Patents by Inventor Lei Duan
Lei Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946002Abstract: Provided is a method for treating an oil gas, which can realize high-efficiency separation for and recovery of gasoline components, C2, C3, and C4 components. The method first conducts separation of light hydrocarbon components from gasoline components, and then performs subsequent treatment on a stream rich in the light hydrocarbon components, during which it is no longer necessary to use gasoline to circularly absorb liquefied gas components, which significantly reduces the amount of gasoline to be circulated and reduces energy consumption throughout the separation process. Besides, in this method, impurities, such as H2S and mercaptans, in the stream rich in the light hydrocarbon components are removed first before the separation for the components. This ensures that impurities will not be carried to a downstream light hydrocarbon recovery section, thus avoiding corrosion issues caused by hydrogen sulfide in the light hydrocarbon recovery section.Type: GrantFiled: June 5, 2020Date of Patent: April 2, 2024Assignees: SINOPEC ENGINEERING INCORPORATION, SINOPEC ENGINEERING (GROUP) CO., LTD.Inventors: Mengqi Huang, Longhong Yu, Lei Wu, Shengyang Jiang, Yuwen Ding, Na Gao, Di Wu, Dan Duan
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Patent number: 11921782Abstract: The present disclosure provides a technical solution of multi-modal chatting, which may provide response to user query by using multi-modal response in the interaction between chatbot and human beings, so that the expressing ways and the expressed content by the chatbot could be richer by using such response in a multi-modal way.Type: GrantFiled: November 1, 2019Date of Patent: March 5, 2024Assignee: Microsoft Technology Licensing, LLCInventors: Nan Duan, Lei Ji, Ming Zhou
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Patent number: 11795475Abstract: Provided are a cell strain HEK293.CS for reducing the production of a replication competent adenovirus, and a construction method and the use thereof. HEK293.CS is a safe adenovirus-producing cell line constructed by knocking out a gene fragment homologous to the Ad5 adenovirus E1 gene in HEK293 and providing a template plasmid to replace said gene fragment with a non-homologous sequence that stabilizes the expression of the E1 gene. Compared with the unmodified HEK293 cell strain, HEK293.CS shows no decrease in growth ability and virus production ability, but does not produce a detectable RCA. HEK293.CS can be used for the mass culture of a recombinant human type 5 adenovirus, and reducing the probability of RCA production in the manufacture process of drugs such as vaccines and antibodies.Type: GrantFiled: March 2, 2020Date of Patent: October 24, 2023Assignee: CANSINO BIOLOGICS INC.Inventors: Tao Zhu, Haiyan Cui, Weiwei Chen, Lei Duan, Junqiang Li, Jin Ma, Chunlin Xin, Zhongqi Shao, Xuefeng Yu, Huihua Mao
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Publication number: 20200255862Abstract: Provided are a cell strain HEK293.CS for reducing the production of a replication competent adenovirus, and a construction method and the use thereof. HEK293.CS is a safe adenovirus-producing cell line constructed by knocking out a gene fragment homologous to the Ad5 adenovirus E1 gene in HEK293 and providing a template plasmid to replace said gene fragment with a non-homologous sequence that stabilizes the expression of the E1 gene. Compared with the unmodified HEK293 cell strain, HEK293.CS shows no decrease in growth ability and virus production ability, but does not produce a detectable RCA. HEK293.CS can be used for the mass culture of a recombinant human type 5 adenovirus, and reducing the probability of RCA production in the manufacture process of drugs such as vaccines and antibodies.Type: ApplicationFiled: March 2, 2020Publication date: August 13, 2020Inventors: Tao ZHU, Haiyan CUI, Weiwei CHEN, Lei DUAN, Junqiang LI, Jin MA, Chunlin XIN, Zhongqi SHAO, Xuefeng YU, Huihua MAO
