Abstract: Disclosed herein are anti-RGMa antibodies and methods of using these antibodies to treat multiple sclerosis, including relapsing forms of multiple sclerosis such as relapsing-remitting multiple sclerosis or relapsing-secondary progressive multiple sclerosis.

Abstract: The present disclosure provides methods of utilizing Syk inhibiting compounds in the treatment for graft versus host disease (GVHD) in a human, including acute graft versus host disease (aGVHD) and chronic graft versus host disease (cGVHD), including the use of compounds selected from the group consisting of the formulas below:

Abstract: Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry. A pulsed solenoid valve can provide a pulsed ion beam from an electrospray in a pre-vacuum chamber. The pulsed ion beam can enter a high vacuum region and a mass analyzer for mass spectrometry.

Abstract: Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation. The glycopeptide Y1 ion is isolated, and the mass spectra of fragmented glycopeptide Y1 ions provide mass spectral peaks corresponding to the amino acid sequence of the glycopeptide.

Abstract: An AC/DC conversion circuit of a power conversion apparatus receives an AC signal and has a switching element. A voltage sensing circuit generates a voltage reference signal according to an AC voltage signal. A harmonic generation circuit generates a harmonic injection signal according to the voltage reference signal. A subtraction circuit of a maximum power tracking circuit outputs a first DC signal and a second DC signal according to the voltage reference signal. An arithmetic circuit outputs a reference signal. A current sensing circuit outputs a feedforward signal according to one phase of an AC current signal. A current control circuit outputs an error signal according to the reference signal and the feedforward signal. A pulse width modulation circuit outputs a control signal to control the switching element according to the error signal and the harmonic injection signal, so that an aerogenerator operates at the maximum power approximation line.

Abstract: Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 105, or analyte with a molecular weight of at least 105 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.

Abstract: Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation. The glycopeptide Y1 ion is isolated, and the mass spectra of fragmented glycopeptide Y1 ions provide mass spectral peaks corresponding to the amino acid sequence of the glycopeptide.

Abstract: Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.

Abstract: Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry. A pulsed solenoid valve can provide a pulsed ion beam from an electrospray in a pre-vacuum chamber. The pulsed ion beam can enter a high vacuum region and a mass analyzer for mass spectrometry.

Abstract: The configurations of an electronic ballast are provided in the present invention. The proposed electronic ballast includes a filter circuit having a first and a second output terminals, a rectifier circuit having a first input terminal, a second input terminal coupled to the second output terminal of the filter circuit, and a first output terminal, and a continuous-conduction-mode charge pump PFC circuit including a first inductor having a first terminal coupled to the first input terminal and a second terminal coupled to the first output terminal of the filter circuit, a second inductor having a first terminal and a first capacitor having a first terminal coupled to the first terminal of the first inductor and a second terminal coupled to the first terminal of the second inductor.

Abstract: Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.

Abstract: An AC/DC conversion circuit of a power conversion apparatus receives an AC signal and has a switching element. A voltage sensing circuit generates a voltage reference signal according to an AC voltage signal. A harmonic generation circuit generates a harmonic injection signal according to the voltage reference signal. A subtraction circuit of a maximum power tracking circuit outputs a first DC signal and a second DC signal according to the voltage reference signal. An arithmetic circuit outputs a reference signal. A current sensing circuit outputs a feedforward signal according to one phase of an AC current signal. A current control circuit outputs an error signal according to the reference signal and the feedforward signal. A pulse width modulation circuit outputs a control signal to control the switching element according to the error signal and the harmonic injection signal, so that an aerogenerator operates at the maximum power approximation line.

Abstract: Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.

Abstract: A stability analyzing apparatus is in cooperation with a DC power system having a bus terminal connected to at least a load, and comprises a perturbation signal generating module, a signal processing module and a determining module. The perturbation signal generating module generates a perturbation signal injected into the bus terminal to obtain a transfer function of the bus terminal impedance. The signal processing module is electrically connected to the perturbation signal generating module and calculates the slope of the transfer function of the bus terminal impedance to obtain a transfer function of the bus terminal impedance slope. The determining module is electrically connected to the signal processing module and determines the stability tendency of the DC power system according to the transfer function of the bus terminal impedance slope. A stability analyzing method is also disclosed.

Abstract: A control circuit controls a power output module and drives a load device. The control circuit includes a conversion unit, a feed-forward unit, a feedback unit and a control unit. The conversion unit generates a driving signal according to an output signal of the power output module for driving the load device. The feed-forward unit generates a duty cycle reference signal according to the output signal. The feedback unit generates a feedback signal according to the driving signal. The control unit outputs a control signal to control the conversion unit according to the duty cycle reference signal and feedback signal, thereby limiting the output power of the power output module within the maximum power region. A tracking method of the maximum power is also disclosed.

Abstract: A retractable safety syringe includes a retractable needle hub holding a needle and having a first guiding means; and a hollow barrel having a second guiding means set correspondingly to the first guiding means; and a collapsible plunger comprising of a first plunger element having a protrusion releasably coupled with a second plunger element having a longitudinal slot with a pinched zone to curb the movement of said protrusion; and a spring disposed between the needle hub and hollow barrel and acts between the needle hub and the hollow barrel. The uncoupling of the collapsible plunger triggers the retraction mechanism to enable the needle hub to retract into the barrel by the decompression force of a spring. The reliability of retraction is further improved by a longitudinal slot and a protrusion to facilitate the retreating of the collapsible plunger in an orderly way.

Abstract: A magnetic navigation control apparatus includes a sensing unit, a control unit and a magnetic field generating unit. The sensing unit generates a sensing signal according to the position of a magnetic element. The control unit is electrically connected with the sensing unit and generates a first control signal and a second control signal according to the sensing signal. The magnetic field generating unit is electrically connected with the control unit and has a housing, a plurality of interpoles, and a plurality of short poles. The interpoles are disposed in the housing. The short poles are disposed between the interpoles evenly. The magnetic field generating unit generates a navigation signal according to the first control signal, thereby controlling the magnetic element to move in at least one direction within a target region. The magnetic navigation control apparatus has greater magnetic navigation effects, and can thus reduce the cost.

Abstract: A discontinuous conduction current mode maximum power limitation photovoltaic converter connects to a ground and a solar cell having a temperature compensation signal and an output power and being solarized and includes a direct current/direct current voltage converter and a maximum power control circuit. The direct current/direct current voltage converter connects to the solar cell, includes an input terminal and an output terminal, offers a stable voltage and has an output voltage signal and an inner current. The maximum power control circuit connects to the direct current/direct current voltage converter and the solar cell, controls the direct current/direct current voltage converter to limit the output power of the solar cell to maximum and includes a temperature compensation feedback circuit, an output voltage feedback circuit, a current detection circuit and a main control circuit.

Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.

Abstract: A magnetization apparatus includes a power supply unit, an energy storage element and a voltage clamp unit. The power supply unit generates at least one exciting signal to excite at least a coil of a magnetic field generating apparatus. The voltage clamp unit has a clamping voltage. The voltage level of the clamp voltage is higher than the voltage level of the exciting signal, and lower than the rated voltage of the energy storage element. When the exciting signal turns to a low voltage level, the voltage clamp unit controls the voltage level of the energy storage element to be less than or equal to the voltage level of the clamp voltage. This configuration with the voltage clamp unit can extend the lifetime of the energy storage element and reduce the energy loss to enhance the efficiency.