Patents by Inventor Liangfang Zhang
Liangfang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230225964Abstract: Disclosed are methods, materials and devices that pertain to a microstirring pill technology with built-in mixing capability for oral drug delivery that greatly enhances bioavailability of its therapeutic payload. In some aspects, a drug delivery device includes a pill matrix dissolvable in a fluid medium and loaded with a plurality of drug payloads; and a plurality of micro stirrers embedded in the pill matrix and configured to create a local fluid transport upon interacting with a biological fluid surrounding the microstirring pill.Type: ApplicationFiled: January 18, 2023Publication date: July 20, 2023Inventors: Joseph Wang, Rodolfo Andres Mundaca Uribe, Berta Esteban-Fernandez de Avila, Ronnie Fang, Liangfang Zhang
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Patent number: 11547667Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.Type: GrantFiled: August 19, 2019Date of Patent: January 10, 2023Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Ulrich H. von Andrian, Omid C. Farokhzad, Robert S. Langer, Tobias Junt, Elliott Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis
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Publication number: 20220331365Abstract: A biomimetic oxygen delivery carrier is provided by employing natural cell membrane as a stabilizer for fluorocarbon nanoemulsions. The resulting formulation exhibits a high capacity for delivering oxygen and can be used to successfully resuscitate subjects in need due to for example hemorrhagic shock. This natural-synthetic platform can alleviate the impact of blood shortages in clinical settings among other uses.Type: ApplicationFiled: September 1, 2020Publication date: October 20, 2022Inventors: Liangfang Zhang, Ronnie H. Fang, Jia Zhuang, Weiwei Gao
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Publication number: 20220221464Abstract: Described are methods, compositions, and devices for early detection and prevention of diseases, including cancer, infectious diseases, and autoimmune diseases, using broad-spectrum enrichment technology and single cell sequencing technology. An example method for detecting circulating tumor cells (CTCs) using platelet membrane-coated nanoparticles (PNPs) and single cell RNA sequencing (scRNA-seq) technology is also provided.Type: ApplicationFiled: April 30, 2020Publication date: July 14, 2022Inventors: Liangfang Zhang, Wei Wang
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Patent number: 11357736Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.Type: GrantFiled: January 31, 2020Date of Patent: June 14, 2022Assignee: The Regents of the University of CaliforniaInventors: Liangfang Zhang, Zhiqing Pang, Ronnie H. Fang, Che-Ming Jack Hu
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Publication number: 20220151948Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.Type: ApplicationFiled: February 1, 2022Publication date: May 19, 2022Inventors: Liangfang Zhang, Che-Ming Jack Hu, Ronnie H. Fang, Brian T. Luk, Kuei-Chun Wang, Shu Chien
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Patent number: 11241394Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.Type: GrantFiled: June 7, 2016Date of Patent: February 8, 2022Assignee: The Regents of the University of CaliforniaInventors: Liangfang Zhang, Che-Ming Jack Hu, Ronnie H. Fang, Brian T. Luk, Kuei-Chun Wang, Shu Chien
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Patent number: 11224577Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.Type: GrantFiled: June 7, 2016Date of Patent: January 18, 2022Assignee: The Regents of the University of CaliforniaInventors: Liangfang Zhang, Che-Ming Jack Hu, Ronnie H. Fang, Brian T. Luk, Soracha Kun Thamphiwatana
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Publication number: 20210299217Abstract: A nanoparticle comprising an outer surface comprising a plasma membrane derived from a cell that can be infected with a respiratory virus, including a human lung epithelial cell expressing ACE-2 receptor. Methods of manufacture and use for preventing or treating viral infections, such as coronavirus infection in a subject in need are disclosed.Type: ApplicationFiled: March 22, 2021Publication date: September 30, 2021Inventors: Liangfang Zhang, Weiwei Gao, Ronnie H. Fang
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Patent number: 11007281Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.Type: GrantFiled: March 28, 2018Date of Patent: May 18, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNAInventors: Joseph Wang, Berta Esteban-Fernández de Ávila, Yi Chen, Chava Angell, Fernando Soto, Liangfang Zhang, Malthe Hansen-Bruhn
