Abstract: Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells.

Abstract: Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells.

Abstract: Disclosed herein are multifunctional antigen-binding proteins comprising at least one multifunctional recombinant protein scaffold and at least one antigen-specific binding domain. Polynucleotides encoding the multifunctional antigen-binding proteins, vectors containing the disclosed polynucleotides, and cells that have been genetically engineered to express the polynucleotide are also provided. Methods of using the multifunctional antigen-binding proteins are disclosed.

Abstract: Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells.

Abstract: Disclosed herein are multifunctional antigen-binding proteins comprising at least one multifunctional recombinant protein scaffold and at least one antigen-specific binding domain, Polynucleotides encoding the multifunctional antigen-binding proteins, vectors containing the disclosed polynucleotides, and cells that have been genetically engineered to express the polynucleotide are also provided. Methods of using the multifunctional antigen-binding proteins are disclosed.

Abstract: The present invention provides a fusion proteins comprising (a) a first stretch of consecutive amino acids, the sequence of which is the sequence of an anti-p185her2/neu polypeptide or an anti-EGFR polypeptide; (b) a second stretch of consecutive amino acids, the sequence of which is the sequence of a polypeptide capable of binding at least one polypeptide other than p185her2/neu or EGFR; and (c) a third stretch of consecutive amino acids, the sequence of which comprises the sequence of a biologically active portion of interferon-gamma (IFN?), wherein (b) is located at the carboxy-terminal end of (a), and (c) is located at the carboxy-terminal end of (b). The present invention provides methods and compositions treating or preventing cancer and for sensitizing cancer cells to radiation or a chemotherapeutic agent, which comprises administering i) an anti-p185her2/neu antibody, an anti-EGFR antibody or an erbB kinase inhibitor and interferon-gamma (IFN?); or ii) a fusion protein of the invention.

Abstract: A hybrid circuit for producing optical signals in response to electrical energizing signals, including: a tilted charge light-emitting device having an electrical input port and an optical output port, the device having an optical output response which is a function of input frequency; and an input interface circuit coupled with the electrical input port of the device, and having a transfer function substantially proportional to an inverse of the optical output response of the device; whereby application of the electrical energizing signals to the input interface circuit is operative to produce optical signals from the output optical port of the device. The input interface circuit includes a passive RLC circuit having a transfer function characterized by a region of increasing amplitude versus frequency.

Abstract: A guide rail system for slidably opening and closing a drawer within an enclosure is disclosed. The system comprises a mounting bracket for fixing the system to the enclosure, the mounting bracket having a fixed rail for receiving an intermediate rail capable of sliding back and forth on the fixed rail, and a pull out rail operatively attached to the drawer and capable of sliding back and forth on the intermediate rail. A resiliently compressible damping device, channel guide with sliding member and a closing device are disposed along the mounting bracket. The pull out rail has a guiding pin on its bottom surface. The sliding member is adapted to travel along the channel guide and locate an end of the damping device that can be pushed inwardly to provide damping. The closing device comprises a housing, a resilient means, and a driver pivotally mounted with the housing and operatively connected to the resilient means.

Abstract: A drawer assembly having a drawer and a sliding guide rail system for slidably opening and closing the drawer within an article of furniture is disclosed. A contact piece is provided on a drawer element. A damping device and a channel guide are provided within the guide rail system. The channel guide has a sliding member that includes an inner portion and an outer portion that extends from the guide so as to be contactable by the contact piece. The sliding member inner portion locates an end of the damping device. During a closing action, the drawer is caused to slide in a closing direction. When the contact piece reaches and contacts the sliding member outer portion, the sliding member travels within the channel guide against the resilience of the damping device and causes deceleration of the closing motion.

Abstract: A guide rail system for slidably opening and closing a drawer within an enclosure is disclosed. The system comprises a mounting bracket for fixing the system to the enclosure, the mounting bracket having a fixed rail for receiving an intermediate rail capable of sliding back and forth on the fixed rail, and a pull out rail operatively attached to the drawer and capable of sliding back and forth on the intermediate rail. A resiliently compressible damping device, channel guide with sliding member and a closing device are disposed along the mounting bracket. The pull out rail has a guiding pin on its bottom surface. The sliding member is adapted to travel along the channel guide and locate an end of the damping device that can be pushed inwardly to provide damping. The closing device comprises a housing, a resilient means, and a driver pivotally mounted with the housing and operatively connected to the resilient means.

Abstract: A hybrid circuit for producing optical signals in response to electrical energizing signals, including: a tilted charge light-emitting device having an electrical input port and an optical output port, the device having an optical output response which is a function of input frequency; and an input interface circuit coupled with the electrical input port of the device, and having a transfer function substantially proportional to an inverse of the optical output response of the device; whereby application of the electrical energizing signals to the input interface circuit is operative to produce optical signals from the output optical port of the device. The input interface circuit includes a passive RLC circuit having a transfer function characterized by a region of increasing amplitude versus frequency.

