Abstract: (S)-4-hydroxy-2-oxo-1-pyrrolidine crystal form III (called crystal form III of (S) -oxiracetam for short) has diffraction peaks at diffraction angles 2?, wherein the diffraction angles 2? are equal to 10.54, 13.70, 14.44, 15.60, 17.12, 18.88, 19.24, 20.66, 20.84, 21.18, 21.82, 22.94, 23.24, 24.88, 27.20, 27.48, 28.24, 30.46, 30.80, 31.52, 32.00, 32.34, 32.90, 33.20, 34.40, 34.62, 37.30, 37.50, 38.28, 38.96, and 40.02°. The (S)-oxiracetam crystal form III of the present invention has an obvious effect on memory dysfunction, is dissolved in water fast, has high bioavailability, and can be used to prepare various pharmaceutical compositions. The (S)-oxiracetam crystal form III obtained by using the preparation method of the present invention is high in purity. The preparation method of the present invention is performed in a mild condition, is easy in operation, introduces less impurities, has desirable reproducibility, is easily controlled during production, and is applicable to industrial production.

Abstract: The present disclosure provides a charging system, charging method, and charging control device. The charging system comprises a charger configured to be coupled to an external power source with its one end; a plurality of secondary batteries configured to be coupled to the charger, respectively; and a control device configured to be coupled to the charger and the plurality of secondary batteries, to control the charger to perform a charging operation on the plurality of secondary battery. According to the present disclosure, the secondary batteries having harmonics with identical frequencies and opposite phases are connected in parallel for charging, to reduce or eliminate the harmonic distortion generated by high order harmonics, and effectively reduce the value of THD.

Abstract: In an approach, a processor predicts a thermal load caused by a door opening event in at least part of a cargo space of a refrigerated transport vehicle based on, at least, an external ambient condition, environmental factors within the cargo space, and a duration of the door opening event. A processor obtains pre-cooling profile information describing cargo space temperature performance with a pre-cooling operation under conditions corresponding to, at least, the predicted thermal load caused by the door opening event. A processor determines a distribution path for the refrigerated transport vehicle based on the predicted thermal load caused by the door opening event and the obtained pre-cooling profile information, wherein the distribution path is associated with the pre-cooling operation.

Abstract: (S)-4-hydroxy-2-oxo-1-pyrrolidine crystal form III (called crystal form III of (S)-oxiracetam for short) has diffraction peaks at diffraction angles 2?, wherein the diffraction angles 2? are equal to 10.54, 13.70, 14.44, 15.60, 17.12, 18.88, 19.24, 20.66, 20.84, 21.18, 21.82, 22.94, 23.24, 24.88, 27.20, 27.48, 28.24, 30.46, 30.80, 31.52, 32.00, 32.34, 32.90, 33.20, 34.40, 34.62, 37.30, 37.50, 38.28, 38.96, and 40.02°. The (S)-oxiracetam crystal form III of the present invention has an obvious effect on memory dysfunction, is dissolved in water fast, has high bioavailability, and can be used to prepare various pharmaceutical compositions. The (S)-oxiracetam crystal form III obtained by using the preparation method of the present invention is high in purity. The preparation method of the present invention is performed in a mild condition, is easy in operation, introduces less impurities, has desirable reproducibility, is easily controlled during production, and is applicable to industrial production.

Abstract: According to embodiments of the present invention, the energy consumption assessment is done by identifying the benchmark production processes or enterprises. First, a process similarity between a target production process and a candidate production process is determined based on energy consumption units (ECUs) involved in the target production process and the candidate production process. In response to the process similarity being greater than a first threshold, an energy consumption similarity between the target production process and the candidate production process is determined based on a factor that has influence on energy consumption of at least one of the ECUs. In response to the energy consumption similarity being greater than a second threshold, the candidate production process is identified as a benchmark for assessing energy consumption of the target production process.

Abstract: Disclosure is a method for detecting the safety driving state of a driver, the method comprises the following steps: (a) detecting the current sight direction of a driver in real time and acquiring a scene image signal in a front view field of the driver when a vehicle runs; (b) processing the acquired current road scene image signal according to a visual attention calculation model to obtain the expected attention distribution of the driver under the current road scene; and (c) performing fusion analysis on the real-time detected current sight direction of the driver in the step (a) and the calculated expected attention distribution of the driver in step (b), and judging whether the current driver is in a normal driving state and whether the driver can timely make a proper response to the sudden road traffic accident.

