Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: Systems and methods for updating a document are provided. A document content updater is configured to determine a web-based source for a section of content that is contained in an electronic document. The document content updater is further configured to determine for the section of content an update that is included in a copy of the web-based source contained in web-content downloaded by a web crawler. The document content updater is further configured to provide the determined update to be included in the electronic document.

Abstract: A system and method is described herein that automatically determines if a user of a search engine is conducting a research mission and then provides one or more research tools, one or more specialized searches, one or more directed ads, and/or one or more marketplace events responsive to determining that the research mission is being conducted. The automatic provision of various events and/or tools responsive to determination of the research mission can advantageously improve the experience of the user conducting the research mission.

Abstract: In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay.

Abstract: A backlight module is used in a lighting keyboard. The backlight module includes a light guiding plate and a masking. The masking is disposed on the light guiding plate. The masking includes a support layer, a cover layer and a reflective layer. The support layer includes a first surface and a second surface opposite to the first surface. The cover layer is disposed on the first surface. The cover layer includes a first opening. The reflective layer is disposed on the second surface and faces the light guiding plate for reflecting light emitted from the light guiding plate, so as to enhance lighting efficiency on the first opening. The reflective layer includes a second opening. A shape and a position of the second opening are respectively corresponding to a shape and a position of the first opening.

Abstract: A method for producing a library of engineered-antibody producing cells is provided. In certain cases, the method includes isolating nucleic acid sequences encoding IgH variable regions and IgL variable regions from a plurality of antibody producing cells, and introducing the nucleic acids into host cells to obtain cells that produce antibodies comprising non-naturally paired IgH and IgL variable chains.

Abstract: In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay.

Abstract: A portable electronic device for reading a compact disc includes a housing including oppositely spaced-apart first and second inner surfaces, and two oppositely spaced-apart third inner surfaces each connected between the first and second inner surfaces. The first, second and third inner surfaces cooperatively define a passage. A compact disc drive is disposed in the housing and includes a base disposed in the passage, and a tray disposed on and movable relative to the base. The tray has an upper surface for the compact disc to be disposed thereon. The upper surface of the tray is immediately adjacent to and faces the first inner surface of the housing.

Abstract: An inertial sensor calibration method has steps of mounting an observer device and an inertial sensor of a vehicle carrying on an inertial move, acquiring actual vehicle motion data from the observer device and inertial signal data of the inertial sensor, calculating an integral corresponding to the vehicular dynamic variation model with respect to the inertial signal data to obtain predicted vehicle sensor data and calculating variations of the actual vehicle motion data, acquiring differences between the two calculated data, applying an energy optimization and a discretization to the differences so as to obtain parametric error variances, and feeding back the parametric error variances to the vehicular dynamic variation model to calibrate the parameters associated with offset and scale factor and acquire a calibrated vehicular dynamic variation model. Under the premise of no GPS, electronic compass or pressure sensor, the present invention can secure positioning continuity and reliability.

Abstract: A light guide plate structure includes a light guide plate, a first medium layer, a micro structure, a second medium layer, and a reflection layer. The light guide plate has a light exit surface and a bottom surface opposite to the light exit surface. The first medium layer is formed on the light exit surface. The micro structure is formed on the bottom surface for redirecting light inside the light guide plate to emit from the light exit surface. The second medium layer is formed on the micro structure. The refractive index of the first medium layer and the refractive index of the second medium layer are less than the refractive index of the light guide plate but greater than the refractive index of air. The reflection layer is formed on the second medium layer for reflecting light inside the light guide plate to emit from the light exit surface.

Abstract: Methods are apparatuses are described for identifying a target object using optical occlusion. A head-mounted display perceives a characteristic of a reference object. The head-mounted display detects a change of the perceived characteristic of the reference object and makes a determination that a detected object caused the change of the perceived characteristic. In response to making the determination, the head-mounted display identifies the detected object as the target object.

