Patents by Inventor Lei Fang

Lei Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11940376
    Abstract: A system for detecting a concentration of free SiO2 in coal dust includes a first sampling tube and a second sampling tube for sampling the coal dust, a three-way control valve communicated with the first sampling tube and the second sampling tube respectively, a photoacoustic spectrometry detection device communicated with the three-way control valve through a connecting pipeline, and a SiO2 reaction tube for reacting SiO2 in the coal dust; and the SiO2 reaction tube is disposed on the second sampling tube. In the present disclosure, a coal dust sampling line is convenient to change by disposing the three-way control valve, and the first sampling tube and the second sampling tube are respectively communicated with the photoacoustic spectrometry detection device, so as to perform a differential accurate detection of the reacted CO content, and to obtain the SiO2 content.
    Type: Grant
    Filed: December 28, 2022
    Date of Patent: March 26, 2024
    Assignee: Anhui University of Science and Technology
    Inventors: Huawei Jin, Fangzheng Yan, Lei Fang
  • Publication number: 20240095563
    Abstract: The present disclosure provides a quantum convolution operator, comprising: a quantum state encoding module, a quantum entanglement module, a quantum convolution kernel module, a measuring module, and a computing module; the quantum state encoding module is configured to encode a current group of input data onto qubits; the quantum entanglement module is configured to associate quantum state information of different qubits; the quantum convolution kernel module is configured to extract feature information corresponding to the quantum state information; the measuring module is configured to measure a quantum state of a preset qubit and obtain a corresponding amplitude; the computing module is configured to compute a convolution result corresponding to the current group of input data according to the measured quantum state and its amplitude.
    Type: Application
    Filed: February 23, 2022
    Publication date: March 21, 2024
    Applicant: ORIGIN QUANTUM COMPUTING TECHNOLOGY (HEFEI) CO., LTD.
    Inventors: Menghan Dou, Yuan Fang, Zhaohui Zhou, Hanchao Wang, Lei Li
  • Patent number: 11926662
    Abstract: Provided are anti-GM-CSF antibodies or fragments thereof including humanized antibodies and fragments. Also provided are uses of the antibodies and fragments for therapeutic, diagnostic and prognostic purposes. Therapeutic uses of the antibodies and fragments, for example include the treatment of inflammatory and autoimmune diseases and disorders.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: March 12, 2024
    Assignee: I-Mab Biopharma (Hangzhou) Co., Ltd.
    Inventors: Zhengyi Wang, Lei Fang, Bingshi Guo, Jingwu Zang
  • Publication number: 20240067036
    Abstract: Disclosed is a charging station capable of realizing mutual capacity aid, which comprises a plurality of charging units, a power bus and a mutual capacity aid bus. Each charging unit is powered by the power bus, and each charging unit provides mutual aid capacity for another charging unit through the mutual capacity aid bus or receives mutual aid capacity from other charging units through the mutual capacity aid bus. The charging station can realize rapid charging of electric vehicles, and can also realize mutual capacity aid.
    Type: Application
    Filed: June 4, 2021
    Publication date: February 29, 2024
    Applicants: JIANGSU ELECTRIC POWER RESEARCH INSTITUTE CO., LTD., STATE GRID JIANGSU ELECTRIC POWER CO., LTD. RESEARCH INSTITUTE
    Inventors: Tiankui SUN, Yubo YUAN, Mingming SHI, Xin FANG, Jinggang YANG, Shuyi ZHUANG, Xiaodong YUAN, Chenyu ZHANG, Lei GAO, Peng LI, Yaojia MA, Shu CHEN, Jing CHEN, Qun LI, Jian LIU
  • Patent number: 11845869
    Abstract: A method for producing a thixotropic curable silicone composition is provided. The curable silicone composition comprises: (A) a silicone base material comprising: an organopolysiloxane having at least two alkoxysilyl-containing groups per molecule and a filler other than fumed silica; (B) a hydrophobic fumed silica; (C) a carbasilatrane derivative; (D) an alkoxysilane or its partial hydrolysis and condensation product; and (E) a condensation reaction catalyst. The method comprises the following steps: (I) mixing components (A) and (B); (II) mixing component (C) with a mixture obtained by step (I); and (III) mixing components (D) and (E) with a mixture obtained by step (II) under free of moisture. The curable silicone composition obtained by the method has an excellent thixotropic property and can cure at room temperature by contact with moisture in air.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: December 19, 2023
    Assignees: DOW SILICONES CORPORATION, DOW TORAY CO., LTD.
