Abstract: Embodiments of the present disclosure include a method for treating Systemic Lupus Erythematosus (SLE) using CD19 CAR T cells. The method includes administering to the human patient a pharmaceutically effective amount of a population of T cells of the human patient that express a chimeric antigen receptor (CAR) that comprises the amino acid sequence of, e.g., SEQ ID NO: 23.

Abstract: A magnetron sputtering device, a magnetron sputtering apparatus, and a magnetron sputtering method are provided. The magnetron sputtering device includes: a target material bearing portion, configured to bear a target material thereon; a magnet bearing section, configured to bear a magnet thereon and to be capable of driving the magnet to perform reciprocating motion along a predetermined path with respect to the target material bearing portion; a limit sensor, configured to determine an end-point position of the predetermined path along which the magnet performs reciprocating motion; the end-point position determined by the limit sensor can be adjusted along the predetermined path during a working procedure of the magnetron sputtering device.

Abstract: The present disclosure relates to compositions and methods for enhancing CAR T therapy through uses of co-stimulation. Some embodiments relate to an isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR) and an agent associated with a co-stimulatory molecule, the CAR comprising an intracellular domain of a costimulatory molecule.

Abstract: Embodiments relate to a modified cell comprising an antigen binding molecule, and the expression and/or function of one or more genes in the modified cell has been enhanced or reduced or eliminated. The one or more genes include CXCR3, SLC1A3, YAP, TIGIT, S1P1, and IL-35. In embodiments, the cell is a T cell, a dendritic cell, a NK cell, or a macrophage cell. In embodiments, the antigen binding molecule comprises a chimeric antigen receptor (CAR) and/or the second antigen binding molecule is a T Cell Receptor (TCR).

Abstract: The present disclosure relates to compositions and methods for enhancing T cell response and/or CAR cell expansion in vivo and/or in vitro. For example, a cell may comprise a first chimeric antigen receptor (CAR) and a second CAR, wherein a binding domain of the first CAR binds a first antigen, and a binding domain of the second CAR binds a second antigen. The first antigen is different from the second antigen. In embodiments, the first CAR may recognize a surface molecule of a blood cell.

Abstract: Embodiments herein relate to humanized CD19 antibodies and disease treatment using the antibodies. For example, a subject having a CD19 positive tumor may be administered a therapeutically effective amount of the humanized antibody.

Abstract: The present invention relates to a method for detecting a gas concentration using a gas detection device, comprising: determining a first relationship between a baseline drift of the gas detection device with respect to a gas concentration and an environmental temperature and performing, based on the baseline drift of the gas detection device with respect to a gas having a first temperature, a first compensation on a gas concentration output value of the gas having the first temperature determined by the gas detection device. With such a method, a gas concentration check result is more accurate, and the gas detection device can be applied to a wider range of application scenarios.

Abstract: A computer implemented method receives a switch session request from a source client device that is running a virtual desktop session. The method identifies a list of one or more potential destination client devices based on the source client device. The method then selects a desired destination client device from the list, disconnects the virtual desktop session from the source client device, and establishes a connection between the virtual desktop session and the desired destination client device.

Abstract: Embodiments herein relate to humanized CD19 antibodies and disease treatment using the antibodies. For example, a subject having a CD19 positive tumor may be administered a therapeutically effective amount of the humanized antibody.

Abstract: Provided by the present application is a method for screening refreshing essential oils or products thereof, comprising: processing cerebral nerve cells using essential oils or products thereof; detecting the concentration of neurotransmitters such as 5-hydroxy tryptamine; obtaining a refreshing score for each neurotransmitter by means of the change in the concentrations of a treatment group and a control group; and calculating the total refreshing score and using the same to screen refreshing essential oils or products thereof.

Abstract: An electrochemical acrylonitrile sensor comprises a housing, an electrolyte disposed within the housing, and a plurality of electrodes in contact with the electrolyte within the housing. The plurality of electrodes comprises a working electrode and a counter electrode. The electrodes comprise a catalytic material, which may comprise gold. A potential is applied between the counter electrode and the working electrode.

Abstract: The present disclosure relates to compositions and methods for enhancing T cell response and/or CAR cell expansion and/or maintenance in vivo and/or in vitro. For example, a method of enhancing T cell-based therapy comprises administering genetically modified T cells comprising a first chimeric antigen receptor (CAR) and a second CAR, wherein a binding domain of the first CAR binds a first antigen, and a binding domain of the second CAR binds a second antigen. The first antigen is different from the second antigen. In embodiments, the first CAR binds a surface molecule or antigen of a white blood cell.

