Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: An asymmetric key cryptographic system is used to generate a cryptographic certificate for authenticating a memory module. This certificate is generated based on information, readable by the authenticator (e.g., host system), from at least one device on the memory module that is not read in order to obtain the certificate. For example, the certificate for authenticating a module may be stored in the nonvolatile memory of a serial presence detect device. The certificate itself, however, is based at least in part on information read from at least one other device on the memory module. Examples of this other device include a registering clock driver, DRAM device(s), and/or data buffer device(s). In an embodiment, the information read from a device (e.g., DRAM) may be based on one or more device fingerprint(s) derived from physical variations that occur naturally, and inevitably, during integrated circuit manufacturing.

Abstract: A memory module comprises an address buffer circuit, a command/address channel, and a plurality of memory components controlled by the address buffer circuit via the command/address channel. At least one memory component comprises a plurality of data ports, a memory core to store data, and a data interface. The data interface is capable of transferring data between the memory core and the data ports. The data interface supports a first data width mode in which the data interface transfers data at a first bit width and a first burst length via the data ports. The data interface also supports a second data width mode in which the data interface transfers data at a second bit width and second burst length via the data ports. The first bit width is greater than the second bit width and the first burst length is shorter than the second burst length.

Abstract: There is described a grindable spherical or substantially spherical culinary bead, comprising at least one comestible powder, a carrier powder, a starter core, a binding agent, at least one essential flavour oil, and a liquid solution. The bead can be ground to provide flavouring to food or beverages. There is also described methods of producing said product.

Abstract: Memory devices, controllers and associated methods are disclosed. In one embodiment, a memory device is disclosed. The memory device includes storage cells that are each formed with a metal-oxide-semiconductor (MOS) transistor having a floating body. Data is stored as charge in the floating body. A transfer interface receives a read command to access data stored in a first group of the storage cells. Sensing circuitry detects the data stored in the first group of storage cells. The transfer interface selectively performs a writeback operation of the sensed data associated with the read command.

Abstract: The invention provides a (drug-containing) lipid nanoparticle with: (i) at least one phospholipid; (ii) at least one lysolipid; and (iii) at least one phospholipid comprising a hydrophilic polymer; and (iv) at least one structural lipid of formula (I) which has the following general structure: wherein R and R? are long hydrocarbyl hydrophobic chains, Y is a linker element, and PHG is a polar head group described as large according to its van der Waals radius, and which is different from the phospholipid (i). The lipid nanoparticle can release a drug (or API) from within the lipid nanoparticle as a result of focused ultrasound (FUS) applied continuously, at least twice, to a desired part of the body to induce hyperthermia (an increase in temperature). FUS is applied after the lipid nanoparticle containing the drug has been administered to the live subject, and causes controlled release of the drug at the desired site of the body.

Abstract: A downhole shunt tube isolation system includes an isolation sleeve housing defining an isolation sleeve chamber and an isolation sleeve moveable within the isolation sleeve chamber between an open position and a closed position. The isolation sleeve has a slurry pathway that fluidically couples a first slurry tube segment to a second slurry tube segment with the isolation sleeve in the open position and fluidically decouples the first slurry tube segment from the second slurry tube segment in the closed position. The downhole shunt tube isolation system further includes a fluid channel in communication with the isolation sleeve chamber. The channel is initially closed to hydraulically lock the isolation sleeve in the open position. Additionally, the downhole shunt tube isolation system includes an actuation mechanism configured to open the fluid channel to hydraulically unlock the isolation sleeve and a biasing member to bias the isolation sleeve to the closed position.

Abstract: A downhole shunt tube isolation system includes an isolation sleeve housing defining an isolation sleeve chamber and an isolation sleeve moveable within the isolation sleeve chamber between an open position and a closed position. The isolation sleeve has a slurry pathway that fluidically couples a first slurry tube segment to a second slurry tube segment with the isolation sleeve in the open position and fluidically decouples the first slurry tube segment from the second slurry tube segment in the closed position. The downhole shunt tube isolation system further includes a fluid channel in communication with the isolation sleeve chamber. The channel is initially closed to hydraulically lock the isolation sleeve in the open position. Additionally, the downhole shunt tube isolation system includes an actuation mechanism configured to open the fluid channel to hydraulically unlock the isolation sleeve and a biasing member to bias the isolation sleeve to the closed position.

Abstract: A memory module comprises an address buffer circuit, a command/address channel, and a plurality of memory components controlled by the address buffer circuit via the command/address channel. At least one memory component comprises a plurality of data ports, a memory core to store data, and a data interface. The data interface is capable of transferring data between the memory core and the data ports. The data interface supports a first data width mode in which the data interface transfers data at a first bit width and a first burst length via the data ports. The data interface also supports a second data width mode in which the data interface transfers data at a second bit width and second burst length via the data ports. The first bit width is greater than the second bit width and the first burst length is shorter than the second burst length.

