Abstract: Disclosed are methods, compositions and uses of high concentration antibody or immunoglobulin formulations for subcutaneous, intramuscular, transdermal or other local (regional) administration, in a volume of than 3, less than 2 or less than 1 ml. Preferably, the formulation contains a high concentration formulation (HCF) buffer comprising phosphate, citrate, polysorbate 80 and mannitol at a pH of about 5.2. The formulation more preferably comprises at least 100, 150, 200, 250 mg/ml or 300 mg/ml of antibody. The methods for preparing the high concentration formulation include ultrafiltration and diafiltration to concentrate the antibody and exchange the medium for HCF buffer. Other embodiments concern use of non-G1m1 (nG1m1) allotype antibodies, such as G1m3 and/or a nG1m1,2 antibodies. The nG1m1 antibodies show decreased immunogenicity compared to G1m1 antibodies.

Abstract: An optical apparatus includes a first beam combining device arranged to receive a first optical beam having a first wavelength at a first location and a second optical beam output having a second wavelength at a second location. The second optical beam has a polarization that is substantially orthogonal to a polarization of the first optical beam. The first beam combining device configured to output a first combined beam that comprises a combination of the first optical beam and the second optical beam. An optical element is arranged to receive the first combined beam and a second combined beam and to transmit an output beam that includes a combination of the first combined beam and the second combined beam.

Abstract: The present disclosure provides for a magnetic writer pole for use in a hard drive. The magnetic writer pole comprises a first bevel formed by a non-magnetic layer, the first bevel formed at a first angle and extending to a first throat height. The magnetic writer pole further comprises a second bevel formed by the non-magnetic layer and extending distally from the first bevel at a second angle that is greater than the first angle and extending to a second throat height. The magnetic writer pole further comprises a third bevel formed by the non-magnetic layer and extending distally from the second bevel at a third angle that is greater than the second angle.

Abstract: Use of low dose streptozocin in the preparation of an animal model for screening drugs for treatment of antoimmune type 1 diabetes is disclosed, in which streptozocin is administrated intravenously at a dose of 15-30 mg/kg per time for 5 days and administrated again on the 7th day and 14th day after last time of offering drug. A method for preparing rhesus monkey model of autoimmune type 1 diabetes and autoimmune type 1 diabetes animal model obtained are also disclosed.

Abstract: Disclosed are methods, compositions and uses of high concentration antibody or immunoglobulin formulations for subcutaneous, intramuscular, transdermal or other local (regional) administration, in a volume of than 3, less than 2 or less than 1 ml. Preferably, the formulation contains a high concentration formulation (HCF) buffer comprising phosphate, citrate, polysorbate 80 and mannitol at a pH of about 5.2. The formulation more preferably comprises at least 100, 150, 200, 250 mg/ml or 300 mg/ml of antibody. The methods for preparing the high concentration formulation include ultrafiltration and diafiltration to concentrate the antibody and exchange the medium for HCF buffer. Other embodiments concern use of non-G1m1 (nG1m1) allotype antibodies, such as G1m3 and/or a nG1m1,2 antibodies. The nG1m1 antibodies show decreased immunogenicity compared to G1m1 antibodies.

Abstract: A method and system provide a magnetic transducer having an air-bearing surface (ABS) and an intermediate layer. A trench having a shape and location corresponding to a main pole is formed in the intermediate layer. The main pole is provided. At least a portion of the main pole is in the trench. Providing the main pole further includes vacuum depositing a first main pole material layer. The first main pole material layer is thin enough to preclude filling of the trench. The first main pole material layer is then ion beam etched. A second main pole layer is vacuum deposited on the first main pole layer. The second main pole material layer is also thin enough to preclude filling of the trench. An additional main pole layer is also deposited.

Abstract: A signal generating method and apparatus in the field of signal technologies are provided. The method includes: adjusting an incident angle of an optical signal entering a polarization beam splitter, so that the polarization beam splitter outputs a first optical signal and a second optical signal that have a preset power ratio; performing QPSK modulation on the first and second optical signal respectively by using a first and second externally input data streams, to obtain a first and a second QPSK optical signal; before the first QPSK optical signal and the second QPSK optical signal are input into a polarization beam combiner, adjusting a polarization state of the first or the second QPSK optical signal; when the polarization states of the two QPSK optical signals are the same, outputting a 16QAM signal; and when the polarization states of the two QPSK optical signals are orthogonal, outputting a DP-QPSK signal.

