Patents by Inventor Lin Zhi

Lin Zhi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic androgen and progesterone receptor modulator compounds and methods
    Publication number: 20100069379
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
    Type: Application
    Filed: November 13, 2009
    Publication date: March 18, 2010
    Inventors: Lin Zhi, Christopher Tegley, Barbara Pio, Corneils Arjan Van Oeveren, Mehrnouch Motamedi, Esther Martinborough, Robert Higuchi, Lawrence G. Hamann
  • Thrombopoietin activity modulating compounds and methods
    Patent number: 7662804
    Abstract: Disclosed herein are novel diazenyl pyrazole compounds and related compounds. Also disclosed herein are methods of using these compounds for the treatment of diseases and conditions associated with modulating a thrombopoietin activity.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: February 16, 2010
    Assignee: SmithKline Beecham Corp.
    Inventors: Lin Zhi, E. Adam Kallel, Dean P. Phillips
  • Indoline derivatives
    Patent number: 7645761
    Abstract: This invention relates to substituted indoline derivative compounds which are antagonists of the progesterone receptor, their preparation and pharmaceutical utility, particularly including contraception and treatment of benign or malignant neoplastic diseases, having the general structure: wherein R1 and R2 may be single substituents or fused to form spirocyclic rings.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: January 12, 2010
    Assignee: Wyeth
    Inventors: Andrew Fensome, Lori L. Miller, John W. Ullrich, Reinhold H. W. Bender, Puwen Zhang, Jay E. Wrobel, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley
  • CYCLOTHIOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS
    Publication number: 20090281096
    Abstract: Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have the structure: wherein R1, R2, R3, R4, R5, and Q1 are defined herein.
    Type: Application
    Filed: April 8, 2009
    Publication date: November 12, 2009
    Applicant: Wyeth
    Inventors: Puwen Zhang, Andrew Fensome, Eugene A. Terefenko, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley, Jay E. Wrobel, Mark A. Collins
  • Androgen Receptor Modulator Compounds and Methods
    Publication number: 20090264455
    Abstract: Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
    Type: Application
    Filed: June 12, 2006
    Publication date: October 22, 2009
    Applicant: LIGAND PHARMACEUTICALS INCORPORATED
    Inventors: Bijan Pedram, Cornelis Arjan Van Oeveren, Lin Zhi, Shuo Zhao, Yixing Shen
  • Androgen Receptor Modulator Compounds and Methods
    Publication number: 20090227571
    Abstract: Provided herein are compounds that bind to androgen receptors and modulate the activity and/or the amount of androgen receptors and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
    Type: Application
    Filed: June 30, 2006
    Publication date: September 10, 2009
    Inventors: Jon C. Loren, Todd Miller, Bijan Pedram, Charlene V. Rowley, Yixing Shen, Cornelis Arjan Van Oeveren, Lin Zhi
  • Androgen Receptor Modulator Compounds and Methods
    Publication number: 20090203725
    Abstract: Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors and/or modulate the amount of androgen receptors; and to methods for making and using such compounds. Also provided are compositions containing such compounds and methods for making and using such compositions.
    Type: Application
    Filed: December 21, 2006
    Publication date: August 13, 2009
    Inventors: Cornelis Arjan Van Oeveren, Yixing Shen, Shuo Zhao, Lin Zhi
  • Cyclothiocarbamate derivatives as progesterone receptor modulators
    Patent number: 7569564
    Abstract: Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have the structure: wherein R1, R2, R3, R4, R5, and Q1 are defined herein.
    Type: Grant
    Filed: February 9, 2006
    Date of Patent: August 4, 2009
    Assignee: Wyeth
    Inventors: Puwen Zhang, Andrew Fensome, Eugene A. Terefenko, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley, Jay E. Wrobel, Mark A. Collins
  • CYCLOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS
    Publication number: 20090111802
    Abstract: This invention provides compounds of Formula (I): wherein R1 and R2 are independent substituents or are fused to form spirocyclic rings; R3, RC, and R4 are as defined herein; and R5 is a substituted benzene ring or a substituted five or six membered heterocyclic ring having in its backbone 1, 2, or 3 heteroatoms including O, S, SO, SO2 or NR6; or pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods using the compounds as antagonists of the progesterone receptor.