Abstract: A protective cover includes a light guide plate, a first flexible layer, a light masking layer and a light source. The light guide plate has a light scattering structure, an upper surface and a lower surface opposite to the upper surface, wherein the light scattering structure is formed in the light guide plate and adjacent to the lower surface. The first flexible layer is formed on the upper surface. The light masking layer is formed on the first flexible layer and has a light transmissible portion formed over the light scattering structure correspondingly. The light source is disposed neighboring to the light guide plate and light emitted by the light source is guided by the light guide plate and then emitted out of the light transmissible portion.

Abstract: A backlight module is used in a lighting keyboard. The backlight module includes a light guiding plate and a masking. The masking is disposed on the light guiding plate. The masking includes a support layer, a cover layer and a reflective layer. The support layer includes a first surface and a second surface opposite to the first surface. The cover layer is disposed on the first surface. The cover layer includes a first opening. The reflective layer is disposed on the second surface and faces the light guiding plate for reflecting light emitted from the light guiding plate, so as to enhance lighting efficiency on the first opening. The reflective layer includes a second opening. A shape and a position of the second opening are respectively corresponding to a shape and a position of the first opening.

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: A backlight module includes a light guide plate, a light source, a light shielding sheet, a light reflecting sheet and a light shielding member. The light guide plate has a hole formed thereon and the hole has a side wall. The light source is disposed neighboring to the light guide plate and used for emitting light into the light guide plate. The light shielding sheet is disposed on the light guide plate. The light reflecting sheet is disposed below the light guide plate. The light shielding member is disposed in the hole and covers the side wall of the hole, so as to block the light guided by the light guide plate from being emitted out of the hole.

Abstract: An image reconstruction method is described as follows. A structural image of an object is obtained. An actual optical detected result of the object is obtained. An inhomogeneous initial state is determined based on the structural image. At least one solution converged with the actual optical detected result is determined by iteratively calculating a physical model from the inhomogeneous initial state. The image of the object is reconstructed based on the solution.

Abstract: A resin composition is provided. The resin composition comprises an epoxy resin, a first filler containing calcium carbonate and hydrated magnesium silicate and a hardener, wherein the first filler has a diameter ranging from about 0.1 ?m to about 100 ?m; and the amount of the first filler is about 1 part by weight to about 150 parts by weight per 100 parts by weight of the epoxy resin.

Abstract: A switch mechanism includes a sliding track disposed inside a host module, and a sliding component. An end of the sliding component is pivotally connected to a display module and the other end of the sliding component is slidably installed inside the sliding track. The sliding component slides in a first direction relative to the sliding track while the display module pivots in a first rotary direction relative to the host module. The switch mechanism further includes an activation component for moving to a first position corresponding to a first switch component to activate a first switch component while the sliding component slides in the first direction.

Abstract: Methods and systems involving a navigable area in a head-mounted display (HMD) are disclosed herein. An exemplary system may be configured to: (a) cause a head-mounted display (HMD) to provide: (i) a viewing window that is fully visible in a field of view of the HMD, (ii) a navigable area that is not fully visible in a field of view of the HMD such that the viewing window displays a first portion of the navigable area, and (iii) a media object that is associated with a viewing-window state; (b) receive first head-movement data that is indicative of head movement from a first position of the HMD to a second position of the HMD; and (c) based on (i) the first head-movement data and (ii) the viewing-window state, cause the viewing window to display a second portion of the navigable area which includes the media object.

Abstract: The present invention provides a method and system for customized search results in an advanced search results page including vertical searching pivot points for personalizing and refining searching operations. The method includes tracking user network activities and receiving a search query from the user, the search query including a plurality of search terms. The method and system includes identifying a plurality of preferred content sources based on the tracked network activities and retrieving content items in response to the search query. The method and system filters the content items based on the preferred content sources and therein generates a search result page displaying at least a portion of the filtered content items and at least one of the preferred content sources, wherein the display of the at least one preferred content source allows the user to pivot the search results portion based solely on the preferred content source.