Patents by Inventor Libing Chen
Libing Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240168721Abstract: A random transient power test signal generator based on three-dimensional memristive discrete map, which utilizes a three-dimensional parallel bi-memristor Logistic map module to generate two pseudo-random sequences, and based on the sequences, uses two waveform output modules to generate transient voltage and transient current signals respectively, thus the random transient power testing signal is obtained. The map can significantly improve the complexity of chaos and greatly extend its range of chaos. In addition, a performance evaluation shows the map has more robust hyperchaotic behavior in much larger chaos range. Moreover, the random sequences generated by the map module combines with DDS, which can generate a transient power signal with completely random period, starting phase and ending phase.Type: ApplicationFiled: January 3, 2024Publication date: May 23, 2024Applicant: UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINAInventors: Bo XU, Libing Bai, Xiaowei Luo, Jia Zhao, Yuhua Cheng, Hang Geng, Kai Chen, Yifan Wang, Gen Qiu
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Publication number: 20240168027Abstract: The invention belongs to the technical field of biomedical testing, and particularly relates to a biomarker for diagnosis, treatment, and prognosis for hepatocellular carcinoma bone metastasis (HCC) and application thereof. The application of biomarker VAPA for preparing a reagent or a kit for diagnosis, treatment, and prognosis for HCC bone metastasis. The application of the reagent that detects VAPA expression levels in blood and tissues for preparing a reagent or kit for diagnosis, treatment, and prognosis for HCC bone metastasis. Compared with the diagnostic kits in the prior art that can only detect bone metastasis after it has occurred, the VAPA described in this invention offers a more specific and sensitive assay kit for the early prediction, diagnosis, disease progression assessment, treatment efficacy evaluation, drug guidance, and prognosis assessment of HCC bone metastasis. Additionally, the VAPA may also serve as a target for therapeutic interventions in bone metastasis.Type: ApplicationFiled: May 30, 2023Publication date: May 23, 2024Inventors: Jun LI, Libing Song, Shuxia ZHANG, Xinyi LIAO, Suwen CHEN, Wanying QIAN
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Publication number: 20240144864Abstract: Provided are a beveled light-emitting lamp bead, a beveled light-emitting lamp bead holder, a manufacturing method therefor, and a display device. The beveled light-emitting lamp bead holder includes a holder body and a metal holder embedded in the holder body, where the holder body is divided by the metal holder into a cup shield located on a top side and a support structure located on a bottom side, a cup bottom in the cup shield is provided with a chip mounting surface parallel to a cup rim top surface, a bottom portion of the support structure is provided with a soldering plane, the soldering plane is electrically connected to the chip mounting surface through the metal holder, and an inclination angle is formed between the chip mounting surface and the soldering plane.Type: ApplicationFiled: August 29, 2023Publication date: May 2, 2024Applicant: FOSHAN NATIONSTAR OPTOELECTRONICS CO., LTD.Inventors: Libing PAN, Zhiguo XIE, Penghui DONG, Xiaoji ZHANG, Danlei GONG, Man ZHAO, Zihao CHEN
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Patent number: 11929515Abstract: The application relates to a battery pack case and a battery pack. The battery pack case includes: a bottom plate and a side plate connected with the bottom plate, the bottom plate and the side plate surround to form an accommodating portion configured to accommodate a unit cell; the bottom plate is provided with a plurality of first grooves and a plurality of second grooves opening toward the accommodating portion, the plurality of first grooves are spaced apart from each other, the plurality of second grooves are spaced apart from each other, and the first grooves and the second grooves are arranged to cross each other. The bottom plate of the battery pack itself has good rigidity, is not prone to warp deformation, and can prevent the overflow of structural glue from contaminating the wiring harness or electrical components.Type: GrantFiled: November 21, 2022Date of Patent: March 12, 2024Assignee: CONTEMPORARY AMPEREX TECHNOLOGY CO., LIMITEDInventors: Zhaolin Xie, Peng Wang, Derong Wang, Libing Chan, Zengzhong Wang, Yifeng Chen
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Patent number: 11922335Abstract: The present disclosure relates to a method and system for evaluating the macro resilience of offshore oil well control equipment. The method for evaluating the macro resilience of offshore oil well control equipment comprises six steps: determining the type and strength of external disaster; calculating the failure rate of components; calculating the recovery rate of the components; modeling the BN for a degradation process; modeling the BN for a maintenance process; and calculating the resilience of the offshore oil well control equipment. A system for evaluating the macro resilience of offshore oil well control equipment comprises an external disaster evaluation module, a component failure rate calculation subsystem, a reliability degradation process simulation module, a fault identification module, a component recovery rate calculation module, a reliability recovery process simulation module, a reliability change curve derivation unit and an resilience calculation unit.Type: GrantFiled: December 5, 2019Date of Patent: March 5, 2024Assignee: China University of Petroleum (East China)Inventors: Baoping Cai, Yonghong Liu, Yanping Zhang, Chuntan Gao, Xiaoyan Shao, Hongqi Xu, Xincheng Li, Yandong Chen, Renjie Ji, Zengkai Liu, Libing Liu, Rikui Zhang, Yuqian Yang, Shitang Liu, Xin Wei
