Abstract: Provided herein are heavy chain constant regions (referred to as “modified heavy chain constant regions”), or functionally equivalent fragments thereof, that enhance biological properties of antibodies relative to the same antibodies in unmodified form. An exemplary modified heavy chain constant region includes an IgG2 hinge and three constant domains (i.e., CH1, CH2, and CH3 domains), wherein one or more of the constant region domains are of a non-IgG2 isotype (e.g., IgG1, IgG3 or IgG4). The heavy chain constant region may comprise wildtype human IgG domain sequences, or variants of these sequences. Also provided herein are methods for enhancing certain biological properties of antibodies that comprise a non-IgG2 hinge, such as internalization, agonism and antagonism, wherein the method comprises replacing the non-IgG2 hinge of the antibody with an IgG2 hinge.

Abstract: A wave energy conversion device mainly includes a pair of one-way flow guiding grates, a hydropower turbine, and a housing containing the above mentioned items. An inlet chamber and an outlet chamber are provided within the housing. The inlet chamber has a first opening, and the outlet chamber has a second opening. Both the first and the second openings are oriented generally facing a front of the device toward incoming waves. The first and second openings are also oriented such that the first and second openings face each other with an angle ranging from 30 degrees (including 30 degrees) to 180 degrees, forming a transverse V-shape in a longitudinal cross-section of the housing. A first one-way flow guiding grate is installed on the first opening, and a second one-way flow guiding grate is installed on the second opening.

Abstract: An endpoint detection system for enhanced spectral data collection is provided. An optical bundle is coupled to a light source configured to generate incident light. The optical bundle includes two or more sets of optical fibers that each include an emitting optical fiber and a receiving optical fiber. The receiving optical fibers are disposed within the optical bundle at a pairing angle relative to a respective emitting optical fiber. The optical bundle is also coupled to a collimator assembly that includes an achromatic lens. The achromatic lens receives a first light beam of incident light from a first emitting optical fiber and directs spectral components of the first light beam to a first and second portion of a surface of a substrate. The first portion of the substrate surface is substantially the same as the second portion. The achromatic lens collects reflected spectral components that are produced by the spectral components directed to the first and second portions of the substrate surface.

Abstract: Disclosed are a computer-implemented method, a system and a computer program product for feature processing. In the computer-implemented method for feature processing, two input features selected from multiple features of each sample in a sample set are projected to one resulting feature by one or more processing units based on a specified curve. The sample set is updated by replacing the two input features with the one resulting feature for each sample in the sample set by one or more processing units. The projecting and the updating for the sample set are repeated by one or more processing units until the number of features of each sample in the sample set reaches a predetermined criterion.

Abstract: The present application relates to the field of lifting equipment, in particular to a crane and a control method thereof.

Abstract: The present application provides an instruction encoding-based data processing method and apparatus, and a device. N-path error correction encoding is performed on an instruction in information to be processed to obtain N encoded instructions, the encoded instructions and encoded meta channel programs obtained by the error correction encoding are used to perform redundant processing on data to be processed to obtain N pieces of response data, and then error correction decoding is performed on the N pieces of response data to obtain processing result information of the information to be processed. Because the N encoded instructions are heterogeneous and the encoded meta channel programs used in the N-path processing are heterogeneous, the randomness of the processing process can be improved, generalized disturbance in the data processing process can be corrected in combination with the error correction encoding and decoding methods, and thus the security of data processing is improved.

Abstract: The present invention relates to a method for screening mobile terminal visual attention abnormalities in children based on multimodal data learning. A calibration video and a testing video are set up, and a head-face video of children while watching the calibration video and the testing video on smartphones is recorded, respectively. An eye-tracking estimation model is constructed to predict the fixation point location from the head-face video corresponding to the testing video frame by frame and to extract the eye-tracking features. Facial expression features and head posture features are extracted. A Long Short-Term Memory (LSTM) network is used to fuse different modal features and realize the mapping from multimodal features to category labels. In the testing stage, the head-face video of children to be classified while watching the videos on smartphones is recorded, and the features are extracted and input into the post-training model to determine whether they are abnormal.