Abstract: The present invention is to provide uses of the L-oxiracetam in preparation of medicines for preventing or treating coma. Experimental results show that L-oxiracetam wake-promoting effects of alcoholism-induced coma is obvious, and D-oxiracetam has basically no effect. The effect of the above wake-promoting effects of L-oxiracetam is 2 times greater than racemic oxiracetam. The wake-promoting effects of L-oxiracetam on trauma or anesthesia-induced coma are both significant.

Abstract: A method for forming a 3D NAND structure includes providing a semiconductor substrate; forming a control gate structure having a plurality of staircase-stacked layers, each layer has a first end and a second end; forming a dielectric layer covering the semiconductor substrate, and the control gate structure; forming a hard mask layer on the dielectric layer; patterning the hard mask layer to form a plurality of openings above corresponding second ends of the layers of the control gate structure; forming a photoresist layer on the hard mask layer; repeating a photoresist trimming process and a first etching process to sequentially expose the openings, and to form a plurality of holes with predetermined depths in the dielectric layer; performing a second etching process to etch the plurality of holes until surfaces of the second ends are exposed to form through holes; and forming metal vias in the through holes.

Abstract: A method for purifying (S)-oxiracetam is disclosed. Crude (S)-oxiracetam with the purity of 89% is dissolved in water; the solution is allowed to stand for 1 to 3 days at 0° C. to 18° C.; a colorless transparent crystal is precipitated; the solution is filtered and top-washed with cold water to 0° C. to 5° C.; and the product is dried in vacuum to obtain high-purity (S)-oxiracetam.

Abstract: A porous tantalum rod is provided, which is a medical implantation used for treating collapsed articular surface of the femoral head or necrosis of the femoral head in phase I or phase II. The implantation includes a fastening structure formed on one end of the porous tantalum rod used for connecting with the osseous tissues and a through hole formed on the center of the porous tantalum rod. The porous tantalum rod is made of the porous tantalum material, which is produced by foam impregnation and had a foam structure with three-dimensional interconnecting pores, wherein the foam structure has a foam skeleton, tantalum particles located on the foam skeleton, and multiple sintering neck structures formed between the tantalum particles.

Abstract: A craniotomy drill includes a main machine, a retarder and a locking seat. A drill transmission rod connected to the output shaft of the retarder is inserted in the locking seat. The main machine comprises a handle at the lower portion and an accommodating part at the upper portion, with a stator and a rotor of a DC electric motor being provided inside the accommodating part and a wall of the accommodating part being the stator housing of the DC electric motor. This craniotomy drill has a simple structure with the wall of the accommodating part as the stator housing of the electric motor, such that the volume and the weight are reduced. It is safe in use without the risk of the electric motor sliding out. By utilizing materials and processes of water resistant technology and an integrative design, a relatively good water resistant performance is achieved.

Abstract: A drill bit locking device and a drill bit are provided. The locking device includes a boss with a through hole, a bearing and a support member are arranged an inner wall of a small cylinder above the boss; a locking sleeve is sleeved over the boss, a first bulge is on an inner wall of an upper part of the locking sleeve, and a second bulge is on an inner wall of a lower part; a spring is between the second bulge and an upper bottom surface of the boss; a press plate is threadedly connected with an outer wall of a top part of the small cylinder and presses against the first bulge; holes of different sizes are on the inner wall of the small cylinder and the support member to form a stepped hole, and a steel ball is arranged in the stepped hole.

Abstract: A surgical milling cutter bracket includes a retaining base having a through hole. The upper part of the retaining base is provided with a finger guide having an L-shaped support frame on the top of the finger guide. A downward protrusion is provided at the end of the short side of the L-shaped support frame. The lowest point of the protrusion is lower than the lowest point of the cylindrical head of the milling cutter during normal operation of the milling cutter. A bolt having a through hole at the center is fixed within the cavity of the finger guide. A depressor is provided on the upper part of the retaining base. The bolt passes through a hole of the depressor and is connected to a nut. The protrusion is able to prevent an object from contacting the cylindrical head, thus avoiding cutting the object unevenly.

Abstract: A drill head locking apparatus and a drill head are provided. The locking apparatus includes a protruding platform having a through hole, a bearing on the inner wall of a small cylinder on the protruding platform, a locking sleeve fitted on the protruding platform, and a protrusion arranged on the upper part of the inner wall of the locking sleeve. The lower part of the inner wall of the locking sleeve is a conical face. A spring is arranged between the bottom face of the conical face and an upper bottom face of the protruding platform. A press plate is connected with a screw thread on the outer wall of the top part of the small cylinder on the protruding platform and presses down on the protrusion. A conical hole is arranged on the wall of the small cylinder and communicates with the through hole of the protruding platform.

