Abstract: Disclosed herein are compounds represented by: therapeutic methods, compositions, and medicaments related thereto are also disclosed.

Abstract: The invention relates to the cancer antigen PRAME (PReferentially expressed Antigen in MElanoma) and its use in a method of treatment of a tumour which comprises administering to a subject in need of treatment an effective amount of an inhibitor of PRAME, in combination with a second agent selected from the group of an inhibitor of HDAC (an HDACi) and a retinoid.

Abstract: An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid.

Abstract: Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and optically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced.

Abstract: This disclosure features use of a paper or polymer film that includes a slip agent that can transfer to its surfaces. Once the paper or film is pressed against a glass sheet, this will leave a thin surface roughness of slip agent that can prevent or reduce glass surface scratches from other surfaces or particles during shipping or finishing (e.g., cutting to size, conveyance of glass), thereby improving the yield of glass shipments between glass forming plants and customers. The thin discontinuous layer of slip agent remaining on the glass surface can be washed off easily in subsequent washing processes. The paper or film can have the slip agent imbibed within the paper or coated on it as a surface member.

Abstract: An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid.

Abstract: Systems, methods, apparatus and products relate to display glass from curved glass ribbons, to improve shape stability in glass ribbons, to creation of reduced stress glass ribbons, and to creation of improved shape stability and reduced stress of display glass, which may include forming slightly a curved glass ribbon in a fusion draw machine (FDM). One or more embodiments may include an isopipe having a desired curvature; an isopipe having a desired incline; an offset draw device operable to draw the glass ribbon in an inclined ribbon draw direction; one or more air jets or vacuum operable to apply air pressure to a first side of the glass ribbon, thereby creating a pressure differential on the first side; and/or one or more electrostatic force generators operable to apply electrostatic force to a first side of the glass ribbon, thereby generating an electric field differential across the glass ribbon.

Abstract: A glass sheet assembly includes a glass sheet having an edge surface and a shaped fiber. The shaped fiber has a first surface bonded to the edge surface of the glass sheet and a convex second surface not bonded to the edge surface for receiving a load.

Abstract: The present invention provides a method and apparatus for ciphertext indexing and searching. Indices of multiple levels are created for the encrypted files. Each item in the primary index includes a primary index item identifier and the ciphertext of the primary indexing information of the related file. The primary indexing information each includes an identifier(s) of the related secondary index item identifier(s) and the corresponding decryption information. Each item in the secondary index includes a secondary index item identifier and the ciphertext of the secondary indexing information. Information necessary for obtaining a file is included in the corresponding secondary indexing information. With the decryption information of the secondary indexing information in the decrypted primary indexing information, the ciphertext of the related secondary indexing information is decrypted so as to obtain information such as the decryption key of the file.

Abstract: The present invention provides a method and apparatus for generating index as well as a search method and a search apparatus. Index entry comprises at least a search item identifier corresponding to a search item, one or a plurality of index items generated from one or plural pieces of search information, and an accumulator for the search information. The accumulator is generated by accumulating the search information, or accumulating ciphertext of information containing the search information, or accumulating data mapped from information containing the search information. At the time of searching, the index items and the accumulator are provided to a searcher. The searcher extracts search information from the index items and checks whether the extracted search information is complete by using the accumulator. In one embodiment, the accumulator is incorporated in an encrypted inverted index.

Abstract: A hybrid imaging device is configured to capture low resolution video and high resolution still images. The imaging device is configured to apply motion information obtained from the low resolution video to a reference high resolution still image to generate a missing moment of interest high resolution still image. The low-resolution video is captured at a high frame rate in conjunction with a few high-resolution still pictures taken at periodic intervals. A user locates a desired scene of interest, e.g. a moment of interest, from the captured video, and a post-processing technique is used to generate the high resolution still picture corresponding to the selected moment of interest. The high resolution still image is generated using texture information from one or more nearby captured high resolution still images and motion information from the low-resolution video frame corresponding to the selected moment of interest.

