Abstract: The present disclosure provides a pharmaceutical composition comprising a Bcl-2/Bcl-xL inhibitor, a chemotherapeutic agent, and a pharmaceutically acceptable carrier. The present disclosure also provides a method of treating cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a Bcl-2/Bcl-xL inhibitor and a therapeutically effective amount of a chemotherapeutic agent. The present disclosure also provides use of a combination of a Bcl-2/Bcl-xL inhibitor and a chemotherapeutic agent in the manufacture of an anti-tumor medicament. In the present disclosure, a significantly enhanced anti-tumor effect can be achieved by administration of a Bcl-2/Bcl-xL inhibitor in combination with a chemotherapeutic agent.

Abstract: Disclosed is a method for preparing an easy-to-swallow composite gel based on high-pressure shear induction and belongs to the technical field of food processing. Marine products are used as raw materials. A cross-linking degree of thermally denatured proteins and a combination degree of functional oil are synchronously regulated, calculated and controlled by one-step of emulsion filling and protein cross-linking. A composite gel prepared has low strength, high water/oil retention rate and the properties of “soft” easy-to-swallow foods. The composite gel is enhanced in efficacy by nutrition regulation, and the prepared easy-to-swallow composite gel achieves precise nutrition regulation. The composite gel is differently shaped by 3D printing according to different people's needs to improve consumers' appetite for easy-to-swallow foods.

Abstract: A method, system, and computer program product for hyper-parameter determination. In a method, a network architecture of a learning model may be determined, and the learning model may be configured for performing a computing task based on machine learning. A metric value record associated with a group of hyper-parameters may be obtained during hyper-parameter determination for the learning model. An estimation of a metric value may be obtained based on the network architecture, and the metric value record and an association relationship representing an association between network architectures and metric values for the network architectures. The group of hyper-parameters may be selected in response to the estimation of the metric value meeting a predefined criterion. With these embodiments, a group of hyper-parameters may be selected, and further the learning model may be trained based on the selected group of hyper-parameters.

Abstract: The present disclosure provides a pharmaceutical composition comprising a Bcl-2/Bcl-xL inhibitor, a chemotherapeutic agent, and a pharmaceutically acceptable carrier. The present disclosure also provides a method of treating cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a Bcl-2/Bcl-xL inhibitor and a therapeutically effective amount of a chemotherapeutic agent. The present disclosure also provides use of a combination of a Bcl-2/Bcl-xL inhibitor and a chemotherapeutic agent in the manufacture of an anti-tumor medicament. In the present disclosure, a significantly enhanced anti-tumor effect can be achieved by administration of a Bcl-2/Bcl-xL inhibitor in combination with a chemotherapeutic agent.

Abstract: A monocrystal furnace with lateral feeding includes: a furnace body, a feeding apparatus, and a thermal insulation layer, a sealing member, a crucible and a lifting apparatus that are provided within the furnace body. The thermal insulation layer is located between the crucible and the furnace body, a first through-hole is provided on a side portion of the furnace body, and a second through-hole is provided in a position of the thermal insulation layer opposite to the first through-hole; the lifting apparatus is connected to the sealing member and is used to drive the sealing member to switch between a rising state and a falling state; in the rising state, the sealing member rises, and the feeding apparatus is capable of passing through the first through-hole and the second through-hole to be opposite to an opening of the crucible.

Abstract: The present invention relates to an engineered human factor VIII polypeptide, which includes at least two substituted amino acids in A1 domain of hFVIII. In some embodiments, the substituted amino acids comprise L50V and L152P. In some embodiments, the substituted amino acids further comprise one or more of amino acid substitutions selected from the group consisting of D20S, G22L, I61T, D115E, F129I, G132D, Q139E, and L159F. The present invention also relates to engineered hFVIII polypeptide encoding nucleic acid fragment, an expression vector or a rAAV vector contains such nucleic acid fragment, and a method of using engineered hFVIII polypeptide to treat hemophilia A patients.

