Abstract: A fusion protein comprises an Fc variant and a GDF15 active domain, wherein the Fc variant has amino acid substitutions at position 356 and/or position 439 of the IgG Fc according to EU numbering and still has the ability to form homodimer. By fusing the Fc variant with the GDF15 active domain, the Fc-GDF15 fusion protein has significantly improved physicochemical properties and recombinant expression levels, has in vitro activity equivalent to or better than natural GDF15 molecules, and has significantly prolonged in vivo circulating half-life, which can support the dosing frequency of once every two weeks or even once a month.

Abstract: A GDF15 fusion protein and a method for treating obesity using same. The fusion protein includes an Fc variant and a GDF15 active domain, wherein the Fc variant has an amino acid substitution at position 356 and/or position 439 of the IgG Fc according to EU numbering and still has the ability to form a homodimer. By means of fusing the Fc variant with the GDF15 active domain, the Fc-GDF15 fusion protein has significantly improved physical and chemical properties and recombinant expression level, has an in vitro activity comparable to or better than that of a natural GDF15 molecule, and has a significantly prolonged in vivo cyclic half-life, which may support the dosing frequency once every two weeks or even once a month.

Abstract: GDF15 fusion proteins and uses thereof, the fusion protein includes an Fc variant and a GDF15 active domain, wherein the Fc variant has amino acid substitutions at position 356 and/or position 439 of the IgG Fc according to EU numbering and still has the ability to form homodimer. By fusing the Fc variant with the GDF15 active domain, the Fc-GDF15 fusion protein has significantly improved physicochemical properties and recombinant expression levels, has in vitro activity equivalent to or better than natural GDF15 molecules, and has significantly prolonged in vivo circulating half-life, which can support the dosing frequency of once every two weeks or even once a month.

Abstract: The present invention relates to an engineered human factor VIII polypeptide, which includes at least two substituted amino acids in A1 domain of hFVIII. In some embodiments, the substituted amino acids comprise L50V and L152P. In some embodiments, the substituted amino acids further comprise one or more of amino acid substitutions selected from the group consisting of D20S, G22L, I61T, D115E, F129I, G132D, Q139E, and L159F. The present invention also relates to engineered hFVIII polypeptide encoding nucleic acid fragment, an expression vector or a rAAV vector contains such nucleic acid fragment, and a method of using engineered hFVIII polypeptide to treat hemophilia A patients.

Abstract: The disclosure relates to a birdstrike avoidance optical flexible film, a preparation method and application thereof. Specifically, a birdstrike avoidance optical flexible film is disclosed in this application. The film has excellent selective transmission and reflection properties for visible light and ultraviolet light, and can realize effects of being transparent to human and being visible to birds. When the film is applied to buildings and/or vehicles. The optical film can be applied to buildings and/or vehicles to achieve effects of no influence on human aesthetic, birdstrike avoidance, and popularization in a large area, with profound significance for harmony between humans and birds.

Abstract: Provided are therapeutic agent including nucleic acid and CAR-modified immune cell and the use thereof. The therapeutic agent comprises first composition and second composition, the first composition comprises a nucleic acid having a labeling polypeptide coding sequence for being introduced into a tumor cell and/or a cancer cell; the labeling polypeptide has an extracellular antigen determining region, a spacer portion, and a transmembrane portion that are operatively linked, which can be expressed to form modification on the surface of the tumor cell and/or cancer cell; the extracellular antigen determining region comprises one or more epitope polypeptides; wherein, amino acid sequences of proteins on cell membrane or secreted proteins of mammal do not comprise the epitope polypeptide amino acid sequence in the natural state; the second composition comprises chimeric antigen receptor modified immune cell which specifically recognize and bind to the extracellular antigen determining region.

Abstract: A disclosed computer-implemented method may include partitioning, based on a social graph representative of social connections among a plurality of users of a social networking system, the plurality of users into a plurality of user buckets. Each user bucket may include at least one user of the social networking system. The method may further include selecting a set of user buckets from the plurality of user buckets, assigning the set of user buckets to a data center included in a networking infrastructure, and routing data sent from a user device associated with a user included in the set of user buckets to the data center. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A support device and a high-speed pulverizer having the support device are disclosed. The support device includes an outer casing. The outer casing has a mounting cavity therein. A bearing is retained in the mounting cavity through a sealing member. The sealing member is a movable structure that is flexibly connected, which realizes automatic centering in the working process, improves the service life of the bearing and the sealing member, and realizes the effect of vibration reduction and noise reduction.

Abstract: A method of isolating a compound 1 and a compound 2 includes: providing Penicillium sp. TR85; inoculating the Penicillium sp. TR85 into a sterilized solid medium; resting for fermentation at room temperature, and obtaining a fermentation product. The fermentation product includes the compound 1 and the compound 2. An herbicidal composition includes a compound 1 or a compound 2; and pesticide-acceptable adjuvants.

Abstract: A support device and a high-speed pulverizer having the support device are disclosed. The support device includes an outer casing. The outer casing has a mounting cavity therein. A bearing is retained in the mounting cavity through a sealing member. The sealing member is a movable structure that is flexibly connected, which realizes automatic centering in the working process, improves the service life of the bearing and the sealing member, and realizes the effect of vibration reduction and noise reduction.

