Patents by Inventor Lin Zhi

Lin Zhi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF
    Publication number: 20170247325
    Abstract: Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
    Type: Application
    Filed: May 9, 2017
    Publication date: August 31, 2017
    Inventor: Lin Zhi
  • GLUCAGON ANTAGONISTS
    Publication number: 20170216229
    Abstract: Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof.
    Type: Application
    Filed: June 11, 2015
    Publication date: August 3, 2017
    Inventor: Lin Zhi
  • Derivatives of uridine 5?-cyclophosphate useful to treat hepatitis C viral infections
    Patent number: 9676809
    Abstract: Some embodiments of the present invention include nucleoside 5?-monophosphate derivative compounds, their preparation and their uses. In some embodiments, such compounds are useful to treat hepatitis C viral infections.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: June 13, 2017
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventor: Lin Zhi
  • Selective androgen receptor modulators (SARMS) and uses thereof
    Patent number: 9675583
    Abstract: Provided herein are compounds, such as compounds, of Formula I, that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: June 13, 2017
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventor: Lin Zhi
  • PRODRUG COMPOUNDS AND USES THEROF
    Publication number: 20170158725
    Abstract: Provided herein are cyclic phosphorus-containing prodrug compounds, their preparation and their uses, such as treating diseases via modulating molecular targets in the liver.
    Type: Application
    Filed: June 26, 2015
    Publication date: June 8, 2017
    Applicant: Ligand Pharmaceuticals, Inc.
    Inventor: Lin Zhi
  • Hematopoietic growth factor mimetic small molecule compounds and their uses
    Patent number: 9622991
    Abstract: The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: April 18, 2017
    Assignee: Ligand Pharmaceuticals Inc.
    Inventors: Lin Zhi, Andrew R. Hudson, Cornelis A. Van Oeveren, Steven L. Roach, Bijan Pedram, Yixing Shen, Lino J. Valdez, Jillian Basinger, Virginia Heather Sharron Grant, Jason C. Pickens
  • PRODRUG COMPOUNDS AND THEIR USES
    Publication number: 20170056429
    Abstract: Provided herein are prodrug compounds, their preparation and their uses, such as treating liver diseases or nonliver diseases via intervening in molecular pathways in the liver. Novel prodrug compounds of acid/alcohol derivatives such as phosphates, phosphonates, phosphonamidates, phosphoramidates, carboxylates, phenolates, and alkoxylates, their preparation and their uses are described. Some of the novel prodrug compounds described herein do not generate a vinyl keto reactive intermediate in the activation process. Another aspect includes the use of prodrugs to treat diseases that benefit from enhanced drug distribution to the liver and like tissues and cells.
    Type: Application
    Filed: February 11, 2015
    Publication date: March 2, 2017
    Applicant: Ligand Pharmaceutical, Inc.
    Inventor: Lin Zhi
  • METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR
    Publication number: 20160374989
    Abstract: Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.
    Type: Application
    Filed: August 25, 2016
    Publication date: December 29, 2016
    Inventors: Lin Zhi, Keith Marschke, Virginia H. Grant, Steven L. Roach, Yixing Shen, Jason C. Pickens, Bijan Pedram, Cornelius Arjan van Oeveren, Lino J. Valdez, Andrew R. Hudson
  • DERIVATIVES OF URIDINE 5'-CYCLOPHOSPHATE USEFUL TO TREAT HEPATITIS C VIRAL INFECTIONS
    Publication number: 20160347783
    Abstract: Some embodiments of the present invention include nucleoside 5?-monophosphate derivative compounds, their preparation and their uses. In some embodiments, such compounds are useful to treat hepatitis C viral infections.
