Abstract: Provided are full human anti-PD-L1 antibodies or fragments thereof. In various examples, the antibodies or fragments thereof include a VH CDR1, a VH CDR2, a VH CDR3, a VL CDR1, a VL CDR2, and a VL CDR3 which are selected from sequence groups of SEQ ID NO: 35-42, SEQ ID NO: 43-51, SEQ ID NO: 52-66, SEQ ID NO: 67-79, SEQ ID NO:80-88 and SEQ ID NO: 89-102, respectively, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.

Abstract: The present patent application provides an instrument for mastitis detection and analysis, comprising: a computing module, a conductivity detection module and a temperature sensor; the conductivity detection module is used to detect the conductivity of a sample, and is used to send the detected sample conductivity data to the computing module; the temperature sensor is used to detect the sample temperature, and is used to send the sample temperature data to the computing module; the computing module is used to calculate the received sample conductivity and the sample temperature through a detection algorithm, and is used to detect and analyze the mastitis of the sample through the detection algorithm. The instrument for mastitis detection and analysis is convenient to be carried and easy-to-use, it can be quickly immerged into a milk sample to complete the detection, and the detection result can be obtained quickly.

Abstract: Provided are pharmaceutical compositions each comprising a glycosylation agent, an antibody that binds to human CD47, and a pharmaceutically acceptable carrier. Also provided are novel CD47 antibodies that bind to human CD47, wherein the antibodies bind to at least one epitope that is at one of the glycosylation sites of the CD47 protein of red blood cells (e. g, at least a glycosylation site near the epitope residues Gln31 and Thr34 in CD47).

Abstract: A conductive far-infrared heat-generating fiber and a preparation method therefor. In the process of preparing the conductive far-infrared heat-generating fiber, the preparation method specifically comprises: A) pretreating a matrix fiber, and then drying same; B) impregnating, in a coating liquid of a conductive material, the matrix fiber obtained in step A, and then drying same; and performing step B) at least once, and obtaining the conductive far-infrared heat-generating fiber. The preparation method for the conductive far-infrared heat-generating fiber is simple and can realize good control of resistivity and heat generation.

Abstract: A dimming track lamp has a detachable assembly housing with a power supply track, a control circuit board electrically connected with the power supply track, a lamp body arranged on the assembly housing, a printed circuit board arranged in the lamp body, a light source on the printed circuit board and an optical element arranged in the light output direction of the light source. The control circuit board has a power supply module which is electrically connected with the power supply track, a signal input module, a signal processing module for analyzing and calculating the input signal and generating a control signal, and a signal output module for outputting the control signal to the printed circuit board. The light source has a warm light source and a cold light source, the control signal is used to control the light output of the warm light source and the cold light source.

Abstract: The present disclosure provides an intelligent roadside unit. The intelligent roadside unit includes: a radar, configured to detect an obstacle within a first preset range of the intelligent roadside unit; a camera, configured to capture an image within a second preset range of the intelligent roadside unit; a radar-signal processor, coupled to the radar and configured to generate an obstacle detection signal according to obstacle information detected by the radar; an image-signal processor, coupled to the camera and configured to generate an image detection signal according to the image captured by the camera; and a general control processor, coupled to the radar-signal processor and the image-signal processor and generating a point cloud image according to the obstacle detection signal and the image detection signal.

Abstract: A computer system and a memory access technology are provided. In the computer system, when load/store instructions having a dependency relationship is processed, dependency information between a producer load/store instruction and a consumer load/store instruction can be obtained from a processor. A consumer load/store request is sent to a memory controller in the computer system based on the obtained dependency information, so that the memory controller can terminate a dependency relationship between load/store requests in the memory controller locally based on the dependency information in the received consumer load/store request, and execute the consumer load/store request.

Abstract: The present disclosure relates to synthesis of porous polymer networks and applications of such materials. The present disclosure relates to a method of fabricating of a porous polymer network comprising: (a) providing: (i) a first reactant comprising a plurality of compounds comprising at least one acetyl group, said plurality of compounds comprising at least one compound type, and (ii) a second reactant comprising an alkylsulfonic acid, and (b) creating a solution of said reactants, (c) casting said solution in a form, and (d) treating said solution under such conditions so as to produce a porous polymer network.

Abstract: Provided are bispecific antibodies capable of binding to human CD73 protein and human PD-L1 protein. These bispecific antibodies are effective in treating cancer.