Abstract: Methods for characterizing relative film density using spectroscopic analysis at the device level are provided. One such method includes obtaining a composition of materials at preselected areas of a workpiece using energy dispersive X-ray spectroscopy, obtaining an electron energy loss spectrum-imaging data at each of the preselected areas using electron energy loss spectroscopy, removing, for each of the preselected areas, a preselected noise component of the electron energy spectrum-imaging data to form a plasmon energy spectrum-imaging data, generating, for each of the preselected areas, a plasmon energy map based on the respective plasmon energy spectrum-imaging data, determining, for each of the preselected areas, an average plasmon energy value from the respective plasmon energy map, and calculating a relative mass density of the preselected areas based on the average plasmon energy value, a number of valence electrons per molecule, and a molecular weight for each of the preselected areas.

Abstract: The present disclosure provides for a magnetic writer pole for use in a hard drive. The magnetic writer pole comprises a first bevel formed by a non-magnetic layer, the first bevel formed at a first angle and extending to a first throat height. The magnetic writer pole further comprises a second bevel formed by the non-magnetic layer and extending distally from the first bevel at a second angle that is greater than the first angle and extending to a second throat height. The magnetic writer pole further comprises a third bevel formed by the non-magnetic layer and extending distally from the second bevel at a third angle that is greater than the second angle.

Abstract: A method and an apparatus for sending an Ethernet physical-layer OAM overhead, and a method and an apparatus for receiving an Ethernet physical-layer OAM overhead are disclosed herein. A method for sending an Ethernet physical-layer OAM overhead includes: adjusting the order of sending a payload block and part of Inter-Packet Gaps (IPGs) in a data stream to be transmitted; and when receiving a request for sending an OAM overhead, substituting the OAM overhead for the part of IPGs, and sending the OAM overhead before sending the payload block. Through the present invention, the order of sending IPGs and payload blocks in an MAC data stream can be adjusted, and the OAM overhead can be sent in time.

Abstract: The present disclosure provides for a magnetic writer pole for use in a hard drive. The magnetic writer pole comprises a first bevel formed by a non-magnetic layer, the first bevel formed at a first angle and extending to a first throat height. The magnetic writer pole further comprises a second bevel formed by the non-magnetic layer and extending distally from the first bevel at a second angle that is greater than the first angle and extending to a second throat height. The magnetic writer pole further comprises a third bevel formed by the non-magnetic layer and extending distally from the second bevel at a third angle that is greater than the second angle.

Abstract: A method for recovering an OTUk frame includes: receiving an optical signal sent by using a method of multi-lane distribution from the OTUk frame to an interface of an optical module; converting the optical signal into an electrical signal, performing electrical equalization and demodulation on the electrical signal, and recovering multi-lane data from the demodulated signal; aligning and rearranging the data on each lane, according to a lane sequence identifier included in an overhead frame header of the data on each lane; and recovering the OTUk frame according to the aligned and rearranged data. According to the present invention, lane rearrangement is performed by detecting the lane sequence identifier, and the recovery of the OTUk frame is achieved. Therefore, a training sequence overhead does not need to be additionally introduced, and the influence on the system performance is avoided.

Abstract: Disclosed herein are materials and methods for culturing cells derived from joint cavities, said culturing being performed in the presence of synovial fluid. Also disclosed herein are cells cultured by the methods described herein, and their use for therapeutic purposes and for identifying therapeutic agents.

Abstract: A method and apparatus for distributing and receiving high-speed Ethernet Media Independent Interface (MII) blocks are provided to moderate the increase of control lines with the increase of the bit width and to simplify the block types in the coding process of the Physical Coding Sublayer (PCS). The technical solution disclosed herein includes: processing received Media Access Control (MAC) layer data, and adjusting distribution of control characters to generate a 64-bit block; obtaining a control signal code of the 64-bit block according to the relation between the form of the 64-bit block and the control signal code; and binding each 64-bit block to the corresponding control signal code respectively, and sending bound data over a separate channel.