Abstract: Memory devices, controllers and associated methods are disclosed. In one embodiment, a memory device is disclosed. The memory device includes storage cells that are each formed with a metal-oxide-semiconductor (MOS) transistor having a floating body. Data is stored as charge in the floating body. A transfer interface receives a read command to access data stored in a first group of the storage cells. Sensing circuitry detects the data stored in the first group of storage cells. The transfer interface selectively performs a writeback operation of the sensed data associated with the read command.

Abstract: A method and apparatus according to which a connection between first and second completion joints is made up. The first and second completion joints each include a base pipe and a shunt tube disposed along the base pipe. The respective base pipes of the first and second completion joints are threadably engaged to form a pin and box connection. The shunt tube of the first completion joint is coupled to the shunt tube of the second completion joint using a jumper tube. The jumper tube is supported at a position longitudinally between the respective shunt tubes of the first and second completion joints using a first support member. In some embodiments, the first support member is longitudinally slidable along the base pipe of the first or second completion joint to the position between the respective shunt tubes of the first and second completion joints.

Abstract: A memory module comprises an address buffer circuit, a command/address channel, and a plurality of memory components controlled by the address buffer circuit via the command/address channel. At least one memory component comprises a plurality of data ports, a memory core to store data, and a data interface. The data interface is capable of transferring data between the memory core and the data ports. The data interface supports a first data width mode in which the data interface transfers data at a first bit width and a first burst length via the data ports. The data interface also supports a second data width mode in which the data interface transfers data at a second bit width and second burst length via the data ports. The first bit width is greater than the second bit width and the first burst length is shorter than the second burst length.

Abstract: A well screen for a borehole. The well screen may include an arcuate outer shroud, a mesh layer, and a drainage layer. The arcuate outer shroud may include perforations, a first longitudinal end, and a second longitudinal end. The first and second longitudinal ends may be spaced arcuately apart such that a gap is formed between the first and the second longitudinal ends of the outer shroud. The mesh layer may restrict flow of particulate materials of a predetermined size from passing therethrough and is positioned radially inward from the outer shroud. The mesh layer may include a first and a second longitudinal end that are radially aligned with the first and the second longitudinal ends of the outer shroud to continue the gap. The drainage layer may be positioned radially inward from to the mesh layer and may include at least one of perforations or louvers.

Abstract: This disclosure provides a downhole debris removal apparatus, a method for operating a downhole debris removal apparatus, and a well system including the same. The downhole debris removal apparatus, in one aspect, includes an inner pipe positioned within a tubular, and a filtration member substantially encircling the inner pipe. The downhole debris removal apparatus, in this aspect, further includes a cleaning assembly positioned radially about at least a portion of the filtration member, the cleaning assembly configured to move relative to the filtration member to dislodge particulate matter from the filtration member.

Abstract: Memory devices, controllers and associated methods are disclosed. In one embodiment, a memory device is disclosed. The memory device includes storage cells that are each formed with a metal-oxide-semiconductor (MOS) transistor having a floating body. Data is stored as charge in the floating body. A transfer interface receives a read command to access data stored in a first group of the storage cells. Sensing circuitry detects the data stored in the first group of storage cells. The transfer interface selectively performs a writeback operation of the sensed data associated with the read command.

Abstract: A method and apparatus according to which a connection between first and second completion joints is made up. The first and second completion joints each include a base pipe and a shunt tube disposed along the base pipe. The respective base pipes of the first and second completion joints are threadably engaged to form a pin and box connection. The shunt tube of the first completion joint is coupled to the shunt tube of the second completion joint using a jumper tube. The jumper tube is supported at a position longitudinally between the respective shunt tubes of the first and second completion joints using a first support member. In some embodiments, the first support member is longitudinally slidable along the base pipe of the first or second completion joint to the position between the respective shunt tubes of the first and second completion joints.

Abstract: JACKPOT 2.0 is a means of adding an additional jackpot game to any or all card-based casino games of chance. The invention is novel in that it is the only iteration of it's kind proposing a dynamic and operable change to the front face of a standard deck of cards. The invention uses this broadly described change in embodiments that are modified to suit the preferences of casinos or other game providers.

Abstract: A mobile bin tipper that is configured to receive, lift, and rotate a bin. The mobile bin tipper quickly and efficiently empty the content of bins into larger containers.

Abstract: Systems are provided for logging transactions in heterogeneous networks that include a combination of one or more instrumented components and one or more non-instrumented components. The instrumented components are configured to generate impersonated log records for the non-instrumented components involved in the transaction processing hand-offs with the instrumented components. The impersonated log records are persisted with other log records that are generated by the instrumented components in a transaction log that is maintained by a central logging system to reflect a complete flow of the transaction processing performed on the object, including the flow through the non-instrumented component(s).

Abstract: Systems are provided for logging transactions in heterogeneous networks that include a combination of one or more instrumented components and one or more non-instrumented components. The instrumented components are configured to generate impersonated log records for the non-instrumented components involved in the transaction processing hand-offs with the instrumented components. The impersonated log records are persisted with other log records that are generated by the instrumented components in a transaction log that is maintained by a central logging system to reflect a complete flow of the transaction processing performed on the object, including the flow through the non-instrumented component(s).