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Patent number: 11007147Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.Type: GrantFiled: March 6, 2020Date of Patent: May 18, 2021Assignee: The Regents of the University of CaliforniaInventors: Liangfang Zhang, Che-Ming Jack Hu, Weiwei Gao, Jonathan Copp
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Patent number: 11000593Abstract: The present invention relates to viral or cellular membrane coated nanostructures. Nanostructure networks, nanoscaffolds and articles of manufacture comprising the nanostructure, and uses thereof, are also provided. The present invention also relates to methods for anchoring, attaching and/or growing a target cell. Target cells, constituent(s) of the target cells, target substances made by the target cells or culture medium of the target cells prepared by the present methods, and uses thereof, are also provided.Type: GrantFiled: January 5, 2017Date of Patent: May 11, 2021Assignee: The Regents of the University of CaliforniaInventors: Liangfang Zhang, Weiwei Gao
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Publication number: 20200276122Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.Type: ApplicationFiled: March 6, 2020Publication date: September 3, 2020Inventors: Liangfang Zhang, Che-Ming Jack Hu, Weiwei Gao, Jonathan Copp
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Publication number: 20200268892Abstract: The present invention relates to viral or cellular membrane coated nanostructures. Nanostructure networks, nanoscaffolds and articles of manufacture comprising the nanostructure, and uses thereof, are also provided. The present invention also relates to methods for anchoring, attaching and/or growing a target cell. Target cells, constituent(s) of the target cells, target substances made by the target cells or culture medium of the target cells prepared by the present methods, and uses thereof, are also provided.Type: ApplicationFiled: January 5, 2017Publication date: August 27, 2020Inventors: Liangfang Zhang, Weiwei Gao
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Patent number: 10736848Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.Type: GrantFiled: October 12, 2008Date of Patent: August 11, 2020Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, The Children's Medical Center CorporationInventors: Ulrich H. Von Andrian, Omid C. Farokhzad, Robert S. Langer, Tobias Junt, Elliott Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis
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Publication number: 20200222334Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.Type: ApplicationFiled: January 31, 2020Publication date: July 16, 2020Inventors: Liangfang Zhang, Zhiqing Pang, Ronnie H. Fang, Che-Ming Jack Hu
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Patent number: 10653803Abstract: Living cells, such as red blood cells (RBCs) modified with functional micromotors with the aid of ultrasound propulsion and magnetic guidance. Iron oxide nanoparticles are loaded into the RBCs, where their asymmetric distribution within the cells results in a net magnetization, thus enabling magnetic alignment and guidance under acoustic propulsion. The RBC motors display efficient guided and prolonged propulsion in various biological fluids, including undiluted whole blood.Type: GrantFiled: November 21, 2016Date of Patent: May 19, 2020Assignee: The Regents of the University of CaliforniaInventors: Joseph Wang, Liangfang Zhang
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Patent number: 10632070Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.Type: GrantFiled: September 24, 2018Date of Patent: April 28, 2020Assignee: The Regents of the University of CaliforniaInventors: Liangfang Zhang, Che-Ming Jack Hu, Weiwei Gao, Jonathan Coop
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Patent number: 10610493Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.Type: GrantFiled: April 13, 2016Date of Patent: April 7, 2020Assignee: The Regents of the University of CaliforniaInventors: Liangfang Zhang, Zhiqing Pang, Ronnie H. Fang, Che-Ming Jack Hu
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Patent number: 10588867Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.Type: GrantFiled: July 18, 2019Date of Patent: March 17, 2020Assignee: The Regents of the University of CaliforniaInventors: Liangfang Zhang, Weiwei Gao, Ronnie H. Fang, Che-Ming Jack Hu