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Patent number: 10376572Abstract: The invention provides an immunogenic composition for preventing pneumococcal diseases, comprising PspA-MRX1, PspA-EF5668, PspA-EF3296 and PlyL460D, wherein the amount of each component is 10-100 ?g/ml; the immunogenic composition is prepared by adding to aluminum adjuvant the corresponding dosages of the four stock solutions PspA-mRX1, PspA-EF5668, PspA-EF3296 and PlyL460D, and mixing them homogeneously; the immunogenic composition can prevent infection and invasion by Streptococcus pneumonia, covering more than 95% of the strains in clinic. The immunogenic composition has a wide application in the prevention of pneumonia, and is suitable for large-scale production in industry for its simple preparation method, low production cost, and short production cycle.Type: GrantFiled: April 28, 2017Date of Patent: August 13, 2019Assignee: CANSINO BIOLOGICS INC.Inventors: Tao Zhu, Lei Duan, Mingming Yang, Zhongqi Shao, Xuefeng Yu, Helen Huihua Mao, Dongxu Qiu
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Publication number: 20180296660Abstract: The invention provides an immunogenic composition for preventing pneumococcal diseases, comprising PspA-MRXI, PspA-EF5668, PspA-EF3296 and PlyL460D, wherein the amount of each component is 10-100 ?g/ml; the immunogenic composition is prepared by adding to aluminum adjuvant the corresponding dosages of the four stock solutions PspA-mRXI, PspA-EF5668, PspA-EF3296 and PlyL460D, and mixing them homogeneously; the immunogenic composition can prevent infection and invasion by Streptococcus pneumonia, covering more than 95% of the strains in clinic. The immunogenic composition has a wide application in the prevention of pneumonia, and is suitable for large-scale production in industry for its simple preparation method, low production cost, and short production cycle.Type: ApplicationFiled: April 28, 2017Publication date: October 18, 2018Inventors: Tao ZHU, Lei DUAN, Mingming YANG, Zhongqi SHAO, Xuefeng YU, Helen Huihua MAO, Dongxu QIU
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Patent number: 9959579Abstract: Architecture that automatically generate concise descriptions of users in social media. The descriptions communicate classification or category of a given social media user in a small amount of viewing space. The description can be based on available metadata (e.g., user profile biography) and/or other information about that person, as may be obtained from the information data sources (e.g., structured knowledge bases) on networks such as the Internet and enterprises, for example. The descriptions can also be query-dependent, by assuming there is some relationship between the social media user and a query, in which case, the descriptions illustrate that relationship.Type: GrantFiled: March 12, 2013Date of Patent: May 1, 2018Assignee: Microsoft Technology Licensing, LLCInventors: Hemant Purohit, Paul Alexander Dow, Lei Duan, Omar Alonso
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Patent number: 9750728Abstract: A method of treating a patient in need of treatment for a disease selected from the group consisting of cancer, hamartoma syndrome and hereditary myopathy, the method comprising administering to the patient an effective dose of at least one PRCP and PREP dual antagonist pyridine compound of Formula (I) or an acid salt thereof, which can be administered either alone or in combination with at least one mTOR inhibitor.Type: GrantFiled: November 22, 2016Date of Patent: September 5, 2017Assignee: Targeted Therapeutics, LLCInventors: Lei Duan, Victor Levenson, GuoGuang Ying
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Patent number: 9646032Abstract: One or more techniques and/or systems are provided for indexing content based upon index features (e.g., temporal features, user engagement features, and/or outlier features), and/or for providing content within a search result interface based upon such index features and/or rankings. For example, user reaction data associated with content (e.g., a microblog message, a social network post, etc.) may be evaluated to generate a user engagement feature that may be constrained to a time window feature (e.g., the number of shares of a message within the first 10 minutes from publication of the message) to create an index feature for indexing the content within a content index. Responsive to the index feature corresponding to a search query, the content may be provided with search results for the search query. For example, the content may correspond to trending or breaking news associated with the search query.Type: GrantFiled: October 24, 2013Date of Patent: May 9, 2017Assignee: Microsoft Technology Licensing, LLCInventors: Wenbo Wang, Lei Duan
