Abstract: Aromatic heterocyclic compounds as ENPP1 inhibitors, a preparation method therefor and the uses thereof. The compounds have structures as shown in formula (I).

Abstract: This application discloses a negative active material and a preparation method thereof, a negative electrode plate, a secondary battery, and an electrical device, and relates to the battery field. The negative active material includes: porous carbon, where a surface of the porous carbon is provided with pore channels communicating to an interior of the porous carbon; and, a deposit, settling in the pore channels and including a silicon layer and a functional layer deposited in sequence from an interior of the pore channels outward, where the functional layer is made of a material that includes at least one of carbon, phosphorus, tin, or germanium.

Abstract: The invention provides an oral solid formulation comprising (a) one or more controlled release components comprising a core comprising levodopa; and (b) one or more immediate release components comprising levodopa. The oral solid formulation also contains a decarboxylase inhibitor wherein the one or more controlled release components are substantially free of the decarboxylase inhibitor.

Abstract: A display substrate and a manufacturing method therefor, and a display device. In the display substrate at least one of a plurality of sub-functional film layers in a light-emitting functional layer is disconnected at the positions where the pixel partition structures are located. Each pixel partition structure includes a first subpixel partition part, a second subpixel partition part, and a third subpixel partition part that are stacked in a direction perpendicular to the base substrate. The second subpixel partition part includes a plurality of sub-partition layers stacked in the direction perpendicular to the base substrate. The first subpixel partition part is provided, in an arrangement direction of two adjacent subpixels, with a first protrusion going beyond at least one sub-partition layer. The third subpixel partition part is provided, in the arrangement direction of two adjacent subpixels, with a second protrusion going beyond at least one sub-partition layer.

Abstract: Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groove of FZD inhibits TcdB entry into cells, and/or inhibits Wnt signaling. Methods of treating Clostridium difficile infection (CDI) and methods of treating cancer are also provided.

Abstract: A selenium-chelating pea oligopeptide, a preparation method thereof and use thereof. After the selenium-chelating pea oligopeptide is subjected to digestion treatment in at least one of following three ways, a change rate of selenium content not more than 3% with respect to the selenium content before the digestion treatment: hydrolyzing for 4 hours by a pepsin at a pH value of 2 and a temperature of 37° C.; hydrolyzing for 6 hours by a trypsin at a pH value of 7.5 and a temperature of 37° C.; maintaining the temperature constant at 37° C., firstly hydrolyzing for 4 hours by the pepsin at a pH value of 2, and then continuing to hydrolyze for 6 hours by a trypsin at a pH value of 6.8. The preparation method thereof includes mixing and reacting an aqueous solution of pea oligopeptide and sodium selenite, and then being subjected to alcohol precipitation and drying.

Abstract: Methods, systems, and apparatus for high-resolution patterning of various substrates with functional materials, including nanomaterials. A technique of preparing a patterned substrate in a high-resolution mold for stick and transfer process is disclosed with promotes integrity of the high-resolution pattern onto the substrate. One example of a substrate is an adhesive tape. The transferred pattern(s) are scalable and can be implemented in different fabrication processes. One example is a roll-to-roll processes. In one embodiment, the transferred pattern comprises nanomaterials and the substrate comprises a flexible substrate for use in flexible and conformal assemblies for a wide variety of applications including, but not limited to, electrical-based sensors on non-planar inanimate surfaces, plant body surface, or human or animal skin.

Abstract: Provided are a display baseplate, a mould assembly, a spliced display module, and a display apparatus. The display baseplate includes a backplate light emitters and an encapsulation layer. The backplate includes a first main surface and a second main surface that are opposite to each other, and side surfaces connected to the first main surface and the second main surface light emitters are located on the first main surface, the encapsulation layer is at least partially located on the first main surface and covers the plurality of light emitters. The spliced display module includes a splicing units, the splicing units each include a splicing frame and a display baseplate, the display baseplate is fixed on the splicing frame with the light emitters away from the splicing frame; and the splicing frames of adjacent splicing units are spliced together. The display apparatus includes a display baseplate or a spliced display module.

Abstract: This application provides an internal series battery, including a series module including three or more battery units, each including a positive active material layer, a solid electrolyte layer and a negative active material layer stacked, and intermediate current collectors, each disposed between the corresponding two adjacent battery units connected in series therethrough; a positive current collector located at one end of the series module and electrically connected to the positive active material layer of the battery unit at the end; and a negative current collector located at the other end of the series module and electrically connected to the negative active material layer of the battery unit at the end. The battery units include a first battery unit and a second battery unit that have an energy density the same as and different from any one of the battery units at the two ends of the series module respectively.

Abstract: A backlight module comprises a driving backplate, which comprises multiple pads; multiple light-emitting diodes, which are electrically connected to the pads; and multiple transparent protection structures, which are located on the sides of the multiple light-emitting diodes that are away from the driving backplate, wherein the transparent protection structures cover the light-emitting diodes, there is a first distance between the center of the orthographic projection of each transparent protection structure on the driving backplate and the center of the orthographic projection of each light-emitting diode on the driving backplate; and the length of the orthographic projection of each light-emitting diode on the driving backplate is a second distance, the width of the orthographic projection of each light-emitting diode on the driving backplate is a third distance, the ratio of the first distance to the second distance is less than or equal to 1:2-1:10.

