Abstract: A dish washing machine including a housing having an interior wash space and a liquid inlet. A spray nozzle sprays the liquid onto dishes. The machine further includes a heating tank for heating the liquid which is supplied to the rotating spray nozzle. A heat exchange system transfers heat from the liquid heated by the heating tank to the liquid added from the liquid inlet. The heat exchange system comprising a pipe system defining a first path therethrough and a second path therethrough, with the first heat exchange system transferring heat from liquid in the second path to liquid in the first path. A first surface portion of the pipe system of the first path engaging the liquid in the first path having a greater thermal conductivity than a second surface portion of the pipe system of the second path engaging the liquid in the second path.

Abstract: A method and a sensor for detecting L-arginine are provided. The method includes synthesizing ferrocene-functionalized hexadecapeptide dithiocyclopentane (FC-P16 Peptide), preparing a polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE), detecting L-Arg and other steps. The results show that the polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE) exhibits excellent electrochemical response properties to L-Arg. In 10 mmol/L phosphate-buffered saline (PBS, pH=7.4), the DPV response peak current of the polypeptide composite membrane-modified electrode has an excellent linear relationship with the L-Arg concentration of 1.0×10?13 mol/L to 1.0×10?7 mol/L, with a detection limit of 1.0×10?13 mol/L. With prominent reproducibility, repeatability and selectivity, the modified electrode has potential application in life science and nutritional health.

Abstract: An approach is disclosed that determines an amount of time before a webpage is ready to use by a user by performing various actions. The approach captures a recording of the webpage from an invocation of the webpage for a period of time sufficient to load completely load the webpage with the capturing resulting in sequenced image frames. An AI system provides a loading point in the sequenced image frames based on an analysis of the frames input to the trained AI system. Image diversity and saturation measurements are calculated on consecutive image frames from the sequenced image frames resulting in an image change analysis. Native webpage events and times are detected from webpage characteristics gathered from the captured digital recording. The amount of time is then calculated based on the loading point from the AI system, the image change analysis; and the webpage events and their corresponding times.

Abstract: The disclosure discloses an L-aspartate ?-decarboxylase mutant and application thereof, and belongs to the technical field of enzyme engineering. In the disclosure, lysine at position 221 of L-aspartate ?-decarboxylase is mutated to arginine, glycine at position 369 is mutated to alanine, and the obtained new mutant enzymes have better temperature tolerance and are beneficial to industrial production. The K221R and G369A recombinant strains are subjected to high-density fermentation, and with sodium L-aspartate as a substrate, a whole cell catalytic reaction is carried out to prepare ?-alanine. Compared with a chemical production method, the method has the advantages that the production process is safe and clean, and has no environmental pollution. Compared with a pure enzyme catalysis method, the method has the advantages that the operation is simple and convenient. The yield of the final product ?-alanine reaches 91% and 90% respectively, and the concentration reaches 162.15 g/L and 160.42 g/L respectively.

Abstract: The present application relates to a chimeric antigen receptor (CAR) which comprises a target-dependent on-switch CAR. The CAR of the invention may reduce cytotoxicity towards normal cells and improve CAR-T safety. CAR molecules were designed using the transmembrane and juxtamembrane motifs of the IL2 receptor ? chain (IL2R? or IL2Rb), the L ow-Density Lipoprotein Receptor (LDLR), the Seizure 6-like Protein 2 (SEZ6L2), and degradation sequence (PSKFFSQL) of IL2R?, which resulted in greatly reduced CAR expression at the cell surface in the absence of target antigen, while retaining downstream activation ability in response to antigen-expressing target cells. In the absence of target antigen, CAR surface expression is undetectable. The present application has shown that primary T cells expressing these surface-unstable CAR variants are able to elicit antigen-dependent target cell killing. By limiting CAR activity in this way, the present application can reduce therapeutic toxicity and T cell exhaustion.

Abstract: The present invention provides an advancement in the art of cardiac pacemakers. The invention provides a novel and unobvious pacemaker system that comprises at least one pacemaker and that is, to a large extent, self-controlled, allows for long-term implantation in a patient, and minimizes current inconveniences and problems associated with battery life. The invention further includes a mechanism in which at least two pacemakers are implanted in a patient, and in which the pacemakers communicate with each other at the time of a given pacing or respiratory event, without any required external input, and adjust pacing parameters to respond to the patient's need for blood flow. The invention further provides a novel design for a pacemaker in which the pacemaker electrode is connected to the pacemaker body by a lead that is configured to allow the pacemaker to lie parallel to the epicardial surface and to reduce stress on the pacemaker and heart tissue.

