Patents by Inventor Le Wang

Le Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRACYCLIC BROMODOMAIN INHIBITORS
    Publication number: 20160039821
    Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3 and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
    Type: Application
    Filed: March 12, 2014
    Publication date: February 11, 2016
    Inventors: Steven D. Fidanze, Dachun Liu, Robert A. Mantei, Keith F. McDaniel, John Pratt, George S. Sheppard, Le Wang, Andrew Bogdan, James H. Holms, Justin D. Dietrich, Jasmina Marjanovic, Lisa A. Hasvold, Yujia Dai
  • METHOD, APPARATUS, AND COMPUTER READABLE MEDIUM FOR ALLOCATING SALES COMMISSIONS
    Publication number: 20160012365
    Abstract: Provided herein are systems, methods and computer readable media for allocating sales commissions. In providing such functionality, a method may include, for example, receiving a set of transaction information for a transaction. The transaction information may include an indication of at least one product or service for which a sales commission is offered. The method may also include determining, based on the transaction information, whether a merchant is eligible to receive the sales commission, in response to determining that the transaction information does not identify a merchant that is eligible to receive the sales commission, selecting, using a processor, at least one merchant from a list of merchants selected from a plurality of merchants to receive the sales commission, and providing the sales commission to the selected at least one merchant.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 14, 2016
    Inventors: Robert Harris, Le Wang
  • Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Patent number: 9227963
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: January 5, 2016
    Assignee: ABBVIE INC.
    Inventors: Le Wang, George Doherty, Xilu Wang, Zhi-Fu Tao, Milan Bruncko, Aaron R. Kunzer, Michael D. Wendt, Xiaohong Song, Robin Frey, Todd M. Hansen, Gerard M. Sullivan, Andrew Judd, Andrew J. Souers
  • GLITCH SUPPRESSION IN AN AMPLIFIER
    Publication number: 20150381161
    Abstract: A driver circuit includes detectors responsive to the operating region that a driven switch is operating in. The driver circuit is operative to drive the gate of the driven switch at a speed responsive to the output of the detectors.
    Type: Application
    Filed: October 10, 2014
    Publication date: December 31, 2015
    Inventors: Xinwang Zhang, Vijayakumar Dhanasekaran, Le Wang, Ankit Srivastava
  • RC OSCILLATOR BASED ON DELAY-FREE COMPARATOR
    Publication number: 20150349710
    Abstract: Cancelling a delay in a comparator of an RC oscillator configured to generate a clock pulse, including: selectively coupling a plurality of current sources to a first capacitor, a second capacitor, and a resistor, wherein the plurality of current source charge and discharge the first capacitor and the second capacitor, and charge the resistor; charging the first capacitor at a higher rate during a first phase of the clock pulse than a second phase of the clock pulse, and charging the second capacitor at a higher rate during a third phase of the clock pulse than a fourth phase of the clock pulse; and generating the clock pulse by enabling the comparator to compare a voltage on the first or second capacitor with a voltage on the resistor.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 3, 2015
    Inventors: Le Wang, Arash Mehrabi
  • Levitated structure of bluetooth speaker
    Patent number: 9197951
    Abstract: A levitated structure of Bluetooth speaker, which is composed of a main frame, a control circuit module, an induced coil module, a speaker, a circular frame and a top frame, which enables the main frame to be levitated over the base, and carry out wireless sensing and transmission of the AC (Alternating Current) signal with electric energy to play external audio signal received by the Bluetooth signal receiver, and provide a better power solution free from the shortage of electric power and also extend the performance period of speaker function.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: November 24, 2015
    Assignee: ASWY ELECTRONICS CO., LTD.
    Inventors: He Chen Yang, Po Le Wang
  • APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
    Publication number: 20150329541
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
    Type: Application
    Filed: April 23, 2015
    Publication date: November 19, 2015
    Inventors: Milan Bruncko, Hong Ding, George A. Doherty, Steven W. Elmore, Lisa A. Hasvold, Laura Hexamer, Aaron R. Kunzer, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt, Robert Mantei, Todd M. Hansen
  • LEVITATED STRUCTURE OF BLUETOOTH SPEAKER
    Publication number: 20150334480
    Abstract: A levitated structure of Bluetooth speaker, which is composed of a main frame, a control circuit module, an induced coil module, a speaker, a circular frame and a top frame, which enables the main frame to be levitated over the base, and carry out wireless sensing and transmission of the AC (Alternating Current) signal with electric energy to play external audio signal received by the Bluetooth signal receiver, and provide a better power solution free from the shortage of electric power and also extend the performance period of speaker function.
    Type: Application
    Filed: February 9, 2015
    Publication date: November 19, 2015
    Applicant: ASWY ELECTRONICS CO., LTD.
