Abstract: A system and a method for generating an arbitrary waveform of a microwave photon based on optical frequency tuning are provided. The system includes an optical frequency comb, a first optical distribution unit, a first photoelectric conversion unit, a frequency-shift drive circuit, and an optical frequency doubling/dividing unit, an optical frequency-shift combining optical circuit, a second photoelectric conversion unit, and a second electrical processing circuit. The optical frequency comb is used as the frequency source, with the features of high stability and low phase noise of the optical frequency comb, the arbitrary waveforms of microwave photons can be generated through optical frequency tuning control; the performance of the optical frequency comb is three orders of magnitude or more higher than that of the common microwave frequency sources, therefore, the waveforms with high-frequency, ultra-wideband, low phase noise, and high stability can be generated.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: The present disclosure relates to the field of microwave and optoelectronic technologies, and in particular to an integrated microwave photon transceiving front-end for a phased array system, including: a ceramic substrate, on which a control integrated circuit, a silicon-based photonic integrated chip, a first amplifying chipset, a second amplifying chipset, and a microwave switch chipset are carried. The control integrated circuit is configured to control the silicon-based photonic integrated chip and the microwave switch chipset by means of an input control signal. The silicon-based photonic integrated chip is connected at one end with an input/output optical fiber, and at the other end with the first amplifying chipset and the second amplifying chipset. The two amplifying chipsets are connected to the microwave switch chipset respectively, and the microwave switch chipset is further connected with a phased array antenna.

Abstract: A treatment for obesity can include: providing a superabsorbent material that includes a porous network structure formed from a mixture of a plurality of water soluble polysaccharides that are not chemically crosslinked together; and administering the superabsorbent material to a subject in an effective amount to provide a treatment for obesity in the subject. The treatment can include at least one of: reducing weight of the subject; reducing rate of weight gain in the subject; or increasing rate of weight loss in the subject. The treatment of obesity can include at least one of: reducing caloric intake into the subject; reducing caloric absorption by the gut of the subject; absorbing caloric material from the gut of the subject into the superabsorbent material; or increasing transfer of caloric material from bloodstream into gut.

Abstract: Methods for reducing cholesterol in a subject can include: providing a superabsorbent material that includes a porous network structure formed from a mixture of a plurality of water soluble polysaccharides that are not chemically crosslinked together; and administering the superabsorbent material to a subject in an effective amount to reduce cholesterol in the subject. The reduction of cholesterol includes at least one of: reducing total cholesterol of the subject; reducing a rate of total cholesterol increase in the subject; or increasing a rate of total cholesterol decrease in the subject. The reduction of cholesterol includes at least one of: reducing cholesterol intake into the subject; reducing cholesterol absorption by the gut of the subject; or absorbing cholesterol material from the gut of the subject into the superabsorbent material. The reduction of cholesterol is by reduction of low-density-lipoprotein cholesterol or high-density-lipoprotein cholesterol.

Abstract: Provided are superabsorbent materials composed of agar, and one or more water-soluble natural polysaccharides, and dietary compositions containing such superabsorbent materials. The disclosed superabsorbent materials have various food and therapeutic applications and can be used as loading vehicles for nutrients and therapeutic agents. Also provided are methods for preparing such superabsorbent materials.

Abstract: A device for forming a prepressing-assembled asphalt mixture surface layer comprises: a wheel compaction module and a prepressing forming module. The wheel compaction module is configured to preliminarily compact a hot mix asphalt mixture. The prepressing forming module comprises a second reaction frame. A second loading device is hung at a top of the second reaction frame. An output end of the second loading device is fixedly connected to a prepressing plate. A conveyor belt passes through lower parts of the wheel compaction module and the prepressing forming module. A base is arranged on the conveyor belt. A surrounding mold is circumferentially fixed to the base. Through the prepressing module and the process, the device continuously applies a compaction load to the hot mix asphalt mixture surface layer, and effectively increases the adhesion between the aggregate and the asphalt to improve the strength of the assembled asphalt pavement.