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Publication number: 20170119747Abstract: A method of treating a patient in need of treatment for a disease selected from the group consisting of cancer, hamartoma syndrome and hereditary myopathy, the method comprising administering to the patient an effective dose of at least one PRCP and PREP dual antagonist pyridine compound of Formula (I) or an acid salt thereof, which can be administered either alone or in combination with at least one mTOR inhibitor.Type: ApplicationFiled: November 22, 2016Publication date: May 4, 2017Inventors: Lei Duan, Victor Levenson, GuoGuang Ying
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Patent number: 9545396Abstract: The present invention relates to a pharmaceutical composition of PRCP antagonist, PREP antagonist, or PRCP-PREP dual antagonist. The present invention also relates to a pharmaceutical composition jointly using PRCP antagonist and mTOR antagonist, or jointly using PREP antagonist and mTOR antagonist, or jointly using PRCP-PREP dual antagonist and mTOR antagonist. In addition, the present invention also relates to a method for utilizing the pharmaceutical compositions to treat and prevent cancers and diseases related to insulin receptor substrate protein and PI3K/AKT/mTOR signal pathway.Type: GrantFiled: September 29, 2013Date of Patent: January 17, 2017Assignee: Targeted Therapeutics, LLCInventors: Lei Duan, Victor Levenson, Guoguang Ying
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Patent number: 9514216Abstract: Exemplary methods and apparatuses are provided which may be used for classifying and indexing segmented portions of web pages and providing related information for use in information extraction and/or information retrieval systems. In an embodiment, an index of segmented portions may be used by a search engine to respond to a search query. In an embodiment, one or more machine learned models may be used to identify one or more feature properties of a plurality of segmented portions within one or more files, or otherwise inferable from the one or more files. In an embodiment, one or more machine learned models may be used to classify one or more of a plurality of segmented portions as being at least one of a plurality of segment types.Type: GrantFiled: September 8, 2014Date of Patent: December 6, 2016Assignee: Yahoo! Inc.Inventors: Lei Duan, Fan Li, Srinivas Vadrevu, Emre Velipasaoglu, Swapnil Hajela, Deepayan Chakrabarti
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Patent number: 9196534Abstract: A method for preparing semiconductor devices in a flip chip process comprises forming deep grooves surrounding each of the semiconductor chips; depositing a first plastic package material to form a first plastic package layer covering front surface of the semiconductor wafer and filling the deep grooves; depositing a metal layer at back surface of the semiconductor wafer after grinding; grinding an outermost portion of the metal layer thus forming a ring area located at back surface around edge of the semiconductor wafer not covered by the metal layer; cutting the first plastic package layer, the semiconductor wafer, the metal layer and the first plastic package material filled in the deep grooves along a straight line formed by two ends of each of the deep grooves filled with the first plastic package material; and picking up the semiconductor devices and mounting on a substrate without flipping the semiconductor devices.Type: GrantFiled: February 24, 2013Date of Patent: November 24, 2015Assignee: Alpha and Omega Semiconductor IncorporatedInventors: Yan Xun Xue, Ping Huang, Hamza Yilmaz, Yueh-Se Ho, Lei Shi, Liang Zhao, Ping Li Wu, Lei Duan, Yuping Gong
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Publication number: 20150328197Abstract: The present invention relates to a pharmaceutical composition of PRCP antagonist, PREP antagonist, or PRCP-PREP dual antagonist. The present invention also relates to a pharmaceutical composition jointly using PRCP antagonist and mTOR antagonist, or jointly using PREP antagonist and mTOR antagonist, or jointly using PRCP-PREP dual antagonist and mTOR antagonist. In addition, the present invention also relates to a method for utilizing the pharmaceutical compositions to treat and prevent cancers and diseases related to insulin receptor substrate protein and PI3K/AKT/mTOR signal pathway.Type: ApplicationFiled: September 29, 2013Publication date: November 19, 2015Applicant: TARGETED THERAPEUTICS, LLCInventors: Lei Duan, Victor Levenson, Guoguang Ying
