.

Abstract: The present invention relates to a method of detecting the presence of Cytomegalovirus and measuring antigenicity through detection and quantification of a pentameric complex by an indirect sandwich ELISA assay which ensures an appropriate concentration of this critical glycoprotein complex is present in the vaccine.

Abstract: An additive manufacturing apparatus includes a support plate and a foil supporting an uncured layer of a resin. A stage is configured to hold a component of one or more cured layers of the resin. One or more actuators is operable to move the stage away from the support plate in a Z-axis direction. A radiant energy device is positioned opposite the stage such that the support plate is positioned between the radiant energy device and the stage. A foil interaction device includes a first pneumatic actuation zone and a second pneumatic actuation zone. Each of the first and second pneumatic actuation zones is configured to apply a force on a surface of the foil. The first and second pneumatic actuation zones are fluidly separable and configured to apply varied pressures relative to one another to the surface of the foil.

Abstract: A wireless tracking device includes circuit components, a battery, and a circuit connecting the circuit components and the battery. The circuit components include a first wireless communication system, a processor, a memory or storage, and a first sensor operable to measure conditions of the wireless tracking device. The wireless tracking device is configured to attach to an overhead electrical line and detect failure events that are experienced by the overhead electrical line based on sensor data monitored by the wireless tracking device.

Abstract: A turbine engine that includes an engine core, an inner cowl, an outer cowl and an accessory gearbox. The engine core includes at least a compressor section, a combustion section, and a turbine section in axial flow arrangement. The accessory gearbox is operably coupled to the engine core and includes a first portion and a second portion.

Abstract: A turbine engine that includes an engine core, an inner cowl, an outer cowl and an accessory gearbox. The engine core includes at least a compressor section, a combustion section, and a turbine section in axial flow arrangement. The accessory gearbox is operably coupled to the engine core and includes a first portion and a second portion.

Abstract: Apparatus and associated methods relate to removing an adhesively-attached component from a circuit board assembly. A complementary pair of high-permeability members are positioned on opposite sides of the circuit board assembly about the adhesively-attached component. Then, a magnetic field is induced within the complementary pair of high permeability members via a coil driver generating an AC current in an inductive coil circumscribing a central pedestal of the complementary pair of high-permeability members. The magnetic field induced is directed through the adhesively-attached component via a central pedestal located proximate the adhesively-attached component. A return path for the magnetic field is provided about a periphery of the adhesively-attached component via a peripheral pedestal.

Abstract: Systems and methods for modeling a three-dimensional protein structure are disclosed. The method includes receiving a primary amino acid sequence of a three-dimensional protein, translating the primary amino acid sequence to a first vector, determining a per-residue conformation index for each amino acid residue in the primary amino acid sequence, determining a vector set for each amino acid residue in the primary amino acid sequence, and using the per-residue interaction vector set to generate a multi-dimensional matrix for the three-dimensional protein structure. The first vector includes a unique numerical descriptor value corresponding to each amino acid residue in the primary amino acid sequence. The vector set includes a plurality per-residue interaction factors corresponding to a plurality of conformation indexes for that amino acid residue.

Abstract: A refrigerated display case chassis includes a first insulated panel and a second insulated panel. The first insulated panel has a first foam layer bounded by a first pair of thermally conductive sheets. The first insulated panel forms a first wall of the refrigerated display case chassis. The second insulated panel has a second foam layer bounded by a second pair of thermally conductive sheets. The second insulated panel forms a second wall of the refrigerated display case chassis. The second insulated panel mates with the first insulated panel to form a thermally insulated joint where, in cross-section, one sheet of the first pair of thermally conductive sheets terminates at a surface of the second foam layer. The thermally conductive sheets have a greater thermal conductivity than the first or second foam layers.

Abstract: Some examples provide a non-transitory computer readable medium having instructions stored thereon and executable by a processor of a client computing device to receive, from a server computing device, a unique identifier associated with the client computing device. The instructions are executable by the processor to receive, at the client computing device, user input including a password associated with the unique identifier. The instructions are executable by the processor to send the password to the server computing device for verification. The instructions are executable by the processor to receive, from the server computing device, a data image for installing a desired operating system on the client computing device, and doing so according to a user selection received at the client computing device.

Abstract: Apparatus and associated methods relate to removing an adhesively-attached component from a circuit board assembly. A complementary pair of high-permeability members are positioned on opposite sides of the circuit board assembly about the adhesively-attached component. Then, a magnetic field is induced within the complementary pair of high permeability members via a coil driver generating an AC current in an inductive coil circumscribing a central pedestal of the complementary pair of high-permeability members. The magnetic field induced is directed through the adhesively-attached component via a central pedestal located proximate the adhesively-attached component. A return path for the magnetic field is provided about a periphery of the adhesively-attached component via a peripheral pedestal.

Abstract: An additive manufacturing apparatus includes a support plate and a foil supporting an uncured layer of a resin. A stage is configured to hold a component of one or more cured layers of the resin. One or more actuators is operable to move the stage away from the support plate in a Z-axis direction. A radiant energy device is positioned opposite the stage such that the support plate is positioned between the radiant energy device and the stage. A foil interaction device includes a first pneumatic actuation zone and a second pneumatic actuation zone. Each of the first and second pneumatic actuation zones is configured to apply a force on a surface of the foil. The first and second pneumatic actuation zones are fluidly separable and configured to apply varied pressures relative to one another to the surface of the foil.

Abstract: A turbine engine that includes an engine core, an inner cowl, an outer cowl and an accessory gearbox. The engine core includes at least a compressor section, a combustion section, and a turbine section in axial flow arrangement. The accessory gearbox is operably coupled to the engine core and includes a first portion and a second portion.

Abstract: Methods, systems, and computer programs are presented for detecting a mission changes in a conversation. A user utterance from a user device is received. The user utterance is part of a conversation with an intelligent assistant. The conversation includes preceding user utterances in pursuit of a first mission. It is determined that the user utterance indicates a mission change from the first mission to a second mission based on an application of a machine-learned model to the user utterance and the preceding user utterances. The machine-learned model has been trained repeatedly with past utterances of other users over a time period, the determining based on a certainty of the indication satisfying a certainty threshold. Responsive to the determining that the user utterance indicates the mission change from the first mission to a second mission, a reply to the user utterance is generated to further the second mission rather than the first mission.

Abstract: Systems for containing a fluid leaked from a pipeline include a flexible, impermeable liner such as like those comprising a coated substrate (or other impermeable liner or material) and disposed to extend along a trench for enveloping the pipeline deployed therein; and separating means disposed between the pipeline and the containment liner for containing the fluid therein; wherein the liner prevents migration of the fluid into the trench of the pipeline or surrounding environment by flowing the fluid laterally within the containment liner, system also protects the steel pipe from corrosion caused by the environment, such as groundwater. Methods for deploying the above systems are provided.