Abstract: Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1—X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.

Abstract: The disclosure provides methods of treating a cancer in a patient by administering a compound (“Compound A”) having the following structure or a pharmaceutically acceptable salt thereof: at particular dosing regimens and, optionally, in combination with one or more compounds that inhibit immune checkpoint proteins.

Abstract: The present disclosure relates to the technical field of biomedicine, in particular to use of circUTRN in preparation of a drug for treating heart failure, a recombinant vector, and a drug for treating heart failure. It is proved by experiments that the drug for treating heart failure prepared by the circUTRN is capable of treating or ameliorating the heart failure, and especially has a desirable therapeutic effect on the heart failure caused by ischemia-reperfusion injury (IRI). Specifically, the circUTRN is capable of improving cardiac systolic dysfunction induced by myocardial IRI 3 weeks. In addition, the circUTRN is also capable of reducing an infarct size of acute myocardial IRI; and overexpression of the circUTRN can inhibit cardiomyocyte apoptosis induced by oxygen-glucose deprivation/recovery.

Abstract: The present disclosure provides a control method and a control apparatus for a communication device, a communication system, and a storage medium. The control method for a communication device includes periodically outputting, a first level signal and a second level signal to the communication bus, and the second communication device establishes a data connection with the first communication device based on that the level signal on the communication bus is the first level signal, and the second communication device establishes a power supply connection with the first communication device based on that the level signal on the communication bus is the second level signal. Since the data connection and the power supply connection do not appear at the same time, the communication bus using the above-mentioned control method does not need to set an inductance compared to the traditional Home Bus.

Abstract: The present disclosure provides a method and system for quantifying a degree of blending of virgin and aged asphalt in HRAM. The method includes the following steps: first, constructing a relational equation between the microscale modulus of recycled asphalt in a fully blended state and the content of the aged asphalt; measuring the microscale modulus of the recycled asphalt, the microscale modulus of the aged asphalt, the microscale modulus of the virgin asphalt, and the content of the aged asphalt in the HRAM in situ; inputting the dates above into the relational equation to obtain the microscale modulus of the recycled asphalt in the fully blended state; and based on the microscale modulus of the recycled asphalt measured in situ and the microscale modulus of the recycled asphalt in the fully blended state, obtaining the degree of blending of the virgin and aged asphalt in the HRAM.

Abstract: A method and device for evaluating truck platooning strategy based on fuel saving rate is provided, which is applied to the technical field of transportation engineering, the method comprising: S1: obtaining the truck platooning strategy, and judging whether the truck platooning strategy has been determined; S2: when the truck platooning strategy has been determined, obtaining fuel-consumption-related parameters of each truck in the truck queue, calculating the fuel saving rate of each truck in the truck queue based on the obtained s parameters, calculating the average fuel saving rate of whole truck queue based on the fuel saving rate of each truck, and evaluating the truck platooning strategy based on the average fuel saving rate. The present disclose can evaluate the fuel economy in the case of different truck types and different platooning strategies.

Abstract: Disclosed are a method for preparing a AgNPs@SASP substrate material and application thereof. The present disclosure uses cyclohexane as an organic phase and ethanol as an inducer, and uses the interfacial tension of an organic/water interface for self-assembly to arrange the nanoparticles in a single layer. The addition of a low-dielectric solvent as an inducer reduces the charge density on the nanoparticles. As a result, the van der Waals force combined with the reduction of the Coulomb repulsion force cause the nanoparticles to reassemble at the organic/water interface to form a new equilibrium, and a SERS platform of AgNPs in a two-dimensional array is prepared. SERS detection and peak attribution analysis of different food-borne pathogen spores are carried out, and qualitative analysis is carried out by a multivariate statistical method to realize the rapid identification of spore-forming bacteria.

Abstract: Disclosed are a compound containing a fused ring, a use thereof and a pharmaceutical composition containing same. Provided are a compound as shown in formula I-A, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof or a crystal form thereof. The compound can significantly reduce the levels of HBsAg, HBeAg and HBV DNA, and can be used for preparing a drug for treating hepatitis B, and has good market prospects.

Abstract: Provided are a communication control method and apparatus for an air conditioner, and a communication system and a readable storage medium. The communication control method for an air conditioner includes acquiring a voltage signal on a bus; determining a voltage slope-rising edge and a voltage slope-falling edge in the voltage signal based on that the voltage signal satisfies a comparison condition of a power supply voltage of a communication device and a reference voltage on the bus; performing time comparison on the voltage signal to obtain a processed voltage signal based on that the voltage slope-rising edge and the voltage slope-falling edge satisfy a slope comparison condition; determining, from a data model library, a target data model that is consistent with the processed voltage signal; and outputting data information corresponding to the target data model.

Abstract: The present invention provides a method for preparing a hot-mixed asphalt mixture, and relates to the technical field of road engineering. In the present invention, asphalt and aggregates are preheated separately, where the aggregates include coarse aggregates and fine aggregates; the coarse aggregates, part of the fine aggregates and asphalt that are preheated are subjected to a first mixing to obtain a first mixture; the remaining fine aggregates are added to the first mixture for a second mixing to obtain a second mixture; and a mineral powder is added to the second mixture for a third mixing, and discharging is conducted to obtain a hot-mixed asphalt mixture.

Abstract: Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1-X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.

Abstract: The disclosure provides, among other things, methods and uses for treating a disease or disorder, particularly tumors of a cancer patient, comprising conjointly administering effective amounts of a STING agonist, a cytokine, and an optional immune checkpoint inhibitor to the patient, wherein the STING agonist or the cytokine is intratumorally administered to the patient.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Disclosed is a method for determining a mixing temperature of an asphalt mixture which includes the following steps: S100, obtaining a test result of surface energy of hot-melt asphalt; S200, obtaining, according to a calculation formula for total adhesion work and in combination with the test result of the surface energy of the hot-melt asphalt, total adhesion work of an asphalt and aggregate interface at different mixing temperatures; S300, determining a temperature range corresponding to peak values of the total adhesion work of the asphalt and aggregate interface; and S400, calculating a median value of the temperature range determined in S300, so as to determine an optimum mixing temperature of the asphalt mixture.

Abstract: The present disclosure relates to the field of microwave and optoelectronic technologies, and in particular to an integrated microwave photon transceiving front-end for a phased array system, including: a ceramic substrate, on which a control integrated circuit, a silicon-based photonic integrated chip, a first amplifying chipset, a second amplifying chipset, and a microwave switch chipset are carried. The control integrated circuit is configured to control the silicon-based photonic integrated chip and the microwave switch chipset by means of an input control signal. The silicon-based photonic integrated chip is connected at one end with an input/output optical fiber, and at the other end with the first amplifying chipset and the second amplifying chipset. The two amplifying chipsets are connected to the microwave switch chipset respectively, and the microwave switch chipset is further connected with a phased array antenna.

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Abstract: Compounds, pharmaceutical compositions, and methods are disclosed for inhibiting interaction between IL18 and IL18R.