Abstract: An implantable medical electrical lead includes a plurality of conductors that extend continuously, without any intermediary junctions, between a plurality of electrodes and a corresponding plurality of contact members of an in-line connector terminal. A junction between each conductor and the corresponding contact member is preferably formed by first fitting a conductive sleeve, which is coupled to a proximal portion of the conductor, into an eyelet feature of the contact member, which is mounted on a strut member, and then welding the sleeve to the contact member at a pre-formed slot of the contact member, which extends along an external recessed surface thereof. The assembly of the connector terminal preferably completes the construction of the lead, wherein the proximal portion of each conductor is positioned in a helical path, which extends between an elongate body of the lead and the connector terminal, and along which a grip zone is formed.

Abstract: A data improvement system, including an initial database, a verification database, and a processing device in communication with the initial database and the verification database. The processing device receives data from the initial database and the verification database, and determines verification data based thereon. A track data improvement system and a track database improvement system are also disclosed.

Abstract: A track-data verification vehicle and method for verifying positive train control (PTC) track data. The vehicle includes a 360° camera and a precision positioning system co-located on a vertical axis on the vehicle. The 360° camera provides a video image with indicators that are useable to align an asset with the positioning system. A second video camera is positioned interior to the vehicle to capture an image of a monitor associated with a train management control (TMC) unit and of operator inputs to the TMC unit; the TMC unit executes a PTC track-data verification application. The process of verifying asset locations is thus recorded and can be reviewed and approved by a Federal Railroad Administration representative without requiring the representative to be physically present within the vehicle during track-data verification.

Abstract: The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal, comprising administering compositions of the invention to the mammal.

Abstract: A surgical grasping instrument is provided which includes a body portion having an elongate tubular member extending from the body portion and a jaw assembly movably mounted on a distal end of the elongate tubular member. The jaw assembly includes first and second jaws having arcuate grasping portions for securely grasping a circular surgical stapler anvil shaft. The jaw assembly is mounted on a movable head portion which is movable relative to a longitudinal axis of the elongate tubular member to rotate and articulate the jaw assembly relative to the longitudinal axis to manipulate the anvil within the body of a patient.

Abstract: A loading unit for use with a surgical stapling apparatus is provided and includes a tool assembly having a cartridge assembly and an anvil assembly that are movable in relation to one another; a surgical buttress releasably secured to a tissue contacting surface of the anvil assembly and/or the cartridge assembly, wherein each surgical buttress is secured to the anvil assembly and/or the cartridge assembly by at least one anchor; a release assembly associated with the anvil assembly and/or the cartridge assembly; and a drive assembly slidably translatable through the tool assembly between proximal and distal positions, wherein the drive assembly actuates the release assembly to thereby release the anchor to free the surgical buttress from the anvil assembly and/or the cartridge assembly.

Abstract: A system and method for controlling movement of a vehicle. A current state of the vehicle is identified. The current state comprises a current location of the vehicle. A next state for the vehicle is selected by a processor unit. The next state comprises a next location for the vehicle. A value for an attribute of the next state of the vehicle is randomly selected. The movement of the vehicle is controlled to move the vehicle from the current state to the next state.

Abstract: A loading unit for use with a surgical stapling apparatus is provided and includes a tool assembly having a cartridge assembly and an anvil assembly that are movable in relation to one another; a surgical buttress releasably secured to a tissue contacting surface of the anvil assembly and/or the cartridge assembly, wherein each surgical buttress is secured to the anvil assembly and/or the cartridge assembly by at least one anchor; a release assembly associated with the anvil assembly and/or the cartridge assembly; and a drive assembly slidably translatable through the tool assembly between proximal and distal positions, wherein the drive assembly actuates the release assembly to thereby release the anchor to free the surgical buttress from the anvil assembly and/or the cartridge assembly.

Abstract: A system and method for controlling movement of a vehicle. A current state of the vehicle is identified. The current state comprises a current location of the vehicle. A next state for the vehicle is selected by a processor unit. The next state comprises a next location for the vehicle. A value for an attribute of the next state of the vehicle is randomly selected. The movement of the vehicle is controlled to move the vehicle from the current state to the next state.

Abstract: A content management system disclosed communicates between commercial participants and social media participants connected by a social media network including a location-centric system that tracks store locations of its commercial participants relative to a location of one or more mobile communication devices of one or more portions of social media participants. A product and service licensing center categorizes the commercial participants in accordance with a level of economic benefit participation in relationship to the location of the one or more mobile communication devices of the social media participants.

