Patents by Inventor Lei S. Qi

Lei S. Qi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210062227
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 4, 2021
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, P.C. Dave P. Dingal
  • Publication number: 20210024924
    Abstract: Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.
    Type: Application
    Filed: March 4, 2020
    Publication date: January 28, 2021
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Intima Bioscience, Inc.
    Inventors: Lei S. Qi, Modassir S. Choudhry, Xueqiu Lin, Xiaoshu Xu
  • Publication number: 20200157611
    Abstract: Provided herein is technology relating to biological imaging and diagnostics and particularly, but not exclusively, to methods, systems, kits, and compositions for imaging, detecting, and isolating biological samples using a ribonucleoprotein.
    Type: Application
    Filed: June 4, 2018
    Publication date: May 21, 2020
    Inventors: Lei S. Qi, Haifeng Wang
  • Publication number: 20200071729
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Application
    Filed: September 13, 2019
    Publication date: March 5, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, P.C. Dave P. Dingal
  • Publication number: 20190345220
    Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.
    Type: Application
    Filed: May 16, 2019
    Publication date: November 14, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, Bing C. Wang
  • Patent number: 10457961
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 29, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Lei S. Qi, P. C. Dave P. Dingal
  • Patent number: 10336807
    Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, Bing C Wang
  • Publication number: 20180346543
    Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.
    Type: Application
    Filed: July 6, 2018
    Publication date: December 6, 2018
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, Bing C Wang
  • Publication number: 20180273980
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Application
    Filed: November 8, 2017
    Publication date: September 27, 2018
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, P.C. Dave P. Dingal
  • Publication number: 20180016601
    Abstract: Provided herein are methods and kits for modulating genome editing of target DNA. The invention includes using small molecules that enhance or repress homology-directed repair (HDR) and/or nonhomologous end joining (NHEJ) repair of double-strand breaks in a target DNA sequence. Also provided herein are methods for preventing or treating a genetic disease in a subject by enhancing precise genome editing to correct a mutation in a target gene associated with the genetic disease. Further provided herein are systems and methods for screening small molecule libraries to identify novel modulators of genome editing. The present invention can be used with any cell type and at any gene locus that is amenable to nuclease-mediated genome editing technology.
    Type: Application
    Filed: July 13, 2017
    Publication date: January 18, 2018
    Inventors: Lei S. Qi, Sheng Ding, Chen Yu
  • Patent number: 9856497
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: January 2, 2018
    Assignee: The Board of Trustee of the Leland Stanford Junior University
    Inventors: Lei S. Qi, P. C. Dave P. Dingal
  • Patent number: 9745610
    Abstract: The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: August 29, 2017
    Assignee: The Regents of the University of California
    Inventors: Jennifer A. Doudna, Lei S. Qi, Rachel E. Haurwitz, Adam P. Arkin
  • Publication number: 20170219596
    Abstract: Methods, compositions, and kits are provided for imaging a polypeptide of interest. Methods, compositions, and kits are also provided for site-specific transcriptional regulation of one or more genetic elements.
    Type: Application
    Filed: July 14, 2015
    Publication date: August 3, 2017
    Inventors: Marvin E Tanenbaum, Luke A Gilbert, Lei S Qi, Jonathan S. Weissman, Ronald D Vale
  • Publication number: 20170204407
    Abstract: Methods, compositions, and kits are provided for CRISPR/Cas mediated transcriptional modulation.
    Type: Application
    Filed: July 14, 2015
    Publication date: July 20, 2017
    Inventors: Luke A GILBERT, Max HORLBECK, Martin KAMPMANN, Lei S QI, Jonathan S WEISSMAN
  • Publication number: 20170198308
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Application
    Filed: January 10, 2017
    Publication date: July 13, 2017
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: LEI S. QI, P.C. DAVE P. DINGAL
  • Patent number: 9593338
    Abstract: Provided herein are nucleic acid constructs that contain a synthetic control element that includes a cis-regulator of translation, and an adapter translation-coupled regulator of transcription. Further provided herein are nucleic acid constructs that contain nucleic acid sequences under the control of the synthetic control elements. Also provided are compositions and methods related to the nucleic acid constructs.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: March 14, 2017
    Assignee: The Regents of the University of California
    Inventors: Chang Liu, Adam P. Arkin, Lei S. Qi
  • Publication number: 20150011007
    Abstract: Provided herein are nucleic acid constructs that contain a synthetic control element that includes a cis-regulator of translation, and an adapter translation-coupled regulator of transcription. Further provided herein are nucleic acid constructs that contain nucleic acid sequences under the control of the synthetic control elements. Also provided are compositions and methods related to the nucleic acid constructs.
    Type: Application
    Filed: September 27, 2012
    Publication date: January 8, 2015
    Inventors: Chang Liu, Adam P. Arkin, Lei S. Qi
  • Publication number: 20140302563
    Abstract: The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.
    Type: Application
    Filed: April 9, 2014
    Publication date: October 9, 2014
    Applicant: The Regents of the University of California
    Inventors: Jennifer A. Doudna, Lei S. Qi, Rachel E. Haurwitz, Adam P. Arkin