    Inventors: Debo Hong, Xiucuo Li, Kazutoshi Okabe, Hiroshi Adachi, Lei Fang, Qi Chen
  • Publication number: 20230323382
    Abstract: Providing a B3 transcription factor gene for simultaneously improving length, strength and elongation of cotton fibers. The cDNA sequence of gene GHFLS in tetraploid upland cotton TM-1 is SEQ ID NO. 1, and the genome sequence is SEQ ID NO. 2; GHFLS contains a non-synonymous mutation SNP, located at 1391 bp of the coding region with the base changing from A to G and the corresponding amino acid changing from Lys to Arg. The GHFLS gene was overexpressed in Arabidopsis thaliana caused a significant reduction in the root length of the T2 generation, demonstrating its important role in the cell elongation mechanism. The fiber quality of the cotton variety (line) with haplotype AA is significantly better than that with haplotype GG. The gene has important research value and application prospect in efficiently identifying high-quality fiber upland cotton varieties, improving cotton fiber quality and cultivating new varieties of high-quality cotton fibers.
    Type: Application
    Filed: May 5, 2023
    Publication date: October 12, 2023
    Inventors: Tianzhen ZHANG, Zegang HAN, Yiwen CAO, Yan HU, Lei FANG
  • Publication number: 20230314308
    Abstract: A system for detecting a concentration of free SiO2 in coal dust includes a first sampling tube and a second sampling tube for sampling the coal dust, a three-way control valve communicated with the first sampling tube and the second sampling tube respectively, a photoacoustic spectrometry detection device communicated with the three-way control valve through a connecting pipeline, and a SiO2 reaction tube for reacting SiO2 in the coal dust; and the SiO2 reaction tube is disposed on the second sampling tube. In the present disclosure, a coal dust sampling line is convenient to change by disposing the three-way control valve, and the first sampling tube and the second sampling tube are respectively communicated with the photoacoustic spectrometry detection device, so as to perform a differential accurate detection of the reacted CO content, and to obtain the SiO2 content.
    Type: Application
    Filed: December 28, 2022
    Publication date: October 5, 2023
    Applicant: Anhui University of Science and Technology
    Inventors: Huawei JIN, Fangzheng YAN, Lei FANG
  • Publication number: 20230314132
    Abstract: Provided is a device for observing and positioning a sharpening angle of a cutting edge. The device includes a spirit bubble for observing a change of a sharpening angle of a cutting edge and positioning the sharpening angle of the cutting edge, and a base for fixing the device on a knife body. The spirit bubble is rotatably connected to the base for adjusting an angle between the spirit bubble and the base. The device enables, in a dynamic process of grinding a cutting edge of a knife, a grinder to continuously remain in a correct sharpening angle range and grind the cutting edge in accordance with a correct sharpening angle of the knife when holding the knife to perform a grinding action, and also meets a requirement for controlling sharpening angles of cutting edges of knives with various edge shapes in respective edge grinding processes of the knives.
    Type: Application
    Filed: March 29, 2023
    Publication date: October 5, 2023
    Inventors: Jianhua Wang, Lei Fang, Xiuying Wang, Liping Ying
  • Publication number: 20230262195
    Abstract: A photographing method and an electronic device The electronic device includes a device body and a camera connected to the device body, and the device body includes a display. The camera collects a video image, obtains a video stream with first resolution based on the video image, and further obtains a photographing stream with second resolution based on the video image. The video stream and the photographing stream are transmitted to the device body through different transmission channels.
    Type: Application
    Filed: July 8, 2021
    Publication date: August 17, 2023
    Inventors: Lei Fang, Yuanying Nie, Xingong Zhang
  • Publication number: 20230219979
    Abstract: Disclosed are a pyrazolo[1,5-a]pyridine compound, a preparation method therefor and a use thereof. Also disclosed is a pharmaceutical composition containing the compound as an active ingredient or a pharmaceutically acceptable salt thereof. The present invention further relates to the use of a compound of formula (I) for treating and preventing diseases that can be treated with wild-type, gene fusion-type and mutant (including but not limited to G804 and G810) RET kinase inhibitors, including diseases or conditions mediated by an RET kinase.
