Abstract: Disclosed herein are RNA methyltransferase inhibitors and methods of using and making the same. The inhibitors may be used in a method for the treatment of a subject in need of a treatment for a cancer by administering an effective amount of the RNA methyltransferase inhibitor and an effective amount of a DNA damaging agent to the subject.

Abstract: A cerium-zirconium-aluminum-based composite material, a cGPF catalyst and a preparation method thereof are provided. The cerium-zirconium-aluminum-based composite material adopts a stepwise precipitation method, firstly preparing an aluminum-based pre-treated material, then coprecipitating the aluminum-based pre-treated material with zirconium and cerium sol, and finally roasting at high temperature to obtain the cerium-zirconium-aluminum-based composite material. The cerium-zirconium-aluminum-based composite material has better compactness and higher density, and when it is used in cGPF catalyst, it occupies a smaller volume of pores on the catalyst carrier, such that cGPF catalyst has lower back pressure and better ash accumulation resistance, which is beneficial to large-scale application of cGPF catalyst.

Abstract: Disclosed herein are RNA methyltransferase inhibitors and methods of using and making the same. The inhibitors may be used in a method for the treatment of a subject in need of a treatment for a cancer by administering an effective amount of the RNA methyltransferase inhibitor and an effective amount of a DNA damaging agent to the subject.

Abstract: Disclosed herein are RNA methyltransferase inhibitors and methods of using the same. The inhibitors may be used in a method for the treatment of a subject in need of a treatment for a cancer by administering an effective amount of an RNA methyl-transferase inhibitor to the subject.

Abstract: A modified naphthalene series water reducing agent for concrete with high slit content, and preparation method and application thereof, belonging to the field of concrete admixtures, and comprising the following components by weight: 20-30 wt % of naphthalene series water reducing agent, 10-20 wt % of high molecular weight polyethylene, 0.1-1 wt % of solid acid catalyst, and the balance of alkane solvent, and the sum of the components is 100 wt %. The present invention provides a simple preparation method for the water reducing agent, and the prepared solvent can be recycled, moreover, on the premises of not increasing costs, the prepared water reducing agent can not only effectively solve the fluidity decline of fresh concrete prepared by aggregate with high slit content, but improves the mechanical strength and other properties of concrete, in order to meet the construction requirements of concrete works.

Abstract: A cerium-zirconium-aluminum-based composite material, a cGPF catalyst and a preparation method thereof are provided. The cerium-zirconium-aluminum-based composite material adopts a stepwise precipitation method, firstly preparing an aluminum-based pre-treated material, then coprecipitating the aluminum-based pre-treated material with zirconium and cerium sol, and finally roasting at high temperature to obtain the cerium-zirconium-aluminum-based composite material. The cerium-zirconium-aluminum-based composite material has better compactness and higher density, and when it is used in cGPF catalyst, it occupies a smaller volume of pores on the catalyst carrier, such that cGPF catalyst has lower back pressure and better ash accumulation resistance, which is beneficial to large-scale application of cGPF catalyst.

Abstract: A water jet debridement and wound bed preparation system includes a handle (22b) with integrated, molded components, for example, a distal tip (26) that receives liquid from a jet tube (28) is integral with a handle housing to which the jet tube is mounted. In another embodiment, in which the handle does not include a distal tip, liquid flows from a jet tube having a straight distal end region. In another embodiment, the system includes a piston pump with integrated, molded components. In another embodiment, the system includes a dual-spike saline bag assembly.

Abstract: A novel power generation type electromagnetic damping tuned mass damper comprises a connecting plate, a supporting guide rail fixed to the connecting plate, an mass block, a mounting assembly fixed to the mass block and a power generation type electromagnetic damping mechanism mounted on the mounting assembly. The power generation type electromagnetic damping mechanism comprises a power generation type electromagnetic damping assembly mounted on the mounting assembly, a roller rotatably mounted on the mounting assembly, a driving wheel mounted on the roller, a driven wheel mounted at an output end of the power generation type electromagnetic damping assembly and a conveyor belt sleeved on the driving wheel and the driven wheel; the roller is mounted on the supporting guide rail in a rolling manner, and the rotating centers of the roller and the driving wheel are the same and the roller and the driving wheel rotate synchronously.

