Abstract: T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.

Abstract: A method for operating a communication station in a communicating environment includes: (a) monitoring the environment to ascertain whether the station is receiving an unintended sensed signal not intended for the station from at least one signal source; (b) if the station has not received a predetermined number of unintended sensed signals during a predetermined time interval, operating the station in an omni-directional mode; and (c) if the station has received a predetermined number of sensed signals during the predetermined time interval, saving an indication of a reception direction from which arrived each unintended sensed signal; and operating the station in a directional mode. While in the directional mode, the station is sensitive to receiving signals arriving from a sensing direction other than from a reception direction, and the station transmits signals toward the sensing direction.

Abstract: Methods and apparatus for transmitting a signal having a first frame duration being correlated to a second frame duration are described herein.

Abstract: In a communication device compatible with either a SISO or MIMO access point, a set of antennas is configured as either sector-directional or omni-directional, depending upon whether the communication channel is characterized by the communication device as either strongly line of sight, or strongly scattering, respectively. In some embodiments, for the case in which a MIMO access point is utilized, the singular values of an estimated channel matrix are generated, and based upon the singular values, the characteristics of the communication channel is estimated. Other embodiments are described and claimed.

Abstract: In a wireless local area network employing multiple-input-multiple-output stations, apparatuses and methods are disclosed to increase throughput of the network when the communication path between two communicating stations has a strong line-of-sight component. An embodiment performs a singular value decomposition on the channel matrix for the strongly line-of-sight channel, and transmits information regarding the singular value decomposition. Other stations may utilize this information to vector encode and vector decode their transmissions so as not to interfere with the two communicating stations, thereby increasing network utilization. Other embodiments are described and claimed.

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Abstract: According to some embodiments, directional and omni-directional messages are exchanged between two nodes during a control message exchange procedure in a wireless network. In other embodiments, only directional messages may be exchanged during the control message exchange. These directional and omni-directional control messages are used to provide location information to neighboring nodes which may overhear the control messages. The neighboring nodes may then be permitted transmit and receive in certain modes, depending on their location relative to one another.

Abstract: The invention provides systems and methods for the generation of lymphocytes having a unique antigen specificity. In a preferred embodiment, the invention provides methods of virally infecting cells from bone marrow with one or more viral vectors that encode antigen-specific antibodies for the production of, for example B cells and T cells. In some embodiments, the viral vectors include an IRES or 2A element to promote separation of, for example, the ? subunit and ? subunit of a T cell receptor (TCR) or heavy and light chains of a B-cell antibody. The resulting lymphocytes, express the particular antibody that was introduced in the case of B cells and TCR in the case of T cells. The lymphocytes generated can be used for a variety of therapeutic purposes including the treatment of various cancers and the generation of a desired immune response to viruses and other pathogens. The resulting cells develop normally and respond to antigen both in vitro and in vivo.

Abstract: Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

Abstract: The present invention provides methods for detecting gene expression in normal and cancerous cells. Specifically, provided are methods utilizing molecular beacons (MB) technology combined with fluorescence imaging techniques for detecting, identifying or quantitating the presence of, or alterations in gene expression of, various tumor markers in a sample of cells.

Abstract: Compositions and methods for reducing cytotoxicity are provided. Compositions and methods for inhibiting angiogenesis are provided. The compositions comprise herbals, natural nutritional supplements, minerals and/or vitamins.

Abstract: Provided are methods for generating immune cells of the desired type and specificity in a host. The methods may be used to treat a disease or disorder, such as a tumor in a patient. Target cells, preferably hematopoietic stem cells such as primary bone marrow cells are transfected with a polynucleotide encoding a T cell receptor with the desired specificity. The transfected cells are then transferred to the host where they develop into mature, functional immune cells. The source of the T cell receptor can determine the stem cell's fate. Thus transfecting stem cells with TCRs from cytotoxic cells will lead to the generation of cytotoxic T cells in the host, while TCRs from helper cells will produce helper cells. Both arms of T cell immunity can be generated simultaneously in a host. Additionally, the immune response to the desired antigen can be further stimulated by immunizing the host with the antigen.

Abstract: The invention provides systems and methods for the generation of lymphocytes having a unique antigen specificity. In a preferred embodiment, the invention provides methods of virally infecting cells from bone marrow with one or more viral vectors that encode antigen-specific T cell receptors. The resulting lymphocytes, and in particular, T cells express the T cell receptor (TCR) that was introduced. The lymphocytes generated can be used for a variety of therapeutic purposes including the treatment of various cancers and the generation of a desired immune response to viruses and other pathogens. The resulting cells develop normally and respond to antigen both in vitro and in vivo. It is also possible to modify the function of lymphocytes by using stem cells from different genetic backgrounds. Thus the system constitutes a powerful tool to generate desired lymphocyte populations both for research and therapy.

Abstract: The invention provides systems and methods for the generation of lymphocytes having a unique antigen specificity. In a preferred embodiment, the invention provides methods of virally infecting cells from bone marrow with one or more viral vectors that encode antigen-specific T cell receptors. The resulting lymphocytes, and in particular, T cells express the T cell receptor (TCR) that was introduced. The lymphocytes generated can be used for a variety of therapeutic purposes including the treatment of various cancers and the generation of a desired immune response to viruses and other pathogens. The resulting cells develop normally and respond to antigen both in vitro and in vivo. We also show that it is possible to modify the function of lymphocytes by using stem cells from different genetic backgrounds. Thus our system constitutes a powerful tool to generate desired lymphocyte populations both for research and therapy.