Patents by Inventor Lei Xiao

Lei Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220045738
    Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may receive a configuration that indicates a channel state information reference signal (CSI-RS) Layer 3 (L3) signal corresponding to a first cell. The UE may select, based at least in part on an angle of arrival (AoA) difference between a first AoA and a second AoA, a UE reception (Rx) beam for receiving the CSI-RS L3 signal, wherein the first AoA is associated with the CSI-RS L3 signal, and wherein the second AoA is associated with a communication corresponding to a second cell. The UE may receive the CSI-RS L3 signal using the UE Rx beam. Numerous other aspects are provided.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 10, 2022
    Inventors: Qunfeng HE, Huilin XU, Awlok Singh JOSAN, Yong LI, Lei XIAO
  • Patent number: 11241803
    Abstract: A robot for testing lower limb performance of a spacesuit includes a pressure maintaining box, an air circulation component, an air cooling unit, heat radiating hose components, and two mechanical legs. The air cooling unit is connected with the pressure maintaining box; the air circulation component is arranged in the pressure maintaining box; the mechanical legs are installed on the pressure maintaining box, and the heat radiating hose components are arranged in the mechanical legs; air in the pressure maintaining box is cooled through the air cooling unit and delivered into the heat radiating hose components through the air circulation component; each mechanical leg comprises a thigh, a knee joint component, a shank, an ankle joint component and a foot; the thigh is connected with the shank through the knee joint component; the shank is connected with the foot through the ankle joint component.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: February 8, 2022
    Assignee: SHENYANG INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES
    Inventors: Jinguo Liu, Haodong Chi, Zheng Li, Tiejun Wang, Keli Chen, Qiang Sun, Lei Xiao, Huaqiang Sun, Xiaoyuan Liu, Cao Tong
  • Patent number: 11235004
    Abstract: Embodiments described herein relate to compositions including genetically modified CAR cells and uses thereof for treating cancer. Some embodiments of the present disclosure relate to compositions and methods for T cell response enhancement and/or CAR cell preparation. For example, a method may include obtaining cells comprising a CAR and culturing the cells in the presence of an agent that is recognized by the extracellular domain of the CAR.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: February 1, 2022
    Assignee: Innovative Cellular Therapeutics Holdings, Ltd.
    Inventors: Lei Xiao, Chengfei Pu, Zhiyuan Cao, Zhao Wu
  • Publication number: 20220015114
    Abstract: Methods, systems, and devices for wireless communications are described. Generally, the described techniques provide for measuring, filtering, and reporting cross-link interference (CLI) in cases where not all aggressor user equipments (UEs) are transmitting signals that can be measured by a victim UE. A UE may obtain a set of CLI measurements by performing CLI measurements during a set of CLI measurement occasions. The UE may determine a first subset of the set of CLI measurements that satisfy a CLI measurement threshold and a second subset of the set of CLI measurements that do not satisfy the CLI measurement threshold. The UE may apply a filter to the first subset of the set of CLI measurements, and suppress the filter for the second subset of the set of CLI measurements, to obtain a filtered CLI measurement value. The UE may transmit the filtered CLI measurement value to a base station.
    Type: Application
    Filed: June 17, 2021
    Publication date: January 13, 2022
    Inventors: Huilin Xu, Umesh Phuyal, Lei Xiao, Jing Lei, Qunfeng He, Xipeng Zhu
  • Publication number: 20220000921
    Abstract: Compositions and methods for enhancing T cell response which increases the efficacy of CAR T cell therapy for treating cancer are described. Embodiments include a modified cell comprising an isolated nucleic acid comprising a first nucleic acid and a second nucleic acid, the first nucleic acid encoding a chimeric antigen receptor (CAR), the second nucleic acid encoding a therapeutic agent comprising at least one of IFN-y, IL-2, IL-6, IL-7, IL-15, IL-17, and IL-23. The modified cell expresses and secretes the therapeutic agent.
    Type: Application
    Filed: November 20, 2019
    Publication date: January 6, 2022
    Applicant: Innovative Cellular Therapeutics Holdings, Ltd.
    Inventors: Lei Xiao, Chengfei Pu, Zhiyuan Cao
  • Publication number: 20210379149
    Abstract: Embodiments relate to a method for increasing or maintaining a population of memory T-cells. The method includes introducing T-cells with a nucleic acid encoding a chimeric antigen receptor (CAR), wherein the CAR includes an extracellular domain, a transmembrane domain, and an intracellular domain, and the extracellular domain binds an antigen; introducing into the T-cells a nucleic acid encoding a modified PD-1, wherein the modified PD-1 lacks a functional PD-1 intracellular domain; and administering an effective amount of a composition comprising the T-cells to a subject having cancer.
    Type: Application
    Filed: October 25, 2019
    Publication date: December 9, 2021
    Applicants: Innovative Cellular Therapeutics Holdings, Ltd., Innovative Cellular Therapeutics, Inc.