Abstract: A sending device sends, by using a first resource and a second resource, a reference signal corresponding to a first port. The first resource and the second resource are respectively on a first OFDM symbol and a second OFDM symbol that are not adjacent to each other. The first port belongs to a first port set or a second port set, a reference signal corresponding to a port in the first port set corresponds to a first cover code on the first resource and the second resource, a reference signal corresponding to a port in the second port set corresponds to a second cover code on the first resource and the second resource, and the first cover code is different from the second cover code.

Abstract: The disclosure provides a substituted phenylpropionic acid derivative and a use thereof. Specifically, the disclosure provides a compound as shown in formula II or a medicinal salt thereof, which can be used in the preparation of a drug for preventing and/or treating cardiovascular diseases.

Abstract: A method for sending a message, performed by a terminal, includes: sending first random access request information to a first access network device on a first random access resource, and sending second random access request information to the first access network device on a second random access resource; receiving first random access response information and second random access response information sent by the first access network device or a second access network device, in which the first random access response information is used to respond to the first random access request information, and the second random access response information is used to respond to the second random access request information; and sending one third message (Msg3) of random access to the first access network device, in which the Msg3 corresponds to the first random access response information and the second random access response information

Abstract: A method of time synchronization between a DS-TT module inside a logical TSN bridge of a communication network with a TSN Grandmaster (GM) in a TSN Time Domain of the communication network. The method comprises, at a NW-TT module inside the logical TSN bridge, determining a frequency rate ratio between a Time Domain clock frequency (f5GS) and a TSN Time Domain clock frequency (fTSN). Then, using the frequency rate ratio and respective times of receipt of a TSN GM synchronization message at an ingress port of the NW-TT module and at an ingress port of the DS-TT module to determine a DS-TT ingress residence time (RDS-TT). Then, using the RDS-TT to synchronize the DS-TT module with the TSN GM.

Abstract: The invention provides an oral solid formulation comprising (a) one or more controlled release components comprising a core comprising levodopa, esters or salts thereof and wherein the one or more controlled release components; and (b) one or more immediate release components comprising levodopa, esters or salts thereof. The oral solid formulation also contains a decarboxylase inhibitor and about 80% to 100% of the decarboxylase inhibitor present in the oral solid formulation is present in the one or more immediate release components.

Abstract: A locking structure of folding knife based on an elastic locking plate comprises a knife handle and a blade. The knife handle is provided with an accommodating groove and a locking structure; the locking structure comprises a pivot, an elastic locking plate and an unlocking button. The blade is connected to the pivot, and a guide groove is defined on the pivot; A front end of the elastic locking plate is arranged in the guide groove; the elastic locking plate is provided with a locking part, and the blade is provided with a locking groove; the unlocking button is arranged on the pivot, the unlocking button abuts against one side of the locking plate, and the pivot is provided with an elastic resetting member.

Abstract: The disclosure discloses a preparation method and application of a non-noble metal single atom catalyst, and belongs to the technical fields of chemistry, chemical engineering and material science. According to the disclosure, cheap raw materials and simple method are used to prepare the single atom catalyst. In essence, metal is anchored on light-absorbing carrier in a single atom form under irradiation to produce the single atom catalyst. In the disclosure, the non-noble metal single atom catalyst is prepared by using a photochemical synthetic route for the first time. The single atom catalyst synthesized in the disclosure is dispersed on the surface of photoactive substance. Using nickel single atom as a co-catalyst in photocatalytic water splitting to produce hydrogen, the cost is low and the catalytic efficiency is greatly improved compared with other types of non-noble metal modified composite photocatalysts.

Abstract: Methods, systems, and apparatus for high-resolution patterning of various substrates with functional materials, including nanomaterials. A technique of preparing a patterned substrate in a high-resolution mold for stick and transfer process is disclosed with promotes integrity of the high-resolution pattern onto the substrate. One example of a substrate is an adhesive tape. The transferred pattern(s) are scalable and can be implemented in different fabrication processes. One example is a roll-to-roll processes. In one embodiment, the transferred pattern comprises nanomaterials and the substrate comprises a flexible substrate for use in flexible and conformal assemblies for a wide variety of applications including, but not limited to, electrical-based sensors on non-planar inanimate surfaces, plant body surface, or human or animal skin.

Abstract: The invention provides an oral solid formulation comprising (a) a controlled release component comprising a core comprising levodopa, wherein the core is coated with a muco-adhesive coating and the muco-adhesive coating is externally coated with an enteric coating; and (b) an immediate release component comprising levodopa. The invention further provides a method for making and using the oral solid formulation.

Abstract: The invention provides an oral solid formulation comprising (a) a controlled release component comprising a core comprising levodopa, wherein the core is coated with a muco-adhesive coating and the muco-adhesive coating is externally coated with an enteric coating; and (b) an immediate release component comprising levodopa. The invention further provides a method for making and using the oral solid formulation.