Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.

Abstract: Provided is a use of Butyribacter intestini in preventing and/or treating inflammation-related diseases. Specifically, in the present disclosure, it was firstly discovered that Butyribacter intestini has the function of preventing and/or treating inflammation-related diseases (for example, inflammatory bowel disease, such as ulcerative colitis, gastritis, and common enteritis; and rheumatoid arthritis).

Abstract: A semiconductor device and a fabricating method thereof are provided. The semiconductor device includes a semiconductor structure and an input/output pad. The semiconductor structure includes a first substrate and a conductive layer, in which the first substrate has a first surface and a second surface opposite to each other, the conductive layer is disposed on the first surface of the first substrate, and the conductive layer includes one or more first trace. The first semiconductor structure has a recess penetrating the first substrate and exposing the one or more first trace, and the input/output pad is disposed on the one or more first trace and in the recess.

Abstract: Disclosed in the present invention is the use of an anti-HER2 antibody-drug conjugate in cancer treatment. Further provided in the present invention is the use of a pharmaceutically acceptable salt, stereoisomer, or metabolite thereof, or a solvate of each of the foregoing in the manufacture of a medicament for the prophylaxis and/or treatment of a cancer insensitive or irresponsive to a treatment with a HER2-targeting agent.

Abstract: Provided are Megamonas funiformis and applications thereof. Specifically, the Megamonas funiformis has the effects for preventing and/or treating inflammation-related diseases, such as inflammatory bowel diseases (such as ulcerative enteritis, gastritis, and general enteritis) and cardiovascular diseases.

Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.

Abstract: The present invention relates to the field of treatment of diseases and immunology. Specifically, the present invention relates to an anti-LAG-3 antibody or an antigen-binding fragment thereof, nucleic acid molecules for encoding said antibody and fragment, and method for preparing said antibody and fragment. The anti-LAG-3 antibody or the antigen-binding fragment thereof according to the present invention has high specificity and high affinity to LAG-3, can effectively block the binding of LAG-3 to MHC II and/or FGL1, and can inhibit and/or block intracellular signaling mediated by LAG-3 binding to MHC II and/or FGL1. Therefore, the present invention further relates to a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, and use of the pharmaceutical composition in the preparation of drugs.

Abstract: Provided are Christensenella intestinihominis and an application thereof, specifically, use of Christensenella intestinihominis in treating and preventing obesity and related diseases thereof. Also provided are a composition for treating and preventing obesity and related diseases thereof, comprising compositions of drugs, drinks, food, or animal feed, and a method for reducing weight and/or blood lipid.

Abstract: Provided are Faecalibacterium longum and an application thereof, specifically, use of Faecalibacterium longum in treating and preventing diabetes and related diseases thereof. Also provided are a composition for treating and preventing diabetes and related diseases thereof, comprising compositions of drugs, drinks, food, or animal feed, and a method for reducing weight, fasting plasma glucose and/or blood lipid, and improving glucose tolerance.

Abstract: The present disclosure relates to a light guide plate and its fabricating method, as well as a backlight module. The light guide plate comprises a light-transmitting plate body provided with a plurality of light guide dots on a light-exiting surface thereof, and further provided with a plurality of dimming pits, wherein a plurality of light guide dots are provided around each of the dimming pits; an inner wall of each of the dimming pits sequentially includes multiple levels of dimming surfaces along a depth direction of the dimming pits, for reflecting light incident thereon to the light guide dots. The backlight module comprises the light guide plate provided in the above-described technical solution.

Abstract: A display device is provided. The display device includes a display screen and an optical film structure arranged on a light exiting side of the display screen. The optical film structure includes a substrate layer and a first micro-lens array layer, where the substrate layer has a first surface and a second surface opposite to each other; the first micro-lens array layer is provided on at least one of the first surface and the second surface, and includes multiple micro-lenses arranged in sequence, each of the multiple micro-lenses has a size smaller than that of a sub-pixel, and edges of adjacent micro-lenses abut on each other.

