Abstract: A conjugate of antibody-eribulin or a derivative thereof, an intermediate thereof, a preparation method therefor, a pharmaceutical composition thereof and use thereof. The conjugate of the antibody-eribulin or the derivative thereof provided herein as shown in general formula I is shown below. The conjugate of general formula I has high anti-tumor activity and high stability in circulation, and has excellent tumor tissue targeting property and therapeutic indexes.

Abstract: The present disclosure provides an exciter and an electronic product. The exciter comprises: a magnetic circuit assembly comprising a first housing and a magnet, and the magnet is connected to the first housing; a coil assembly comprising a second housing and a coil, and the coil is disposed in a magnetic field formed by the magnet, wherein the coil assembly is configured to be capable of generating a vibration relative to the magnetic circuit assembly, the coil is formed by winding a wire having a polygonal cross section. According to the present disclosure, the coil wire has a polygonal cross section, so that an interval between the wires can be reduced in the wound coil, the number of turns of the coil is increased in the same space, the effective length of the coil is increased, and the driving force generated from the coil is increased.

Abstract: Provided are a humanized anti-A? monoclonal antibody and use thereof. The humanized anti-A? monoclonal antibody provided can inhibit the polymerization of A? monomers, protect nerve cells from the toxicity of A?, and have a certain effect on improving the cognitive learning and memory ability of Alzheimer's dementia model mice, and can be used for the treatment and diagnosis of diseases and disorders related to amyloidosis, such as Alzheimer's disease.

Abstract: The present invention relates to the field of therapeutic monoclonal antibodies, and specifically provides an anti-FXI/FXIa antibody or an antigen-binding fragment thereof, nucleic acid molecules encoding same, and methods for preparing same. The anti-FXI/FXIa antibody or antigen-binding fragment thereof described in the present invention has specificity and high affinity to FXI/FXIa, and can effectively inhibit the activity of FXI/FXIa. Therefore, the present invention further provides a pharmaceutical composition comprising the antibody or antigen-binding fragment thereof, and a use thereof in the preparation of a drug which is used for the prevention and/or treatment of diseases or disorders related to coagulation or thromboembolism.

Abstract: Provided is a use of Megamonas funiformis in the prevention and/or treatment of metabolic diseases. Megamonas funiformis has the function of preventing and/or treating metabolic diseases (such as obesity, diabetes, atherosclerosis-related diseases, cardiovascular disease and hyperuricemia).

Abstract: Semiconductor structures, forming methods thereof and semiconductor devices are provided. In one aspect, a semiconductor structure includes: a stack structure, a semiconductor layer on the stack structure, a channel structure extending through the stack structure and into the semiconductor layer, a contact structure extending along a stacking direction of the stack structure, and a first soldering structure and a second soldering structure. The first soldering structure penetrates through the semiconductor layer and is connected with the contact structure and the second soldering structure is connected with the semiconductor layer.

Abstract: Systems, devices, and methods for managing conductive connections for semiconductor devices are provided. In one aspect, a method includes: providing an integrated structure including an array structure in a first region and a conductive connection structure in a second region adjacent to the first region, at least one portion of at least one polysilicon layer being over the conductive connection structure; etching the at least one portion of the at least one polysilicon layer to expose one or more conductive connections in the conductive connection structure; depositing an isolating material over the array structure and the conductive connection structure; and forming conductive vertical interconnect accesses (VIAs) through the isolating material to be in contact with the one or more conductive connections and a conductive layer in the array structure.

Abstract: Provided are an anti-Nectin-4 antibody or antigen-binding fragment thereof, an antibody conjugate comprising the same, and use thereof in the manufacture of a medicament, particularly in the manufacture of a medicament for treating and/or preventing cancer.

Abstract: An anti-PD-1 antibody or an antigen-binding fragment thereof, nucleic acid molecules encoding same, and methods for preparing same. The anti-PD-1 antibody or the antigen-binding fragment thereof has high specificity and high affinity to PD-1, and can effectively block the binding of PD-1/PD-L1 and PD-1/PD-L2 so as to activate the immune system, thereby achieving the effect of inhibiting tumor growth. Therefore, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof and a use of the pharmaceutical composition in preparation of drugs are further comprised. The drugs are used for preventing and/or treating tumors, infections, or autoimmune diseases.

