Abstract: An inertial sensor calibration method has steps of mounting an observer device and an inertial sensor of a vehicle carrying on an inertial move, acquiring actual vehicle motion data from the observer device and inertial signal data of the inertial sensor, calculating an integral corresponding to the vehicular dynamic variation model with respect to the inertial signal data to obtain predicted vehicle sensor data and calculating variations of the actual vehicle motion data, acquiring differences between the two calculated data, applying an energy optimization and a discretization to the differences so as to obtain parametric error variances, and feeding back the parametric error variances to the vehicular dynamic variation model to calibrate the parameters associated with offset and scale factor and acquire a calibrated vehicular dynamic variation model. Under the premise of no GPS, electronic compass or pressure sensor, the present invention can secure positioning continuity and reliability.

Abstract: The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method involves identifying a substitutable position in a parent antibody by comparing its amino acid sequence to the amino acid sequences of a number of related antibodies that each bind to the same antigen as the parent antibody. The amino acid at the substitutable position may be substituted for a different amino acid without significantly affecting the activity of the antibody. The subject methods may be employed to change the amino acid sequence of a CDR without significantly reducing the affinity of the antibody of the antibody, in humanization methods, or in other antibody engineering methods. The invention finds use in a variety of therapeutic, diagnostic and research applications.

Abstract: A bidirectional optical scanner assisting in mammography is revealed. The optical scanner that calculates functional images obtained by diffuse optical tomography, used in combination with a mammography machine can reduce the number of mammograms taken and the dose exposure. The bidirectional optical scanner includes a first compression plate, a first optical detection module, a second optical detection module and a second compression plate. The same test position of the tested breast can be detected twice in different directions by the first and the second optical detection modules. No matter where the tumor is located, the tumor can be detected. Besides structural images provided by the mammography machine, functional tomographic images of the breast are obtained by the bidirectional optical scanner. Thus diagnostic accuracy in the detection of breast cancer is improved.

Abstract: The present invention relates to providing vector terms for use in formulating search requests in response to a user query. The method according to one embodiment comprises receiving a search query from a client and identifying links to one or more content items corresponding to the search query. One or more term vectors are then generated corresponding to the content items and one or more vector terms are selected from the term vectors. The links to the one or more content items and selected vector terms are combined to form a final result page.

Abstract: A bidirectional optical scanner assisting in mammography is revealed. The optical scanner that calculates functional images obtained by diffuse optical tomography, used in combination with a mammography machine can reduce the number of mammograms taken and the dose exposure. The bidirectional optical scanner includes a compression module, a first optical detection module, and a second optical detection module. The same test position of the tested breast can be detected twice in different directions by the first and the second optical detection modules. No matter where the tumor is located, the tumor can be detected. Besides structural images provided by the mammography machine, functional tomographic images of the breast are obtained by the bidirectional optical scanner. Thus diagnostic accuracy in the detection of breast cancer is improved.

Abstract: Exemplary wearable computing systems may include a head-mounted display that is configured to provide indirect bone-conduction audio. For example, an exemplary head-mounted display may include at least one vibration transducer that is configured to vibrate at least a portion of the head-mounted display based on the audio signal. The vibration transducer is configured such that when the head-mounted display is worn, the vibration transducer vibrates the head-mounted display without directly vibrating a wearer. However, the head-mounted display structure vibrationally couples to a bone structure of the wearer, such that vibrations from the vibration transducer may be indirectly transferred to the wearer's bone structure.

Abstract: A parking space detection device and method thereof, wherein, firstly, store a plurality of border data relating to moved distance of a vehicle, and distance between vehicle and an obstacle for reverse transmission of ultrasonic waves; then determine if said border data satisfy evaluation conditions, such that it is in a first detecting parking space then obstacle state, or in a first detecting obstacle then parking space state. Wherein, in case that any of evaluation conditions is satisfied, start to calculate a first difference between each of said border data and their average, to determine if it is grater than a standard deviation; in case that answer is positive, fetch at least two data points, a first data point and a second data point, corresponding to border data, then calculate their difference to adjust weights of first data point and second data point, in obtaining a highly accurate parking space.

Abstract: The present application discloses systems and methods for accessing digital content between multiple devices. The systems and methods may be directed to providing access to an interaction with a first application on a head-mounted display (HMD) to a second device. Contextual information relating information of the HMD and information associated with the interaction to describe an interaction state may be stored. A second device may be selected upon which the interaction state may be accessed and a determination of attributes of the second device may be made. The HMD may transfer to the second device the stored contextual information such that the second device may provide via the second application access to the interaction state. Information associated with a user input to the first application may also be transferred. In one example, the contextual information may describe an identified occurrence of digital content accessed via the first application.