Abstract: Embodiments of this application relate to the field of terminal technologies, and describe a method for displaying a dynamic image and a terminal, which resolve a problem that power consumption of a terminal caused by an existing method in which three-dimensional real-time rendering is used is relatively high. The method may be applied to a terminal, and can includes obtaining, from a video file based on a preset factor, a plurality of pieces of image frame data in a one-to-one correspondence to a plurality of image frames. The method may also include decoding the plurality of pieces of image frame data, to obtain the plurality of image frames. Furthermore, the method can include successively displaying the plurality of image frames obtained through the decoding, to present the dynamic image. The dynamic image includes the plurality of image frames, and the preset factor includes at least one of the following factors: a time point and orientation data.

Abstract: The present invention discloses an application of Bacteroides cellulosilyticus in preparing a preparation for preventing and/or treating lipid metabolism related diseases, such as atherosclerosis related diseases, cardiovascular diseases and obesity.

Abstract: The present invention relates to the field of plant molecular breeding, and provides methods for estimating additive and dominant genetic effects of single methylation polymorphisms (SMPs) on quantitative traits. The method comprises the following steps: 1) collecting samples and measuring phenotype in a natural population, and extracting genomic DNA from the samples; 2) constructing MethylC-seq libraries using the sample genomic DNA, and sequencing; 3) identifying the SMPs from the DNA methylation sequencing reads, and performing genotyping; and 4) performing epigenome-wide association study on the SMPs and the phenotypic data using a Mixed Linear Model (MLM), identifying SMPs that are significantly associated with the phenotype, and estimating the additive and dominant genetic effects. The method can provide a new technical guidance for gene marker-assisted breeding, and has important theoretical and breeding values.

Abstract: Provided are a recombinant bispecific antibody against CTLA-4 and PDL-1, a nucleic acid molecule for encoding the antibody, a vector and a host cell comprising the nucleic acid molecule, and a method for preparing the antibody. Also provided are a pharmaceutical composition comprising the bispecific antibody, and usage of the bispecific antibody in preparation of the pharmaceutical composition.

Abstract: A method for forming a dual damascene interconnect structure. A substrate having a conductor layer, an etch stop layer on the conductor layer, a dielectric stack on the etch stop layer, and a hard mask layer on the dielectric stack is provided. A photoresist layer having a resist opening is formed on the hard mask layer. The hard mask layer is etched through the resist opening to form a hard mask opening. The dielectric stack is etched through the hard mask opening to form a partial via hole. The photoresist layer is trimmed to form a widened resist opening above the partial via hole. The hard mask layer is etched through the widened resist opening to form a widened hard mask opening above the partial via hole. The dielectric stack is etched through the widened hard mask opening and the partial via hole to form a dual damascene via.

Abstract: The present invention discloses an application of Alistipes shahii in preparing a composition for preventing and/or treating lipid metabolism related diseases, for example but not limited to, atherosclerosis related diseases, cardiovascular diseases and obesity.

Abstract: A method for forming a dual damascene interconnect structure. A substrate having a conductor layer, an etch stop layer on the conductor layer, a dielectric stack on the etch stop layer, and a hard mask layer on the dielectric stack is provided. A photoresist layer having a resist opening is formed on the hard mask layer. The hard mask layer is etched through the resist opening to form a hard mask opening. The dielectric stack is etched through the hard mask opening to form a partial via hole. The photoresist layer is trimmed to form a widened resist opening above the partial via hole. The hard mask layer is etched through the widened resist opening to form a widened hard mask opening above the partial via hole. The dielectric stack is etched through the widened hard mask opening and the partial via hole to form a dual damascene via.

Abstract: A method for identifying plant lncRNA and gene interaction includes obtaining population SNP genotype data of the lncRNA and the gene; obtaining population expression abundance data of the gene in the studied tissue; and obtaining target trait population phenotypic data. When three restrictive conditions defined by the method are satisfied at the same time, it is indicated that the lncRNA and the gene are interacted with each other and together affect the phenotypic variation of the target trait of the plant. The method is used to accurately detect the interaction relationship between P. tomentosa lncRNA LNC-0052611 and gene Pto-COMT25, and the interaction relationship affects the phenotypic variation of a diameter at breast height of P. tomentosa.