Abstract: A system and method for analyzing the size distribution and chemical composition of neutral clusters below 3 nm, which achieves efficient sampling based on a core sampling method. The system utilizes the high charging efficiency of the unipolar charging device to charge the nanoparticles and efficiently transport them to the inlet of the nanoparticle electrical mobility size classification device. Through a specialized aerodynamic design, the nanoparticles pass through the electric field between the electrode plates and are efficiently transmitted to both the particle number concentration detector and the chemical composition detector, demonstrating excellent application prospects.

Abstract: An integrated circuit (IC) design layout may be partitioned into a set of content areas. A content area in the set of content areas may be divided into a set of zones based on an image-based representation of the content area. A repetition unit may be identified in a zone in the set of zones, where the repetition unit is a portion of the zone, and where the zone includes multiple instances of the repetition unit. A skeleton layout may be generated corresponding to the IC design layout, where the skeleton layout specifies locations of the multiple instances of the repetition unit in the IC design layout.

Abstract: According to one aspect, there is provided a computer-implemented method for training artificial intelligence models with specialized biologic data in an AI-guided analytic platform for development of a biologic synthesis process, comprising: collecting multimodal biologic data including at least one of a gene expression level, mRNA, metabolic reaction fluxes, or intracellular metabolite concentrations from biologic systems; processing the collected biologic data through data normalization and quality assurance steps to create model-ready data; and generating at least one output predicting an effect of genetic modification on a metabolite level or a reaction flux.

Abstract: A system may include a plurality of sensors configured to measure fermentation parameters. The system may include a control system operatively coupled to the fermentation chamber and the plurality of sensors, the control system comprising: at least one processor; memory storing instructions that, when executed by the at least one processor, cause the control system to: receive sensor data from the plurality of sensors; process the sensor data using a set of AI-based learning models to determine a set of improved fermentation parameters; generate control signals based on the determined set of improved fermentation parameters; and adjust operating conditions of the fermentation chamber based on the control signals.

Abstract: A data deduplication method, including determining, in response to a data deduplication request, a plurality of duplicate blocks from data blocks stored in a persistent medium, determining a to-be-deduplicated block from the plurality of duplicate blocks based on deduplication priorities of the plurality of duplicate blocks, where the deduplication priority of the duplicate block is determined based on an attribute of the duplicate block, and performing deduplication on the to-be-deduplicated block, where a fragmentation degree of data in the persistent medium after the to-be-deduplicated block is deduplicated is less than a fragmentation degree of data in the persistent medium after a data block other than the to-be-deduplicated block in the plurality of duplicate blocks is deduplicated.

Abstract: Use of OsHIPP36 gene in the regulation of arsenic tolerance in rice is provided, which belongs to the field of genetic engineering. The present disclosure provides the use of OsHIPP36 gene in the regulation of arsenic tolerance in rice, where protein encoded by the OsHIPP36 gene has the amino acid sequence of SEQ ID NO: 1. The present disclosure obtains a oshipp36 mutant plant by constructing a transgenic vector. After treatment with the external addition of As(III), the mutant plant is found to have significantly increased tolerance to As(III). In particular, the oshipp36 mutant plant after As(III) treatment has significantly longer roots than a Nipponbare wild-type plant, suggesting that the OsHIPP36 gene plays an important role in regulating arsenic tolerance in rice.

Abstract: A system may receive data from a plurality of sources. The system may perform a data quality assurance on the received data to identify at least one anomalous data point. The system may apply a Bayesian statistical normalization model to the data to: model a batch-specific systemic variation, account for a technical factor contributing to a batch effect, separate a signal from the technical factor; and generate normalized data. The system may output the normalized data for processing by a machine learning model.

Abstract: According to one aspect, there is provided a computer-implemented system for evaluating and improving strain production using three integrated components: a prototype system for evaluating candidate strains, an optimization system for enhancing strain performance, and a scale-up system for adapting laboratory results to commercial-scale parameters. The system employs artificial intelligence models trained on data from all three components. The system continuously receives performance data from these systems to update its AI models. Using these updated models, the system generates modified operational parameters for the prototype, optimization, and scale-up systems, creating a feedback loop for continuous process improvement.

Abstract: A system may include data integration facilities for integrating content of publication data sets relating to strains and proprietary data sets including parameters of a process in which the strain produces functional outputs, wherein integrated data is input to machine learning models. The machine learning models generate recommendations relating to modifications of the strain.

Abstract: A semiconductor package comprises a lead frame, a first high-voltage field-effect transistor (FET), a source clip, a gate clip, a second high-voltage FET, a drain clip or a bond wire, and a molding encapsulation. A method comprises the steps of providing a lead frame; mounting a first high-voltage FET; attaching a source clip and a gate clip; mounting a second high-voltage FET; attaching a drain clip or a bond wire, forming a molding encapsulation; and applying a singulation process.

Abstract: The present disclosure relates to method and apparatus for processing media materials, a device and a product. The method comprises obtaining a first identification of each of a plurality of slots, wherein each of the plurality of slots is used for filling a media material and the first identification is used for indicating whether respective slots belong to a same freeze-frame effect. The method also comprises obtaining a second identification of each of the plurality of slots, wherein the second identification is used for indicating whether respective slots are filled with a same media material. In addition, the method further comprises determining, based on the first identification and the second identification, a freeze-frame combination for media materials, to play the media materials based on the freeze-frame combination, such that a freeze-frame media material in the media materials is continuously displayed for a period of time.

