Patents by Inventor Lily Lu

Lily Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240418734
    Abstract: The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, Fuchs' dystrophy, diabetic macular edema (DME), geographic atrophy, Stargardt's disease, or retinal vein occlusion (RVO), and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.
    Type: Application
    Filed: August 29, 2024
    Publication date: December 19, 2024
    Inventors: Peter A. Campochiaro, Lili Lu
  • Patent number: 12078641
    Abstract: The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, Fuchs' dystrophy, diabetic macular edema (DME), geographic atrophy, Stargardt's disease, or retinal vein occlusion (RVO), and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: September 3, 2024
    Assignee: The Johns Hopkins University
    Inventors: Peter A. Campochiaro, Lili Lu
  • Publication number: 20240117903
    Abstract: An ultrahigh-pressure acid-fracturing isodiametric hose assembly, comprising a hose body and a metal joint. The metal joint comprises an inner tube, a first outer tube the inner tube, and a second outer tube. The first outer tube and the second outer tube each is an independent pressing part. An external groove is provided at an outer wall of the inner tube. An end of the first outer tube comprises an internal ridge which matches the external groove for snapping. The terminal of the inner tube comprises a connecting portion. An outer wall of the inner tube comprises a first protrusion, and an inner wall of the first outer tube comprises a second protrusion engaging with the first protrusion. The hose body is clamped between the first protrusion and the second protrusion that are engaged. An inner wall of the second outer tube comprises multiple micro-protrusions.
    Type: Application
    Filed: July 27, 2023
    Publication date: April 11, 2024
    Applicant: LUOHE LETONE HYDRAULICS TECHNOLOGY CO., LTD.
    Inventors: Hongliang ZHAO, Zhian LIU, Peiyuan WU, Feilong ZHANG, Xingpeng YANG, Lili LU, Yong ZHANG, Yanhui ZHAO, Pengfei ZHANG, Ning LI
  • Publication number: 20220146533
    Abstract: The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, Fuchs' dystrophy, diabetic macular edema (DME), geographic atrophy, Stargardt's disease, or retinal vein occlusion (RVO), and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.
    Type: Application
    Filed: January 24, 2022
    Publication date: May 12, 2022
    Inventors: Peter A. Campochiaro, Lili Lu
  • Patent number: 11268964
    Abstract: The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, Fuchs' dystrophy, diabetic macular edema (DME), geographic atrophy, Stargardt's disease, or retinal vein occlusion (RVO), and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: March 8, 2022
    Assignee: The Johns Hopkins University
    Inventors: Peter A. Campochiaro, Lili Lu
  • Patent number: 10941439
    Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: March 9, 2021
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Steven M. Menchen, Guobing Xiang, Prasanna Thwar, Jeffrey Frediani, Allen Wong, Alfred Lui, Lily Lu
  • Publication number: 20190390018
    Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
    Type: Application
    Filed: January 21, 2019
    Publication date: December 26, 2019
    Inventors: Geir FONNUM, Steven M. MENCHEN, M. Talha GOKMEN, Pontus LUNDBERG, Prasanna Krishnan THWAR, Alfred LUI, Lily LU, Wolfgang HINZ, Lene HUSABOE, Elisabeth BREIVOLD, Astrid Evenroed MOLTEBERG, Synne LARSEN
  • Publication number: 20190062807
    Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.
