Abstract: A system for dialysis is disclosed. An example peritoneal dialysis system includes a peritoneal dialysis machine including a pumping mechanism, and a sensor configured to measure a property of peritoneal dialysis fluid. The peritoneal dialysis system also includes a disposable cassette operable with the peritoneal dialysis machine. The disposable cassette includes a fluid source inlet for accepting fluid from a fluid source and a fluid flow path in fluid communication with the fluid source inlet. The fluid flow path includes a pump chamber operable with the pumping mechanism to pump fluid through the fluid flow path. The disposable cassette also includes a concentrate inlet for fluidly communicating concentrate to the fluid flow path, and a sensor chamber located along the fluid flow path and operable with the sensor. The sensor is configured to provide feedback to the peritoneal dialysis machine for mixing the concentrate for forming peritoneal dialysis fluid.

Abstract: Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.

Abstract: Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.

Abstract: A system for dialysis is disclosed. An example peritoneal dialysis system includes a peritoneal dialysis machine including a pumping mechanism, and a sensor configured to measure a property of peritoneal dialysis fluid. The peritoneal dialysis system also includes a disposable cassette operable with the peritoneal dialysis machine. The disposable cassette includes a fluid source inlet for accepting fluid from a fluid source and a fluid flow path in fluid communication with the fluid source inlet. The fluid flow path includes a pump chamber operable with the pumping mechanism to pump fluid through the fluid flow path. The disposable cassette also includes a concentrate inlet for fluidly communicating concentrate to the fluid flow path, and a sensor chamber located along the fluid flow path and operable with the sensor. The sensor is configured to provide feedback to the peritoneal dialysis machine for mixing the concentrate for forming peritoneal dialysis fluid.

Abstract: A disposable set and system for dialysis are disclosed. An example peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine comprising a pumping mechanism and a peritoneal dialysis fluid heater. The example peritoneal dialysis system also includes a disposable set comprising a disposable cassette operable with the pumping mechanism and a heater bag operable with the heater. The example peritoneal dialysis system additionally includes a conductivity sensor positioned and arranged to provide feedback to the APD machine. The example APD machine is configured to mix a peritoneal dialysis fluid for treatment in the heater bag using a plurality of peritoneal dialysis constituent fluids. In addition, the example APD machine is configured to use feedback from the conductivity sensor to evaluate the mixed peritoneal dialysis fluid for treatment.

Abstract: Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.

Abstract: Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.

Abstract: A disposable cassette and system for dialysis are disclosed. An example disposable cassette includes a rigid portion, a fluid source inlet configured to be placed in fluid communication with a fluid source, and a fluid pumping receptacle placed in fluid communication with the fluid source inlet. The fluid pumping receptacle is configured to operate with a fluid pump actuator to pump fluid from the fluid source. The example disposable cassette also includes a dampening chamber formed as part of the rigid portion and in fluid communication with the fluid pumping receptacle. The dampening chamber is sized and arranged to reduce pressure fluctuations in the fluid delivered from the fluid pumping receptacle. The example disposable cassette further includes an outlet in fluid communication with the dampening chamber. The outlet provides dialysis fluid for a dialysis treatment.

Abstract: A disposable set and system for dialysis are disclosed. An example peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine comprising a pumping mechanism and a peritoneal dialysis fluid heater. The example peritoneal dialysis system also includes a disposable set comprising a disposable cassette operable with the pumping mechanism and a heater bag operable with the heater. The example peritoneal dialysis system additionally includes a conductivity sensor positioned and arranged to provide feedback to the APD machine. The example APD machine is configured to mix a peritoneal dialysis fluid for treatment in the heater bag using a plurality of peritoneal dialysis constituent fluids. In addition, the example APD machine is configured to use feedback from the conductivity sensor to evaluate the mixed peritoneal dialysis fluid for treatment.

Abstract: A disposable cassette and system for dialysis are disclosed. An example disposable cassette includes a rigid portion, a fluid source inlet configured to be placed in fluid communication with a fluid source, and a fluid pumping receptacle placed in fluid communication with the fluid source inlet. The fluid pumping receptacle is configured to operate with a fluid pump actuator to pump fluid from the fluid source. The example disposable cassette also includes a dampening chamber formed as part of the rigid portion and in fluid communication with the fluid pumping receptacle. The dampening chamber is sized and arranged to reduce pressure fluctuations in the fluid delivered from the fluid pumping receptacle. The example disposable cassette further includes an outlet in fluid communication with the dampening chamber. The outlet provides dialysis fluid for a dialysis treatment.

Abstract: A hemodialysis system including (i) a dialyzer, (ii) a blood circuit including a blood pump in fluid communication with the dialyzer, (iii) a dialysate circuit including a dialysate circulation pump in fluid communication with the dialyzer, the dialysate circuit further including a sorbent cartridge for cleaning used dialysate, (iv) a dialysate reservoir, (v) a reservoir pump in fluid communication with the dialysate circuit and the dialysate reservoir, (vi) a supply of concentrate for reconstituting dialysate in the dialysate circuit, and (vii) wherein the hemodialysis system is configured to electronically weigh the dialysate reservoir and the supply of concentrate.

Abstract: A regenerative peritoneal dialysis system includes a dialysis fluid loop; a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

Abstract: Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.

Abstract: A regenerative peritoneal dialysis system includes a dialysis fluid loop; a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

Abstract: Peritoneal dialysis solutions including a glucose polymer and methods of using the dialysis solutions are disclosed herein. In a general embodiment, the peritoneal dialysis solution includes a glucose polymer in an amount to provide an increased ultrafiltration fluid volume for a given amount of carbohydrate absorbed compared to conventional dialysis solutions containing icodextrin as the active pharmaceutical ingredient. The increased ultrafiltration fluid volume for a given amount of carbohydrate absorbed is obtained by providing specific combinations of weight-average molecular weight, polydispersity index and concentration of the glucose polymer in the dialysis solution.

Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

Abstract: A hemodialysis system including (i) a dialyzer, (ii) a blood circuit including a blood pump in fluid communication with the dialyzer, (iii) a dialysate circuit including a dialysate circulation pump in fluid communication with the dialyzer, the dialysate circuit further including a sorbent cartridge for cleaning used dialysate, (iv) a dialysate reservoir, (v) a reservoir pump in fluid communication with the dialysate circuit and the dialysate reservoir, (vi) a supply of concentrate for reconstituting dialysate in the dialysate circuit, and (vii) wherein the hemodialysis system is configured to electronically weigh the dialysate reservoir and the supply of concentrate.

Abstract: Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.

Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

Abstract: A hemodialysis system including (i) a dialyzer; (ii) a blood circuit including a blood pump in fluid communication with the dialyzer; (iii) a dialysate circuit including a dialysate circulation pump in fluid communication with the dialyzer, the dialysate circuit further including a sorbent cartridge for cleaning used dialysate; (iv) a container holding an initial supply of dialysate; (v) a container pump in fluid communication with the dialysate circuit and the container; (vi) a supply of concentrate; and (vii) an electronic weight balance positioned and arranged to weigh the supply of concentrate.