Abstract: The present disclosure describes a PTPN2/PTP1B degrader compounds having the structure of Formula (I), that are useful for treating PTPN2/PTP1B-mediated disorders or conditions,

Abstract: Provided is a polypeptide combination, a targeting component thereof comprising a shielding peptide, a cleavable part, an antigen-binding part and a first intein fragment, the shielding peptide and the antigen-binding part being connected by means of the cleavable part, and the antigen-binding part being directly or indirectly connected to the first intein fragment; a toxin component thereof comprises a second intein fragment and a toxin, and the second intein fragment is directly or indirectly connected to the toxin; the targeting component and the toxin component form an immunoconjugate by means of the interactive action between the first intein fragment and the second intein fragment; in the immunoconjugate, the shielding peptide and the antigen-binding part are connected by means of the cleavable part, and the antigen-binding part is connected to the toxin. Also provided are a preparation method and a pharmaceutical use for the polypeptide combination.

Abstract: A process and a device for continuous flow side-chain alkylation which relate to the technical field of organic synthesis. In this process and the device for continuous flow side-chain alkylation, an ibuprofen raw material is prepared with alkylbenzene as a raw material. This raw material alkylbenzene is easily available and has a low cost, and is suitable for scale-up production. Moreover, an entire preparation process adopts continuous chemical synthesis, and a reaction time of each stage can be precisely controlled, which is beneficial to control a total reaction time and reduce an amount of impurities produced. In this way, a purity and a yield of the ibuprofen raw material are improved. In summary, a continuous synthesis method for side-chain alkylation of alkylbenzene provided by the present disclosure shows a low cost and a high yield.

Abstract: Apparatuses and associated methods of manufacturing are described that provide for an anti-bacterial fiber. The method of manufacturing includes adding a ultra-high molecular weight polyethylene structure into an extrusion device. The method of manufacturing also includes providing an anti-bacterial low-density polyethylene (LDPE) into the ultra-high molecular weight polyethylene at a predetermined temperature to create a combined filament. The method of manufacturing further includes passing the combined filament through a bath. The bath is configured for coagulating the combined filament and extracting a solvent. The method of manufacturing still further includes drying the combined filament via an oven. The method of manufacturing also includes hot-drawing the combined filament. The combined filament is heated during the hot-drawing within the oven and the combined filament generated has anti-bacterial qualities. A corresponding anti-bacterial fiber is also provided.

Abstract: This application provides a flow rate control method and apparatus. The flow rate control method in this application includes: receiving N explicit congestion notification packets CNPs from a first device, where the N CNPs correspond to a first data flow, and N is a natural number; and sending M CNPs to a second device based on the N CNPs, where the M CNPs correspond to the first data flow, and M is an integer greater than N. This application resolves a problem that rate increase processing is still performed on a data flow when the data flow is congested.

Abstract: A wave energy conversion device mainly includes a pair of one-way flow guiding grates, a hydropower turbine, and a housing containing the above mentioned items. An inlet chamber and an outlet chamber are provided within the housing. The inlet chamber has a first opening, and the outlet chamber has a second opening. Both the first and the second openings are oriented generally facing a front of the device toward incoming waves. The first and second openings are also oriented such that the first and second openings face each other with an angle ranging from 30 degrees (including 30 degrees) to 180 degrees, forming a transverse V-shape in a longitudinal cross-section of the housing. A first one-way flow guiding grate is installed on the first opening, and a second one-way flow guiding grate is installed on the second opening.

Abstract: The invention provides an induced polarization method and system mounted on a while drilling-type drill rig based on a long-length power source for water detection in tunnels, wherein the IP system comprises a long-length power source module for power supply while drilling, comprising a long-length power source and an electrode being a drill pipe of the while drilling-type drill rig; an array-type data collection module; and, a positioning and interpretation module, that may interpret and image data induced separately when a point power source is located near a drill bit at a current time obtained by differentiating an IP signal for water detection in tunnel at the current time from an IP signal for water detection in the tunnel at a previous time, to realize a dynamic identification of hazardous water sources in front of the tunnel face, and the detection while drilling or multi-detection while drilling.

Abstract: A motor controller includes a measurement interface configured to measure a mechanical angle of a shaft driven by a motor and a rotational speed of the shaft, and generate a speed feedback signal representative of the rotational speed, a speed regulator, and a current regulator. The speed regulator includes an error component configured to generate a speed error signal based on a difference between a speed reference signal and the speed feedback signal; a proportional integral controller configured to, based on the speed error signal, regulate a torque reference value that is configured to sustain a speed reference value; and a load torque ripple compensator configured to apply a torque feedforward function to reduce a load torque ripple in the torque reference value. The current regulator is configured to drive motor currents of the motor for generating a torque corresponding to the torque reference value.

Abstract: A formulation, comprising erythropoietin, a buffer ingredient, a surfactant and an osmotic pressure regulator. The present invention also relates to a method for preparing the formulation and the use of the formulation. The formulation is safe and stable and has a long validity period, and the preparation method is simple and easy to implement.

