Patents by Inventor Lihong Sun

Lihong Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20230113598
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: July 21, 2022
    Publication date: April 13, 2023
    Inventors: Joseph ARNDT, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cheng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt Van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • Control system of electronic-controlled oil-gas dual fuel engine
    Patent number: 11603804
    Abstract: A control system of an electronic-controlled oil-gas dual fuel engine includes electronic control pumps, fuel gas injection electromagnetic valves, a fuel gas control device and a fuel oil control device. The fuel gas control device and the fuel oil control device are electrically connected with a control device of the engine. The fuel gas control device is electrically connected with the fuel gas injection electromagnetic valves and controls the opening time and the opening duration of each fuel gas injection electromagnetic valve installed on a pipeline between a natural gas rail and a cylinder cover air inlet channel of the engine. The fuel oil control device is electrically connected with the electronic control pumps, and controls the starting time and the operation duration of the electronic control pump, and the electronic control pumps are installed on a pipeline between an engine fuel oil rail and a cylinder cover fuel injector.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: March 14, 2023
    Assignees: Zichai Machinery Co., Ltd., Zichai Power Co., Ltd.
    Inventors: Meng Huang, Qiangzhi Xin, Baofu Jia, Yanrui Wang, Shanggang Yang, Hongxiang Zhang, Li Yan, Lei Yuan, Xinliang Zhang, Jin Guo, Lihong Sun, Gaojie Wang, Hongxia Zhang, Ying Zhang, Hui Zhao, Juan Li, Xigao Wang
  • Biaryl inhibitors of Bruton's tyrosine kinase
    Patent number: 11572356
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: February 7, 2023
    Assignee: BIOGEN MA INC.
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • CONTROL SYSTEM OF ELECTRONIC-CONTROLLED OIL-GAS DUAL FUEL ENGINE
    Publication number: 20220364518
    Abstract: A control system of an electronic-controlled oil-gas dual fuel engine includes electronic control pumps, fuel gas injection electromagnetic valves, a fuel gas control device and a fuel oil control device. The fuel gas control device and the fuel oil control device are electrically connected with a control device of the engine. The fuel gas control device is electrically connected with the fuel gas injection electromagnetic valves and controls the opening time and the opening duration of each fuel gas injection electromagnetic valve installed on a pipeline between a natural gas rail and a cylinder cover air inlet channel of the engine. The fuel oil control device is electrically connected with the electronic control pumps, and controls the starting time and the operation duration of the electronic control pump, and the electronic control pumps are installed on a pipeline between an engine fuel oil rail and a cylinder cover fuel injector.
    Type: Application
    Filed: December 10, 2021
    Publication date: November 17, 2022
    Applicants: Zichai Machinery Co., Ltd., Zichai Power Co., Ltd.
    Inventors: Meng Huang, Qiangzhi Xin, Baofu Jia, Yanrui Wang, Shanggang Yang, Hongxiang Zhang, Li Yan, Lei Yuan, Xinliang Zhang, Jin Guo, Lihong Sun, Gaojie Wang, Hongxia Zhang, Ying Zhang, Hui Zhao, Juan Li, Xigao Wang
  • BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20220332705
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: August 27, 2020
    Publication date: October 20, 2022
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20210070752
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: June 18, 2020
    Publication date: March 11, 2021
    Inventors: Joseph ARNDT, Timothy R. CHAN, Kevin GUCKIAN, Gnanasambandam KUMARAVEL, Wen-Cherng LEE, Edward Yin-Shiang LIN, Daniel SCOTT, Lihong SUN, Jermaine THOMAS, Kurt VAN VLOTEN, Deping WANG, Lei ZHANG, Daniel ERLANSON
  • Biaryl inhibitors of Bruton'S tyrosine kinase
    Patent number: 10759783
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: September 1, 2020
    Assignee: BIOGEN MA INC.
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20190218204
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: August 22, 2018
    Publication date: July 18, 2019
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • Compounds that are S1P modulating agents and/or ATX modulating agents
    Patent number: 10273234
    Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: April 30, 2019
    Assignee: BIOGEN MA INC.
