Abstract: The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity.

Abstract: Systems and methods are disclosed that recommend one or more electronic presentations to a user based on one or more factors. These factors may include contextual information, behavioral information, profile information, or combinations of the foregoing. Contextual information may include content and/or features extracted from a given electronic presentation. Behavioral information may include user behavioral data, such as the number of times a user has viewed a presentation, the amount of the presentation viewed by the user, presentations previously viewed by the user, and other such behavioral data. Profile information may include user professional profile information, such as skills the user has identified as possessing, employment history information, and other such user professional profile information.

Abstract: When a user of a social network accepts an invitation message to connect with another user of the social network, a system may use a history of user activity to determine where the user is subsequently directed within the social-network website. In particular, based on the history of user activity associated with an in-network page with recommendations for possible connections for the user within the network of users, the system may determine whether or not there have been too many impressions of the in-network page. If not, the system may present the in-network page with a recommendation for a possible in-network connection for the user within the network of users. Then, if the system receives a user selection of the possible in-network connection, the system may provide an invitation message inviting the possible in-network connection to connect with the user by activating a link in the invitation message.

Abstract: In an example embodiment, for each of a plurality of possible presented actions corresponding to a particular flow of actions in a computer network, and for each of one or more possible performed actions for each possible presented action, a likelihood that a user will perform the possible performed action is determined. Then, a first presented action is identified by determining a presented action having a maximum determined likelihood, based on the determined likelihood, wherein the identifying a first presented action includes utilizing a machine learning model having one or more user covariates and one or more performed action covariates, and interactions between the one or more user covariates and the one or more performed action covariates, the user covariates including information specific to the user, the one or more performed action covariates including information specific to one or more of the possible performed actions.

Abstract: A system receives and stores in a database identifications and attributes of jobs viewed by a user in a job posting service, and creates a job browsing history profile for the user using the identifications and attributes. The system compares the job browsing history profile to jobs in the job posting service, generates a listing of jobs based on the comparison, and displays the listing of jobs to the user.

Abstract: A method and system to present an optimum action in response to a flow of actions in a computer network from a user are provided. For each of a plurality of possible presented actions corresponding to a particular flow of actions in a computer network, and for each of one or more possible performed actions for each possible presented action, a likelihood that a user will perform the possible performed action is determined. Then each of the determined likelihoods is weighted by applying a weight assigned to a corresponding possible presented action. An optimum presented action is identified determining a presented action having a weighted maximum determined likelihood, based on the weighted determined likelihood.

Abstract: A method and system to present an optimum action in response to a flow of actions in a computer network from a user are provided. For each of a plurality of possible presented actions corresponding to a particular flow of actions in a computer network, and for each of one or more possible performed actions for each possible presented action, a likelihood that a user will perform the possible performed action is determined. Then each of the determined likelihoods is weighted by applying a weight assigned to a corresponding possible presented action. An optimum presented action is identified determining a presented action having a weighted maximum determined likelihood, based on the weighted determined likelihood.

Abstract: A powered pallet truck is provided having a base support portion and a load lift portion. The powered pallet truck has a lift cylinder device connected at a lower portion to a forward extending lift cylinder device seat on the base frame and pivotally connected at an upper portion within a recessed channel in the load lift frame.

Abstract: A method and system to present an optimum action in response to a flow of actions in a computer network from a user are provided. For each of a plurality of possible presented actions corresponding to a particular flow of actions in a computer network, and for each of one or more possible performed actions for each possible presented action, a likelihood that a user will perform the possible performed action is determined. Then each of the determined likelihoods is weighted by applying a weight assigned to a corresponding possible presented action. An optimum presented action is identified determining a presented action having a weighted maximum determined likelihood, based on the weighted determined likelihood.

Abstract: The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity.

Abstract: Benzimidazoles having inhibitory activity on RSV replication and having the formula the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

Abstract: The present disclosure relates generally to lift vehicles that include a carriage having at least three wheels, a lift and a load carrying frame. The load carrying frame is connected to the lift, which is connected to the carriage. A selectively deployable platform is disclosed that is pivotably connected to the carriage and movable between a stowed position and a support position. At least two rollers may be spaced apart and configured to engage and slidably support a battery above the carriage.

Abstract: The present disclosure relates generally to personnel lift vehicles that include a carriage, a telescoping lift and a load carrying frame. The telescoping lift is connected to a rear portion of the carriage and the load carrying frame is connected to and extends forward from the telescoping lift. The load carrying frame includes a bottom portion that provides an operator platform that is disposed at a central portion of the carriage between a front portion and the rear portion of the carriage. The configuration of the disclosed personnel lift vehicle provides an integral solution for counterweight requirements for the carriage while reducing the overall driving space required for the vehicle.

Abstract: The present invention provides a transcription amplification system, comprising an effector nucleic acid molecule and a reporter molecule, which work together to produce a heterologous gene product in a cell-type, specific manner. The present invention also relates to methods for producing, detecting, imaging, and monitoring the heterologous gene product in a cell or in a subject.

Abstract: The present invention provides a transcription amplification system, comprising an effector nucleic acid molecule and a reporter molecule, which work together to produce a heterologous gene product in a cell-type, specific manner. The present invention also relates to methods for producing, detecting, imaging, and monitoring the heterologous gene product in a cell or in a subject.