    Type: Application
    Filed: October 31, 2018
    Publication date: February 28, 2019
    Inventors: Steven M. Menchen, Guobing Xiang, Prasanna Thwar, Jeffrey Frediani, Allen Wong, Alfred Lui, Lily Lu
  • Patent number: 10189956
    Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: January 29, 2019
    Assignees: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATION
    Inventors: Geir Fonnum, Steven M. Menchen, M. Talha Gokmen, Pontus Lundberg, Prasanna Krishnan Thwar, Alfred Lui, Lily Lu, Wolfgang Hinz, Lene Husaboe, Elisabeth Breivold, Astrid Evenroed Molteberg, Synne Larsen
  • Patent number: 10150992
    Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: December 11, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Steven M. Menchen, Guobing Xiang, Prasanna Krishnan Thwar, Jeffrey Frediani, Allen Wong, Alfred Lui, Lily Lu
  • Publication number: 20180237595
    Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
    Type: Application
    Filed: January 15, 2018
    Publication date: August 23, 2018
    Inventors: Geir FONNUM, Steven M. MENCHEN, M. Talha GOKMEN, Pontus LUNDBERG, Prasanna Krishnan THWAR, Alfred LUI, Lily LU, Wolfgang HINZ, Lene Husaboe, Elisabeth BREIVOLD, Astrid Evenroed MOLTEBERG, Synne LARSEN
  • Patent number: 9868826
    Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: January 16, 2018
    Assignees: Life Technologies Corporation, Life Technologies AS
    Inventors: Geir Fonnum, Steven M. Menchen, Talha M. Gokmen, Pontus Lundberg, Prasanna Krishnan Thwar, Alfred Lui, Lily Lu, Wolfgang Hinz, Lene Husaboe, Elisabeth Breivold, Astrid Evenroed Molteberg, Synne Larsen
  • Publication number: 20170370945
    Abstract: The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, Fuchs' dystrophy, diabetic macular edema (DME), geographic atrophy, Stargardt's disease, or retinal vein occlusion (RVO), and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.
    Type: Application
    Filed: November 11, 2015
    Publication date: December 28, 2017
    Inventors: Peter A. Campochiaro, Lili LU, Craig S. Rosenfeld
  • Publication number: 20170315135
    Abstract: The present invention provides biomarkers of oxidative stress in subjects with Retinitis Pigmentosa and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.
    Type: Application
    Filed: November 11, 2015
    Publication date: November 2, 2017
    Inventors: Peter A. Campochiaro, Lili Lu
  • Publication number: 20170009275
    Abstract: A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 12, 2017
    Inventors: Steven M. MENCHEN, Guobing XIANG, Prasanna Krishnan THWAR, Jeffrey FREDIANI, Allen WONG, Alfred LUI, Lily LU
  • Publication number: 20170002152
    Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
    Type: Application
    Filed: July 1, 2016
    Publication date: January 5, 2017
    Inventors: Geir FONNUM, Steven M. MENCHEN, Talha M. GOKMEN, Pontus LUNDBERG, Prasanna Krishnan THWAR, Alfred LUI, Lily LU, Wolfgang HINZ, Lene HUSABOE, Elisabeth BREIVOLD, Astrid Evenroed MOLTEBERG, Synne LARSEN
  • Publication number: 20140314740
    Abstract: The invention provides compositions and methods for the prevention, amelioration, and/or treatment of diabetes complications, including ocular diseases associated with increased glucose transport and/or oxidative stress.
    Type: Application
    Filed: December 10, 2012
    Publication date: October 23, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Peter A. Campochiaro, Lili Lu
  • Patent number: 8563285
    Abstract: The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: October 22, 2013
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Tzann-Wei Wang, Dongen Lily Lu
  • Patent number: 8464503
    Abstract: An engine comprises a tank of compressed air and a piston. The tank of compressed air is connected to a conduit and the conduit is connected to a cylinder comprising a first valve and an inlet to a chamber. The chamber comprises the piston, which reciprocates. The chamber also has a second outlet connected to a second valve. The air traverses from the tank of compressed into the chamber by opening the first valve. Both the first valve and second valve are closed and the compressed air moves the piston in the chamber to produce work. The second valve opens and the air escapes from the chamber and the piston.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: June 18, 2013
    Assignee: ShalyMac Energy Systems
    Inventors: Frank W. McCuin, Shapour Bakhtiari, Clinton Johnson, Charles C. McCuin, Eric Morton, Lily Lu
  • Publication number: 20120073280
    Abstract: An engine comprises a tank of compressed air and a piston. The tank of compressed air is connected to a conduit and the conduit is connected to a cylinder comprising a first valve and an inlet to a chamber. The chamber comprises the piston, which reciprocates. The chamber also has a second outlet connected to a second valve. The air traverses from the tank of compressed into the chamber by opening the first valve. Both the first valve and second valve are closed and the compressed air moves the piston in the chamber to produce work. The second valve opens and the air escapes from the chamber and the piston.
    Type: Application
    Filed: September 27, 2010
    Publication date: March 29, 2012
    Inventors: Frank W. McCuin, Shapour Bakhtian, Clinton Johnson, Charles C. McCuin, Eric Morton, Lily Lu