    Inventors: He Chen YANG, Po Le WANG
  • Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Patent number: 9174982
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: November 3, 2015
    Assignees: ABBVIE INC., GENENTECH, INC., THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
    Inventors: Milan Bruncko, Hong Ding, George A. Doherty, Steven W. Elmore, Lisa A. Hasvold, Laura Hexamer, Aaron R. Kunzer, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt, Robert A. Mantei, Todd M. Hansen
  • TRANSMISSION GATE FOR BIAS VOLTAGE GENERATION
    Publication number: 20150304137
    Abstract: An apparatus includes a transmission gate configured to generate a signal based on a first differential input signal and a second differential input signal. The apparatus further includes biasing circuitry responsive to the transmission gate and configured to output a bias voltage based on the signal.
    Type: Application
    Filed: April 21, 2014
    Publication date: October 22, 2015
    Applicant: QUALCOMM Incorporated
    Inventors: Meysam Azin, Wenchang Huang, Le Wang
  • 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS
    Publication number: 20150284328
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
    Type: Application
    Filed: April 10, 2015
    Publication date: October 8, 2015
    Inventors: Xilu Wang, Xiaohong Song, Steven W. Elmore, Milan Bruncko, David J. Madar, Andrew J. Souers, Lisa A. Hasvold, Le Wang, Zhi-Fu Tao, Aaron R. Kunzer
  • Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
    Patent number: 9125913
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: September 8, 2015
    Assignee: AbbVie Inc.
    Inventors: Milan Bruncko, Hong Ding, George A. Doherty, Steven W. Elmore, Lisa Hasvold, Laura A. Hexamer, Aaron R. Kunzer, Robert A. Mantei, William J. McClellan, Chang H. Park, Cheol-Min Park, Andrew M. Petros, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt
  • Method for fabricating small-scale MOS device
    Patent number: 9093464
    Abstract: A method for fabricating a small-scale MOS device, including: preparing a substrate; forming a first trench in the substrate along a first side of the gate region and forming a second trench in the substrate along a second side of the gate region, the first side of the gate region opposite the second side of the gate region; forming a first lightly doped drain region and a second lightly doped drain region in the first trench and the second trench, respectively; forming a third trench in the substrate overlapping at least a first portion of the first lightly doped drain region and a fourth trench in the substrate overlapping at least a first portion of the second lightly doped drain region; and forming a source region and a drain region in the third trench and the fourth trench, respectively.
    Type: Grant
    Filed: October 9, 2011
    Date of Patent: July 28, 2015
    Assignees: CSMC TECHNOLOGIES FAB1 CO., LTD., CSMC TECHNOLOGIES FAB2 CO., LTD.
    Inventor: Le Wang
  • BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
    Patent number: 9072748
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: July 7, 2015
    Assignee: AbbVie Inc.
    Inventors: Milan Bruncko, Hong Ding, George A. Doherty, Steven W. Elmore, Lisa Hasvold, Laura A. Hexamer, Aaron R. Kunzer, Robert A. Mantei, William J. McClellan, Chang H. Park, Cheol-Min Park, Andrew M. Petros, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt
  • BCL-2 selective apoptosis-inducing agents for the treatment of cancer and immune diseases
    Patent number: 9073855
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 7, 2015
    Assignee: ABBVIE INC.
    Inventors: George A. Doherty, Steven W. Elmore, Lisa Hasvold, Laura Hexamer, Robert A. Mantei, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt, Todd M. Hansen
  • APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
    Publication number: 20150183775
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
    Type: Application
    Filed: December 23, 2014
    Publication date: July 2, 2015
    Inventors: Milan BRUNCKO, Yujia DAI, Hong DING, George A. DOHERTY, Steven W. ELMORE, Lisa HASVOLD, Laura HEXAMER, Aaron R. KUNZER, Robert A. MANTEI, Chang H. PARK, Cheol-Min PARK, Andrew M. PETROS, Xiaohong SONG, Andrew J. SOUERS, Gerard M. SULLIVAN, Zhi-Fu TAO, Gary T. WANG, Le WANG, Xilu WANG, Michael D. WENDT, William J. MCCLELLAN
  • BROMODOMAIN INHIBITORS
    Publication number: 20150158873
    Abstract: The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
    Type: Application
    Filed: December 9, 2014
    Publication date: June 11, 2015
    Inventors: Andrew Bogdan, Warren M. Kati, Keith F. McDaniel, Chang H. Park, George S. Sheppard, Le Wang
  • BROMODOMAIN INHIBITORS
    Publication number: 20150150884
    Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
    Type: Application
    Filed: February 9, 2015
    Publication date: June 4, 2015
    Inventors: Dachun Liu, John Pratt, Le Wang, Lisa A. Hasvold, Andrew Bogdan
  • APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
    Publication number: 20150152097
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
    Type: Application
    Filed: December 3, 2014
    Publication date: June 4, 2015
    Inventors: Le Wang, George Doherty, Xilu Wang, Zhi-Fu Tao, Milan Bruncko, Aaron R. Kunzer, Michael D. Wendt, Xiaohong Song, Robin Frey, Todd M. Hansen, Gerard M. Sullivan, Andrew Judd, Andrew Souers
  • Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
    Patent number: 9045420
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: June 2, 2015
    Assignee: ABBVIE INC.
    Inventors: George A. Doherty, Steven W. Elmore, Lisa Hasvold, Laura A. Hexamer, Robert A. Mantei, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt, Todd M. Hansen