Abstract: The invention relates to the cancer antigen PRAME (PReferentially expressed Antigen in MElanoma) and its use in a method of treatment of a tumour which comprises administering to a subject in need of treatment an effective amount of an inhibitor of PRAME, in combination with a second agent selected from the group of an inhibitor of HDAC (an HDACi) and a retinoid.

Abstract: A mobile refrigeration equipment with DC drive, comprising a heat preservation library body with inner refrigeration system which compressor is DC variable frequency compressor supplied power by second DC voltage and power supply system which consists of double power DC generator that output the first DC voltage and second DC voltage and battery charging with the second DC voltage. The battery and double power DC generator constitute two kinds of power for DC variable frequency compressor. The power controller is linked among the battery, double power DC generator and DC variable frequency compressor.

Abstract: The present invention relates to novel pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract: Glass substrates and methods for forming glass substrates are disclosed. The glass substrates include a planar A-side surface having a surface roughness Ra1 of less than 0.5 nm and a planar B-side having a surface roughness Ra2 wherein the ratio Ra2:Ra1 is greater than or equal to about 1.5. A plurality of texturing features are formed in the B-side surface. The plurality of texturing features have a peak-to-valley height H such that 0.05 ?m?H?3.75 ?m. The texturing features are distributed in the B-side surface such that a center-to-center pitch P between adjacent texturing features is at least 1.5 mm in at least one direction. The plurality of texturing features are formed in the B-side surface while the glass substrate is at a temperature T1, wherein 600° C.?T1?1200 ° C. and a viscosity of the glass substrate is from greater than 150,000 Poise and less than 1013 Poise.

Abstract: Process for removing peripheral portions such as bead regions of a glass sheet including a step of pushing the glass sheet in the peripheral portion using a pushing mechanism such as a pushing bar, and corresponding apparatus. As a result of the use of the pushing mechanism, the engagement completion time for suction cups, if used, are reduced significantly. A process without using suction cups is enabled with enhanced yield. The increased process stability and enlarged process window are particularly advantageous for processing glass sheets having high flexibility.

Abstract: The present invention relates to novel N-(imidazolidin-2-ylidene)quinoline derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract: The present invention relates to novel N-(imidazolidin-2-ylidene)-heterocyclopenta[b]pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract: The present invention relates to a field of optical fibre communication. A safeguard device for a fibre adapter used to connect an input optical fibre connector with an output optical fibre connector is provided. In a preferred embodiment, the safeguard device comprises a shutter and a shutter locking unit. The shutter is operably provided at an interface of said fibre adapter to allow the interface to switch between an open position and a closed position, wherein, the shutter at least shuts off the optical beam emitted from the input optical connector when in said closed position. The shutter locking unit is adapted for selectively locking the shutter in the open position or in the closed position.

Abstract: An encoding apparatus for encoding progressive image data and interlace image data corresponding to this progressive image data, having a first encoding unit configured to encode picture data composing the interlace image data to generate first encoded data and decoding and recomposing the first encoded data to generate recomposed image data, an up sample processing unit configured to up sample the generated recomposed image data to generate image data having the same resolution as that of the progressive image data, and a second encoding unit configured to encode the picture data composing the progressive image data to generate second encoded data using the generated image data as predictive image data.

Abstract: Embodiments of the present invention provide a domain name system as well as an information processing method and apparatus of the domain name system. The information processing method includes: receiving a domain name system query request sent by a recursive server, where the domain name system query request includes identifier information of a terminal device that sends the query request; resolving the received domain name system query request to obtain the identifier information of the terminal device; and exercising query control according to the identifier information of the terminal device. In the domain name system as well as the information processing method and apparatus of the domain name system, the domain name system query request carries the identifier information of the terminal device that sends the query request, and therefore, effective control is exercised on the information query actions of the terminal device in the domain name system.

Abstract: Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.

Abstract: A lifting apparatus, especially a cable traction mechanism, comprising a base frame that has at least two base plates, further comprising at least two longitudinal beams which have a first end and an opposite second end and which interconnect the base plates and keep the same apart from each other. The lifting apparatus, especially a cable traction mechanism, comprises a simple design and can readily be mounted, dismounted, or modified by detachably fastening the first end and the second end of the longitudinal beams to the base plates in such a way in an operational state of the lifting apparatus and designing one of the at least two base plates in such a way that the longitudinal beams can be inserted or removed in the direction of the longitudinal axis thereof when mounting, dismounting, or modifying the base frame.

Abstract: The present invention relates to novel alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract: Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor, in particular the alpha 2C receptor. The compounds can include N-(2,3-substituted phenyl)-3,4-dihydro-2H-pyrrol-5-amine derivatives.

Abstract: The present invention provides a method and apparatus for generating index as well as a search method and a search apparatus. Index entry comprises at least a search item identifier corresponding to a search item, one or a plurality of index items generated from one or plural pieces of search information, and an accumulator for the search information. The accumulator is generated by accumulating the search information, or accumulating ciphertext of information containing the search information, or accumulating data mapped from information containing the search information. At the time of searching, the index items and the accumulator are provided to a searcher. The searcher extracts search information from the index items and checks whether the extracted search information is complete by using the accumulator. In one embodiment, the accumulator is incorporated in an encrypted inverted index.

Abstract: The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these compounds selected from the group consisting of wherein A, B, C, D, X, Y, Z and R3 are defined in the specification. Said compounds are useful for treating a disease or condition of a mammal selected from the group consisting of ocular diseases; systemic vascular barrier related diseases; allergies and other inflammatory diseases; cardiac diseases or conditions; fibrosis; pain and wounds.

Abstract: Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.

Abstract: An encoding apparatus for encoding progressive image data and interlace image data corresponding to this progressive image data, having a first encoding unit configured to encode picture data composing the interlace image data to generate first encoded data and decoding and recomposing the first encoded data to generate recomposed image data, an up sample processing unit configured to up sample the generated recomposed image data to generate image data having the same resolution as that of the progressive image data, and a second encoding unit configured to encode the picture data composing the progressive image data to generate second encoded data using the generated image data as predictive image data.

Abstract: A coding apparatus for hierarchically (layered data) coding two field data associated with each of a plurality of picture data composing a moving picture image. The coding apparatus comprising: a first coding unit configured to encode one of the two field data; a conversion unit configured to interpolate first predicted image data generated by the first coding unit encoding the one of the two field data and generate second predicted image data of a scanning position of the other field data of the two field data; and a second coding unit configured to encode the other field data of the two field data based on the second predicted image data generated by the conversion unit.

Abstract: A decoding apparatus for decoding two encoded field data obtained by hierarchically encoding two field data associated with each of a plurality of picture data composing a moving picture image. The decoding apparatus comprising: a first decoding unit configured to decode one of the two encoded field data and obtain information associated with the two encoded field data; a conversion unit configured to interpolate first predicted image data generated by decoding by the first decoding unit according to the information and generate second predicted image data of a scanning position of the other encoded field data of the two encoded field data; and a second decoding unit configured to decode the other encoded field data of the two encoded field data based on the second predicted image data generated by the conversion unit.