Abstract: This application provides a flow rate control method and apparatus. The flow rate control method in this application includes: receiving N explicit congestion notification packets CNPs from a first device, where the N CNPs correspond to a first data flow, and N is a natural number; and sending M CNPs to a second device based on the N CNPs, where the M CNPs correspond to the first data flow, and M is an integer greater than N. This application resolves a problem that rate increase processing is still performed on a data flow when the data flow is congested.

Abstract: In embodiments of this application, a key is divided into a plurality of key fields. Then, a corresponding first bit is determined from a BT based on a first key field in a front part. Finally, a target BB is determined, based on a second key field in a rear part, from a plurality of BBs corresponding to the first bit. In this way, for keys having a same first key field, a plurality of same BBs can be located through the BT.

Abstract: A method and apparatus for constructing a drug knowledge graph are provided. The method may include: identifying entities in a drug text; replacing medical key entities among the entities with character strings that conform to a preset rule, to obtain a replaced text; restoring the character strings in a word segmentation result, determined based on the replaced text, to the medical key entities replaced by the character strings; forming a linear entity relationship between the entities based on the entities; and generating a drug knowledge graph according to a parsing result obtained by syntactically parsing the linear entity relationship.

Abstract: This application discloses a wireless communication method, apparatus, and system, to ensure service quality of terminal communication in a non-standalone (NSA) networking architecture. The wireless communication method includes starting, by a terminal, radio resource control (RRC) connection establishment with a new radio (NR) cell based on an indication of a network device, and starting a timer based on a quantity of RRC connection establishment failures of the NR cell. The timer is set to a first duration. Within the first duration, when the network device indicates to the terminal to report measurement results of the NR cell and another cell, the terminal only reports the measurement result of the other cell, not the measurement result of the NR cell.

Abstract: Embodiments of the present disclosure provide a packet processing method and a network device, so as to effectively resolve a problem that a quantity of concurrent packet processing policies is limited in a network device due to scarce hardware resources of a packet forwarding chip. A method part in the embodiments of the present disclosure includes: obtaining, by a first network device, identification information; processing, by the first network device, a packet when receiving the packet, where a processed packet includes the identification information, and packets corresponding to different preset policy information include different identification information; and sending, by the first network device, the processed packet to a second network device, so that the second network device matches a corresponding policy for the processed packet based on the identification information.

Abstract: A parameter adjustment method and apparatuses are provided. The method includes: a first exploration device corresponding to a first service node receives a first parameter set from a management device, where the first parameter set includes one or more parameters used by the first exploration device to perform parameter adjustment, the first service node is any one of a plurality of service nodes included in a data center network, and the plurality of service nodes one-to-one correspond to a plurality of exploration devices. The first exploration device obtains a network status of the first service node based on each parameter adjustment until the network status reaches a preset condition, where each parameter adjustment includes: adjusting one parameter in the first parameter set. The parameter is flexibly adjusted based on the network status, to be applicable to different services.

Abstract: A white nanozymes test strip includes a substrate, an organic developer, and a manganese-based metal-organic framework nanozyme is provided, the manganese-based metal-organic framework nanozymes and the organic developer are fixed on the substrate. The present invention uses a white nanozymes test strip as described above, which is inexpensive, simple to prepare and high stability, can resist the interference of oxygen, and the test results are easier to observe, solving the problem that the color development results of colored nanomaterials are not easy to observe, thus improving the detection sensitivity.

Abstract: A word mining method and apparatus, an electronic device and a readable storage medium are disclosed. The method includes: acquiring search data; taking first identification information, a search sentence and second identification information in the search data as nodes, and taking a relationship between the first identification information and the search sentence, a relationship between the first identification information and the second identification information and a relationship between the search sentence and the second identification information as sides to construct a behavior graph; obtaining a label vector of each search sentence in the behavior graph according to a search sentence with a preset label in the behavior graph; determining a target search sentence in the behavior graph according to the label vector; and extracting a target word from the target search sentence, and taking the target word as a word mining result of the search data.

Abstract: Embodiments provide clock synchronization methods and control systems. In some embodiments a control system includes a first controller and a second controller. In some embodiments the first controller includes a first clock unit and a second clock unit, and the second controller includes a third clock unit. In some embodiments, a clock of the first clock unit may be different from a clock of the third clock unit, and a clock of the second clock unit may be the same as the clock of the third clock unit. In some embodiments, a method includes the first controller and the second controller add a timestamp to sensor data by using a first clock. In some embodiments the first clock is the clock of the first clock unit or the clock of the third clock unit.

Abstract: Embodiments of this application disclose a communication method, and may be applied to a scenario such as switch networking (for example, high-performance computing HPC), the industrial Ethernet, or the like. The method includes: receiving first information sent by a second device, where the first information indicates a second MAC frame length supported by the second device; determining a third MAC frame length based on a first media access control MAC frame length and the second MAC frame length, where the first MAC frame length is a MAC frame length supported by the first device, and the first MAC frame length is the same as or different from the second MAC frame length; and communicating with the second device based on the third MAC frame length.