Patents by Inventor Lihong Liu

Lihong Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal compound
    Patent number: 9802902
    Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: October 31, 2017
    Assignee: Agency for Science, Technology and Research
    Inventors: Yugen Zhang, Jackie Y. Ying, Lihong Liu, Hong Wu
  • ANTIFUNGAL COMPOUND
    Publication number: 20170037013
    Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
    Type: Application
    Filed: October 19, 2016
    Publication date: February 9, 2017
    Inventors: Yugen Zhang, Jackie Y. Ying, Lihong Liu, Hong Wu
  • Antifungal compound
    Patent number: 9493424
    Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: November 15, 2016
    Assignee: Agency for Science, Technology and Research
    Inventors: Yugen Zhang, Jackie Y. Ying, Lihong Liu, Hong Wu
  • ANTIFUNGAL COMPOUND
    Publication number: 20150203454
    Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
    Type: Application
    Filed: August 7, 2013
    Publication date: July 23, 2015
    Inventors: Yugen Zhang, Jackie Y. Ying, Lihong Liu, Hong Wu
  • ANTIMICROBIAL COMPOSITION
    Publication number: 20130210881
    Abstract: The present disclosure relates to an antimicrobial composition comprising at least one polymer or oligomer, the polymer and oligomer being comprised of repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer the antimicrobial activity to the composition, methods of producing the same and uses of the antimicrobial composition.
    Type: Application
    Filed: October 13, 2011
    Publication date: August 15, 2013
    Applicant: Agency for Science ,Technology and Research
    Inventors: Yugen Zhang, Lihong Liu
  • Methods of making Efavirens and intermediates thereof
    Patent number: 8378143
    Abstract: The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1: may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: February 19, 2013
    Assignee: Apotex Pharmachem Inc.
    Inventors: Bo Chen, Zhi-Xian Wang, Yutao Xue, Lihong Liu, Hao Chen
  • METHODS OF MAKING EFAVIRENS AND INTERMEDIATES THEREOF
    Publication number: 20120095249
    Abstract: The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1: may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes.
    Type: Application
    Filed: December 19, 2011
    Publication date: April 19, 2012
    Applicant: APOTEX PHARMACHEM INC.
    Inventors: Bo CHEN, Zhi-Xian WANG, Yutao XUE, Lihong LIU, Hao CHEN
  • Methods of making efavirenz and intermediates thereof
    Patent number: 8080655
    Abstract: The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1: may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: December 20, 2011
    Assignee: Apotex Pharmachem Inc.
    Inventors: Bo Chen, Zhi-Xian Wang, Yutao Xue, Lihong Liu, Hao Chen
  • CATIONIC CORE-SHELL PEPTIDE NONOPARTICLES
    Publication number: 20110223202
    Abstract: The invention discloses an amphiphilic antimicrobial substance comprising a hydrophobic portion coupled to a cationic oligopeptide portion. The cationic oligopeptide portion may comprise a protein transduction domain coupled to a cationic oligopeptide group.
    Type: Application
    Filed: December 18, 2008
    Publication date: September 15, 2011
    Inventors: Yi-Yan Yang, Lihong Liu
  • METHODS OF MAKING EFAVIRENZ AND INTERMEDIATES THEREOF
    Publication number: 20110015189
    Abstract: The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1 may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes.
    Type: Application
    Filed: July 20, 2009
    Publication date: January 20, 2011
    Applicant: APOTEX PHARMACHEM INC.
    Inventors: Bo CHEN, Zhi-Xian WANG, Yutao XUE, Lihong LIU, Hao CHEN
  • Implantable biomaterial and method for the preparation thereof
    Publication number: 20050266037
    Abstract: The present invention relates to a method for the preparation of an implantable biomaterial comprising the steps of: obtaining bone tissue; boiling the bone tissue; and treating the bone tissue to remove the collagen. It also provides an implantable biomaterial prepared according to the process.
    Type: Application
    Filed: May 25, 2004
    Publication date: December 1, 2005
    Inventors: Pei-Lin Mao, Yuri Pek, Lihong Liu, Yuan Yu