Abstract: In certain embodiments, the method may comprises: a) contacting a population of permeabilized, cross-linked antibody-producing cells with a labeled antigen to produce a labeled sample in which cells that produce an antibody that specifically binds to said antigen are intracellularly labeled; b) using FACS to isolate cells that are intracellularly labeled, thereby producing labeled cells; c) uncrosslinking said labeled cells to produce uncrosslinked cells; and d) amplifying heavy and light chain-encoding nucleic acid from individual uncrosslinked cells, thereby obtaining nucleic acid that encodes the variable domain of antibody that specifically binds to said antigen.

Abstract: Methods and apparatus related to processing speech input at a wearable computing device are disclosed. Speech input can be received at the wearable computing device. Speech-related text corresponding to the speech input can be generated. A context can be determined based on database(s) and/or a history of accessed documents. An action can be determined based on an evaluation of at least a portion of the speech-related text and the context. The action can be a command or a search request. If the action is a command, then the wearable computing device can generate output for the command. If the action is a search request, then the wearable computing device can: communicate the search request to a search engine, receive search results from the search engine, and generate output based on the search results. The output can be provided using output component(s) of the wearable computing device.

Abstract: The present application discloses systems and methods for a virtual input device. In one example, the virtual input device includes a projector and a camera. The projector projects a pattern onto a surface. The camera captures images that can be interpreted by a processor to determine actions. The projector may be mounted on an arm of a pair of eyeglasses and the camera may be mounted on an opposite arm of the eyeglasses. A pattern for a virtual input device can be projected onto a “display hand” of a user, and the camera may be able to detect when the user uses an opposite hand to select items of the virtual input device. In another example, the camera may detect when the display hand is moving and interpret display hand movements as inputs to the virtual input device, and/or realign the projection onto the moving display hand.

Abstract: The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method involves identifying a substitutable position in a parent antibody by comparing its amino acid sequence to the amino acid sequences of a number of related antibodies that each bind to the same antigen as the parent antibody. The amino acid at the substitutable position may be substituted for a different amino acid without significantly affecting the activity of the antibody. The subject methods may be employed to change the amino acid sequence of a CDR without significantly reducing the affinity of the antibody of the antibody, in humanization methods, or in other antibody engineering methods. The invention finds use in a variety of therapeutic, diagnostic and research applications.

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: Disclosed are systems, methods, and devices for interfacing with a wearable heads-up display via a finger-operable input device. The wearable heads-up display may include a display element for receiving and displaying display information received from a processor, and may also include a wearable frame structure supporting the display element and having a projection extending away from the display element. The projection may be configured to secure the heads-up display to a user's body in a manner such that the display element is disposed within a field of view of the user. A finger-operable input device secured to the wearable frame structure is configured to sense at least one of a position and movement of a finger along a planar direction relative to a surface of the input device, and to provide corresponding input information to the processor.

Abstract: In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay.

Abstract: The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.

Abstract: In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay.

Abstract: The present application discloses systems and methods for accessing digital content between multiple devices. The systems and methods may be directed to providing access to an interaction with a first application on a head-mounted display (HMD) to a second device. Contextual information relating information of the HMD and information associated with the interaction to describe an interaction state may be stored. A second device may be selected upon which the interaction state may be accessed and a determination of attributes of the second device may be made. The HMD may transfer to the second device the stored contextual information such that the second device may provide via the second application access to the interaction state. Information associated with a user input to the first application may also be transferred. In one example, the contextual information may describe an identified occurrence of digital content accessed via the first application.

Abstract: The present application discloses methods and systems for augmenting a field of view of a user. In one embodiment, a device may include a detector, a processor, and an array of visual indicators. According to an embodiment of the method, the detector may image an environment. The processor may identify within the environment imaged by the detector an object of interest. The processor may also determine a relative spatial location of the identified object of interest. Further, the array of visual indicators may be used to indicate the determined relative spatial location of the identified object of interest. In particular, a set of one or more visual indicators may be selected that has a relative spatial location in the array of visual indicators that is indicative of the relative spatial location of the identified object of interest.

Abstract: Treatment of picornavirus infection by inhibiting miR-141 activity. Also disclosed herein are a method for identify miR-141 inhibitory compounds and a method for identifying a target viral infection to be treated by anti-miR-141 therapy.