Abstract: A display module, a preparing method therefor and a display device are provided. The display module includes a back plate and a mold frame, the back plate includes a base plate, the base plate includes an edge region, the mold frame is disposed on the edge region, the edge region is provided with a rough structure region, the rough structure region includes multiple rough structures, an orthographic projection of at least part of the rough structures on the base plate overlaps with an orthographic projection of the mold frame on the base plate, and a material of the mold frame fills at least part of space of the rough structures.

Abstract: Disclosed in the present invention is the use of an anti-HER2 antibody-drug conjugate in cancer treatment. Further provided in the present invention is the use of a pharmaceutically acceptable salt, stereoisomer, or metabolite thereof, or a solvate of each of the foregoing in the manufacture of a medicament for the prophylaxis and/or treatment of a cancer insensitive or irresponsive to a treatment with a HER2-targeting agent.

Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.

Abstract: The present invention discloses an application of Alistipes shahii in preparing a composition for preventing and/or treating lipid metabolism related diseases, for example but not limited to, atherosclerosis related diseases, cardiovascular diseases and obesity.

Abstract: An optical imaging system, along an optical axis from an object side to an image side, sequentially includes: a stop; a first lens having a refractive power; a second lens having a positive refractive power; a third lens having a positive refractive power, an object-side surface and an image-side surface of the third lens being convex surfaces; a fourth lens having a refractive power, and an image-side surface of the fourth lens being a convex surface; a fifth lens having a refractive power, and an image-side surface of the fifth lens being a concave surface; a sixth lens having a refractive power; and a seventh lens having a refractive power. A half of a maximum field-of-view Semi-FOV of the optical imaging system satisfies: Semi-FOV?6°; and a total effective focal length f of the optical imaging system satisfies: f?25 mm.

Abstract: A method includes forming storage channel structures including a functional layer, a channel layer, a filling layer and a slit in the filling layer, thinning a first substrate to form a second substrate, removing a second bottom section outside the second substrate to expose a first bottom section slit, filling a dielectric material layer in the first bottom section slit, removing the second substrate and a first bottom section functional layer to form a first dielectric section filled in the first bottom section slit and expose a first bottom section channel layer, forming a common source layer contacting the first bottom section channel layer, the first bottom section filling layer and the first dielectric section. After inverting the stack structure, the substrate is thinned, and the exposed functional layer and the channel layer are removed.

Abstract: Provided are an anti-Nectin-4 antibody or antigen-binding fragment thereof, an antibody conjugate comprising the same, and use thereof in the manufacture of a medicament, particularly in the manufacture of a medicament for treating and/or preventing cancer.

Abstract: Three-dimensional (3D) NAND memory devices and methods are provided. In one aspect, a fabrication method includes preparing a stacked device having a first array device and a second array device, forming an opening on a back side of the second array device, and forming one or more contact pads in the opening. The first array device includes first front pads on a face side of the first array device and first back pads on a back side of the first array device. The second array device includes second front pads on a face side of the second array device and bonded with the first back pads. The one or more contact pads are disposed at a level proximate to the second front pads with respect to the first array device.

Abstract: A memory device includes a memory array, disposed on a substrate of a peripheral-circuit structure; a conductive plug, extending through the memory array and connected to the peripheral-circuit structure; and a conductive pad layer, disposed over the memory array and including a plurality of conductive pads spaced apart from each other. The conductive plug protrudes into a corresponding conductive pad of the plurality of conductive pads.

Abstract: The present disclosure provides a memory device. The memory device can include an alternating layer stack comprising dielectric layers and conductive layers stacked in a first direction. The memory device can also include a channel structure extending through the alternating layer stack in a first direction in a first region. A first material layer may be disposed on the channel structure. The memory device can also include a first dummy channel structure extending through the alternating layer stack in the first direction in a second region abutting the first region. A second material layer may be disposed on the first dummy channel structure. The first material layer and the second material layer may be different materials. The first material layer may be spaced apart from the first dummy channel structure in a second direction. The first direction may be perpendicular to the second direction.

Abstract: A three-dimensional (3D) memory device and methods for forming the same are provided. The 3D memory device includes a first semiconductor structure having a core region and a non-array region. The first semiconductor structure includes: an array of channel structures in the core region; a substrate layer extending from the non-array region to the core region and being in contact with the array of channel structures; an insulating structure including a first portion extending along a lateral direction from the non-array region to the core region and a second portion extending along a vertical direction through the substrate layer in the non-array region, where the second portion of the insulating structure surrounds the core region; and contact structures penetrating through the second portion of the insulating structure, where the contact structures are electrically insulated from the substrate layer by the insulating structure.