Abstract: The invention discloses a motor (501) and a hair dryer having the same, the motor (501) comprises a rotor assembly (16) and a stator assembly (15), wherein the motor (501) also comprises a bracket (17) for supporting the rotor assembly (16) and the stator assembly (15), and the rotor assembly (16) is connected with a fan blade (502); the bracket (17) comprises a first cylinder (8) for supporting the rotor assembly (16) and a second cylinder (9) for protecting the fan blade (502); the first cylinder (8) is connected with the second cylinder (9), and at least a part of the first cylinder (8) is located outside the second cylinder (9). By integrating the fan blade (502) and the motor (501) as a component, the assembly steps of the whole machine are simplified and the difficulty of assembly is reduced. The user experience is good by using the hair dryer with the motor.

Abstract: A method includes for a designated pilot symbol of at least one pilot symbol to be inserted into a data sequence, determining a first subcarrier and a second subcarrier adjacent to a position of the designated pilot symbol in a frequency domain; at least separately determining a first position and a second position on the first subcarrier and the second subcarrier; determining a first symbol and a second symbol, so that the first symbol is capable of neutralizing interference on the designated pilot symbol of data symbols in positions other than the first position within a predetermined range of the first subcarrier, and the second symbol is capable of neutralizing interference on the designated pilot symbol of data symbols in positions other than the second position within a predetermined range of the second subcarrier; and respectively inserting the first symbol and the second symbol in the first and second positions.

Abstract: A method of isolating a compound 1 and a compound 2 includes: providing Penicillium sp. TR85; inoculating the Penicillium sp. TR85 into a sterilized solid medium; resting for fermentation at room temperature, and obtaining a fermentation product. The fermentation product includes the compound 1 and the compound 2. An herbicidal composition includes a compound 1 or a compound 2; and pesticide-acceptable adjuvants.

Abstract: Embodiments of the present disclosure disclose methods and devices of data de-duplication. The method of data de-duplication performed at a client comprises: in response to receiving data to be backed up at a client, sampling the data to be backed up to obtain the sampled data; generating a signature for the sampled data; transmitting the signature to a master storage node in a storage cluster including a plurality of storage nodes, to allow the master storage node to select one storage node from the plurality of storage nodes; receiving an indication of the selected storage node from the master storage node; and transmitting, based on the indication, the data to be backed up to the selected storage node. Embodiments of the present disclosure also provide methods of data de-duplication performed at the master storage node and the slave storage node, and corresponding devices.

Abstract: A disclosed computer-implemented method may include receiving, via a monitoring infrastructure that monitors an operational state of a networking infrastructure, data representative of the operational state of the networking infrastructure during a period of time. The networking infrastructure may include (1) a plurality of data centers, and (2) at least one point-of-presence (POP) edge node. The method may also include (1) accessing data representative of a set of predefined policies associated with the networking infrastructure, and (2) based on the data representative of the operational state (a) determining a set of edge load factors associated with the edge node, and (b) generating, via a linear solver and further based the set of edge load factors associated with the edge node and the set of predefined policies associated with the networking infrastructure, a routing table for the POP edge node. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A soluble dietary fiber having a xylooligosaccharide purity of 70% or greater. The xylooligosaccharide has a total xylobiose and xylotriose content of 45% or great. The soluble dietary fiber has a higher content of an effective component, thus improving the proliferation of a Bifidobacterium and Lactobacillus, and significantly reducing blood glucose.

Abstract: A processing unit can successively operate layers of a multilayer computational graph (MCG) according to a forward computational order to determine a topic value associated with a document based at least in part on content values associated with the document. The processing unit can successively determine, according to a reverse computational order, layer-specific deviation values associated with the layers based at least in part on the topic value, the content values, and a characteristic value associated with the document. The processing unit can determine a model adjustment value based at least in part on the layer-specific deviation values. The processing unit can modify at least one parameter associated with the MCG based at least in part on the model adjustment value. The MCG can be operated to provide a result characteristic value associated with test content values of a test document.

Abstract: Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

Abstract: A method includes for a designated pilot symbol of at least one pilot symbol to be inserted into a data sequence, determining a first subcarrier and a second subcarrier adjacent to a position of the designated pilot symbol in a frequency domain; at least separately determining a first position and a second position on the first subcarrier and the second subcarrier; determining a first symbol and a second symbol, so that the first symbol is capable of neutralizing interference on the designated pilot symbol of data symbols in positions other than the first position within a predetermined range of the first subcarrier, and the second symbol is capable of neutralizing interference on the designated pilot symbol of data symbols in positions other than the second position within a predetermined range of the second subcarrier; and respectively inserting the first symbol and the second symbol in the first and second positions.

Abstract: Methods, systems, and program products for integrating data sources are disclosed. A sync port utilized by a source interface tool is monitored and in response to a first sync request detected on the sync port, a second sync request that conforms to a native inventory description format of the data source is generated and transmitted to a data source. Inventory information including inventory item description information that is returned in response to the second sync request is transmitted to the source interface tool. A query port utilized by the source interface tool is monitored, and in response to a first query on the query port that requests performance data for at least one inventory item specified by the inventory item description information, a second query conforming to a native query schema of the data source is generated and transmitted to the data source. Query results from the data source are normalized and transmitted to the source interface tool.