    Type: Application
    Filed: December 11, 2020
    Publication date: July 13, 2023
    Applicant: SHENZHEN ZHONGGE BIOLOGICAL TECHNOLOGY CO., LTD.
    Inventors: Huimin CHENG, Lei FANG, Xiaoming WEN, Zhiqiang LIU, Yu CHEN, Songling MA, Ping CHEN, Zhenzhen QI, Chunyi NIU, Peiyu ZHANG, Lipeng LAI, Jian MA, Shuhao WEN
  • Publication number: 20230192861
    Abstract: The present disclosure provides an anti-PD-L1/anti-B7-H3 multispecific antibody capable to effectively block the interaction between PD-L1 and its receptor PD-1, and suppress the T-cell inhibitory effect of B7-H3 protein. The multispecific antibody may have high binding affinity to both of a PD-L1 protein and a B7-H3 protein.
    Type: Application
    Filed: November 23, 2020
    Publication date: June 22, 2023
    Inventors: Eunsil Sung, Eunyoung Park, Jaehyoung Jeon, Junhyun Jeong, Daehae Song, Sunju Lee, Lei Fang, Wenqing Jiang, Feifei Cui
  • Patent number: 11662301
    Abstract: Disclosed are a mine dust real-time detection system based on double-photoacoustic spectrometry and a detection method. The mine dust real-time detection system based on double-photoacoustic spectrometry includes a first sampling unit, a first photoacoustic detection cavity, a second sampling unit, a second photoacoustic detection cavity, a signal unit and a processing unit; the first sampling unit is used for sampling in respective, the first photoacoustic detection cavity provides a photoacoustic effect field to substances sampled by the first sampling unit, the second sampling unit is used for sampling in respective, the second photoacoustic detection cavity provides the photoacoustic effect field to substances sampled by the second sampling unit, the signal unit is used for providing a laser signal, and the processing unit is used for collecting and processing a photoacoustic signal.
    Type: Grant
    Filed: November 10, 2022
    Date of Patent: May 30, 2023
    Assignee: Anhui University of Science and Technology
    Inventors: Huawei Jin, Lei Fang, Haowei Wang
  • Publication number: 20230159523
    Abstract: The present invention relates to a pyrazolo[1,5-a]pyridine derivative, a preparation method therefor, and a composition and a use thereof. Specifically, the present invention relates to the compound of formula (I) and the use thereof for the treatment and/or prevention of wild type, gene-fusion type (including but not limited to KIF5B, CCDC6 and NCOA4) and mutant type (including but not limited to V804, G810 and M918) RET kinases-related diseases, including diseases or conditions mediated by RET kinase.
    Type: Application
    Filed: April 22, 2021
    Publication date: May 25, 2023
    Applicant: SHENZHEN ZHONGGE BIOLOGICAL TECHNOLOGY CO., LTD.
    Inventors: Huimin CHENG, Xiaoming WEN, Zhiqiang LIU, Lei FANG, Yu CHEN, Yong WEI, Guogang ZHANG, Chuansheng LI, Songling MA, Zhenzhen QI, Ping CHEN, Chunyi NIU, Peiyu ZHANG, Lipeng LAI, Jian MA, Shuhao WEN
  • Patent number: 11635399
    Abstract: The present patent application provides an instrument for mastitis detection and analysis, comprising: a computing module, a conductivity detection module and a temperature sensor; the conductivity detection module is used to detect the conductivity of a sample, and is used to send the detected sample conductivity data to the computing module; the temperature sensor is used to detect the sample temperature, and is used to send the sample temperature data to the computing module; the computing module is used to calculate the received sample conductivity and the sample temperature through a detection algorithm, and is used to detect and analyze the mastitis of the sample through the detection algorithm. The instrument for mastitis detection and analysis is convenient to be carried and easy-to-use, it can be quickly immerged into a milk sample to complete the detection, and the detection result can be obtained quickly.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: April 25, 2023
    Assignee: APTACAM HONG KONG LIMITED
    Inventors: Yang Zhang, Lei Fang
  • Publication number: 20230102289
    Abstract: Provided are fast curing two-part condensation curable silicone compositions which cure by using titanium and/or zirconium based catalysts to generate cured gel materials which are suitable for encapsulating and/or potting electrical and/or electronic articles.