    Inventors: Kevin Guckian, Gnanasambandam Kumaravel, Bin Ma, Lihong Sun, Zhili Xin, Lei Zhang
  • HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
    Publication number: 20190119268
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Application
    Filed: May 23, 2018
    Publication date: April 25, 2019
    Inventors: Joseph ARNDT, Timothy CHAN, Kevin GUCKIAN, Gnanasambandam KUMARAVEL, Wen-Cherng LEE, Edward Yin-Shiang LIN, Daniel SCOTT, Lihong SUN, Jermaine THOMAS, Kurt VAN VLOTEN, Deping WANG, Lei ZHANG, Daniel ERLANSON
  • METHODS OF TREATMENT USING PYRIDINONYL PDK1 INHIBITORS
    Publication number: 20180370966
    Abstract: The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
    Type: Application
    Filed: January 22, 2018
    Publication date: December 27, 2018
    Inventors: Kenneth Egnard LIND, Kathy CAO, Edward Yin-shiang LIN, Thinh Ba NGUYEN, Bradley T. TANGONAN, Daniel A. ERLANSON, Kevin GUCKIAN, Robert Lowell SIMMONS, Wen-cherng LEE, Lihong SUN, Stig HANSEN, Nuzhat PATHAN, Lei ZHANG
  • Biaryl inhibitors of bruton's tyrosine kinase
    Patent number: 10081619
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: September 25, 2018
    Assignee: BIOGEN MA INC.
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • Heterocyclic compounds useful as PDK1 inhibitors
    Patent number: 10030016
    Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: July 24, 2018
    Assignees: Sunesis Pharmaceuticals, Inc., Millenium Pharmaceuticals, Inc.
    Inventors: Joseph Arndt, Timothy Chan, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Daniel Scott, Lihong Sun, Jermaine Thomas, Kurt van Vloten, Deping Wang, Lei Zhang, Daniel Erlanson
  • ATX modulating agents
    Patent number: 10017506
    Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: July 10, 2018
    Assignee: BIOGEN MA INC.
    Inventors: Kevin M. Guckian, Gnanasambandam Kumaravel, Bin Ma, Sha Mi, Hairuo Peng, Zhaohui Shao, Lihong Sun, Arthur G. Taveras, Deping Wang, Zhili Xin, Lei Zhang
  • Compounds that are S1P modulating agents and/or ATX modulating agents
    Patent number: 9944666
    Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: April 17, 2018
    Assignee: BIOGEN MA INC.
    Inventors: Kevin M. Guckian, Gnanasambandam Kumaravel, Bin Ma, Sha Mi, Hairuo Peng, Zhaohui Shao, Lihong Sun, Arthur G. Taveras, Zhili Xin, Lei Zhang
  • BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20180093973
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 5, 2018
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • Methods of treatment using pyridinonyl PDK1 inhibitors
    Patent number: 9873693
    Abstract: The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: January 23, 2018
    Assignees: Sunesis Pharmaceuticals, Inc., Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth Egnard Lind, Kathy Cao, Edward Yin-shiang Lin, Thinh Ba Nguyen, Bradley T. Tangonan, Daniel A. Erlanson, Kevin Guckian, Robert Lowell Simmons, Wen-cherng Lee, Lihong Sun, Stig Hansen, Nuzhat Pathan, Lei Zhang
  • Biaryl inhibitors of Bruton's tyrosine kinase
    Patent number: 9809577
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: November 7, 2017
    Assignee: Biogen MA Inc.
    Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
  • S1P and/or ATX modulating agents
    Patent number: 9771326
    Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: September 26, 2017
    Assignee: BIOGEN MA INC.
    Inventors: Hairuo Peng, Zhili Xin, Lihong Sun, Timothy Chan, Gnanasambandam Kumaravel, Arthur G. Taveras
  • COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS
    Publication number: 20170174710
    Abstract: Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).
    Type: Application
    Filed: December 2, 2016
    Publication date: June 22, 2017
    Inventors: Kevin M. Guckian, Gnanasambandam Kumaravel, Bin Ma, Sha Mi, Hairuo Peng, Zhaohui Shao, Lihong Sun, Arthur G. Taveras, Zhili Xin, Lei Zhang