Abstract: A crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, or named (S)-oxiracetam, is provided, which is characterized by a powder x-ray diffraction pattern that exhibits data of d-values versus the relative intensities as: 7.075(M), 5.355(S), 5.092(S), 4.590(M), 4.325(M), 4.259(S), 4.041(VS), 3.808(M), 3.542(M), 3.445(M), 3.393(M), 2.972(M), 2.914(S). A method for preparing a crystal form I of (S)-oxiracetam is also provided, which includes preparing the crude product and crystallizing A use of the crystal form I of (S)-oxiracetam in the manufacture of a medicament for preventing and treating memory dysfunction is also provided. Accordingly, the crystal form I of (S)-oxiracetam prepared by the method has high purity of more than 99.3% based on the percentages of the mass, with better efficacy than (S)-oxiracetam for preventing or treating memory dysfunction.

Abstract: Disclosed is a 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I which is prepared by the following steps: dissolving crude 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate in a solvent such as a micromolecular alcohol to form a saturated solution; heating and stirring the solution overnight at 38˜42° C. to obtain a suspended precipitate; filtering and drying the solution to obtain a crystal. Such 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has a purity as high as 99.5%, which has significant treatment effect on curing respective diseases, and the 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has the features of simple manufacturing method, mild control condition, and low production cost, and its yield rate is as high as 99.5% which is applicable for mass production.

Abstract: An (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide racemate referred to as (S)-oxiracetam crystal form II has a diffraction peak at a diffraction angle 2? of 10.669, 13.25, 13.847, 14.198, 16.729, 17.934, 18.746, 18.816, 20.273, 20.413, 21.431, 21.617, 21.663, 23.38, 24.324, 24.415, 26.069, 26.107, 27.901, 28.621, 28.925, 29.449, 29.484, 31.702, 36.516, 37.685, or 39.721 degrees. The purity of the (S)-oxiracetam crystal form II can be up to 98.5%, and the (S)-oxiracetam crystal form II has the advantages of simple preparation method, mild control condition, low production cost, and the produced oxiracetam hydrate crystal form II has a high purity (the oxiracetam hydrate crystal form having a purity of 8%˜98.5% can be prepared by a crude levo-oxiracetam having a purity of 92%, and thus having a good reproducibility in production.

Abstract: A method for preparing a porous tantalum medical implant material, which includes (a) mixing a polyethylene glycol aqueous solution and tantalum powder to form a tantalum slurry, (b) casting the tantalum slurry into an organic foam body through vibrant pressurization, and (c) performing steps of drying, degreasing, vacuum sintering and thermal treatment to obtain the porous tantalum. The solution is a 2-8 wt % polyethylene glycol aqueous solution, the frequency of vibration is 20-80 times/min, the thermal treatment is performed under 10?4-10?3 Pa of vacuity and the temperature is first increased to 800-900° C. at a rate of 10-20° C./min and kept at 800-900° C. for 240-480 minutes, then is decreased to 400° C. at a rate of 2-5° C./min and kept at 400° C. for 120-300 minutes, and is cooled down to room temperature naturally in the furnace.

Abstract: A surgical milling cutter includes a milling cutter holder, a locking device, a locking seat, and a main machine. The milling cutter holder includes a fixing seat with a through hole. A finger guider with an L-type holder on a top end thereof is arranged at an upper part of the fixing seat. A distal end of a short side of the L-type holder is disposed with a downward projection, and a lowest point of the projection is lower than that of a cylindrical head when the milling cutter works normally. A bolt with a central through hole is fixed in a cavity of the finger guider. A pressing disk is arranged at the upper part of the fixing seat, and a nut is connected to the bolt through a hole in the pressing disk.

Abstract: An optical isolator capable of creating a larger safe buffer area for optical beam(s) and a manufacturing method thereof are disclosed. The optical isolator includes a sandwich type wafer, a first polarizer, a Faraday rotator and a second polarizer. The first polarizer works as the incident plane of the FSI (free space isolator), while the second polarizer works as the outgoing plane of the FSI. The direction in which the second polarizer passes the polarized beam is at a 45° angle with respect to the first polarizer. The manufacturing method includes marking the edge of the second polarizer. FSIs processed by this method provide a larger buffer area for the optical beam(s) and/or a lower manufacturing cost, even though the size of the FSI is unchanged.