Abstract: A dish washing machine including a housing having an interior wash space for washing dishes. The housing has a liquid inlet for adding a liquid to the dish washing machine. At least one spray nozzle sprays the liquid onto dishes positioned within the interior wash space. The machine further includes a heating tank for heating the liquid which is supplied to the at least one spray nozzle for spraying onto the dishes in the interior wash space. At least one heat exchange system is within the housing. The at least one heat exchange system transfers heat from the liquid heated by the heating tank to the liquid added to the dish washing machine from the liquid inlet.

Abstract: A method of packaging a battery device with a metal shell, comprising: applying a waterborne two-component polyurethane composition to the metal shell of the battery device, and drying the applied polyurethane composition to form a packaging layer; wherein the polyurethane composition comprises, (A) an aqueous dispersion comprising a hydroxyl-functional polymer, wherein the hydroxyl-functional polymer comprises, by weight based on the weight of the hydroxyl-functional polymer, from 20% to 50% of structural units of a hydroxy-functional alkyl (meth)acrylate; from 0.1% to 10% of structural units of an acid monomer, a salt thereof, or mixtures thereof; and structural units of a monoethylenically unsaturated nonionic monomer; and (B) a polyisocyanate.

Abstract: An aqueous coating composition comprising (a) from 12.5% to 87% by weight based on the weight of the aqueous coating composition, of a film-forming polymer; (b) from 9.5% to 85% by weight based on the weight of the film-forming polymer, of a specific oligomer; and (c) from 2.5% to 50% by weight based on the weight of the film-forming polymer, of beads with a mean particle size of from 5.0 to 10.5 ?m; and a process for preparing the aqueous coating composition.

Abstract: An X-ray-based test device for a plugging removal effect of a sulfur dissolvent on a sulfur deposition rock sample includes a constant speed and pressure pump, a first intermediate container, a second intermediate container, a first pressure transmitter, a core holder, a second pressure transmitter, a first electric pump, a third intermediate container, a back-pressure valve, a gas flow meter, an H2S neutralization tank, a second electric pump, a back-pressure transmitter, a confining pressure transmitter, an X-ray generator, an X-ray detector and a thermotank. A sour gas sample is placed in the first intermediate container, and nitrogen is filled in the second intermediate container. The sulfur dissolvent is placed into the third intermediate container. A confining pressure inlet is formed in the core holder. The test device may be used for evaluating the plugging removal effect of the sulfur dissolvent injected into the sulfur deposition rock sample.

Abstract: The present disclosure provides a pixel driving circuit, an array substrate and a display panel. The pixel driving circuit of the present disclosure includes a switch transistor and N redundant switch transistors, the switch transistor and the N redundant switch transistors are connected in series, a second electrode of an Nth redundant switch transistor is coupled to a first electrode of the switch transistor, and a second electrode of the switch transistor is coupled to a display electrode.

Abstract: This application provides a method and apparatus for distributed processing of a UX element, and pertains to the field of terminal artificial intelligence. The method includes: obtaining UX capability information of at least two terminal devices, where the UX capability information is used to indicate a UX capability corresponding to each of interaction manners supported by the terminal device; receiving a target task request, where the target task includes UX requirement information of at least two UX elements; determining, based on the UX capability information of the at least two terminal devices and the UX requirement information of the at least two UX elements, a UX element that needs to be processed by each of the at least two terminal devices; and providing, for each of the at least two terminal devices, the UX element that needs to be processed by each of the at least two terminal devices.

Abstract: A clamping device and a machining method. The clamping device comprises: a base; a clamping head comprising a blind rivet and a locking member, the blind rivet comprising a middle column segment and enlarged portions at two ends, and the locking member being connected to an upper end of the blind rivet and defining a clamping opening; a lower cavity connected to the base; an upper cavity comprising an annular peripheral wall and a top wall having a central hole, the top wall being clamped between the two enlarged portions, the middle column segment of the blind rivet movably passing through the central hole, and the upper cavity being connected to the lower cavity in a fit manner; an elastic member located in the peripheral wall and supported between the enlarged portion at a lower portion of the blind rivet and the top wall; and a support cylinder movably fitted in the lower cavity, the support cylinder being supported below the elastic member.