    Inventors: Chengfei Pu, Zhiyuan Cao, He Sun, Zhao Wu, Lei Xiao
  • Publication number: 20210371492
    Abstract: The present disclosure relates to compositions and methods of treating a subject having digestive tract cancer, the method comprising: administering an effective amount of a composition to the subject, the composition comprising a first population of cells comprising a first CAR binding a first antigen, and a second population of cells comprising a second CAR binding GCC, wherein the first antigen comprises a cell surface molecule of a white blood cell (WBC).
    Type: Application
    Filed: May 26, 2021
    Publication date: December 2, 2021
    Applicants: Innovative Cellular Therapeutics Holdings, Ltd., Innovative Cellular Therapeutics, Inc.
    Inventors: Lei Xiao, Xiaogang Shen, Wensheng Wang, Dongqi Chen, Beibei Jia, Chengfei Pu, Le Tian
  • Publication number: 20210366082
    Abstract: In one embodiment, a method includes receiving a first frame associated with a first time and one or more second frames of a video having a resolution lower than a target resolution, wherein each second frame is associated with a second time prior to the first time, generating a first feature map for the first frame and one or more second feature maps for the one or more second frames, up-sampling the first feature map and the one or more second feature maps to the target resolution, warping each of the up-sampled second feature maps according to a motion estimation between the associated second time and the first time, and generating a reconstructed frame having the target resolution corresponding to the first frame by using a machine-learning model to process the up-sampled first feature map and the one or more up-sampled and warped second feature maps.
    Type: Application
    Filed: September 30, 2020
    Publication date: November 25, 2021
    Inventors: Lei Xiao, Salah Eddine Nouri, Douglas Robert Lanman, Anton S. Kaplanyan, Alexander Jobe Fix, Matthew Steven Chapman
  • Publication number: 20210347893
    Abstract: The present disclosure relates to a modified cell comprising a polynucleotide encoding a secretable scFv binding SIGLEC-15 and/or encoding a dominant negative form of CD44. In embodiments, the modified cell further comprises an antigen-binding molecule, which for example, is a CAR comprising an antigen-binding domain, a transmembrane domain, and an intracellular signaling domain.
    Type: Application
    Filed: July 22, 2021
    Publication date: November 11, 2021
    Applicant: Innovative Cellular Therapeutics Holdings, Ltd.
    Inventors: Zhiyuan Cao, Chengfei Pu, Lei Xiao
  • Patent number: 11161913
    Abstract: The compositions and methods described herein are directed to treating solid tumor using CAR T therapy. The compositions include CAR comprising an extracellular domain that binds a siglec protein or a receptor that binds the peptide hormone kisspeptin.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: November 2, 2021
    Assignees: Innovative Cellular Therapeutics Holdings, Ltd., Innovative Cellular Therapeutics, Inc.
    Inventors: Lei Xiao, He Sun, Zhiyuan Cao, Wensheng Wang, Chengfei Pu, Li Mao
  • Patent number: 11150605
    Abstract: In one embodiment, a system may generate a hologram by processing a first image using a machine-learning model. The system may generate a second image based on at least a portion of the hologram using a processing model that is configured to simulate interactions between a light source and the hologram. The system may compare the second image to the first image to calculate a loss based on a loss function. The system may update the machine-learning model based on the loss between the first image and the second image. The updated machine-learning model is configured to process one or more input images to generate one or more corresponding holograms.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: October 19, 2021
    Assignee: Facebook Technologies, LLC
    Inventors: Lei Xiao, Andrew Maimone, Robin Joseph Swanson, Douglas Robert Lanman
  • Patent number: 11144950
    Abstract: An information delivery method is provided, including: determining a candidate information list in response to a page request sent by a user, where the candidate information list comprises a plurality pieces of information; generating ranks of the pieces of information in the candidate information list by sorting the plurality pieces of information in the candidate information list in accordance with a predetermined rule; acquiring a current average rank of the information of a designated type in the candidate information list based on the ranks of the pieces of information in the candidate information; and selecting designated delivery information from the information of the designated type, based on the current average rank of the information of the designated type and a historical average rank corresponding to the information of the designated type.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: October 12, 2021
    Assignee: Tencent Technology (Shenzhen) Company Limited
    Inventors: Dapeng Liu, Lei Xiao
  • Publication number: 20210288730
    Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may transmit, to a base station, information indicating a Layer 1 signal to interference plus noise ratio (L1-SINR) measurement capability of the UE. In some aspects, the information indicating the L1-SINR measurement capability may include one or more individual configurations for one or more resources to carry a reference signal. The UE may receive, from the base station, a reference signal carried on the one or more resources based at least in part on the L1-SINR measurement capability. Numerous other aspects are provided.
