Abstract: Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include naphthalenesulfones, phenylsulfones, and certain peptides with unnatural amino acids and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.

Abstract: Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include thioureas, diphenyldiazerenes, xanthenes, and isoindoles and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.

Abstract: Novel and optimized classes of pipemidic acid derivative compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes of compounds exhibit exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.

Abstract: A novel class of compounds to inactivate autotaxin enzymes is provided. Such compounds include mono- and di-fluoromethylphenyl C12-C18 phosphodiesters and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds are non-cytotoxic, and can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of producing such novel compounds are encompassed within this invention as well as methods of inactivating autotaxin to certain degrees therewith.

Abstract: Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include naphthalenesulfones, phenylsulfones, and certain peptides with unnatural amino acids and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.

Abstract: The vehicle mounted edging device provides a safe and efficient means for edging grass and soil adjacent to improved surfaces. The device is attached to the remotely actuated bed of a utility vehicle and utilizes the lifting capabilities of the bed for its operation. When the disc is in the cutting position, the operator of the utility vehicle positions the vehicle near the edge of the surface to be maintained and lowers the remotely actuated bed of the utility vehicle to place the disc adjacent to the surface to be maintained. The operator then drives the vehicle parallely to the edge of the path and remove the unwanted grass. The vehicle mounted edging device effectively guides the utility vehicle along the edge of the path so that minimal steering is required and is oriented to enable the operator to easily monitor the edging operation.

Abstract: A novel class of compounds to inactivate autotaxin enzymes is provided. Such compounds include mono- and di-fluoromethylphenyl C12-C18 phosphodiesters and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds are non-cytotoxic, and can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of producing such novel compounds are encompassed within this invention as well as methods of inactivating autotaxin to certain degrees therewith.

Abstract: The novel vehicle mounted edging device provides a safe and efficient means for edging grass and soil adjacent to improved surfaces. The device is attached to the remotely actuated bed of a utility vehicle and utilizes the lifting capabilities of the bed for its operation. When the disc is in the cutting position, the operator of the utility vehicle positions the vehicle near the edge of the surface to be maintained and lowers the remotely actuated bed of the utility vehicle to place the disc adjacent to the surface to be maintained. The operator then drives the vehicle parallely to the edge of the path and remove the unwanted grass. The novel vehicle mounted edging device effectively guides the utility vehicle along the edge of the path so that minimal steering is required and is oriented to enable the operator to easily monitor the edging operation.

Abstract: The present invention relates to methods of affecting expression of a target gene, suitably brain-derived neurotrophic factor (BDNF) or related genes in a nerve cell in the central nervous system of a mammal. The method includes formulating and delivering an siRNA composition to a target site on the mammal to affect expression of the target gene in the nerve cell, wherein the target site is cerebrospinal space or muscle tissue innervated by a nerve cell, to down-regulate the target gene. Also disclosed are kits for use in practicing the novel methods of in vivo siRNA.delivery into target cells and gene regulation.

Abstract: Embodiments for a toner auger for use in an image forming device. The image forming device includes a channel through which toner is moved. The auger is positioned within the channel and has an axis of rotation and at least one offset section extending radially outward from the axis of rotation. The offset section forms a sweep envelope that extends outward from the axis of rotation. The auger may be positioned within the channel for the offset to contact the channel. Contact may cause a vibratory force that prevents the toner from clogging and bridging within the channel.

Abstract: Embodiments of a device to move waste toner within an image forming device. In one embodiment, waste toner is formed during the image formation process. The waste toner is captured and moved through a first conduit. The conduit includes an outlet for passing the waste toner to a second conduit. The door is positionable between an open orientation to allow the waste toner to discharge into the second conduit, and a closed orientation. The second conduit includes an inlet for receiving the waste toner. The interface between the first and second conduits allows for the door to move between the open and closed orientations. The interface also greatly reduces or prevents the waste toner from leaking as it passes from the first conduit into the second conduit.

Abstract: A method for estimating a cylinder specific performance parameter for a specific cylinder of an internal combustion engine for each firing attempt, which relies on production sensors commonly equipped onboard production vehicles, is disclosed.

Abstract: Tuftable primary backings comprise a closed-weave, woven tape fabric to which is affixed a coherent web layer comprising staple fibers with fibers oriented in at least two directions and a plurality of the fibers being fused. The web layer is affixed to the fabric by penetration of fibers from the web into the fabric. The backings have substantial weftline straightness and stability against deformations in the machine, cross and off-axis directions. Improved tufted goods and methods for making the composites and tufted goods are also provided.

Abstract: A method for estimating a cylinder specific performance parameter for a specific cylinder of an internal combustion engine for each firing attempt, which relies on production sensors commonly equipped onboard production vehicles, is disclosed.

Abstract: A diverter to direct media within an image forming apparatus along one of three media paths. A first gate and a second gate are positioned in an overlapping arrangement and each is movable between up and down positions. Each of the gates includes a biasing member to bias the gates towards the down position. An actuator contacts the second gate to move it to the up position. The overlapping arrangement of the first and second gates causes the first gate to also be moved to the up position when the second gate moves to the up position. A second actuator contacts the first gate to move the gate from the down position to the up position independently of the second gate.

Abstract: A diverter to direct media within an image forming apparatus along one of three media paths. A first gate and a second gate are positioned in an overlapping arrangement and each is movable between up and down positions. Each of the gates includes a biasing member to bias the gates towards the down position. An actuator contacts the second gate to move it to the up position. The overlapping arrangement of the first and second gates causes the first gate to also be moved to the up position when the second gate moves to the up position. A second actuator contacts the first gate to move the gate from the down position to the up position independently of the second gate.

Abstract: A wheel barrow having three wheels is disclosed. A forward wheel is positioned adjacent the point of intersection between two convergent longitudinal frame members, and a pair of rearward wheels are disposed intermediately of the forward and rear ends of the longitudinal frame members. Frame members provide a support carriage for a container. Rear wheels are connected by an axle, and rear axle is connected at each end to frame members by downwardly depending bracket members. The wheels enable the operator to use the wheelbarrow without having to lift up to move the wheel barrow. The wheelbarrow can be moved merely by pushing the rearwardly extending, divergent frame members.

Abstract: Tuftable primary backings comprise a closed-weave, woven tape fabric to which is affixed a coherent web layer comprising staple fibers with fibers oriented in at least two directions and a plurality of the fibers being fused. The web layer is affixed to the fabric by penetration of fibers from the web into the fabric. The backings have substantial weftline straightness and stability against deformations in the machine, cross and off-axis directions. Improved tufted goods and methods for making the composites and tufted goods are also provided.

Abstract: A printer fir printing on a print medium includes a base unit with a primary media supply tray. An input option unit is positioned below the primary media supply tray. An output option unit is coupled with the input option unit.