    Type: Application
    Filed: October 22, 2020
    Publication date: March 30, 2023
    Inventors: Lei FANG, Frederic GUBBELS
  • Patent number: 11613577
    Abstract: Provided are anti-CD73 antibodies or fragments thereof. The antibodies or fragments therefore include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. More generally, antibodies or fragments thereof are described which have specificity to one or more amino acid residues selected from the C-terminal half of a human CD73 protein, such as those in the C-terminal domains. Specific epitope amino acids in these domains include Y345, D399, E400, R401 and R480. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer are also provided.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: March 28, 2023
    Assignee: I-MAB
    Inventors: Zhengyi Wang, Lei Fang, Bingshi Guo, Jingwu Zang
  • Publication number: 20230062408
    Abstract: The invention discloses an adaptive path planning method based on neutral networks trained by the evolutional algorithms, the neutral network training method comprises input and output of the data acquired by the mobile sensors installed on the mobile robots as the neutral networks, and training and optimization of the recurrent neutral networks based on the evolutional algorithms; the path planning method refers to the application of the trained neutral networks to the path planning of the mobile robot, the invention effectively improves local quick search capability and global search capability of the algorithms by applying the evolutional algorithms to the optimization of the recurrent neutral networks, so that the robot can plan a rational path in a dense and uncertain environment.
    Type: Application
    Filed: October 18, 2021
    Publication date: March 2, 2023
    Inventors: Yongduan SONG, Lihui TAN, Lei FANG, Shilei TAN, Shuai WANG
  • Patent number: 11579285
    Abstract: The present disclosure provides an intelligent roadside unit. The intelligent roadside unit includes: a radar configured to detect an obstacle within a first preset range of the intelligent roadside unit; a camera configured to capture an image of a second preset range of the intelligent roadside unit; a master processor coupled to the radar and the camera, and configured to generate a point cloud image according to information on the obstacle detected by the radar and the image detected by the camera; and a slave processor coupled to the radar and the camera, and configured to generate a point cloud image according to the information on the obstacle detected by the radar and the image detected by the camera, in which the slave processor checks the master processor, and when the original master processor breaks down, it is switched from the master processor to the slave processor.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: February 14, 2023
    Assignee: BAIDU ONLINE NETWORK TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Lei Fang, Haisong Wang, Xing Hu, Sheng Tao, Yifeng Shi, Huo Cao
  • Patent number: 11542814
    Abstract: A combined telemetry system that can be used while drilling a wellbore consists of a multi-hop telemetry method and a single-hop telemetry method combined in parallel. The multi-hop and single-hop methods can be operated in parallel, for example, so that each telemetry method caries data concurrently from the Measuring-While-Drilling tool located in the Bottom-Hole-Assembly. The multi-hop and single-hop methods can also be operated in series, for example, so that data from the Measuring-While-Drilling tool located in the Bottom-Hole-Assembly are first carried with the single-hop telemetry method and then transferred to the multi-hop telemetry method at one or more node(s) close to the surface. Preferably, the multi-hop telemetry method can also carry data from along-string sensors. Another combined telemetry system that can be used while drilling a wellbore consists of two single-hop telemetry methods combined in parallel.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: January 3, 2023
    Inventors: John Macpherson, Andrew Hawthorn, Lei Fang, John-Peter Van Zelm, Volker Peters, Andreas Peter
  • Patent number: 11535703
    Abstract: The present disclosure relates to synthesis of porous polymer networks and applications of such materials. The present disclosure relates to a method of fabricating of a porous polymer network comprising: (a) providing: (i) a first reactant comprising a plurality of compounds comprising at least one acetyl group, said plurality of compounds comprising at least one compound type, and (ii) a second reactant comprising an alkylsulfonic acid, and (b) creating a solution of said reactants, (c) casting said solution in a form, and (d) treating said solution under such conditions so as to produce a porous polymer network.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: December 27, 2022
    Assignee: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Lei Fang, Zi-Hao Guo, Chenxu Wang, Qiang Zhang, Hong-Cai Zhou