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Patent number: 11427610Abstract: The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.Type: GrantFiled: October 16, 2018Date of Patent: August 30, 2022Assignee: Bristol-Myers Squibb CompanyInventors: Brian E. Fink, Yufen Zhao, Libing Chen, Audris Huang
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Patent number: 11339185Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.Type: GrantFiled: November 14, 2019Date of Patent: May 24, 2022Assignee: Bristol-Myers Squibb CompanyInventors: Brian E. Fink, Dharmpal S. Dodd, Steven J. Walker, Libing Chen, Yufen Zhao, Zheming Ruan, Lan-Ying Qin, Peter Kinam Park, Muthoni G. Kamau, Lalgudi S. Harikrishnan
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Publication number: 20210253624Abstract: The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.Type: ApplicationFiled: October 16, 2018Publication date: August 19, 2021Inventors: Brian E. FINK, Yufen Zhao, Libing Chen, Audris Huang
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Patent number: 10947263Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.Type: GrantFiled: August 30, 2018Date of Patent: March 16, 2021Assignee: Bristol-Myers Squibb CompanyInventors: Lan-Ying Qin, Zheming Ruan, Libing Chen, Scott Hunter Watterson, Brian E. Fink
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Publication number: 20200223883Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.Type: ApplicationFiled: August 30, 2018Publication date: July 16, 2020Inventors: Lan-Ying Qin, Zheming Ruan, Libing Chen, Scott Hunter Watterson, Brian E. Fink
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Publication number: 20200079815Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.Type: ApplicationFiled: November 14, 2019Publication date: March 12, 2020Inventors: Brian E. FINK, Dharmpal S. Dodd, Steven J. Walker, Libing Chen, Yufen Zhao, Zheming Ruan, Lan-Ying Qin, Peter Kinam Park, Muthoni G, Kamau, Lalgudi S. Harikrishnan
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Patent number: 10519187Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.Type: GrantFiled: February 11, 2019Date of Patent: December 31, 2019Assignee: Bristol-Myers Squibb CompanyInventors: Brian E. Fink, Dharmpal S. Dodd, Steven J. Walker, Libing Chen, Yufen Zhao, Zheming Ruan, Lan-Ying Qin, Peter Kinam Park, Muthoni G. Kamau, Lalgudi S. Harikrishnan
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Publication number: 20190248828Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.Type: ApplicationFiled: February 11, 2019Publication date: August 15, 2019Inventors: Brian E. Fink, Dharmpal S. Dodd, Steven J. Walker, Libing Chen, Yufen Zhao, Zheming Ruan, Lan-Ying Qin, Peter Kinam Park, Muthoni G. Kamau, Lalgudi S. Harikrishnan
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Patent number: 9758492Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.Type: GrantFiled: August 26, 2014Date of Patent: September 12, 2017Assignees: Bristol-Myers Squibb Company, Syngene International Limited, Syngene International LimitedInventors: Jay A. Markwalder, Steven P. Seitz, James Aaron Balog, Audris Huang, Sunil Kumar Mandal, Shefali Srivastava, David K. Williams, Libing Chen
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Patent number: 9675571Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.Type: GrantFiled: March 12, 2014Date of Patent: June 13, 2017Assignee: Bristol-Myers Squibb CompanyInventors: James Aaron Balog, Audris Huang, Bin Chen, Libing Chen, Steven P. Seitz, Amy C. Hart, Jay A. Markwalder
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Patent number: 9624188Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention. Formula (I).Type: GrantFiled: March 12, 2014Date of Patent: April 18, 2017Assignee: Bristol-Myers Squibb CompanyInventors: James Aaron Balog, Audris Huang, Bin Chen, Libing Chen, Weifang Shan
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Patent number: 9427442Abstract: Disclosed are compounds of Formula (I): (Formula (I)) wherein: R1 is —CH2CH2CF3; R2 is —CH2CH2CH2F, —CH2CF2CH3, —CH2CH2CF3, —CH2CH(CH3)CF3, —CH2CH2CF2CH3, (Formulae (II), (III), (IV), (V) or (VI): R3 is H or —CH3; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.Type: GrantFiled: September 20, 2013Date of Patent: August 30, 2016Assignee: Bristol-Myers Squibb CompanyInventors: Yufen Zhao, Ashvinikumar V. Gavai, Patrice Gill, Soong-Hoon Kim, Brian E. Fink, Libing Chen, Mark G. Saulnier, Wen-Ching Han
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Publication number: 20160200674Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.Type: ApplicationFiled: August 26, 2014Publication date: July 14, 2016Applicant: Bristol-Myers Squibb CompanyInventors: Jay A. Markwalder, Steven P. Seitz, James Aaron Balog, Audris Huang, Sunil Kumar Mandal, Shefali Srivastava, David K. Williams, Libing Chen
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Patent number: 9371328Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.Type: GrantFiled: February 27, 2014Date of Patent: June 21, 2016Assignee: Bristol-Myers Squibb CompanyInventors: Brian E. Fink, Libing Chen, Ashvinikumar V. Gavai, Liqi He, Soong-Hoon Kim, Andrew James Nation, Yufen Zhao, Litai H. Zhang
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Publication number: 20160108050Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.Type: ApplicationFiled: December 21, 2015Publication date: April 21, 2016Inventors: Ashok Vinayak Purandare, Brian E. Fink, Walter Lewis Johnson, Amy C. Hart, Liqi He, Tram N. Huynh, Jennifer lnghrim, Harold Mastalerz, Xiaopeng Sang, Christine M. Tarby, Honghe Wan, Wayne Vaccaro, Guifen Zhang, Yufen Zhao, Kurt Zimmermann, Yong Zhang, Libing Chen, Bin Chen, John S. Tokarski, Ashvinikumar V. Gavai