Abstract: A method for remotely shutting down a downhole unit of a rotary steering system from ground includes steps of: a: calculating a pressure difference P1 between a front end and a rear end of the drill water hole; b: calculating an extension loss ?P; c: calculating a pressure P2 at the riser after turning on the downlink device; d: calculating an opening area S1 of the throttle valve of the downlink device; and e: adjusting the throttle valve to a calculated opening degree; automatically targeting the function block that needs to be cut off according to a flow change detected downhole, and shutting down the downhole unit. The method can realize self-protection and continuous operation of the entire rotary steering system, reduce frequency of inspection that needs to pull back the drill when the rotary steering system is abnormal, improve drilling efficiency, and reduce costs.

Abstract: Embodiments of this application disclose a data protection method and system, a medium, and an electronic device, and belong to the field of communication technologies. In embodiments of this application, a first electronic device establishes a communication connection to a second electronic device. The first electronic device is a trusted device of the second electronic device. When detecting a first trigger condition, the first electronic device sends first data to the second electronic device. The first data is used to trigger the second electronic device to enter a maintenance mode. According to embodiments of this application, the first electronic device triggers the second electronic device to enter the maintenance mode, to protect data of the electronic devices.

Abstract: A constant current generation circuit for optocoupler isolation amplifier and a current precision adjustment method are provided. The constant current generation circuit includes a start circuit, a current generation circuit and a precision adjustment and output circuit integrated into a same substrate. The start circuit can generate and output a first start current and a second start current. The current generation circuit includes a negative temperature change rate current generation circuit connected to a first start current output and a positive temperature change rate current generation circuit connected to a second start current output. The precision adjustment and output circuit outputs constant current meeting application requirements of optocoupler isolation amplifier by adjusting proportional precision of two currents output from a current generation circuit.

Abstract: A method includes selecting N cells waiting to be camped on from a candidate cell list, decoding a Physical Broadcast Channel (PBCH) of each of the selected N cells waiting to be camped on, selecting, from at least one cell whose PBCH is successfully decoded, one cell as a cell continuing waiting to be camped on, and when a remaining minimum system information (RMSI) decoding result of the cell continuing waiting to be camped on indicates that the cell continuing waiting to be camped on meets a camping criterion, determining the cell continuing waiting to be camped on as the cell to be camped on.

Abstract: This application describes examples of a data processing method and apparatus. In one example, the method includes: If a target buffer that is corresponding to a target priority and that is on a network device reaches a first threshold, the network device sends a pause message to an upstream device, so that the upstream device stops sending a first data packet corresponding to the target priority. If a duration in which the network device stops buffering a second data packet is greater than a preset duration, and the target buffer falls back below a second threshold, the network device sends a sending resumption message to the upstream device, so that the upstream device sends a third data packet corresponding to the target priority.

Abstract: A multilayered rail guide vehicle system for use in three-dimensional planting in a plant factory and a control method therefor, the system includes an upper computer, cultivation shelves, traveling devices, lifting devices, and an electric control system. The traveling devices and the lifting devices are arranged in a body of a rail guide vehicle. The upper computer is in wireless communication with the electric control system. A nutrient solution tank is arranged on each of the cultivation shelves, and a plurality of cultivation positions are arranged on the nutrient solution tank. The electric control system is arranged in the body of the rail guide vehicle, so as to obtain an operation mode and target information after receiving a task instruction transmitted by the upper computer, select and switch a positioning mode, and drive the traveling devices and the lifting devices to perform traveling and lifting positioning according to operation procedures.

Abstract: The invention belongs to the field of welding technology and discloses a CMT automatic overlaying method for opening in side wall of bimetallic composite pipes. The method includes: establishing a mathematical model of the opening in a side wall to be welded; Based on the mathematical model, determining the trajectory of the saddle line during overlaying; dividing the trajectory of the saddle line into several welding runs, all of which adopt the downslope welding process; establishing a three-dimensional model of the opening in the side wall to be welded and a CMT overlaying system simulation model; Based on the simulation model, planning the overlaying path of the CMT overlaying, and generating an overlaying offline instruction; Based on the offline instruction, performing CMT overlaying on the opening in the side wall to be welded according to the overlaying sequence, so as to obtain a weld overlay.

