Abstract: The present application discloses a class of guaianolide sesquiterpene lactone derivatives and pharmaceutical use thereof. The guaianolide sesquiterpene lactone derivative or a pharmaceutically acceptable salt thereof is shown as general formula I. In the present application, a class of novel guaianolide sesquiterpene lactone derivatives are found by structural optimization with abundant natural ingredients such as parthenolide and dehydrocostus lactone as raw materials, which derivatives have good inhibitory activity on the activation of the NLRP3 inflammasome, and the chemical stability, water solubility and oral bioavailability of which are significantly improved, and it is verified by experiments that the derivatives have inhibitory effects on the activity of the NLRP3 inflammasome and have potential pharmaceutical applications.

Abstract: The present disclosure relates to the field of biotechnology, and particularly to use of a tomato gene mSlBZR1L in changing the morphology of tomato fruits. The present disclosure discloses a tomato gene mSlBZR1L comprising a nucleotide sequence as set forth in SEQ ID No: 3, and the gene can extend the length of the tomato fruits.

Abstract: A method involves determining a threshold error rate that will result on data stored on a magnetic disk surface of a disk drive being unrecoverable. The method also involves determining a seek velocity that will overwrite sufficient portions of the data such the data will exhibit at least the threshold error rate. The disk drive performs at least one traversal of the magnetic disk surface with a head of the disk drive that emits an erase field during the at least one traversal at the seek velocity. The at least one traversal sanitizes the data.

Abstract: A recording head has a magnetic write transducer having a first crosstrack width operable to write a single track of data at a time to a magnetic disk. The recording head also has a magnetic erase transducer separate from the magnetic write transducer. The magnetic erase transducer has a second crosstrack width operable to simultaneously erase multiple tracks of data from the magnetic disk.

Abstract: Disclosed herein is a kit for detecting or quantifying a SARS-CoV-2 nucleocapsid phosphoprotein, including a first antibody, wherein a variable heavy chain domain comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 1, 3, 5, 7, 11, 13, 15, 17, 19, and 21, and a variable light chain domain comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 4, 6, 8, 12, 14, 16, 18, 20, and 22; and a second antibody, wherein a variable heavy chain domain comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 9 and 13, and a variable light chain domain comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 10 and 14.

Abstract: Provided is a method for optimizing a lithography quality, including: determining a wave function stray term introduced by a surface roughness of a metal film layer based on Eigen matrix method and Bloch theorem; inputting the wave function stray term into a lithography quality deviation mathematical model for calculation and simulation to obtain an influence analysis curve of a roughness of the metal film layer on a lithography quality, the influence analysis curve characterizes an influence result of the roughness of the metal film layer on the lithography quality; reducing the surface roughness of the metal film layer and/or providing a metal-dielectric multilayer film structure between a mask above a metal-dielectric unit and air according to the influence result, so as to optimize the lithography quality of the metal-dielectric unit. Provided is an apparatus for optimizing a lithography quality, an electronic device, a computer-readable storage medium and computer program product.

Abstract: The subject matter described herein relates to potent monoclonal and bispecific antibodies capable of neutralizing a SARS-CoV-2 viruses and methods of generating the antibodies.

Abstract: A semiconductor processing liquid including hydrofluoric acid, and an organic solvent, in which the organic solvent contains a compound represented by the formula below in which X1 is a single bond or an alkylene group having 1 to 6 carbon atoms, in which an ether bond may be interposed, Y10 is one of —O—, —(C?O)—, —O—(C?O)—, and —(C?O)—O—, Y20 is one of —(C?O)—, —O—(C?O)—, and —(C?O)—O—, and Y11 and Y21 are each independently a single bond or an alkylene group having 1 to 6 carbon atoms in which an ether bond may be interposed, provided that, X1, Y11, and Y21 do not contain hydroxyl groups in structures thereof, and when X1 is a single bond, Y10 is not —O—) H3C—Y11—Y10—X1—Y20—Y21—CH3??(1).

Abstract: A semiconductor processing liquid including hydrofluoric acid, and an organic solvent, in which the organic solvent contains a compound represented by the formula below in which X1 is a single bond or an alkylene group having 1 to 6 carbon atoms, in which an ether bond may be interposed, Y10 is one of —O—, —(C?O)—, —O—(C?O)—, and —(C?O)—O—, Y20 is one of —(C?O)—, —O—(C?O)—, and —(C?O)—O—, and Y11 and Y21 are each independently a single bond or an alkylene group having 1 to 6 carbon atoms in which an ether bond may be interposed, provided that, X1, Y11, and Y21 do not contain hydroxyl groups in structures thereof, and when X1 is a single bond, Y10 is not —O—) H3C—Y11—Y10—X1—Y20—Y21—CH3??(1).