Abstract: A combined telemetry system that can be used while drilling a wellbore consists of a multi-hop telemetry method and a single-hop telemetry method combined in parallel. The multi-hop and single-hop methods can be operated in parallel, for example, so that each telemetry method caries data concurrently from the Measuring-While-Drilling tool located in the Bottom-Hole-Assembly. The multi-hop and single-hop methods can also be operated in series, for example, so that data from the Measuring-While-Drilling tool located in the Bottom-Hole-Assembly are first carried with the single-hop telemetry method and then transferred to the multi-hop telemetry method at one or more node(s) close to the surface. Preferably, the multi-hop telemetry method can also carry data from along-string sensors. Another combined telemetry system that can be used while drilling a wellbore consists of two single-hop telemetry methods combined in parallel.

Abstract: A method for accessing a non-volatile memory comprises that an NVM controller receive a first access request from a processor and determines whether the first access request is used to access a page table. If the first access request is used to access the page table, the NVM controller obtains an AIT entry by reading a page table entry indicated by the first address information and caches the AIT entry to an AIT cache. The NVM controller monitors access of the processor to the page table, prefetches the to-be-accessed AIT entry.

Abstract: The present disclosure provides antibodies and fragments thereof having specificity to a human T cell immunoreceptor with Ig and ITIM domains (TIGIT) protein. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and viral infections are also provided.

Abstract: Provided are a vehicle positioning method, an apparatus and a device. The method includes: sending an auxiliary positioning request to an auxiliary positioning device within a preset distance range; receiving an auxiliary positioning message returned by the auxiliary positioning device with respect to the auxiliary positioning request, where the auxiliary positioning message carries location information of the auxiliary positioning device; and determining a current location of a current vehicle according to the location information of the auxiliary positioning device and distance information between the current vehicle and the auxiliary positioning device. The method of the present disclosure can implement vehicle positioning without a satellite positioning signal. The vehicle positioning can be performed when the vehicle is blocked by an obstacle such as a tunnel, a building and the satellite positioning signal cannot be received, improving the accuracy of the vehicle positioning.

Abstract: The present invention provides fusion proteins containing cytokines and novel CD47 antibodies or immunologically active fragments thereof, as well as pharmaceutical compositions containing such fusion proteins that can be used for treatment diseases mediated by CD47 or inhibition of phagocytosis or platelet aggregation. These fused proteins have low immunogenicity in humans and cause low or no level of red blood cell depletion or hemagglutination.

Abstract: Systems and methods for adjusting a drilling operation, the methods and systems include obtaining, at a control system, a first drilling characteristic associated with a first drilling operation device that is part of a drilling system on a drill string; obtaining, at the control system, a second drilling characteristic associated with a second drilling operation device located apart from the first drilling operation device along the drill string; and controlling, with the control system, at least one adjustable element of the first drilling operation device in response to at least one of the obtained first drilling characteristic and the second drilling characteristic, wherein adjustment of the at least one adjustable element causes a change in at least one of the first drilling characteristic and the second drilling characteristic.

Abstract: Provided are anti-GM-CSF antibodies or fragments thereof including humanized antibodies and fragments. Also provided are uses of the antibodies and fragments for therapeutic, diagnostic and prognostic purposes. Therapeutic uses of the antibodies and fragments, for example include the treatment of inflammatory and autoimmune diseases and disorders.

Abstract: The present disclosure relates to synthesis of porous polymer networks and applications of such materials. The present disclosure relates to a method of fabricating of a porous polymer network comprising: (a) providing: (i) a first reactant comprising a plurality of compounds comprising at least one acetyl group, said plurality of compounds comprising at least one compound type, and (ii) a second reactant comprising an alkylsulfonic acid, and (b) creating a solution of said reactants, (c) casting said solution in a form, and (d) treating said solution under such conditions so as to produce a porous polymer network.

Abstract: The present invention provides novel CD47 antibodies or immunologically active fragments thereof that have low immunogenicity in humans and cause low or no level of red blood cell depletion or hemagglutination, as well as pharmaceutical compositions containing such antibodies that can be used for treatment diseases mediated by CD47 or inhibition of phagocytosis or platelet aggregation.

Abstract: A method of forming a casing window in a casing tubular includes introducing a bottom hole assembly (BHA) into a casing tubular, running the bottom hole assembly to a selected position in the casing tubular, directing an ultrasonic wave from the BHA toward the casing tubular, receiving a reflection of the ultrasonic wave at the BHA, and evaluating the reflection of the ultrasonic wave to determine one or more parameters associated with the casing tubular and supporting structure.

Abstract: The present disclosure provides antibodies and fragments thereof having specificity to a human T cell immunoreceptor with Ig and ITIM domains (TIGIT) protein. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and viral infections are also provided.