Abstract: Provided are a non-aqueous electrolyte and a preparation method thereof, and a secondary battery and an electric apparatus containing the same. The non-aqueous electrolyte contains a non-aqueous solvent and lithium ions, first cations, and first anions dissolved therein, where the first cation is a metal cation Men+ other than the lithium ion, n representing a chemical valence of the metal cation; the first anion is a difluoroxalate borate anion DFOB?; mass concentration of the first cations in the non-aqueous electrolyte is D1 ppm, and mass concentration of the first anions in the non-aqueous electrolyte is D2 ppm, both based on total mass of the non-aqueous electrolyte; and the non-aqueous electrolyte satisfies that D1 is 0.5 to 870 and that D1/D2 is 0.02 to 2. The non-aqueous electrolyte in this application enables the secondary battery to have good cycling performance, safety performance, and kinetic performance.

Abstract: The present disclosure discloses an earphone. The earphone may include a hook-shaped component, a connecting component, and a holding component. When the earphone is in a wearing state, the hook-shaped component may be configured to hang between a rear side of an ear of a user and a head of the user. The holding component may be configured to contact a front side of the ear. The connecting component may be configured to connect the hook-shaped component and the holding component and extend from the head to an outside of the head to cooperate with the hook-shaped component to provide the holding component with a pressing force on the front side of the ear.

Abstract: Provided are a current transaction method, system and apparatus based on a blockchain. The solution is: receiving types of service requests related to medication usage data of different users, and acquiring first money corresponding to the types of service requests of the different users, wherein the first money is obtained by performing medication rationality analysis on the medication usage data of the users; determining second money in a blockchain reward pool corresponding to the first money, according to the first money corresponding to the types of service requests of the different users; and completing a transfer of the second money and completing a transaction by means of a smart contract mechanism, wherein the transfer is used for representing that the second money is issued to the users in a reward manner, and an aim of the transaction is in exchange for an article or a service.

Abstract: The disclosure provides an ultrasonic signal detection circuit including a sensing circuit, a unidirectional conduction circuit and a source follower circuit. The sensing circuit is connected to an input terminal of the source follower circuit through the unidirectional conduction circuit; the sensing circuit is configured to generate a piezoelectric signal according to a received ultrasonic echo signal and output the piezoelectric signal to the unidirectional conduction circuit. The piezoelectric signal is an alternating current signal; the unidirectional conduction circuit is configured to rectify the alternating current signal to only allow a forward or a reverse current portion thereof to pass through. The forward/reverse current portion charges/discharges the input terminal of the source follower circuit after passing through the unidirectional conduction circuit.

Abstract: A cut resistant fabric and a method of manufacturing a cut resistant fiber is disclosed herein. The fabric comprises a Ultra High Molecular Weight Polyethylene (UHMWPE) material and a sheet shaped wollastonite filler. The sheet shaped wollastonite filler is treated with a coupling agent and mixed with the UHMWPE material. A thickness of the sheet shaped wollastonite filler is less than 10 micrometers (?m). The method comprises providing the sheet shaped wollastonite filler having a thickness of less than 10 ?m and treating the sheet shaped wollastonite filler with a coupling agent at a first predefined temperature to obtain a uniform solution. The method further comprises mixing the uniform solution with a fiber solution comprising UHMWPE resin at a second predefined temperature.

Abstract: A first communication apparatus obtains a sampling cycle. The sampling cycle is a time interval at which the first communication apparatus samples occupancy of a first buffer. The first buffer is used to store a data packet of a first priority. The first communication apparatus determines occupancy of the first buffer at a first sampling moment based on the sampling cycle. The first communication apparatus determines first duration based on the sampling cycle and the occupancy of the first buffer at the first sampling moment. The first duration is duration for which a second communication apparatus stops sending data to the first communication apparatus. The first communication apparatus sends first indication information to the second communication apparatus based on the first duration.