    Type: Application
    Filed: January 11, 2021
    Publication date: September 16, 2021
    Inventors: Yan ZHOU, Tao LUO, Lei XIAO, Muhammad Nazmul ISLAM, Yong LI
  • Patent number: 11120030
    Abstract: A high qualified pattern mining method is provided. The high qualified pattern mining method is performed by one or more processors, and includes determining a support degree of an item set to be processed in a transaction database; determining a weight occupancy of the item to be processed in the transaction database; and determining that the item set to be processed is a high qualified pattern based on the support degree not being less than a product of a preset lowest support degree threshold value and a total number of transactions in the transaction database, and the weight occupancy not being less than a preset minimum weight occupancy threshold value.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: September 14, 2021
    Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    Inventors: Chun-wei Lin, Wensheng Gan, Lei Xiao, Wei Chen
  • Patent number: 11113794
    Abstract: In one embodiment, a computing system may receive current eye-tracking data associated with a user of a head-mounted display. The system may dynamically adjust a focal length of the head-mounted display based on the current eye-tracking data. The system may generate an in-focus image of a scene and a corresponding depth map of the scene. The system may generate a circle-of-confusion map for the scene based on the depth map. The circle-of-confusion map encodes a desired focal surface in the scene. The system may generate, using a machine-learning model, an output image with a synthesized defocus-blur effect by processing the in-focus image, the corresponding depth map, and the circle-of-confusion map of the scene. The system may display the output image with the synthesized defocus-blur effect to the user via the head-mounted display having the adjusted focal length.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: September 7, 2021
    Assignee: Facebook Technologies, LLC
    Inventors: Douglas Robert Lanman, Matthew Steven Chapman, Alexander Jobe Fix, Anton S. Kaplanyan, Lei Xiao
  • Patent number: 11104732
    Abstract: The present disclosure relates to a modified cell comprising a polynucleotide encoding a secretable scFv binding SIGLEC-15 and/or encoding a dominant negative form of CD44. In embodiments, the modified cell further comprises an antigen-binding molecule, which for example, is a CAR comprising an antigen-binding domain, a transmembrane domain, and an intracellular signaling domain.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: August 31, 2021
    Inventors: Zhiyuan Cao, Chengfei Pu, Lei Xiao
  • Publication number: 20210258970
    Abstract: Certain aspects of the present disclosure provide techniques for determining an energy per resource element (EPRE) ratio for non-zero power (NZP) channel state information reference signals (CSI-RSs) when a device is measuring a wireless channel. A method that may be performed by a user equipment (UE) includes determining, based on an indication, an energy per resource element (EPRE) ratio for a non-zero power (NZP) channel state information reference signal (CSI-RS) resource; and measuring a channel based on the determined EPRE ratio and CSI-RSs associated with the NZP CSI-RS resource.
    Type: Application
    Filed: February 10, 2021
    Publication date: August 19, 2021
    Inventors: Hamed PEZESHKI, Yan ZHOU, Tao LUO, Lei XIAO
  • Publication number: 20210252059
    Abstract: The present disclosure relates to compositions and methods for treating cancer. For example, a modified cell may include a polynucleotide comprising an NFAT promoter, a nucleotide sequence encoding therapeutic agent, and a nucleotide sequence encoding a VHL-interaction domain of HIF1?, wherein the therapeutic agent comprises, for example, IL-12, IL-6, and/or IFN?.
    Type: Application
    Filed: February 11, 2021
    Publication date: August 19, 2021
    Applicants: Innovative Cellular Therapeutics Holdings, Ltd., Innovative Cellular Therapeutics, Inc.
    Inventors: Chengfei Pu, Zhiyuan Cao, Zhao Wu, Lei Xiao
  • Patent number: 11094075
    Abstract: In one embodiment, a system may access a training sample that includes training images and corresponding training depth maps of a scene, with the training images being associated with different predetermined viewpoints of the scene. The system may generate elemental images of the scene by processing the training images and the training depth maps using a machine-learning model. The elemental images are associated with more viewpoints of the scene than the predetermined viewpoints associated with the training images. The system may update the machine-learning model based on a comparison between the generated elemental images of the scene and target elemental images that are each associated with a predetermined viewpoint. The updated machine-learning model is configured to generate elemental images of a scene of interest based on input images and corresponding depth maps of the scene of interest from different viewpoints.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: August 17, 2021
    Assignee: Facebook Technologies, LLC
    Inventors: Douglas Robert Lanman, Matthew Steven Chapman, Alexander Jobe Fix, Anton S. Kaplanyan, Lei Xiao
  • Patent number: 11085896
    Abstract: A gas sensor includes know types of electrodes such has sensing electrodes, counter electrodes or reference electrodes to sense the presence of a predetermined gas. In addition, at least one diagnostic electrode is carried in the sensor. The diagnostic electrode implements at least one diagnostic function without substantially impairing the gas sensing function. The diagnostic electrode is immersed in sensor electrolyte.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: August 10, 2021
    Assignee: LIFE SAFETY DISTRIBUTION GMBH
    Inventors: Keith Francis Edwin Pratt, Martin G. Jones, John Chapples, Lei Xiao