    Type: Application
    Filed: November 19, 2014
    Publication date: December 1, 2016
    Inventor: Lin Zhi
  • HETEROCYCLE AMINES AND USES THEREOF
    Publication number: 20160347767
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Application
    Filed: January 26, 2016
    Publication date: December 1, 2016
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • METHODS AND COMPOSITIONS FOR MODULATING HORMONE LEVELS
    Publication number: 20160338995
    Abstract: Provided herein are compositions and methods for the treatment of androgen and estrogen receptors mediated conditions. Specifically, a composition that includes an effective amount of a selective estrogen receptor modulator (SERM) and an effective amount of a 5a-reductase inhibitor, or a pharmaceutically acceptable salt, ester or prodrug of the foregoing is provided. Also provided are methods for the treatment of aging related conditions and diseases.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 24, 2016
    Inventor: Lin Zhi
  • Methods and compositions associated with the granulocyte colony-stimulating factor receptor
    Patent number: 9492430
    Abstract: Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: November 15, 2016
    Assignee: Ligand Pharmaceuticals, Incorporated
    Inventors: Lin Zhi, Keith Marschke, Virginia H. Grant, Steven L. Roach, Yixing Shen, Jason C. Pickens, Bijan Pedram, C. Arjan van Oeveren, Lino J. Valdez, Andrew R. Hudson
  • IMIDAZO-FUSED HETEROCYCLES AND USES THEREOF
    Publication number: 20160297824
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using imidazole-fused heterocycle amines. Some of the disclosed embodiments include imizazo-fused heterocycle compounds useful to treat leukemia and other hematopoietic disorders.
    Type: Application
    Filed: March 15, 2016
    Publication date: October 13, 2016
    Inventor: Lin Zhi
  • DEPLOYING A VIRTUAL MACHINE IN A COMPUTING ENVIRONMENT
    Publication number: 20160162308
    Abstract: A method and associated system. A request to deploy a virtual machine in a computing environment is received. The request identifies an ordered sequence of attributes that the virtual machine to be deployed includes. In response to the request, a virtual machine resource usage pattern having attributes matching a subset of attributes in the ordered sequence of attributes is selected, based on an ordering of the attributes in the ordered sequence of attributes. A node on which the virtual machine is to be deployed is selected from two or more nodes in the computing environment, based on the selected virtual machine resource usage pattern and predicted runtime resource requirements of the virtual machine to be deployed.
    Type: Application
    Filed: August 22, 2014
    Publication date: June 9, 2016
    Inventors: Li Long Chen, Randy A. Rendahl, Xiao Yang Zhu, Lin Zhi Zou
  • Androgen receptor modulator compounds and methods
    Patent number: 9359285
    Abstract: Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: June 7, 2016
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Robert I. Higuchi, Cornelis Arjan Van Oeveren, Thomas Lot Stevens Lau
  • Nucleotide prodrug compounds and use
    Patent number: 9326991
    Abstract: Embodiments of the present invention include nucleoside 5?-monophosphate derivative compounds, their preparation and their uses. In some embodiments, nucleoside 5?-monophosphate derivative compounds are useful to treat viral infections.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: May 3, 2016
    Assignee: LIGAND PHARMACEUTICALS, INC.
    Inventors: Lin Zhi, K. Raja Reddy
  • Waterproof cap for ports in electronic devices
    Patent number: 9326403
    Abstract: A waterproof cap for electronic devices includes a cover plate and sealing base located on a surface of the cover plate for sealing a port of a housing of the electronic devices. A first lip and a second lip are located on an outer periphery of the sealing base and are spaced apart from each other. The first lip is located between the cover plate and the second lip. When the sealing base is inserted into the port of the housing of the electronic devices, the first lip is configured to tilt toward the cover plate, and the second lip is configured to tilt away from the cover plate.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: April 26, 2016
    Assignees: AMBIT MICROSYSTEMS (SHANGHAI) LTD., HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Xiang-Hong Xie, Lin-Zhi Duan, Deng-Lai Ke
  • Heterocycle amines and uses thereof
    Patent number: 9266874
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 23, 2016
    Assignee: LIGAND PHARMACEUTICALS INCORPORATED
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF
    Publication number: 20160038461
    Abstract: Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 11, 2016
    Inventor: Lin Zhi
  • METHODS OF TREATMENT ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR
    Publication number: 20160022638
    Abstract: Some embodiments include methods for treating, preventing, reversing, halting, or slowing the progression of cancer, comprising administering to a subject in need thereof an effective amount of one or more chemotherapeutic agents, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition, wherein at least one of the chemotherapeutic agents is a cytotoxic granulocyte colony-stimulating factor receptor (GCFR) modulator. Methods are also disclosed for treating, preventing, reversing, halting, or slowing the progression of a hematopoietic disorder, comprising administered a therapeutically effective cytotoxic amount of a GCFR modulator to a subject in need thereof.
    Type: Application
    Filed: March 10, 2014
    Publication date: January 28, 2016
    Inventors: Keith B. Marschke, Lin Zhi