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Patent number: 9104751Abstract: Systems, methods, and computer-readable storage media for presenting supplemental search results having indications that identified documents have been endorsed by the user and/or social network connections of the user are provided. A search query is received and it is determined that the user's social networking data is available. Documents that have been endorsed by the user and/or social network connections of the user are searched to identify those that satisfy the input search query. The satisfying documents are assigned a relevance score to determine whether each satisfying document is relevant enough to be shown and to determine placement of the document on the SERP relative to standard search results. Upon rendering of the SERP, a supplemental search result identifying documents that were endorsed by the user and/or social network connections of the user is presented, as is an indication about which social network connection(s) of the user endorsed the document.Type: GrantFiled: December 30, 2011Date of Patent: August 11, 2015Assignee: MICROSOFT TECHNOLOGY LICENSING, LLCInventors: Yajie Siamwalla, Rajesh Krishna Shenoy, Lei Duan, Satish Kumar Musukula, Charles C. Carson, Jr., Michael Ching
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Publication number: 20150120753Abstract: One or more techniques and/or systems are provided for indexing content based upon index features (e.g., temporal features, user engagement features, and/or outlier features), and/or for providing content within a search result interface based upon such index features and/or rankings. For example, user reaction data associated with content (e.g., a microblog message, a social network post, etc.) may be evaluated to generate a user engagement feature that may be constrained to a time window feature (e.g., the number of shares of a message within the first 10 minutes from publication of the message) to create an index feature for indexing the content within a content index. Responsive to the index feature corresponding to a search query, the content may be provided with search results for the search query. For example, the content may correspond to trending or breaking news associated with the search query.Type: ApplicationFiled: October 24, 2013Publication date: April 30, 2015Applicant: Microsoft CorporationInventors: Wenbo Wang, Lei Duan
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Patent number: 9015174Abstract: A plurality of web documents that include indicators corresponding to one or more selectable like objects may be obtained. A corresponding web domain associated with each of the plurality of obtained web documents may be determined. A domain total like object count of the indicators corresponding to the one or more selectable like objects may be determined for each one of the obtained plurality of web documents, for each determined corresponding web domain. A candidate group of the corresponding web domains may be determined based on a comparison of a predetermined first threshold value with one or more of the domain total like object counts. A likefarm domain confidence score may be determined for each one of a second group of the corresponding web domains based on a decision tree function that is based on a plurality of domain attributes.Type: GrantFiled: December 16, 2011Date of Patent: April 21, 2015Assignee: Microsoft Technology Licensing, LLCInventors: Lei Duan, Will Chin, Seokkyung Chung, Lei Guo, Guenther Schmuelling
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Publication number: 20150066934Abstract: Exemplary methods and apparatuses are provided which may be used for classifying and indexing segmented portions of web pages and providing related information for use in information extraction and/or information retrieval systems.Type: ApplicationFiled: September 8, 2014Publication date: March 5, 2015Inventors: Lei Duan, Fan Li, Srinivas Vadrevu, Emre Velipasaoglu, Swapnil Hajela, Deepayan Chakrabarti
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Patent number: 8849725Abstract: Exemplary methods and apparatuses are provided which may be used for classifying and indexing segmented portions of web pages and providing related information for use in information extraction and/or information retrieval systems.Type: GrantFiled: August 10, 2009Date of Patent: September 30, 2014Assignee: Yahoo! Inc.Inventors: Lei Duan, Fan Li, Srinivas Vadrevu, Emre Velipasaoglu, Swapnil Hajela, Deepayan Chakrabarti
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Patent number: D1019030Type: GrantFiled: October 16, 2021Date of Patent: March 19, 2024Assignee: Beijing Shunzao Technology Co., Ltd.Inventors: Lei Zhao, Chongyue Xu, Cheng Tang, Fei Duan, Liang Zhong