Abstract: Cell-specific reference signal (CRS)-based unicast physical downlink shared channel (PDSCH) transmission is discussed for multicast-broadcast single frequency network (MBSFN) subframes. When one or more CRS-based transmissions are scheduled during an MBSFN subframe in an MBSFN region of a transmission frame, a transmitter can transmit CRS and CRS-based unicast transmissions when no multicast-broadcast transmissions are present in the MBSFN subframe. The transmitter will signal the intent to transmit such CRS-based transmissions, thus, allowing receivers to monitor for the CRS-based transmissions, or ignore monitoring if the receivers are configured in incompatible transmission modes. Additionally, capable receivers may enable CRS-based channel estimation for those MBSFN subframes in the MBSFN region when CRS-based transmission is activated.

Abstract: In order to enable a UE receiving a narrowband signal transmitted using in-band resources to use the LTE reference signals to assist the UE in receiving the narrowband signal using an in-band deployment, a phase rotation employed by the base station may be fixed relative to a known reference position in time. An apparatus for wireless communication at a base station may determine a phase offset for a narrowband signal for transmission using wideband resources, the phase offset having a relationship to a reference point in time and transmit the narrowband signal using the determined phase offset. An apparatus for wireless communication at a UE may receive a narrowband signal having a frequency location within a wideband signal and rotate a symbol of the wideband signal by a per symbol phase offset having a relationship of the phase offset to a reference point in time.

Abstract: The present invention discloses a real-time and time-distributed information recommendation system, method and apparatus. Specifically, when first clients of the information recommendation system running on first terminal devices access and operate on pieces of information, influence values of the pieces of information on friend clients of the first clients are calculated, accumulated and recorded in a database based on fried intimacy and types of the operations at the times the pieces of information are accessed and operated on. As such, the influence values of the pieces of information on friend clients are updated over time and in real-time. The speed and efficiency of processes for recommending information to the friend clients, when requested, are thus improved.

Abstract: A gas sensor including a housing containing a potassium permanganate element sandwiched between two polytetrafluoroethylene elements, a carbon element, a polytetrafluoroethylene element located adjacent to the carbon element, a sensing electrode, a reference electrode, and a counter electrode with attached current collectors, and an electrolyte.

Abstract: A rotor temperature monitoring method and system for a permanent magnet synchronous motor are provided. According to the method and system, an a-phase line current and a b-phase line current of a stator of a permanent magnet synchronous motor are obtained as a first line current and a second line current; further, a line voltage between the a-phase and the b-phase of the stator is obtained and a rotating speed of the rotor of the permanent magnet synchronous motor is obtained; and then, the first line current, the second line current, the line voltage, the rotating speed of the rotor, an inductance parameter of the permanent magnet synchronous motor and a temperature characteristic equation of a permanent magnet of the rotor are substituted into a preset rotor permanent magnet temperature expression to calculate and obtain the temperature of the rotor.

Abstract: The present disclosure relates to compositions and methods for enhancing T cell response and/or CAR cell expansion in vivo and/or in vitro. For example, a cell may comprise a first chimeric antigen receptor (CAR) and a second CAR, wherein a binding domain of the first CAR binds a first antigen, and a binding domain of the second CAR binds a second antigen. The first antigen is different from the second antigen. In embodiments, the first CAR may recognize a surface molecule of a blood cell.

Abstract: Disclosed is a heterogeneous field devices control management system based on an industrial internet operating system. In order to solve the problems that it is difficult to add new heterogeneous field devices to an existing system, as well as that the system has low security and a real-time performance, on one hand, according to embodiments of the present disclosure, on the basis of the differences of real-time requirements of services operated by heterogeneous field devices, a real-time virtual machine processes a real-time service and a non-real-time virtual machine processes a non-real-time service, thus different operating environments could be customized for a real-time service and a non-real-time service, avoiding the situation that when a system upgrade is made for a non-real-time service or a non-real-time virtual service fails, a real-time service is also affected, service isolation is realized, and, stability and reliability of industrial field control are enhanced.

Abstract: A high qualified pattern mining method is provided. The high qualified pattern mining method is performed by one or more processors, and includes determining a support degree of an item set to be processed in a transaction database; determining a weight occupancy of the item to be processed in the transaction database; and determining that the item set to be processed is a high qualified pattern based on the support degree not being less than a product of a preset lowest support degree threshold value and a total number of transactions in the transaction database, and the weight occupancy not being less than a preset minimum weight occupancy threshold value.