Abstract: The present invention relates to the field of fluid heat transfer, and discloses a heat transfer enhancement pipe as well as a cracking furnace and an atmospheric and vacuum heating furnace including the same. The heat transfer enhancement pipe (1) includes a pipe body (10) of tubular shape having an inlet (100) for entering of a fluid and an outlet (101) for said fluid to flow out; internal wall of the pipe body (10) is provided with a fin (11) protruding towards interior of the pipe body (10), the fin (11) spirally extends in an axial direction of the pipe body (10), wherein a height of the fin (11) gradually increases from one end in at least a part extension of the fin. The heat transfer enhancement pipe can reduce thermal stress of itself, thereby increasing service life of the heat transfer enhancement pipe.

Abstract: The present disclosure provides a risk assessment method of water inrush in tunnels constructed in water-rich grounds. The method includes the following steps: simulating a tunnel excavation process by finite element software MIDAS GTS NX and fluid-structure interaction; according to a research method of control variables, analyzing effects of a groundwater level, an elastic modulus and advanced pipe shed grouting on the stability of surrounding rock, and improving an algorithm of a radial basis function (RBF) neural network using a Grey Relation Analysis (GRA)-based Partitioning Around Medoid (PAM) clustering algorithm to assess risks of water inrush occurring in Qingdao area.

Abstract: Provided is a pixel driving circuit configured to provide a signal to a to-be-driven element. The pixel driving circuit includes: a current control sub-circuit, configured to transmit a current signal; a time length control sub-circuit, configured to transmit a time signal; and an output sub-circuit, electrically connected with the time length control sub-circuit and the current control sub-circuit, respectively; where the time length control sub-circuit is further configured to control the output sub-circuit to be turned on or off based on the time signal; the output sub-circuit is configured to, when turned on, control a current applied to the to-be-driven element based on the current signal, where duration of two adjacent turn-ons of the output sub-circuit is same and duration of two adjacent turn-offs of the output sub-circuit is same.

Abstract: The present invention disclosure also relates to a pharmaceutical composition that ccomprises the compound as an active ingredient.

Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted. Moreover, in the present disclosure, the arctigenin is dissolved in an oil phase, and the oil phase is dissolved in water by emulsification to further make the arctigenin dissolve in the water and increase water solubility of the arctigenin.

Abstract: Embodiments of the present disclosure relate to an autonomous vehicle and a system for the autonomous vehicle. The system may include: a power supply including a first power output and a second power output; a master computing unit arranged to be powered by the first power output, configured to control operations of the autonomous vehicle in response to detecting the second power output, and configured to provide a third power output by adjusting the first power output; and a slave computing unit arranged to be powered by the second power output, and configured to control the operations of the autonomous vehicle in response to detecting a failure of the master computing unit.

Abstract: A phase shifter, an electrically regulated antenna, a network device, and a phase shifter manufacturing method are provided. The phase shifter includes: a shielding member, and an adjustable dielectric layer provided in a shielding space formed by the shielding member; the adjustable dielectric layer includes a line layer and a dielectric member. The line layer includes a feed circuit and an empty slot arranged corresponding to the feed circuit and used to form an air strip line. The dielectric member is inserted into the empty slot, and a dielectric constant of the feed circuit is changed by controlling a depth of the dielectric member inserted into the empty slot.

Abstract: A method for determining a transmission channel in a millimeter wave system, a signal transmission method, an apparatus for determining a transmission channel in a millimeter wave system, a signal transmission apparatus, a millimeter wave system, a computer device, and a computer readable medium, the method includes: constructing a beam spatial channel model of a millimeter wave system, wherein the beam spatial channel model uses a matrix with sparsity to represent sub-beams in the millimeter wave system, and elements in the matrix represent channel gains of respective sub-beams in the millimeter wave system, respectively; acquiring a beam spatial channel matrix of a legitimate user in the beam spatial channel model; and using a sub-beam with concentrated energy in the beam spatial channel matrix of the legitimate user as a transmission channel.

Abstract: Disclosed are a key generation method, apparatus, an electronic device, and a storage medium. The key generation method comprises: obtaining a channel characteristic parameter of a wireless channel; generating a key according to the channel characteristic parameter; capturing after continuously generating multiple keys, a first key matrix by means of a sliding window having a preset length, to obtain a second key matrix; determining a correlation between keys in the second key matrix, and performing key substitution on the keys in the second key matrix when the correlation between the keys in the second key matrix is greater than a preset threshold; and adding the keys in the second key matrix to a key pool until the number of keys in the key pool reaches a preset number.

Abstract: Provided are certain Bcl-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Provided are certain CDK2/4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Provided are certain TRK inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Provided are certain URAT1 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: The present invention provides a drug virtual screening system for crystal complexes, and method of using the same, comprising a visualization subsystem, an evaluation tool box subsystem, an AI model management subsystem, a large-scale sampling subsystem, a virtual screening subsystem, and a data log storage subsystem. Starting with the known crystal complexes, a batch of candidate compounds that meet the requirements are recommended after going through the visualization subsystem, evaluation tool box subsystem, AI model management subsystem, large-scale sampling subsystem, and virtual screening system in turn. Based on this system, the generation of the compound library is organically combined with the subsequent virtual screening. Users only need to describe the action mode of the drug on the protein and the requirements for the drug to generate a batch of compounds that meet the expectations. The automated system reduces user intervention and improves the efficiency of research and development.

Abstract: PbI2 thin film crystallization control is prerequisite of high-quality perovskite layer for the sequentially solution-processed perovskite solar cells. According to the present invention, an efficient-and-simple method has been developed by adding halogen acid additive to improve perovskite thin-film quality and an efficiency of at least 15.2% is obtained. This approach improves coverage, uniformity and stability of pervoskite thin-film. In addition, a nanofiber scaffold is incorporated into the perovskite layer so as to reduce the amount of grain boundaries, thus substantially reducing electron recombination within these boundaries.

Abstract: Provided are certain IDO inhibitors or pharmaceutically acceptable salts thereof which can inhibit enzymatic activity of indoleamine 2,3-dioxygenase (IDO) and may be useful for the treatment of diseases and disorders mediated by IDO. In addition, pharmaceutical compositions thereof and methods of use thereof are also provided.

Abstract: Provided are certain TRK inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Provided are certain IDO inhibitors or pharmaceutically acceptable salts thereof which can inhibit enzymatic activity of indoleamine 2,3-dioxygenase (IDO) and may be useful for the treatment of diseases and disorders mediated by IDO. In addition, pharmaceutical compositions thereof and methods of use thereof are also provided.

Abstract: Certain CDK4/6 inhibitors and pharmaceutically acceptable salts thereof are described. In particular, these compounds can inhibit kinase activity of CDK4/6 and may be useful for the treatment of hyper-proliferative diseases like cancer and inflammation. In addition, the pharmaceutical compositions thereof and methods of use thereof are also described.

Abstract: Provided are certain compounds or pharmaceutically acceptable salts thereof which can inhibit kinase activity of Bruton's tyrosine kinase (BTK) and may be useful for the treatment of diseases like cancer, immunological disease and inflammation.