Abstract: The present invention discloses SNP markers associated with PCOS and provides probes, chips, primers, kits and methods for detecting the SNP markers. Furthermore, the present invention relates to the use of SNPs in predicting or diagnosing the risk of PCOS.

Abstract: An automatic airview correction method comprises steps: moving a vehicle to an airview alignment pattern; capturing a plurality of airview alignment images of the surroundings of the vehicle; correcting distortion of the airview alignment images to obtain a plurality of corrected images; performing alignment compensation on the corrected images; searching for corner points of the corrected images and converting view point s to obtain a plurality of view angle-converted images; and searching for corner points of the view angle-converted images, and seaming the view angle-converted images to form a panoramic airview and obtain parameters corresponding to the panoramic airview. The present invention can automatically align images and can also automatically detect corner points to seam the images of the surroundings of a vehicle, whereby to form a panoramic airview.

Abstract: A self-adaptive image-based obstacle detection method comprises steps: capturing an original image; transforming the original image to an HSV color space, and retrieving a hue component (H) and a saturation component (S) of the HSV color space to form an HS-based image; dividing the HS-based image into image blocks; selecting one image block as a background block; using an obstacle recognition equation to determine whether each of the image blocks is similar to the background block; if no, deleting the image block; if yes, preserving the image block to form a binary obstacle image; and overlaying the binary obstacle image on the original image to filter out the background and obtain an initial ambit of an obstacle image. Then, three orderly movement flow equations are used to determine whether it is an obstacle.

Abstract: The present invention discloses SNP markers associated with PCOS and provides probes, chips, primers, kits and methods for detecting the SNP markers. Furthermore, the present invention relates to the use of SNPs in predicting or diagnosing the risk of PCOS.

Abstract: The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.

Abstract: The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.

Abstract: Described is a technology by which artificial words are generated based on seed words, and then used with a letter-to-sound conversion model. To generate an artificial word, a stressed syllable of a seed word is replaced with a different syllable, such as a candidate (artificial) syllable, when the phonemic structure and/or graphonemic structure of the stressed syllable and the candidate syllable match one another. In one aspect, the artificial words are provided for use with a letter-to-sound conversion model, which may be used to generate artificial phonemes from a source of words, such as in conjunction with other models. If the phonemes provided by the various models for a selected source word are in agreement relative to one another, the selected source word and an associated artificial phoneme may be added to a training set which may then be used to retrain the letter-to-sound conversion model.

Abstract: The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.

Abstract: A multichannel audio format provides a truly discrete as well as a backward compatible mix for surround-sound, front or other discrete audio channels in cinema, home theater, or music environments. The additional discrete audio signals are mixed with the existing discrete audio channels into a predetermined format such as the 5.1 audio format. In addition these additional discrete audio channels are encoded and appended to the predetermined format as extension bits in the bitstream. The existing base of multichannel decoders can be used in combination with a mix decoder to reproduce truly discrete N.1 multichannel audio.

Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.

Abstract: A multichannel audio format provides a truly discrete as well as a backward compatible mix for surround-sound, front or other discrete audio channels in cinema, home theater, or music environments. The additional discrete audio signals are mixed with the existing discrete audio channels into a predetermined format such as the 5.1 audio format. In addition these additional discrete audio channels are encoded and appended to the predetermined format as extension bits in the bitstream. The existing base of multichannel decoders can be used in combination with a mix decoder to reproduce truly discrete N.1 multichannel audio.

Abstract: The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.

Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or —S—R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby R2 is C1 to C6 alkyl with a lipase derived from Mucor meihei to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).

Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.

Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.

Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: 1

Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.

Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or —S—R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby R2 is C1 to C6 alkyl with a lipase derived from Mucor meihei to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).

Abstract: New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid sequence which differs at least in one amino acid from the wild-type penicillin G acylase.

Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: 1