Abstract: An X-ray-based test device for a plugging removal effect of a sulfur dissolvent on a sulfur deposition rock sample includes a constant speed and pressure pump, a first intermediate container, a second intermediate container, a first pressure transmitter, a core holder, a second pressure transmitter, a first electric pump, a third intermediate container, a back-pressure valve, a gas flow meter, an H2S neutralization tank, a second electric pump, a back-pressure transmitter, a confining pressure transmitter, an X-ray generator, an X-ray detector and a thermotank. A sour gas sample is placed in the first intermediate container, and nitrogen is filled in the second intermediate container. The sulfur dissolvent is placed into the third intermediate container. A confining pressure inlet is formed in the core holder. The test device may be used for evaluating the plugging removal effect of the sulfur dissolvent injected into the sulfur deposition rock sample.

Abstract: A toxicity-removed and medicinal effect-retained Fuzi decoction granule and a preparation method thereof are provided, belonging to the technical field of traditional Chinese medicine preparation. The preparation method of the toxicity-removed and medicinal effect-retained Fuzi decoction granule includes the following steps: subjecting Radix Aconiti Lateralis Preparata to immersion and decoction in advance for 60 min to 120 min, and then mixing with Poria, Radix Ginseng, bran-fried Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Radix Paeoniae Rubra, and Ramulus Cinnamomi to allow immersion for 30 min to 60 min; and subjecting a filtrate obtained by filtration to concentration and granulation in sequence to obtain the toxicity-removed and medicinal effect-retained Fuzi decoction granule. The Fuzi decoction granule prepared by the preparation method can remove inherent toxicity and retain a medicinal effect on osteoarthritis.

Abstract: The present disclosure provides methods for the prevention and treatment of Langerhans cell sarcoma (LCS) and Langerhans cell histiocytosis (LCH) in a subject comprising administering an effective or therapeutically effective dose of a HDAC3 inhibitor to the subject in need thereof.

Abstract: The present invention provides a method for integrating a nucleic acid analysis system and measuring at least one target nucleic acid in a sample. The integrated nucleic acid analysis system includes one DMF device, which includes a substrate, a cover plate, and an instrument for performing a series of operations including magnetic beads based nucleic acid extraction, purification, thermal amplification, and optical measurement of nucleic acids in samples in a DMF device. The nucleic acid extraction and purification are based on the magnetic bead method, which uses instruments to move magnetic beads in different functional areas of the digital microfluidic chip, such as lysis reservoirs, cleaning reservoirs, and elution reservoirs, etc. The present invention integrates sample processing and detection on the same microfluidic chip, and the entire process is automatically completed by the corresponding instrument.

Abstract: Novel cyclic ?-AA peptides and methods of use thereof in modulating E3 activity are presented. Each novel compound is comprised of four ?-AA building blocks. It was found that in particular, compound P6 activated E6AP to stimulate self-ubiquitination of E6AP and E6AP-catalyzed substrate ubiquitination as well as enhance the ubiquitination of E6AP substrates in the cell and accelerate their degradation.

Abstract: Provided are compounds as potent inhibitors of cyclin-dependent kinase (CDK), or pharmaceutically acceptable salts thereof. Corresponding compositions are also provided.

Abstract: A collaborative-manipulation robotic arm for kitchen waste and a working method thereof are provided. The robotic arm includes: a base, including a transverse first mounting seat and a second mounting seat connected to the first mounting seat and extending downward; a driving mechanism, disposed at an end of the first mounting seat away from the second mounting seat; a front guide claw, an upper end of the front guide claw being connected to the driving mechanism; a fixed blade, disposed on a side of the second mounting seat facing the front guide claw; and a retractable finger, disposed at a lower end on the side of the second mounting seat facing the front guide claw. The fixed blade, the retractable finger, and the second mounting seat form a rear cutting claw.

Abstract: The present invention provides a device and method for analyzing quality indicators of a natural gas product and an application.

Abstract: The present disclosure discloses a method for constructing an efficient Bacillus subtilis promoter, and belongs to the technical field of gene engineering. According to the present disclosure, natural promoters identified by different sigma subunits are connected in series to obtain some double-series and triple-series promoters, the lengths of intervening sequences between core areas of the promoters are optimized on the basis of series connection of the promoters to further improve the activity of the promoters, finally, different RBS designs are performed on the promoters, and it is verified that this strategy can not only improve the compatibility between the promoters and other gene expression regulating and controlling elements, but also controllably regulate the expression of exogenous genes.

Abstract: An ROR1 CAR or ROR1/CD19 Dual CAR for the treatment of tumors. The T cells expressing ROR1 CAR or ROR1/CD19 Dual CAR can be stimulated by ROR1-positive or ROR1/CD19-positive cells, and have cytotoxicity against ROR1-positive or ROR1/CD19-positive cells.

