Abstract: Disclosed in the present invention are a distributed container image construction scheduling system and method. The system includes a construction node and a management node. The construction node includes an image constructor for executing a construction task issued by the management node. The management node includes a console and a scheduler. The console is responsible for acquiring the relevant parameters such as a development dependency library and system configuration required by a user, and generating tasks with these parameters and sending same to the scheduler. The scheduler is used for receiving the tasks sent by the console, detecting the legitimacy of the tasks, and sending the tasks to the corresponding construction node to be run.

Abstract: Provided are a CD22-targeted chimeric antigen receptor, a preparation method therefor and an application thereof. The chimeric antigen receptor comprises a leader sequence, a CD22-targeted scFv, a hinge region, a transmembrane region, and an intracellular signal domain. Provided are a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and an application thereof. The chimeric antigen receptor targets CD22 positive cells and can be used for treating CD22-positive B-cell leukemia, and some CD19-negative and CD22-positive patients in which acute B-cell leukemia has recurred after anti-CD19 CAR-T treatment.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A focus detection method includes: acquiring an image of a test object through a to-be-tested image acquisition device, the test object including a character, and a clarity of the character corresponding to a minimum clarity with which a content of the character is still able to be recognized using a character recognition technology; performing character recognition on the image to obtain a recognition result; and determining a focus detection result for the to-be-tested image acquisition device based on the recognition result.

Abstract: A processing method includes obtaining a processing image of a apparatus and performing a second processing on the processing image to generate a target image to analyze the target image according to a target defect detection method to realize defect detection of the apparatus. The processing image is obtained by performing a first processing on an initial image of the apparatus. The first processing includes performing scale processing on the initial image according to defect parameters corresponding to the initial image.

Abstract: Apparatuses, computer readable medium, and methods are disclosed for verifying skills of members of an online connection network. The apparatus, computer readable medium, and methods may include a method including responding to a first member of the online connection network indicating a skill possessed by the first member by selecting a skill verification user interface (UI) to present to a second member of the online connection network where the first member and the second member are connected via the online connection network. The method may further include presenting the skill verification UI to the second member, where the skill verification UI presents an indication of the first member, an indication of the skill, and a query regarding a competence level of the skill possessed by the first member. The method may further include receiving a response to the query and determining a skill validation value of the skill for the first member based on the response and a machine learning model.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A brainwave signal collecting device includes a main part and an elastic sleeve having a first opening. The main part is installed on the elastic sleeve, and the elastic sleeve can be positioned by suction on a user's head through the first opening after being pressed. The main part is in contact with the head to collect brainwave signals. The brainwave signal collecting device has an elastic sleeve serving as a flexible piece. When the brainwave signal collecting device is worn, the elastic sleeve can be pressed to partly exhaust the air therein so as to be positioned by suction on the head by the first opening of the elastic sleeve, which can improve the comfort of the head in contact with the elastic sleeve; and the position and angle at which the main part contacts the head can be adjusted through the deformation of the elastic sleeve.

Abstract: Techniques for predicting specialty data for a knowledge base using a machine learning model are disclosed herein. In some embodiments, a computer-implemented method comprises: for each skill in a plurality of skills, computing a skill-to-specialty distribution for specialties using a first machine learning model; for each skill in the plurality of skills, computing a user-to-skill distribution for the plurality of skills based on feature data of a first user of an online service using a second machine learning model; computing a user-to-specialty distribution for the plurality of specialties based on the skill-to-specialty distribution and the user-to-skill distribution, the user-to-specialty distribution comprising a corresponding user-to-specialty probability value for each specialty in the plurality of specialties given the first user; and using the user-to-specialty distribution in an application of the online service.

Abstract: In an example embodiment, a framework to infer a user's value for a particular attribute based upon a multi-task machine learning process with uncertainty weighting that incorporates signals from multiple contexts is provided. In an example embodiment, the framework aims to measure a level of a user attribute under a certain context. Rather than attempting to devise a universal, one-size-fits-all value for the attribute, the framework acknowledges that the user's value for that attribute can vary depending on context and factors in the context under which the user's attribute levels are measured. Multiple contexts are defined depending on different situations where users and entities such as companies and organizations need to evaluate user attribute levels. Signals for attribute levels are then collected for each context. Machine learning models are utilized to estimate attribute values for different contexts. Multi-task deep learning is used to level attributes from different contexts.

Abstract: A packaging structure and a packaging method of edge couplers and a fiber array are provided. The packaging structure includes a silicon substrate, an edge coupler, and a fiber array. Multiple edge couplers are arranged in a main body portion of the silicon substrate, and an end of the edge coupler extends to a step groove of the silicon substrate. At least a part of the cover of the fiber array is accommodated in the step groove. Multiple fibers in the fiber array correspondingly pass through multiple lead channels of the cover and are then coupled with the edge couplers in the step groove. The edge couplers butt the fibers in the fiber array. The cover is moved until a part of the cover is accommodated in the step groove, so that the fibers can be aligned with the edge couplers in the step groove.