Abstract: The subject matter described herein relates to potent monoclonal and bispecific antibodies capable of neutralizing a SARS-CoV-2 viruses and methods of generating the antibodies.

Abstract: The subject matter described herein relates to potent monoclonal and bispecific antibodies capable of neutralizing a SARS-CoV-2 viruses and methods of generating the antibodies.

Abstract: The present application discloses an information push method and apparatus, a device, and a storage medium, which relate to the field of intelligent search technology. A specific implementation of the method in the present application lies in: acquiring a user feature and an item feature, where both the user feature and the item feature include click through rate information; determining a degree of similarity between the user feature and the item feature; determining, according to the degree of similarity, item information that is recalled; and pushing the item information to a user terminal. According to the present application, item information having a high click through rate may be acquired through a one-channel recall approach, so that information push efficiency is improved and the pushed item information better conforms to user needs.

Abstract: A semiconductor processing liquid including hydrofluoric acid, and an organic solvent, in which the organic solvent contains a compound represented by the formula below in which X1 is a single bond or an alkylene group having 1 to 6 carbon atoms, in which an ether bond may be interposed, Y10 is one of —O—, —(C?O)—, —O—(C?O)—, and —(C?O)—O—, Y20 is one of —(C?O)—, —O—(C?O)—, and —(C?O)—O—, and Y11 and Y21 are each independently a single bond or an alkylene group having 1 to 6 carbon atoms in which an ether bond may be interposed, provided that, X1, Y11, and Y21 do not contain hydroxyl groups in structures thereof, and when X1 is a single bond, Y10 is not —O—) H3C—Y11—Y10—X1—Y20—Y21—CH3??(1).

Abstract: The present disclosure relates to the field of biotechnology, and particularly to use of a tomato gene mSlBZR1L in changing the morphology of tomato fruits. The present disclosure discloses a tomato gene mSlBZR1L comprising a nucleotide sequence as set forth in SEQ ID No: 3, and the gene can extend the length of the tomato fruits.

Abstract: A semiconductor processing liquid including hydrofluoric acid, and an organic solvent, in which the organic solvent contains a compound represented by the formula below in which X1 is a single bond or an alkylene group having 1 to 6 carbon atoms, in which an ether bond may be interposed, Y10 is one of —O—, —(C?O)—, —O—(C?O)—, and —(C?O)—O—, Y20 is one of —(C?O)—, —O—(C?O)—, and —(C?O)—O—, and Y11 and Y21 are each independently a single bond or an alkylene group having 1 to 6 carbon atoms in which an ether bond may be interposed, provided that, X1, Y11, and Y21 do not contain hydroxyl groups in structures thereof, and when X1 is a single bond, Y10 is not —O—) H3C—Y11—Y10—X1—Y20—Y21—CH3??(1).

Abstract: The present disclosure publishes a vulnerable plaque identification method. The method includes: receiving an angiocarpy image sent by a terminal device; transforming the angiocarpy image in an original Cartesian coordinate system into a polar coordinate system to form a polarization image; constructing a faster RCNN architecture and accomplishing a training; inputting the polarization image into the faster RCNN architecture accomplished the training to identify the polarization image, and outputting the image with the marked vulnerable plaques; feed backing the image with the marked vulnerable plaques to the terminal device. The present disclosure also publishes an application server and a computer readable medium. The vulnerable plaque identification method, the application server, and the computer readable medium can quickly and correctly conform the position of the vulnerable plaque.

Abstract: The present application discloses an information push method and apparatus, a device, and a storage medium, which relate to the field of intelligent search technology. A specific implementation of the method in the present application lies in: acquiring a user feature and an item feature, where both the user feature and the item feature include click through rate information; determining a degree of similarity between the user feature and the item feature; determining, according to the degree of similarity, item information that is recalled; and pushing the item information to a user terminal. According to the present application, item information having a high click through rate may be acquired through a one-channel recall approach, so that information push efficiency is improved and the pushed item information better conforms to user needs.

Abstract: The present disclosure publishes a vulnerable plaque identification method. The method includes: receiving an angiocarpy image sent by a terminal device; transforming the angiocarpy image in an original Cartesian coordinate system into a polar coordinate system to form a polarization image; constructing a faster RCNN architecture and accomplishing a training; inputting the polarization image into the faster RCNN architecture accomplished the training to identify the polarization image, and outputting the image with the marked vulnerable plaques; feed backing the image with the marked vulnerable plaques to the terminal device. The present disclosure also publishes an application server and a computer readable medium. The vulnerable plaque identification method, the application server, and the computer readable medium can quickly and correctly conform the position of the vulnerable plaque.

Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.