Abstract: Disclosed are methods, compositions and uses of high concentration antibody or immunoglobulin formulations for subcutaneous, intramuscular, transdermal or other local (regional) administration, in a volume of than 3, less than 2 or less than 1 ml. Preferably, the formulation contains a high concentration formulation (HCF) buffer comprising phosphate, citrate, polysorbate 80 and mannitol at a pH of about 5.2. The formulation more preferably comprises at least 100, 150, 200, 250 mg/ml or 300 mg/ml of antibody. The methods for preparing the high concentration formulation include ultrafiltration and diafiltration to concentrate the antibody and exchange the medium for HCF buffer. Other embodiments concern use of non-G1m1 (nG1m1) allotype antibodies, such as G1m3 and/or a nG1m1,2 antibodies. The nG1m1 antibodies show decreased immunogenicity compared to G1m1 antibodies.

Abstract: Disclosed are methods, compositions and uses of high concentration antibody or immunoglobulin formulations for subcutaneous, intramuscular, transdermal or other local (regional) administration, in a volume of than 3, less than 2 or less than 1 ml. Preferably, the formulation contains a high concentration formulation (HCF) buffer comprising phosphate, citrate, polysorbate 80 and mannitol at a pH of about 5.2. The formulation more preferably comprises at least 100, 150, 200, 250 mg/ml or 300 mg/ml of antibody. The methods for preparing the high concentration formulation include ultrafiltration and diafiltration to concentrate the antibody and exchange the medium for HCF buffer. Other embodiments concern use of non-G1m1 (nG1m1) allotype antibodies, such as G1m3 and/or a nG1m1,2 antibodies. The nG1m1 antibodies show decreased immunogenicity compared to G1m1 antibodies.

Abstract: A method for implementing Polarization Division Multiplexing Binary Phase Shift Keying (PDM-BPSK) modulation and Quadrature Phase Shift Keying (QPSK) modulation in a compatible manner includes: dividing a direct current (DC) light into a first channel of light and a second channel of light with the same power; separately performing optoelectrical modulation on the first channel of light and the second channel of light and correspondingly outputting a first optical signal and a second optical signal in a Binary Phase Shift Keying (BPSK) format; performing polarization state control on the first optical signal; performing a phase shift on the first optical signal or the second optical signal; and performing optical signal combination with the polarization state preserved on the first optical signal and the second optical signal after the polarization state control and the phase shift, and outputting a PDM-BPSK modulation optical signal or a QPSK modulation optical signal.

Abstract: Embodiments of the present invention relate to the optical communication field and disclose an optical signal multiplexing method and an optical multiplexer. The method provided in the present invention includes: adjusting polarization states of two of four optical signals to be multiplexed, and preferably, mutually orthogonal to, the polarization states of the remaining two optical signals; combining one optical signal in the adjusted polarization state with one optical signal in the unadjusted polarization state into one optical signal through polarization multiplexing; and combining the two optical signals obtained through polarization multiplexing into one optical signal.

Abstract: Disclosed are methods, compositions and uses of high concentration antibody or immunoglobulin formulations for subcutaneous, intramuscular, transdermal or other local (regional) administration, in a volume of than 3, less than 2 or less than 1 ml. Preferably, the formulation contains a high concentration formulation (HCF) buffer comprising phosphate, citrate, polysorbate 80 and mannitol at a pH of about 5.2. The formulation more preferably comprises at least 100, 150, 200, 250 mg/ml or 300 mg/ml of antibody. The methods for preparing the high concentration formulation include ultrafiltration and diafiltration to concentrate the antibody and exchange the medium for HCF buffer. Other embodiments concern use of non-G1m1 (nG1m1) allotype antibodies, such as G1m3 and/or a nG1m1,2 antibodies. The nG1m1 antibodies show decreased immunogenicity compared to G1m1 antibodies.

Abstract: Compositions, methods and kits are provided for modulating the trans-differentiation of cells for example muscle satellite cells. The compositions, methods and kits include a modulator of trans-differentiation of the muscle satellite cells selected from the group of: a transcription factor, a nucleic acid sequence or vector encoding expression of the transcription factor, and an agent that binds to the transcription factor. The transcription factor is selected for example from a homeodomain class transcription factor such as Nkx3.2 and a TATA binding protein class transcription factor such as Sox9, and includes at least one nucleotide binding-domain, so that the transcription factor modulates the process of trans-differentiation of the cells or tissue to form a phenotype selected from: cartilage, muscle, and bone.