Abstract: The Bacillus velezensis M173 was deposited with the Guangdong Microbial Culture Collection Center with a deposit number of GDMCC No. 61434. After being prepared into a seed-coating agent, Bacillus velezensis M173 can promote the growth and germination of plants and significantly improve the control effect on pathogens. Moreover, Bacillus velezensis M173 can relieve the condition of dead seedlings of crops at seedling stage after being applied to the crops. In particular, both pot experiments and field experiments prove that the Bacillus velezensis M173 of the present invention has a significant control effect on fungal and bacterial diseases, in particular, bacterial wilt and stem rot. Therefore, the Bacillus velezensis M173 of the present invention has broad application prospects.

Abstract: The present disclosure provides raw material re-feeding apparatus for manufacturing a monocrystal and monocrystal manufacturing apparatus including the same. The raw material re-feeding apparatus is provided outside a monocrystal furnace and includes a storage and a feeder in communication with the storage. A discharging end of the feeder is located in the monocrystal furnace and movable relative to the monocrystal furnace, so that the discharging end of the feeder is immersed in a silicon melt when the material re-feeding is performed, and thus the material is melted and re-fed.

Abstract: Natural brochosomes are hollow, nanoscopic, buckyball-shaped spheroids with through-holes distributed across their surfaces. Synthetic brochosomes can be prepared utilizing a microscopic three-dimensional printing method. The printed structures possess spherical, hemispherical, buckyball-like geometries. And the secondary features on these printed synthetic brochosomes are either in a shape of circular or a shape of hexagon and pentagon. The secondary feature can be open-pores or closed-pores. The brochosome can be made with polymers or comprised of composite materials including polymers and metals. These synthetic brochosomes can be used as antireflective coatings, optical encryption, and camouflage coatings in the infrared range from 750 nm to over 20 ?m.

Abstract: A method performed by one or more computers may comprise: receiving information about an entity; generating a set of representations based on the information about the entity; generating a set of edits of the entity based on the set of representations; and generating a performance prediction for each edit of the set of edits of the entity based on a pre-trained generalization machine learning model applied to each edit of the set of edits.

Abstract: A system may include a data collection facility that collects strain data including biological information for multiple biological strain candidates and receives assay data from experiments. A prototype prediction system generates initial fitness predictions using first AI models trained on historical performance data and identifies an initial strain candidate subset. A scale-up prediction system receives assay data for the initial candidates, analyzes this data using second AI models to generate scale-up performance predictions for bioreactor production conditions, and selects strain candidates for production based on these predictions.

Abstract: Disclosed are a data migration method, system and device for a storage server, and a non-transitory readable storage medium. The method includes: according to storage information of a storage server, determining the number n of strips to be migrated; selecting n stripes to be migrated from among c full stripes according to a preset migration rule, and selecting, from the n stripes to be migrated, data blocks to be migrated and migrating the data blocks to the newly inserted disks, so that after the migration is completed, the difference in stripe usage between any two disks in the storage server does not exceed 1; and determining data content of check data blocks of the strips so as to complete data migration of the storage server, and determining data content of check data blocks of the c-n strips by means of incremental update of an erasure code.

Abstract: A method for producing ?? T cells modified by a chimeric antigen receptor, comprising: transfecting K562 cells with shFPPS targeted to FPP synthase by means of a lentiviral vector, such that the expression of FPPS in the K562 cells is lowered and a K562-shFPPS cell line with reduced FPPS expression is constructed; adding the K562-shFPPS cell line into a ?? T cell culture system for co-culturing with the ?? T cells, wherein it is found that the K562-shFPPS cell line can facilitate in vitro differentiation and proliferation of the ?? T cells; and adding a CAR-expressing lentiviral vector to the ?? T cell culture system comprising the cell line for co-culturing, wherein it is found that the K562-shFPPS cell line can further effectively improve the transfection rate of CAR genes. The provided solution effectively overcomes the technical challenge of the large-scale production of CAR-?? T cells, and has a good application prospect.

Abstract: Examples of the present disclosure provide a method and an apparatus for denoising a low-light image, wherein the method includes: acquiring a low-light image in RAW domain; performing a preset image enhancement transformation on the low-light image in the RAW domain, and inputting the transformed image into a pre-trained denoising network model to obtain an output image; wherein, the denoising network model is trained based on sample images, and the sample images include a low-light image with simulated dead pixels and a noiseless image; performing an inverse transformation of the preset image enhancement transformation on the output image to obtain a denoised image. It can significantly reduce the influence of dead pixels of images on the process of denoising the low-light image and improve the quality of low-light image denoising.

Abstract: The present invention relates to a pharmaceutically acceptable salt and a crystal form of a tetrahydronaphthalene derivative, and a preparation method. Specifically, the present disclosure provides a pharmaceutically acceptable salt and a crystal form of (S)-3-(5-(4-((1-(4-((1R,2R)-6-hydroxy-2-isobutyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione, and a preparation method therefor. The corresponding salt has good stability and can be better used for clinical treatment.