Abstract: A novel power generation type electromagnetic damping tuned mass damper comprises a connecting plate, a supporting guide rail fixed to the connecting plate, an mass block, a mounting assembly fixed to the mass block and a power generation type electromagnetic damping mechanism mounted on the mounting assembly. The power generation type electromagnetic damping mechanism comprises a power generation type electromagnetic damping assembly mounted on the mounting assembly, a roller rotatably mounted on the mounting assembly, a driving wheel mounted on the roller, a driven wheel mounted at an output end of the power generation type electromagnetic damping assembly and a conveyor belt sleeved on the driving wheel and the driven wheel; the roller is mounted on the supporting guide rail in a rolling manner, and the rotating centers of the roller and the driving wheel are the same and the roller and the driving wheel rotate synchronously.

Abstract: Disclosed herein, are compositions comprising one or more therapeutic agents non-covalently conjugated to a nanomaterial (e.g., graphene oxide). Also, described herein, are methods of preparing stable compositions, the methods comprising a plurality of antibodies non-covalently bound to graphene oxide; physiologically acceptable compositions including them; and methods of administering the compositions to patients for the treatment of a disease such as cancer and autoimmune disorders as well as for the prevention of graft rejection.

Abstract: Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyses. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique.

Abstract: Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyses. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique.

Abstract: Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyzes. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique.

Abstract: An image array includes pixels, each representing an image-based feature value of a patient obtained from imaging. The array includes first and second dimensions. Pixels corresponding to a specific patient of a plurality of patients extend in the first dimension and pixels corresponding to a specific feature of a plurality of features extend in the second dimension. Patients represented in the image array are grouped into two or more groups. Each indicates a known condition, such that patients having a first and second conditions are respectively part of a first and a second group and are in a first and a second portion of the array, respectively. The groups are separately organized according to a selected feature. Patients of the first and second groups are respectively arranged in an order of values for the selected feature within the first and second portions.

Abstract: A temperature estimation method including: receiving a scan signal generated by scanning the target region using the ultrasound signal, and estimating, based on the scan signal, an echo shift which is an amount of change in time required for the ultrasound signal to pass through the target region, the time changing depending on the temperature in the target region; estimating, based on the estimated echo shift, a strain which is an apparent change rate of a travel distance required for the ultrasound signal to pass through the target region, the travel distance changing depending on the temperature in the target region; estimating, based on the estimated strain, a strain rate which is a temporal change rate of the strain; and estimating the temperature in the target region corresponding to the strain and the strain rate, based on a predetermined relationship between a strain, a strain rate, and a temperature.

Abstract: Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyses. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique.

Abstract: A solution for determining a neutral point of a drillstring in drilling a borehole is disclosed. The solution includes receiving depth-time log data for drilling the borehole with the drillstring, the depth-time log data including data related to a torque and drag factor and data related to a hydraulic factor; and determining the neutral point of the drillstring at a time point during the drilling based on the torque and drag factor and the hydraulic factor.

Abstract: A method for computer-assisted interpretation of medical images that factor in characteristics of an individual performing the interpretation. The method automatically determines and/or incorporates prevalence-based computer analysis based on an estimated likelihood of a pathological state, e.g., a malignancy. A system implementing the method includes the calculation of features or other characteristics of images in a known database, calculation of features of an unknown case, calculation of the probability (or likelihood) of disease state, calculation of the modified computer output that includes the internal prevalence (or internal decision-making process) of the user (or group of users), and output of the result.

Abstract: A solution for determining a neutral point of a drillstring in drilling a borehole is disclosed. A method may comprise: receiving depth-time log data for drilling the borehole with the drillstring, the depth-time log data including data related to a torque and drag factor and data related to a hydraulic factor; and determining the neutral point of the drillstring at a time point during the drilling based on the torque and drag factor and the hydraulic factor.

Abstract: A method, system, and computer program product for identifying at least one three-dimensionally extended lesion within a volumetric region encompassing an inner surface, an outer surface, and intervening tissue of a target organ. The method includes: (1) generating a set of voxels representing a total scanned volume from a set of cross-sectional images of the target organ; (2) performing segmentation to extract a set of voxels representing the volumetric region from the set of voxels representing the total scanned volume; (3) detecting a set of candidate lesions based on geometric feature values of each voxel in the set of voxels representing the volumetric region; and (4) selecting the at least one three-dimensionally extended lesion from the set of candidate lesions based on at least one of volumetric, morphologic, and texture feature values of each lesion in the set of candidate lesions.