Abstract: The present application provides novel fusion proteins for dephosphorylating proteins that regulate T cell activation through the TCR signaling pathway, nucleic acids encoding said proteins, vectors comprising said nucleic acids, compositions comprising said nucleic acids or vectors, host cells comprising said nucleic acids, vectors or compositions or related pharmaceutical compositions. The present application also provides methods for dephosphorylation of proteins that regulate T cell activation through the TCR signaling pathway of a cell, methods of producing a cell having dephosphorylated proteins that regulate T cell activation through the TCR signaling pathway (e.g. a CAR T cell having dephosphorylated Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) of endogenous CD3), methods of treating a disease, and methods of reducing or preventing GvHD in a subject associated with the administration of one or more CAR T-cells to the subject.

Abstract: A high-efficiency active layer includes a strained quantum well layer and, at one side thereof, a first strained barrier layer configured to transport electrons. The first strained barrier layer and the strained quantum well layers are configured to form strain compensation. A second barrier layer is positioned on the other side of the strained quantum well layer and is configured to transport holes. A band offset between conduction bands of the first strained barrier layer and of the strained quantum well layer is less than a band offset between valence bands of the strained quantum well layer and of the first strained barrier layer. A band offset between valence bands of the strained quantum well layer and of the second barrier layer is less than a band offset between conduction bands of the second barrier layer and of the strained quantum well layer. Light-emitting efficiency and reliability are improved.

Abstract: The disclosure discloses a mutant of nitrile hydratase derived from Caldalkalibacillus thermarum, and belongs to the technical field of enzyme engineering. The nitrile hydratase mutant Cal. t Nhase-A20V provided by the disclosure has a half-life of about 10 min at 70° C., which does not change much compared with the thermal stability of the wild enzyme. The specific enzyme activity of the mutant Cal. t Nhase-A20V is 128% of that of the wild enzyme. At the same time, the mutant also has better tolerance to a substrate and a product, and the final yield of nicotinamide produced by whole-cell catalysis reaches 598 g/L. Therefore, the nitrile hydratase mutant Cal. t Nhase-A20V provided by the disclosure has good enzymatic properties and is beneficial to future industrial production.

Abstract: Provided in the present invention is an antibody against human CD3 or an antigen-binding fragment thereof; also provided are a nucleic acid molecule encoding the antibody, an expression vector expressing the antibody and a host cell, as well as a method for producing the antibody. In addition, also provided in the present invention are a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, a use thereof in the preparation of a drug, and a use of the drug as a drug for the prevention and/or treatment of various diseases, including tumors, organ transplantation and autoimmune diseases.

Abstract: This application discloses a touch panel and a human-computer interaction method based on a touch panel. The touch panel includes a base substrate, at least one pressure detector and at least one actuator arranged on the base substrate, and a driving circuit. The at least one pressure detector is electrically connected to the driving circuit, and the driving circuit is electrically connected to the at least one actuator.

Abstract: The present disclosure discloses a Bacillus subtilis efficiently-induced expression system based on an artificial series promoter, and belongs to the technical field of gene engineering. According to the present disclosure, an efficient artificial series constitutive promoter is used, and by compositely designing the promoter and elements (a repressor and a binding site thereof) relevant to an operon, the activity of the constitutive promoter is regulated and controlled by an inducer to finally construct the B. subtilis efficiently-induced expression system induced by the inducer. The result indicates that compared with a P43 strongly constitutive promoter, the activity of the artificial series promoter in the system is about 15 times higher. The activity of the promoter can be accurately controlled by adding different concentrations of inducers.

Abstract: An aqueous dispersion contains multistage polymeric particles and optionally a polyfunctional carboxylic hydrazide containing at least two hydrazide groups per molecule, where the multistage polymeric particles are prepared by a multistage free-radical polymerization process comprising: (i) preparing a first polymer by a free-radical polymerization, followed by neutralizing the first polymer to a pH value of greater than 7.1; and (ii) preparing a second polymer in the presence of the neutralized first polymer obtained from step (i), to obtain the multistage polymeric particles comprising the first polymer and the second polymer at a weight ratio of the first polymer to the second polymer of from 27:73 to 60:40; where the first polymer comprises from 6% to 18% of structural units of an acid monomer, a salt thereof, or mixtures thereof; from 1.

Abstract: Systems and methods are described herein for utilizing a photoacoustic sensor for estimating analyte concentration levels. Also described here are training methods for training an analyte sensor to more accurately estimate an analyte concentration level on the basis of a received acoustic signal.

Abstract: The present application discloses a positioning adjustment method, a positioning tool, an apparatus, a device, and a storage medium. The positioning adjustment method includes: determining a target movement distance according to target position information and start position information of the adjusted member; and moving an adjusted member to a target position according to the target movement distance.

Abstract: A deep learning model implements continuous, lifelong machine learning (LML) based on a Bayesian neural network using an inventive framework including wide, deep, and prior components that employ diverse algorithms to leverage available real-world healthcare data differently to improve prediction performance. The outputs from each component of the framework are fed into a wide and shallow neural network and the posterior structure of the final model output may be utilized as a prior structure when the deep learning model is refreshed with new data in a deep learning process. Lifelong learning is implemented by dynamically integrating present learning from the wide and deep learning components with past learning from traditional tree models in the prior component into future predictions. Thus, the present Bayesian deep neural network-based LML model increases accuracy in identifying patient profiles by continuously learning, as new data become available, without forgetting prior knowledge.