Abstract: A method of manufacturing an exhaust gas sensor allows the manufacturer to selectively control the air-voltage range of the manufactured sensor between a first air-voltage range and a second air-voltage range. The sensor includes a signal wire and a ground wire. The method includes using a high nickel alloy for both of the signal wire and the ground wire to manufacture a sensor in the first air-voltage range, and using a high nickel alloy for only one of the signal wire and the ground wire to manufacture a sensor in the second air-voltage range. The air-voltage ranges are those associated with a lean-application normalized air/fuel ratio of ?>1.

Abstract: The present invention discloses an radiation imaging system, comprising: an accelerator for generating rays which penetrate through the objects to be inspected and an synchronous signal; a detector with a plurality of detecting modules, adapted for detecting rays; a signal processor for generating a selection signal according to the synchronous signal, so as to select a detecting module for detecting the rays; a data converter for converting the signal detected by said detecting module into digital data, and then buffering the digital data in said signal processor; and a communication controller connected to an image processor, adapted for transmitting the digital data buffered in said signal processor to said image processor. The system according to the present invention allows high-speed and stable data acquisition and data conversion and accurate and reliable data transmission, when the data amount is significant.

Abstract: A device (and methods of using and manufacturing the device) that utilize a plurality of photomultipliers (PMT)s or a photodiodes coupled with a set of filters to collect Raman signal from samples. Also a method of detecting Raman signals includes receiving Raman signals from a sample utilizing a plurality of photomultiplier tubes (PMT)s or photodiodes, wherein at least one PMT or photodiode provides a different Raman signal than at least one other PMT or photodiode.

Abstract: Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.

Abstract: The present invention provides a method, apparatus and system for fast searchable encryption. The data owner encrypts files and stores the ciphertext to the server. The data owner generates an encrypted index according to each keyword of the files, and stores the encrypted index to the server. The index is composed of keyword item sets each being identified by a keyword item set locator and containing at least one or more file locators of the files associated with the corresponding keyword. Each file locator contains ciphertext of information for retrieval of an encrypted file and only with the correct file locator decryption key can the ciphertext be decrypted. Data owner issues a keyword item set locator as well as file locator decryption key to a searcher to enable the searcher to search on the encrypted index and retrieve files related to a certain keyword.

Abstract: Described herein are compounds that can be useful as bioactive agents. More specifically, the compounds described herein can be useful as both ?2B and ?2C adrenergic agonists. Methods of synthesis and administration of the compounds are also disclosed.

Abstract: An encoding apparatus for encoding progressive image data and interlace image data corresponding to this progressive image data, having a first encoding unit configured to encode picture data composing the interlace image data to generate first encoded data and decoding and recomposing the first encoded data to generate recomposed image data, an up sample processing unit configured to up sample the generated recomposed image data to generate image data having the same resolution as that of the progressive image data, and a second encoding unit configured to encode the picture data composing the progressive image data to generate second encoded data using the generated image data as predictive image data.

Abstract: The present invention discloses a method for inspecting an object using multi-energy radiations and an apparatus thereof. The method comprises the steps of: causing multi-energy radiations to interact with an object under inspection; detecting and recording detection values after an interaction between the multi-energy radiations and the object under inspection; substituting a portion of the detection values into a predetermined calibration function to obtain information comprising primary material attribute; and determining further material attributes of the object by applying a set of functions suitable for a energy band corresponding to the information. The present invention is applicable to the large container cargo inspection without opening containers at customs, ports and airports.

Abstract: Singulation of individual electronic packages fabricated as part of a common matrix, is accomplished by mask patterning and chemical exposure in combination with physical sawing. In one embodiment of a singulation process in accordance with the present invention, an initial, shallow saw cut into inter-package regions of the matrix exposes underlying metal to subsequent chemical etching steps. In an alternative embodiment, a separate photoresist mask may be patterned over the matrix to selectively expose metal in inter-package regions to chemical etching.