Abstract: The invention provides a enhancement to stairlift safety by separately monitoring the angular movement of a stairlift chair levelling motor, and the angular position of a chair leveled by that motor. By comparing the angular positions, any failure in the levelling system can be readily determined and, in response, a seat locking device can be deployed.

Abstract: The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.

Abstract: The invention describes an over-speed governor for a stairlift which not only triggers a safety gear or brake upon the carriage exceeding a pre-determined speed, but also triggers the safety gear in the event the carriage unexpectedly reverses its direction. In a preferred embodiment, the over-speed governor also triggers the safety gear in the event the chair departs from the horizontal by more than a predetermined angle. The speed determining function is preferably electronic and the safety gear operates in both directions without adaptation. Other aspects are described including setting the trip speed as a function of carriage position on the rail.

Abstract: Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the synaptosomal proteins, SNAP-25, VAMP, or syntaxin at discrete sites. The present invention relates to the construction, expression, purification, and use of synthetic or recombinant botulinum neurotoxin genes. For example, a synthetic gene for the LC of the botulinum neurotoxin serotype A (BoNT/A) was constructed and overexpressed in Escherichia coli. The gene product was purified from inclusion bodies. The methods of the invention can provide 1.1 g of the LC per liter of culture. The LC product was stable in solution at 4° C. for at least 6 months. This rBoNT/A LC was proteolytically active, specifically cleaving the Glu-Arg bond in a 17-residue synthetic peptide of SNAP-25, the reported cleavage site of BoNT/A.

Abstract: Aspects relate to a cognitive agent that performs functions associated with a desired result. The functions performed by cognitive agent supplement other activities performed at a same time. In such a manner, the cognitive agent can function as a surrogate for a user. A performed activity can trigger implementation of another activity that is an extension of the performed activity. Cognitive agent can perform functions that can be represented as an avatar. Further, cognitive agent can be associated with a diagnostics component that evaluates an operating condition. Based on the operating condition cognitive agent can implement automatic actions associated with mitigating failures and/or prolonging the life of machinery.

Abstract: Aspects relate to providing markers related to a mapping application, wherein the provided markers are selectively modified as a function of the relevancy of the markers to a person that has requested the markers. The relevancy is determined based on one or more indicators included in the marker. The indicators answer questions related to who, what, when, where, and why. Markers can be ranked based on the association between the person that requested the marker and the person that provided the marker. Further, a copy of an original marker can be modified to conform with the relevancy of the marker to the requestor.

Abstract: Various entities might desire to leave markers at various locations in a mapping application for themselves and others. These markers can be provided by an entity physically located near the location associated with the marker and/or at a different location (e.g., entity is at a first location and the marker is associated with a second location). Further, different entities can provide markers associated with a similar geographic area. A user visiting the location (virtually or physically) can review the various markers left by others. In such a manner, the user visiting the location can have further details associated with the location. Different categories of markers can be combined and rendered to the user as a hybrid of markers.

Abstract: Disclosed are novel tangible financial instruments that allow entities to effectively and efficiently hedge the highly volatile fluctuations associated with predicting healthcare costs and revenues by converting healthcare services into commodities and constructing a financial derivative and a security with an underlying value based on the commodity. The financial instruments create a more efficient marketplace for the exchange of healthcare related products and services.

Abstract: This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as well as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.

Abstract: The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.

Abstract: Provided is a single repository for capturing, connecting, sharing, and visualizing information based on a geographic location, for example. Detailed information about a structure or other object information can be displayed as mode information. An object of interest can be identified by monitoring a user activity or inactivity with regard to a displayed map. If the user hovers a pointing device over an object within the displayed map for longer than a predetermined amount of time, it can be inferred that the user should be presented with additional information regarding the object.

Abstract: Disclosed is a system and method for creating a financial index related to healthcare costs. A financial derivative instrument can be created from the index. Using the financial derivative instrument, an entity can hedge against unexpected fluctuations of healthcare costs.

Abstract: Provided is a single repository for capturing, connecting, sharing, and visualizing information based on a geographic location, for example. Detailed information about a structure or other object information can be displayed as mode information. An object of interest can be identified by monitoring a user activity or inactivity with regard to a displayed map. If the user hovers a pointing device over an object within the displayed map for longer than a predetermined amount of time, it can be inferred that the user should be presented with additional information regarding the object.

Abstract: Disclosed is a system and method for creating a financial index related to healthcare costs. A financial derivative instrument can be created from the index. Using the financial derivative instrument, an entity can hedge against unexpected fluctuations of healthcare costs.

Abstract: A spatial data handling and map generation system comprises a receiver component that receives a request for information associated with a geographic region and data associated with an initiator of the request. A mapping component renders a representation of the geographic region, the representation is customized according to a role assigned to the initiator of the request, the role is assigned based at least in part upon the received data.

Abstract: The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.

Abstract: This invention relates to a method of automatically setting the gain of an echo signal in a Doppler ultrasound haemodynamic monitor. In essence the invention comprises monitoring the strength of velocity components measured by the apparatus, and identifying a group of such components occupying a particular band within the overall velocity spectrum. The signal gain is then adjusted so that the perceived with of the band falls within predetermined limits. The monitoring or assessment of the velocity components is preferably undertaken when the overall flow velocity is high e.g. during systole.

Abstract: Provided is a single repository for capturing, connecting, sharing, and visualizing information based on a geographic location, for example. Detailed information of a structure or object information can be displayed on a rooftop or over an area of interest. The detailed information can be provided for a single structure or for each structure shown on a map area. According to an embodiment is a system that facilitates surface overlay and bounding on a map. The system can include a receiver component that receives information for an object, a boundary component that ascertains a perimeter of the object, and a rendering component that selectively displays the object information and object on a map based in part on a user perspective.

Abstract: Provided is a single repository for capturing, connecting, sharing, and visualizing information based on a geographic location, for example. Detailed information of a structure or object information can be displayed on a rooftop or over an area of interest. The detailed information can be provided for a single structure or for each structure shown on a map area. According to an embodiment is a system that facilitates surface overlay and bounding on a map. The system can include a receiver component that receives information for an object, a boundary component that ascertains a perimeter of the object, and a rendering component that selectively displays the object information and object on a map based in part on a user perspective.

Abstract: The claimed subject matter provides a system and/or a method that facilitates automatically generating an advertisement. An interface component can receive a portion of image data related to at least one of a good or a service associated with a transaction. An automatic posting component can automatically generate an advertisement with a portion of descriptive data related to at least one of the good or the service based at least in part upon the image data, wherein the created advertisement is published to an environment for exposure.