Patents by Inventor Liangfang Zhang
Liangfang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160136106Abstract: Provided are methods, combinations and pharmaceutical compositions for treating or preventing an infection in a subject using a nanoparticle comprising a) an inner core comprising a non-cellular material, and b) an outer surface comprising a cellular membrane configured for adhesion of a pathogen that causes said infection. Exemplary infection includes infection caused by a virus, bacterium, fungus, or protozoan.Type: ApplicationFiled: January 19, 2016Publication date: May 19, 2016Inventors: Liangfang Zhang, Che-Ming Jack Hu
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Patent number: 9333179Abstract: The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.Type: GrantFiled: October 5, 2009Date of Patent: May 10, 2016Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Liangfang Zhang, Aleksandar F. Radovic-Moreno, Frank X. Gu, Frank Alexis, Robert S. Langer, Omid C. Farokhzad
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Patent number: 9333163Abstract: This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.Type: GrantFiled: October 6, 2009Date of Patent: May 10, 2016Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hosptial, Inc.Inventors: Omid C. Farokhzad, Carolina Salvador-Morales, Weiwei Gao, Liangfang Zhang, Juliana M. Chan, Robert S. Langer
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Publication number: 20130287857Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.Type: ApplicationFiled: March 15, 2013Publication date: October 31, 2013Inventors: Ulrich H. von Andrian, Omid C. Farokhzad, Robert S. Langer, Tobias Junt, Elliott Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis
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Publication number: 20130236533Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.Type: ApplicationFiled: March 15, 2013Publication date: September 12, 2013Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, IMMUNE DISEASE INSTITUTE, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, PARTNERS HEALTHCARE SYSTEM, INC.Inventors: Ulrich H. von Andrian, Omid C. Farokhzad, Robert S. Langer, Tobias Junt, Elliott Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis
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Publication number: 20130028962Abstract: Control of the fusion activity of liposomes by adsorbing biocompatible nanoparticles to the outer surface of phospholipid liposomes is disclosed. The biocompatible nanoparticles effectively prevent liposomes from fusing with one another. Release of cargo from the liposome is accomplished via trigger mechanisms that include pH triggers, pore forming toxing triggers and photosensitive triggers. Dermal drug delivery to treat a variety of skin diseases such as acne vulgaris and staph infections is contemplated.Type: ApplicationFiled: September 7, 2012Publication date: January 31, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Liangfang Zhang, Dissaya Pornpattananangkul, Chun-Ming E. Huang
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Publication number: 20120156135Abstract: This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.Type: ApplicationFiled: October 6, 2009Publication date: June 21, 2012Inventors: Omid C. Farokhzad, Carolina Salvador-Morales, Weiwei Gao, Liangfang Zhang, Juliana M. Chan, Robert S. Langer
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Patent number: 8193334Abstract: A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanoparticle formation by nanoprecipitation. This method can be coupled to other techniques that improve intracellular drug targeting, ultimately enhancing intracellular delivery of the aforementioned nucleic acids.Type: GrantFiled: October 5, 2009Date of Patent: June 5, 2012Assignees: The Brigham and Women's Hospital, Massachusetts Institute of TechnologoyInventors: Aleksandar F. Radovic-Moreno, Liangfang Zhang, Robert S. Langer, Omid C. Farokhzad
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Publication number: 20110052697Abstract: The present invention provides systems, methods, and compositions for targeted delivery of a therapeutic agent organs, tissues, cells, extracellular matrix components, and intracellular compartments. The present invention provides a complex comprising a therapeutic or diagnostic agent and a nucleic acid targeting moiety, wherein the agent non-covalently associates with base pairs of the nucleic acid targeting moiety. The invention provides targeted particles comprising a particle and an inventive complex. The present invention provides methods of designing, manufacturing, and using inventive complexes and targeted particles.Type: ApplicationFiled: May 17, 2007Publication date: March 3, 2011Applicants: GWANGJU INSTITUTE OF SCIENCE & TECHNOLOGY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Omid C. Farokhzad, Sangyong Jon, Vaishali Bagalkot, Liangfang Zhang, Benjamin Teply, Etgar Levy-Nissenbaum, Robert S. Langer
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Publication number: 20110027172Abstract: The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo.Type: ApplicationFiled: December 10, 2008Publication date: February 3, 2011Inventors: Zhuang Wang, Omid C. Farokhzad, Liangfang Zhang, Aleksandar Filip Radovic-Moreno, Frank X. Gu, Robert S. Langer
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Publication number: 20100233251Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.Type: ApplicationFiled: October 12, 2008Publication date: September 16, 2010Inventors: Ulrich H. Von Andrian, Omid C. Farokhzad, Robert S. Langer, Tobias Junt, Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis
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Publication number: 20100203142Abstract: The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.Type: ApplicationFiled: October 5, 2009Publication date: August 12, 2010Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Liangfang ZHANG, Aleksandar F. RADOVIC-MORENO, Frank X. GU, Frank ALEXIS, Robert S. LANGER, Omid C. FAROKHZAD
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Publication number: 20100196482Abstract: A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanoparticle formation by nanoprecipitation. This method can be coupled to other techniques that improve intracellular drug targeting, ultimately enhancing intracellular delivery of the aforementioned nucleic acids.Type: ApplicationFiled: October 5, 2009Publication date: August 5, 2010Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, The Brigham and Women's Hospital, Inc.Inventors: Aleksandar F. RADOVIC-MORENO, Liangfang ZHANG, Robert S. LANGER, Omid C. FAROKHZAD
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Publication number: 20090074828Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.Type: ApplicationFiled: April 4, 2008Publication date: March 19, 2009Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Frank Alexis, Liangfang Zhang, Aleksandar F. Radovic-Moreno, Frank X. Gu, Pamela Basto, Etgar Levy-Nissenbaum, Juliana Chan, Robert S. Langer, Omid C. Farokhzad