Abstract: A social media exchange center is disclosed to communicate likes between social media participants in exchange for economic benefits. The center includes categories of the social media participants created in accordance with a level of social participation between and among members of a group of social media participants. A location aware system monitors a location of at least one portion of the group of social media participants. An economic benefit system exchanges leads or tips on retailers products or services for economic benefits responsive to the location of the at least one portion of the group of social media participants between and among groups of social media participants in accordance with the level of social participation between and among the members of the group social media participants.

Abstract: A surgical buttress includes a body portion and a band disposed on each of the distal and proximal ends thereof. The surgical buttress is configured to attach to an end effector of a surgical stapling apparatus. The body portion, having perforations disposed thereon, overlies the working surface of one of the first or second jaws of the end effector. A resilient portion extends transversely beyond the side edges of the first or second jaws. Each band remains attached to the end effector following the firing thereof. The proximal band is removably attachable to a hook feature disposed on one of the first or second jaws of the end effector. The surgical buttress can be made from suitable degradable or non-degradable materials. One embodiment contemplates a detachable and disposable single use loading unit. A method of attaching the surgical buttress to a surgical apparatus is also envisioned.

Abstract: An implantable medical electrical lead includes a plurality of conductors that extend continuously, without any intermediary junctions, between a plurality of electrodes and a corresponding plurality of contact members of an in-line connector terminal. A junction between each conductor and the corresponding contact member is preferably formed by first fitting a conductive sleeve, which is coupled to a proximal portion of the conductor, into an eyelet feature of the contact member, which is mounted on a strut member, and then welding the sleeve to the contact member at a pre-formed slot of the contact member, which extends along an external recessed surface thereof. The assembly of the connector terminal preferably completes the construction of the lead, wherein the proximal portion of each conductor is positioned in a helical path, which extends between an elongate body of the lead and the connector terminal, and along which a grip zone is formed.

Abstract: A loading unit for use with a surgical stapling apparatus is provided and includes a tool assembly having a cartridge assembly and an anvil assembly that are movable in relation to one another; a surgical buttress releasably secured to a tissue contacting surface of the anvil assembly and/or the cartridge assembly, wherein each surgical buttress is secured to the anvil assembly and/or the cartridge assembly by at least one anchor; a release assembly associated with the anvil assembly and/or the cartridge assembly; and a drive assembly slidably translatable through the tool assembly between proximal and distal positions, wherein the drive assembly actuates the release assembly to thereby release the anchor to free the surgical buttress from the anvil assembly and/or the cartridge assembly.

Abstract: A system and method for controlling movement of a vehicle. A current state of the vehicle is identified. The current state comprises a current location of the vehicle. A next state for the vehicle is selected by a processor unit. The next state comprises a next location for the vehicle. A value for an attribute of the next state of the vehicle is randomly selected. The movement of the vehicle is controlled to move the vehicle from the current state to the next state.

Abstract: The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.

Abstract: A staple cartridge includes outer and inner rows of retention slots that are adapted and configured to retain staples. The staple cartridge further includes a staple pusher including a plurality of pusher plates. A staple pusher includes pusher plates that are laterally spaced apart to engage staples within the outer rows of at least three rows of retention slots.

Abstract: An implantable medical electrical lead includes a plurality of conductors that extend continuously, without any intermediary junctions, between a plurality of electrodes and a corresponding plurality of contact members of an in-line connector terminal. A junction between each conductor and the corresponding contact member is preferably formed by first fitting a conductive sleeve, which is coupled to a proximal portion of the conductor, into an eyelet feature of the contact member, which is mounted on a strut member, and then welding the sleeve to the contact member at a pre-formed slot of the contact member, which extends along an external recessed surface thereof. The assembly of the connector terminal preferably completes the construction of the lead, wherein the proximal portion of each conductor is positioned in a helical path, which extends between an elongate body of the lead and the connector terminal, and along which a grip zone is formed.

Abstract: A flex circuit package includes a package body enclosing an electronic component and a first surface of the substrate. Columns are physically and electrically connected to first traces of the substrate, the columns extending through the package body. A flexible circuit connector has first terminals connected to the columns. The flexible circuit connector further includes second terminals that provide an electrical interconnection structure for electrical connection to a second electronic component structure. By connecting the flexible circuit connector to the columns extending through the package body, special routing of traces of the substrate of the flex circuit package to provide an interface for the flexible circuit connector is avoided.

Abstract: A staple cartridge includes outer and inner rows of retention slots that are adapted and configured to retain staples. The staple cartridge further includes a staple pusher including a plurality of pusher plates. A staple pusher includes pusher plates that are laterally spaced apart to engage staples within the outer rows of at least three rows of retention slots.