Abstract: The present invention provides a BCMA-targeted chimeric antigen receptor (CAR) as well as a preparation method therefor and an application thereof. Specifically, the present invention provides the BCMA-targeted CAR, which comprises a BCMA-targeted scFv, a hinge region, a transmembrane region, and an intracellular signal structure domain. The present invention provides a nucleic acid molecule for coding the CAR and a corresponding expression vector as well as CAR-T cells and application thereof. The CAR of the present invention targets BCMA-positive cells, and can be used for treating BCMA-positive B-cell lymphoma, multiple myeloma and plasma cell leukemia.

Abstract: A method for forming a current collector is provided. At least two carbon nanostructure reinforced copper composite substrates are provided. The at least two carbon nanostructure reinforced copper composite substrates are stacked to form a composite substrate. An active metal layer is disposed on a surface of the composite substrate to form a first a composite structure. The first composite structure is pressed to form a second composite structure. The second composite structure is annealed to form a third composite structure. The third composite structure is de-alloyed to form a porous copper composite.

Abstract: A contact lens includes a contact lens body and a glucose detection sheet disposed on the contact lens body. The glucose detection sheet includes a glucose recognition layer, a photonic crystal array is provided in the glucose recognition layer, and the glucose recognition layer is configured to recognize glucose.

Abstract: Methods, systems, and computer readable mediums for protecting and controlling a microgrid with a dynamic boundary are disclosed. One method includes detecting a fault in a microgrid that includes a dynamic point-of-common-coupling (PCC), in response to determining that the microgrid is operating in a grid-connected mode, isolating the fault by tripping a microgrid side smart switch and a grid side smart switch that are located immediately adjacent to the fault, initiating the reclosing of the grid side smart switch, and initiating the reclosing for the microgrid side smart switch via resynchronization if the grid side smart switch is successfully reclosed, and in response to determining that the microgrid is operating in an islanded mode, isolating the fault by tripping a microgrid side smart switch that is located immediately adjacent to the fault, and initiating the reclosing of the microgrid side smart switch.

Abstract: An electrochemical detection electrode includes: a plurality of electrode structures; and a plurality of groups of detection structures on the plurality of electrode structures; wherein: the plurality of groups of detection structures include a first group of detection structures and a second group of detection structures, each of the first group of detection structures on one of the plurality of electrode structures having a first shape in a plane parallel to a surface of one of the plurality of electrode structures is configured to combine with a first detection object, each of the second group of detection structures on one of the plurality of electrode structures having a second shape in a plane parallel to a surface of one of the plurality of electrode structures is configured to combine with a second detection object; and wherein the first shape is different from the second shape.

Abstract: To achieve high-power single transverse mode laser, we here propose a supersymmetry (SUSY)-based triple-ridge waveguide semiconductor laser structure, which is composed of an electrically pumped main broad-ridge waveguide located in the middle and a pair of lossy auxiliary partner waveguides. The auxiliary partner waveguides are designed to provide dissipative modes that can phase match and couple with the higher-order modes in the main waveguide. By appropriately manipulating the gain-loss discrimination of the modes in the laser cavity, one can effectively suppress all the undesired higher-order transverse modes while keeping the fundamental one almost unaffected, thereby ensuring stable single-mode operation with a larger emitting aperture and accordingly a higher output power than a conventional single-transverse-mode ridge waveguide diode laser.

Abstract: The present invention provides a BCMA-targeted chimeric antigen receptor (CAR) as well as a preparation method therefor and an application thereof. Specifically, the present invention provides the BCMA-targeted CAR, which comprises a BCMA-targeted scFv, a hinge region, a transmembrane region, and an intracellular signal structure domain. The present invention provides a nucleic acid molecule for coding the CAR and a corresponding expression vector as well as CAR-T cells and application thereof. The CAR of the present invention targets BCMA-positive cells, and can be used for treating BCMA-positive B-cell lymphoma, multiple myeloma and plasma cell leukemia.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: The present invention discloses a high step-down modular DC power supply, belonging to the field of power electronics technology, and the high step-down modular DC power supply includes an upper modular cascade circuit string, a lower modular cascade circuit string, a load, and an input source, where the upper modular cascade circuit string includes i upper sub-module circuits, and the lower modular cascade circuit string includes j lower sub-module circuits. A combination manner of module circuits includes: upper module string cascading, lower module string cascading, and hybrid cascading of the upper module string and the lower module string. The power supply is formed to be a high voltage step-down ratio power supply with high voltage direct current input and low voltage direct current output through modular cascading.