Abstract: A drawer fitting fixes a drawer side to a drawer front panel. The fitting includes a holding plate for mounting the fitting to the drawer front panel, the holding plate having a flange extending in a direction parallel to a drawer side, the flange having forwardly-disposed guide noses, a clamping plate having a forwardly-disposed angled flange, a guide clip mountable on the clamping plate such that the drawer side front end can be positioned between the holding plate flange and the guide clip, the guide clip having resiliently depressible projecting tails and an assembly screw that passes through and couples together the clamping plate and guide clip, and is received in an aperture in the holding plate flange through a recess in the front end of the drawer side.

Abstract: A drawer assembly including a drawer and a sliding guide rail system for slidably opening and closing the drawer within an article of furniture is provided. A support bracket for supporting the drawer is provided at each side of the drawer. The sliding guide rail system includes a pull-out rail disposed within each of the support brackets. One of the support brackets has a slot and the pull-out rail disposed within one of the brackets has a recess. A stabilizer arrangement for stabilizing the sliding movement of the drawer is also provided. The stabilizer arrangement includes a guide bracket and a lever. The guide bracket has a protrusion engageable within the support bracket slot. The guide bracket has a resilient grip portion that allows for the guide bracket protrusion to be adjustable laterally within the support bracket slot when the guide bracket is locked onto the support bracket.

Abstract: A drawer assembly is provided and includes a drawer and a sliding guide rail system for opening and closing the drawer within an article of furniture. A support bracket for supporting the drawer is provided at each side of the drawer. The system includes a fixed rail disposed within each of the support brackets. Each side of the drawer assembly has a first member located at a rear corner of the drawer assembly between the support bracket and the fixed rail, and a second member located at a forward corner of the drawer assembly between the support bracket and the fixed rail, when the drawer is fully closed. The drawer is guided against skewing by engagement at two diagonally opposing corners, of the support bracket and fixed rail through the first member on one side of the drawer and through the second member on the other side of the drawer.

Abstract: A drawer assembly having a drawer and a sliding guide rail system is disclosed. The system includes a mounting bracket, a fixed rail for receiving an intermediate rail capable of sliding back and forth on the fixed rail, and an outer pull out rail attached to the drawer and that slides back and forth on the intermediate rail. A contact piece is provided on a drawer element. A resiliently compressible damping device and a channel guide are disposed along the mounting bracket. The guide has a sliding member with an inner portion that travels along the guide and an outer portion that extends from the guide contactable by the contact piece. The sliding member inner portion locates an end of the damping device that is pushed inwardly to provide damping. During a closing action both the drawer and outer pull out rail are caused to slide in a drawer-closing direction.

Abstract: A corner fitting for securing a drawer side to a drawer rear panel in a drawer assembly. The fitting comprises a substantially L-shaped bracket having a first flange and a second flange. A hollow support structure connects the first and second flanges and provides internal support surfaces for engagement by a component of the drawer assembly. A slot is defined by a gap between opposing surfaces of one of the flanges and one of the support surfaces. The support structure includes a resilient locking flap biased so as to protrude into the slot to lock the component of the drawer assembly and a tab extending from the flap into the hollow support structure with the tab accessible externally of the drawer assembly to permit retraction of the flap from the slot.

Abstract: A sliding guide rail system for slidably opening and closing a drawer within an article of furniture or other equipment, the system comprises a mounting bracket (10) for fixing the system to the article of furniture, a fixed guide (20) mounted on the mounting bracket, an intermediate rail (30) and a pull-out guide (40). The fixed (20) and pull-out guides (40) each have a slidably movable housing, a first slidable housing (50) enabling the intermediate rail (30) to be slidable on the fixed guide (20) and a second slidable housing (50?) enabling the pull-out guide (40) to be in turn slidable on the intermediate rail (30). Each of the fixed guide (20), intermediate rail (30) and pull-out guide (40) have stops (60) disposed thereon for limiting the sliding movement of the first (50) and second slidable housings (50?), wherein a resiliently deformable damping member (52, 52?) is located in a respective chamber (51) provided at each longitudinal end of the first and second slidable housings.

Abstract: A sliding guide rail system for slidably opening and closing a drawer within an article of furniture or other equipment, the system comprises a mounting bracket (10) for fixing the system to the article of furniture, a fixed guide (20) mounted on the mounting bracket, an intermediate rail (30) and a pull-out guide (40). The fixed (20) and pull-out guides (40) each have a slidably movable housing, a first slidable housing (50) enabling the intermediate rail (30) to be slidable on the fixed guide (20) and a second slidable housing (50?) enabling the pull-out guide (40) to be in turn slidable on the intermediate rail (30). Each of the fixed guide (20), intermediate rail (30) and pull-out guide (40) have stops (60) disposed thereon for limiting the sliding movement of the first (50) and second slidable housings (50?), wherein a resiliently deformable damping member (52, 52?) is located in a respective chamber (51) provided at each longitudinal end of the first and second slidable housings.

Abstract: A closing device for a drawer comprising an elongate hollow housing which includes front and rear portions, a rotating member slidably mounted in the front portion and a resilient member mounted in the rear portion. The front portion includes first and second portions with the first portion having a rotation-preventing internal surface and the second portion having a rotation-admitting internal surface. A locking step is defined by the differing internal cross sections of the first and second portions. The rotation of the rotating member in the first portion is prevented by the internal shape of the first portion relative to the external shape of the rotating member. The rotating member has an angular slot for receiving a guiding pin which is downwardly extending from the bottom surface of a top roller guide.