Abstract: Methods of forming and processing semiconductor devices are described. Certain embodiments related to electronic devices which comprise a dipole region having an interlayer dielectric, a high-? dielectric material, and a dipole layer. The dipole layer comprises one or more of titanium aluminum nitride (TiAlN), titanium tantalum nitride (TiTaN), titanium oxide (TiO), tantalum oxide (TaO), and titanium aluminum carbide (TiAlC).

Abstract: Aspects of the invention include systems and methods to obtain meta features of a dataset for training in a deep learning application. A method includes selecting an initial search space that defines a type of deep learning architecture representation that specifies hyperparameters for two or more neural network architectures. The method also includes applying a search strategy to the initial search space. One of the two or more neural network architectures are selected based on a result of an evaluation according to the search strategy. A new search space is generated with new hyperparameters using an evolutionary algorithm and a mutation type that defines one or more changes in the hyperparameters specified by the initial search space, and, based on the mutation type, the new hyperparameters are applied to the one of the two or more neural networks or the search strategy is applied to the new search space.

Abstract: A system (100) for producing an epitaxial monocrystalline layer on a substrate (20) comprising: an inner container (30) defining a cavity (5) for accommodating a source material (10) and the substrate (20); an insulation container (50) arranged to accommodate the inner container (30) therein; an outer container (60) arranged to accommodate the insulation container (50) and the inner container (30) therein; and heating means (70) arranged outside the outer container (60) and configured to heat the cavity (5), wherein the inner container (30) comprises a support structure for supporting a solid monolithic source material (10) at a predetermined distance above the substrate (20) in the cavity (5) such that a growth surface of the substrate (20) is entirely exposed to the source material (10). A corresponding method is also disclosed.

Abstract: Edge device video processing with encryption of confidential image content is provided. The process includes obtaining, by the edge device, a video stream, and partitioning image content of the video stream into a confidential part and a non-confidential part. Further, the process includes encrypting, by the edge device, the confidential part of the image content to obtain encrypted image content from the confidential part and non-encrypted image content from the non-confidential part of the image content. In addition, the process includes encoding, by the edge device, the encrypted image content and the non-encrypted image content into an encoded video stream, and transmitting the encoded video stream to one or more processing servers.

Abstract: A roly-poly toy with adjustable center of gravity, comprising a first and second base part arranged at an interval, a first winding mandrel mounted on the first base part, a second winding mandrel mounted on the second base part, a reel belt, and a drive assembly. The reel belt is annular and has a first end wound around the first winding mandrel and a second end wound around the second winding mandrel. The drive assembly can switch between a first driving state and a second driving state. When the drive assembly is in the first driving state, the first winding mandrel rotates to roll up the reel belt, and the second winding mandrel rotates to release the reel belt. When it is in the second driving state, the second winding mandrel rotates to roll up the reel belt, and the first winding mandrel rotates to release the reel belt.

Abstract: A computer-implemented method for training a machine learning model includes receiving a first training job at a processing device of a computer system having a plurality of graphics processing unit (GPU) resources, the first training job being part of a set of training jobs, and determining an amount of available memory in each GPU resource of the plurality of GPU resources. The method also includes loading the training job into one or more GPU resources with at least one second training job. The loading includes determining a cost model indicating an efficiency cost of each of a plurality of packing patterns, and packing the first training job and the second training job into the one or more GPU resources according to a packing pattern associated with a lowest efficiency cost.

Abstract: Provided is a system (100) for simultaneously producing a first and a second epitaxial monocrystalline layer on a respective first and second substrate, comprising a first inner container (3) defining a first cavity for accommodating a first source material and the first substrate, a second inner container (4) defining a second cavity for accommodating a second source material and the second substrate, an insulation container (6) arranged to accommodate the first and second inner containers (3, 4) therein, an outer container (7) arranged to accommodate the insulation container (6) and the first and second inner containers (3, 4) therein and heating means (8) arranged outside the outer container (7) and configured to heat the first and second cavities simultaneously.