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Provided are superabsorbent materials composed of one or more water-soluble polysaccharides, such as gelling polysaccharides and gelling-compatible polysaccharides, and one or more insoluble fibers. The disclosed superabsorbent materials have a porous network structure and highly stable gelling properties as well as high absorption ratio and volume expansion capacity upon hydration or rehydration. Also provided are methods for preparing such superabsorbent materials and uses thereof.

Abstract: A method and system for active control of road network traffic congestion, and in particular, to the technical field of traffic congestion control includes: constructing a directed graph according to the positions of detectors in a road network; determining a free-flow reachability matrix of the directed graph and a plurality of neighborhood matrices with different orders according to a free-flow vehicle speed between cross-sections where the detectors are located and the directed graph; calculating a convolution operator of the directed graph within a set time period; inputting the convolution operator of the directed graph within the set time period into a long short-term memory neural network model to obtain a traffic state of each cross-section at each moment within a predicted time period; and determining whether a control method for each cross-section is single-point control or circle layer control.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1—X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.

Abstract: The disclosure provides methods of treating a cancer in a patient by administering a compound (“Compound A”) having the following structure or a pharmaceutically acceptable salt thereof: at particular dosing regimens and, optionally, in combination with one or more compounds that inhibit immune checkpoint proteins.

Abstract: The invention discloses a slope one-way loading rutting test device, wherein the upper part of a loading frame is slidably connected with an upper cross beam of a frame through a loading frame rotating assembly, and a variable speed motor and a runner wheel are embedded in the lower part of the loading frame. The variable speed motor is in transmission connection with the runner wheel to realize one-way continuous loading of the runner wheel on a test piece. The lower part of a bearing frame is slidably connected with a lower cross beam of a frame through a bearing frame rotating assembly, a test piece mounting frame and a height adjusting device are sequentially embedded into the upper part of the bearing frame from top to bottom, and the height of the test piece mounting frame is adjusted through the height adjusting device.

Abstract: The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

Abstract: The present disclosure provides a method and system for quantifying a degree of blending of virgin and aged asphalt in HRAM. The method includes the following steps: first, constructing a relational equation between the microscale modulus of recycled asphalt in a fully blended state and the content of the aged asphalt; measuring the microscale modulus of the recycled asphalt, the microscale modulus of the aged asphalt, the microscale modulus of the virgin asphalt, and the content of the aged asphalt in the HRAM in situ; inputting the dates above into the relational equation to obtain the microscale modulus of the recycled asphalt in the fully blended state; and based on the microscale modulus of the recycled asphalt measured in situ and the microscale modulus of the recycled asphalt in the fully blended state, obtaining the degree of blending of the virgin and aged asphalt in the HRAM.

Abstract: A method and device for evaluating truck platooning strategy based on fuel saving rate is provided, which is applied to the technical field of transportation engineering, the method comprising: S1: obtaining the truck platooning strategy, and judging whether the truck platooning strategy has been determined; S2: when the truck platooning strategy has been determined, obtaining fuel-consumption-related parameters of each truck in the truck queue, calculating the fuel saving rate of each truck in the truck queue based on the obtained s parameters, calculating the average fuel saving rate of whole truck queue based on the fuel saving rate of each truck, and evaluating the truck platooning strategy based on the average fuel saving rate. The present disclose can evaluate the fuel economy in the case of different truck types and different platooning strategies.

Abstract: The present invention provides a method for preparing a hot-mixed asphalt mixture, and relates to the technical field of road engineering. In the present invention, asphalt and aggregates are preheated separately, where the aggregates include coarse aggregates and fine aggregates; the coarse aggregates, part of the fine aggregates and asphalt that are preheated are subjected to a first mixing to obtain a first mixture; the remaining fine aggregates are added to the first mixture for a second mixing to obtain a second mixture; and a mineral powder is added to the second mixture for a third mixing, and discharging is conducted to obtain a hot-mixed asphalt mixture.