Abstract: This application discloses a notification display method. The method comprises: when there is a to-be-notified event, displaying, by a terminal, a notification by classification based on a notification type of the notification corresponding to the to-be-notified event; and displaying, by the terminal, in different display modes based on a priority of the notification, wherein the different display modes comprise: displaying in expanded form or displaying in collapsed form in the corresponding display pane, or the different display modes comprise: displaying in a first mode or displaying in a second mode in the corresponding display pane, and content displayed in the first mode is more than content displayed in the second mode.

Abstract: The present invention discloses a preparation method for the plant-based nano corrosion inhibition bactericide for oilfield, comprising the following steps: Step 1. Prepare the aloin liquid; Step 2. Stir the carbon nanotube, hydroxyethyl methacrylate and acrylic acid to react for 4 h at a constant temperature of 80° C. to get the carbon nanotube after fiber treatment, namely the modified carbon nanotube; Step 3. Mix the aloin liquid with imidazoline-ammonium-salt, add acetonitrile, and then add modified carbon nanotube, increase the temperature to 95° C. stir and react for 12 hours, and filter after naturally cooling down to room temperature and get the carbon nanotube loaded with bactericide; Step 4. Stir the carbon nanotube loaded with bactericide, diphenylmethane diisocyanate and polycaprolactone to react for 6 hours at a constant temperature of 95° C. and in the reaction process, continuously inject helium to get the target bactericide.

Abstract: A method and a sensor for detecting L-arginine are provided. The method includes synthesizing ferrocene-functionalized hexadecapeptide dithiocyclopentane (FC-P16 Peptide), preparing a polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE), detecting L-Arg and other steps. The results show that the polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE) exhibits excellent electrochemical response properties to L-Arg. In 10 mmol/L phosphate-buffered saline (PBS, pH=7.4), the DPV response peak current of the polypeptide composite membrane-modified electrode has an excellent linear relationship with the L-Arg concentration of 1.0×10?13 mol/L to 1.0×10?7 mol/L, with a detection limit of 1.0×10?13 mol/L. With prominent reproducibility, repeatability and selectivity, the modified electrode has potential application in life science and nutritional health.

Abstract: A quantizer for a sigma-delta modulator, a sigma-delta modulator, and a method of shaping noise are provided. The quantizer includes: an integrator configured to generate, in a Kth sampling period, a quantization error signal for a Kth period according to an internal signal, a quantization error signal for a (K?1)th period, a filtered quantization error signal for the (K?1)th period and a filtered quantization error signal for a (K?2)th period; an integrating capacitor configured to store the quantization error signal for the Kth period, to weight the internal signal in a (K+1)th sampling period; a passive low-pass filter configured to acquire the quantization error signal for the Kth period in a Kth discharge period, and feed back the filtered quantization error signal to the integrator in a (K+1)th sampling period and a (K+2)th sampling period; and a comparator configured to quantize the quantization error signal for the Kth period.

Abstract: The present invention provides novel CD3 antigen binding fragments with particularly advantageous properties such as producibility, stability, binding affinity, biological activity, specific targeting of certain T cells, targeting efficiency, remaining tumor cell killing and reduced toxicity. The present invention also provides bispecific antigen binding molecules for activating T cells. In addition, the invention further provides methods of treating cancer in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising the above said bispecific antigen binding molecules.

Abstract: An approach is disclosed that determines an amount of time before a webpage is ready to use by a user by performing various actions. The approach captures a recording of the webpage from an invocation of the webpage for a period of time sufficient to load completely load the webpage with the capturing resulting in sequenced image frames. An AI system provides a loading point in the sequenced image frames based on an analysis of the frames input to the trained AI system. Image diversity and saturation measurements are calculated on consecutive image frames from the sequenced image frames resulting in an image change analysis. Native webpage events and times are detected from webpage characteristics gathered from the captured digital recording. The amount of time is then calculated based on the loading point from the AI system, the image change analysis; and the webpage events and their corresponding times.