Abstract: A system (100) for producing an epitaxial monocrystalline layer on a substrate (20) comprising: an inner container (30) defining a cavity (5) for accommodating a source material (10) and the substrate (20); an insulation container (50) arranged to accommodate the inner container (30) therein; an outer container (60) arranged to accommodate the insulation container (50) and the inner container (30) therein; and heating means (70) arranged outside the outer container (60) and configured to heat the cavity (5), wherein the inner container (30) comprises a plurality of spacer elements (320) arranged to support the substrate (20) at a predetermined distance above a solid monolithic source material (10), wherein each spacer element (320) comprises a base portion (321) and a top portion (322), wherein at least part of the top portion (322) tapers towards an apex (323) arranged to contact the substrate (20). A corresponding method is also disclosed.

Abstract: A computer-implemented method for compressing a machine learning model includes converting an input machine learning model into a standard machine learning model. The method further includes converting the standard machine learning model into a plurality of pruned machine learning models, each of the pruned machine learning models converted using a corresponding pruning ratio from a pruning ratio candidate list. The method further includes determining, for each of the pruned machine learning models, a size-to-error ratio. The method further includes selecting, based on the size-to-error ratio of the pruned machine learning models, a first pruning ratio from the pruning ratio candidate list. The method further includes generating a compressed machine learning model by compressing the input machine learning model using the first pruning ratio that is selected. The method further includes deploying the compressed machine learning model for production.

Abstract: Methods of forming and processing semiconductor devices are described. Certain embodiments related to electronic devices which comprise a dipole region having an interlayer dielectric, a high-? dielectric material, and a dipole layer. The dipole layer comprises one or more of titanium lanthanum nitride (TiLaN), titanium yttrium nitride (TiYN), titanium strontium nitride (TiSrN), titanium magnesium nitriride (TiMgN, titanium aluminum nitride (TiAlN), titanium tantalum nitride (TiTaN), hafnium carbide (HfC), hafnium nitride (HfN), hafnium oxynitride (HfON), hafnium oxycarbide (HfOC), hafnium carbide aluminum (HfCAl), hafnium aluminum nitride (HfAlN), or hafnium carbonitride (HfCN).

Abstract: A traffic forwarding method and an apparatus, related to the field of communication technologies, to reduce a rate of traffic loss. The method includes: during graceful restart of a device in a network, when a restart device in the network enters a restart state, a neighbor device of the restart device updates, from first routing information to second routing information, routing information used to forward target traffic. In addition, the neighbor device forwards the target traffic based on the second routing information. The first routing information indicates the neighbor device to send the target traffic to the restart device. The second routing information indicates the neighbor device to send the target traffic to another device.

Abstract: A packet transmission method, a transmission control method, an apparatus, and a system are disclosed. A SR path includes a first network node and a second network node. There are a plurality of communication links between the first network node and the second network node. After obtaining a first packet, the first network node determines a first communication link based on a first link quality identifier carried in the first packet, and forwards the first packet to the second network node through the first communication link. The first link quality identifier indicates a first quality requirement on the communication link between the first network node and the second network node. The plurality of communication links between the first network node and the second network node include the first communication link, and link quality of the first communication link meets the first quality requirement.

Abstract: A piezoelectric energy harvester has a layered structure comprising a first electrode, a polymeric piezoelectric material, and a second electrode, the layered structure coupled to receive mechanical stress from the environment, and the first and second electrode electrically coupled to a power converter. The power converter is adapted to charge an energy storage device selected from a capacitor and a battery. The method of harvesting energy from the environment includes providing a piezoelectric device comprising a layer of a polymeric piezoelectric material disposed between a first and a second electrode; coupling mechanical stress derived from an environment to the piezoelectric device; and coupling electrical energy from the piezoelectric device.

Abstract: Methods for pre-cleaning substrates having metal and dielectric surfaces are described. The substrate is exposed to a strong reductant to remove contaminants from the metal surface and damage the dielectric surface. The substrate is then exposed to an oxidation process to repair the damage to the dielectric surface and oxidize the metal surface. The substrate is then exposed to a weak reductant to reduce the metal oxide to a pure metal surface without substantially affecting the dielectric surface. Processing tools and computer readable media for practicing the method are also described.