    Type: Application
    Filed: December 2, 2008
    Publication date: April 30, 2009
    Applicant: Wyeth
    Inventors: Puwen Zhang, Eugene A. Terefenko, Andrew Fensome, Jay E. Wrobel, Horace Fletcher, III, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley
  • Glucocorticoid Receptor Modulator Compounds and Methods
    Publication number: 20090105292
    Abstract: Disclosed herein are compounds of Formula I: and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof. Certain of such compounds are selective glucocorticoid receptor modulators and/or selective glucocorticoid binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
    Type: Application
    Filed: February 24, 2005
    Publication date: April 23, 2009
    Applicant: LIGAND PHARMACEUTICALS INCORPORATED
    Inventors: Lin Zhi, Robert Ardecky, Dean Phillips, John Tyhonas, Donald Karanewsky, Robert Higuchi, A.R. Hudson, S.L. Roach, A.C. Vassar, Yongkai Li, Mark Adams, L.J. Valdez, C. Cuervo
  • Cyclocarbamate derivatives as progesterone receptor modulators
    Patent number: 7488822
    Abstract: This invention provides compounds of Formula (I): wherein R1 and R2 are independent substituents or are fused to form spirocyclic rings; R3, RC, and R4 are as defined herein; and R5 is a substituted benzene ring or a substituted five or six membered heterocyclic ring having in its backbone 1, 2, or 3 heteroatoms including O, S, SO, SO2 or NR6; or pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods using the compounds as antagonists of the progesterone receptor.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: February 10, 2009
    Assignee: Wyeth
    Inventors: Puwen Zhang, Eugene A. Terefenko, Andrew Fensome, Jay E. Wrobel, Horace Fletcher, III, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley
  • Androgen Receptor Modulator Compounds and Methods
    Publication number: 20090030027
    Abstract: Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
    Type: Application
    Filed: June 12, 2006
    Publication date: January 29, 2009
    Applicant: LIGAND PHARMACEUTICALS INCORPORATED
    Inventors: Bijan Pedram, Cornelis Arjan Van Oeveren, Lin Zhi, Shuo Zhao, Yixing Shen
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Publication number: 20080300241
    Abstract: Non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Application
    Filed: November 17, 2006
    Publication date: December 4, 2008
    Inventors: Robert Higuchi, Lin Zhi, Donald Karanewsky, Anthony Thompson, Thomas Caferro, Neelakandha Mani, Jyun-Hung Chen, Marquis Cummings, James Edwards, Mark Adams, Charlotte Deckhut
  • Mineralocorticoid receptor modulator compounds, processes for their preparation, and their uses
    Patent number: 7442696
    Abstract: This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein R1 —R10 are as defined herein.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: October 28, 2008
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Robert I. Higuchi, Lin Zhi, Mark E. Adams, Yan Liu, Donald S. Karanewsky
  • Mineralocorticoid receptor modulator compounds and methods, and pharmaceutical compositions containing these compounds
    Patent number: 7435733
    Abstract: This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein R1-R10 are as defined herein.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: October 14, 2008
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Robert I. Higuchi, Lin Zhi, Donald S. Karanewsky
  • 6-Cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
    Publication number: 20080227810
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions.
    Type: Application
    Filed: August 23, 2004
    Publication date: September 18, 2008
    Inventors: Lin Zhi, Esther Martinborough, Yixing Shen, Thomas Lau, Min Wu, Yun Long
  • THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS
    Publication number: 20080146594
    Abstract: Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
    Type: Application
    Filed: November 8, 2007
    Publication date: June 19, 2008
    Applicant: Ligand Pharmaceutical, Inc.
    Inventors: Jyun-Hung Chen, E. Adam Kallel, Thomas Lau, Matthew H. McNeill, Todd A. Miller, Bao N. Nguyen, Richard J. Penuliar, Dean P. Phillips, Daniel A. Ruppar, Lin Zhi, Jackline E. Dalgard
  • THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS
    Publication number: 20080103190
    Abstract: Disclosed herein are compounds, pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
    Type: Application
    Filed: December 21, 2007
    Publication date: May 1, 2008
    Applicant: Ligand Pharmaceuticals, Inc.
    Inventors: Jyun-Hung Chen, E. Kallel, Thomas Lau, Matthew McNeill, Todd Miller, Bao Nguyen, Richard Penuliar, Dean Phillips, Daniel Ruppar, Lin Zhi, Jackline Dalgard
  • Thrombopoietin activity modulating compounds and methods
    Patent number: 7314887
    Abstract: Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
    Type: Grant
    Filed: October 21, 2005
    Date of Patent: January 1, 2008
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Jyun-Hung Chen, E. Adam Kallel, Thomas Lau, Matthew H. McNeill, Todd A. Miller, Bao N. Nguyen, Richard J. Penuliar, Dean P. Phillips, Daniel A. Ruppar, Lin Zhi, Jackline E. Dalgard
  • Tricyclic androgen receptor modulator compounds and methods
    Publication number: 20070293528
    Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.
    Type: Application
    Filed: January 31, 2006
    Publication date: December 20, 2007
    Inventors: Lin Zhi, Cornelis Van Oeveren, Jyun-Hung Chen, Robert Higuchi