Abstract: Systems and methods for coating surgical needles are provided.

Abstract: The invention describes compositions that include amine-containing silsesquioxane or an amine-containing alkyltrialkoxysilane and a thermoplastic elastomer as well as methods of preparation of the compositions that are useful as self-bonding adhesives for various substrates.

Abstract: Novel apparatus and methods for coating surgical needles in batch processes are disclosed.

Abstract: Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Abstract: The invention describes compositions that include amine-containing silsesquioxane or an amine-containing alkyltrialkoxysilane and a thermoplastic elastomer as well as methods of preparation of the compositions that are useful as self-bonding adhesives for various substrates.

Abstract: Provided are rapidly cross-linkable silicone foam compositions, kits, and methods for filling implanted medical devices in situ or in vivo, the implanted medical devices, including for example, body implants and tissue expanders, the compositions including a platinum divinyl disiloxane complex; a low viscosity vinyl terminated polydimethylsiloxane; a low viscosity hydride terminated polydimethylsiloxane; a silicone cross-linker; and a gas and/or gas-filled microcapsules, where the rapidly cross-linkable silicone foam composition has a viscosity of ?150 cPs for ?1 min. post-preparation and ?300 cPs?5 min. post-preparation, at ambient temperature.

Abstract: Provided are rapidly cross-linkable silicone compositions, systems, kits, and methods for filling implanted medical devices in situ, the implanted medical devices, including for example, body implants and tissue expanders, the compositions including a platinum divinyl disiloxane complex; a low viscosity vinyl terminated polydimethylsiloxane; a low viscosity hydride terminated polydimethylsiloxane; and a silicone cross-linker, where the rapidly cross-linkable silicone composition has a viscosity of ?150 cPs for ?1 min. post-preparation and ?300 cPs ?5 min. post-preparation, at ambient temperature.

Abstract: A silicone coating process that improves the durability of silicone coatings on the surfaces of surgical needles and other medical devices. The silicone coated surgical needles or medical devices produced by this process have both superior lubricity and durability for ease of repeated and successive passes through tissue. The coating compositions used in the novel process contain an excess amount of polymethylhydrosiloxane cross-linker. After curing, the process utilizes gamma radiation to treat the lubricious coatings. The coatings have improved durability and performance. The penetration performance of needles coated by this novel method remains constant and flat over at least one hundred repeat passes through tissue or tissue simulation media. This provides a consistent or flat tactile response from the needles to the hand of the surgeon during a lengthy closure process, rather than an unpredictably increasing force profile.

Abstract: A novel method of blackening surgical needles is disclosed. Surgical needles having outer surfaces are first placed into a first pretreatment bath having a novel composition. The needles are then placed into a second blackening bath having a novel composition for a sufficient period of time to effectively blacken the surfaces of the needles. The novel methods for blackening the surfaces of a stainless steel alloy surgical needle provide a chromium (VI)-free alternative to current needle manufacturing processes. Another unique feature of this novel method is its short processing time. The blackening processes of the present invention can be utilized for in-line treatment processes which can be easily incorporated into high speed needle manufacturing processes, such as strip mounted processes. In addition, the processes of the present invention are readily adaptable to batch processes. Also disclosed are novel systems for blackening surgical needles and novel blackening baths for surgical needles.

Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic IDUA or IDS protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of MPS I or MPS II disease.

Abstract: Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Abstract: Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Abstract: Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Abstract: A novel two-step process for batch coating surgical needles with cross-linked silicone coatings is disclosed. The surgical needles are cured using a two-step process. The coatings on the needles are partially cured in the first step and mechanically separated. The coatings on the needles are then fully cured in the second step.

Abstract: An object is formed on a component with a positive flash shut-off during insert molding operations. The mold has a base with a cavity and a port that delivers a liquid to the cavity. The base has a component support structure for supporting the component and pockets formed on opposite sides of the cavity. The pockets are slightly spaced apart from the cavity by thin partitions. Inserts located in the pockets and are formed from a polymer. Both the partitions and inserts comprise the component support structure. The inserts have a dimension that is smaller than that of the base and partitions so as to form a compression fit around the component to reduce or eliminate flash down the component during the molding process.

Abstract: A window-stopped method for applying to turbo decoding is disclosed, and proceeds a window detection to decoding information via a window-based detector and detects and records a convergent condition of each window of the decoding information when a turbo decoding is proceeded in every iteration operation and a soft-input soft-output decoder executes the turbo decoding.

Abstract: A novel silicone coating process for surgical needles is disclosed. Coating solutions are applied to a surgical needle and a stream of air is directed at the needle in a direction substantially parallel to the central longitudinal axis of the distal section of the needle, providing superior coatings and performance.

Abstract: A novel silicone coating process for surgical needles is disclosed. Coating solutions are applied to a surgical needle and a stream of air is directed at the needle in a direction substantially parallel to the central longitudinal axis of the distal section of the needle, providing superior coatings and performance.

Abstract: A polymeric article may include a first layer and a second layer directly contacting the first layer. The first layer may include a low surface energy polymer and may have a contact index of at least 5%. The second layer may include an elastomer.

Abstract: The disclosure is directed to a sealing assembly. The sealing assembly includes a cap having a top surface and a bottom surface, an adhesive layer adjacent the bottom surface of the cap, and a septum adjacent to the adhesive layer. The adhesive layer includes a self-bonding silicone composition and the septum includes at least one fluoropolymer layer. The disclosure is further directed to methods for making the aforementioned sealing assembly.