Abstract: The present invention discloses a high step-down modular DC power supply, belonging to the field of power electronics technology, and the high step-down modular DC power supply includes an upper modular cascade circuit string, a lower modular cascade circuit string, a load, and an input source, where the upper modular cascade circuit string includes i upper sub-module circuits, and the lower modular cascade circuit string includes j lower sub-module circuits. A combination manner of module circuits includes: upper module string cascading, lower module string cascading, and hybrid cascading of the upper module string and the lower module string. The power supply is formed to be a high voltage step-down ratio power supply with high voltage direct current input and low voltage direct current output through modular cascading.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: Techniques for ranking skills using an ensemble machine learning approach are described. The outputs of two heterogenous, machine-learned models are combined to rank a set of skills that may be possessed by an end-user of an online service. Some subset of the highest-ranking skills is then presented to the end-user with a recommendation that the skills be added to the end-user's profile. The ensemble learning technique involves a concept referred to as “boosting”, in which a weaker performing model is enhanced (e.g., “boosted”) by a stronger performing model, when ranking the set of skills. Accordingly, by using a combination of models, better results are achieved than might be with either one of the individual models alone. Furthermore, the approach is scalable in ways that cannot be achieved with heuristic-based approaches.

Abstract: A hearing aid includes a plurality of electrode units, where each of the plurality of electrode units includes an electrode configured to provide an electrical stimulation to a user of the hearing aid and/or to measure a bio response signal of the user; a plurality of electrode channel circuits, where each of the plurality of electrode channel circuits includes: an operational amplifier comprising a first input terminal configured to receive the bio response signal and provide an amplified bio response signal, and the operational amplifier includes a first load input; a first DC offset unit configured to reduce the impact of DC offset in the electrode channel circuit of the plurality of electrode channel circuits by receiving a part of the amplified bio response signal and converting it to a feedback current signal which is transmitted to the first load input for providing balanced drain currents in the operational amplifier.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A method for making a three-dimensional hierarchical layered porous copper, the method includes providing a copper-zinc alloy precursor being composed of a ?? phase and a ? phase, and treating the copper-zinc alloy precursor by electrochemical dealloying. The present application further provides a three-dimensional hierarchical layered porous copper including a first surface layer, an intermediate layer, and a second surface layer stacked in that order. The first surface layer includes a plurality of micron-scale pores and a plurality of first nanoscale pores. The intermediate layer includes a plurality of second nanoscale pores. The second surface layer includes the plurality of micron-scale pores and the plurality of first nanoscale pores.

Abstract: A powertrain torque roll restrictor includes a first bracket having an elongated body defining a first bracket opening at a distal end and a central axis, a second bracket coaxial with and adjacent to the first bracket, and a third bracket coaxial with and adjacent to the second bracket opposite from the first bracket, with the third bracket defining a third bracket opening cooperable with the first bracket opening. The second bracket defines a second bracket opening receiving the elongated body such that the second bracket is positioned about the elongated body. The powertrain torque roll restrictor further includes a first rubber element positioned between the first bracket and the second bracket, and a second rubber element positioned between the second bracket and the third bracket, with the brackets being configured to hold the respective rubber element in compression.

Abstract: A transmission and a power system for use in a hybrid vehicle. A first ring gear or a first planetary frame is drivingly connected with an output gear of the transmission to serve as an output member, when either the first ring gear or the first planetary frame is drivingly connected with the output gear, the other one is connected with a casing of the transmission via a brake. A second clutch is configured as: when the brake is disengaged, the second clutch is engaged to make the rotational speed of the output member equal to the rotational speed of an input shaft. The transmission and the power system are structurally compact, work steadily, and effectively increase the acceleration performance of the hybrid vehicle.

Abstract: A pyranoglucose-substituted pyrazole compound, used as a pharmaceutical intermediate, having the structural formula represented by formula (9c). The present invention further relates to an intermediate compound represented by formula (10c) or a salt thereof. The present invention further relates to a preparation method of the aforementioned intermediate compound and a method of using the same to prepare an SGLT inhibitor. By means of the novel key intermediate, the preparation technique of an SGLT inhibitor is greatly simplified. In addition, because the intermediate can be precipitated in the form of a salt and is easy to purify, the purity of the SGLT inhibitor is significantly increased, compared with the original preparation pathway (crude product purity can reach 99% or more).

Abstract: Techniques for ranking skills using an ensemble machine learning approach are described. The outputs of two heterogenous, machine-learned models are combined to rank a set of skills that may be possessed by an end-user of an online service. Some subset of the highest-ranking skills is then presented to the end-user with a recommendation that the skills be added to the end-user's profile. The ensemble learning technique involves a concept referred to as “boosting”, in which a weaker performing model is enhanced (e.g., “boosted”) by a stronger performing model, when ranking the set of skills. Accordingly, by using a combination of models, better results are achieved than might be with either one of the individual models alone. Furthermore, the approach is scalable in ways that cannot be achieved with heuristic-based approaches.

Abstract: An automobile hub with a hollow rim includes a wheel disc and the rim with at least one hollow cavity, in which the rim includes at least two mutually nested rings and an axial end cap at the same ends of the at least two rings, and the hollow cavity consists of the rings and the axial end cap. The outer side of one end of the wheel disc includes axial rim mounting grooves, and the rim is inserted into the rim mounting grooves and fixed to the wheel disc through the end without the axial end cap. By employing the automobile hub with the hollow rim, the hub assembling method, and the automobile having the hub, the weight of the hub can be further reduced, and the hub has sufficient strength.

Abstract: This disclosure provides agents and methods for treating a traumatic brain injury (TBI) with Annexin A5 or variant thereof.

Abstract: The invention relates to the field of biomedicine, in particular to the use of annexin A5 in the treatment of cerebral stroke. The invention provides a method for treating cerebral stroke and a drug combination containing annexin A5. The method can reduce cerebral infarction, improve symptoms of neurobehavioral deficits in the brain and treating stroke.

Abstract: Disclosed in the present invention are a distributed container image construction scheduling system and method. The system includes a construction node and a management node. The construction node includes an image constructor for executing a construction task issued by the management node. The management node include, a console and a scheduler. The console is responsible for acquiring the relevant parameters such as a development dependency library and system configuration required by a user, and generating tasks with these parameters and sending same to the scheduler. The scheduler is used for receiving the tasks sent by the console, detecting the legitimacy of the tasks, and sending the tasks to the corresponding construction node to be run.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A method includes performing by a processor: receiving a plurality of synchrophasor measurements of a power system signal associated with a time interval from a plurality of phasor measurement units (PMUs), respectively, each of the plurality of synchrophasor measurements including a phase angle, frequency value, and a timestamp associated with the synchrophasor measurement; determining, for each of the plurality of PMUs, a dominant mode frequency of a forced oscillation signal component of the power system signal based on the frequency value and the phase angle; determining, for each of the plurality of PMUs, a mode angle of the forced oscillation signal component at the dominant mode frequency; and determining a geographic forced oscillation source location for a source of the forced oscillation signal component based on the plurality of mode angles associated with each of the plurality of PMUs, respectively, and geographic locations of the plurality of PMUs.

Abstract: In an embodiment, the present disclosure relates to a targeting platform that includes a targeted delivery system including an agent. In some embodiments, the targeted delivery system is modified by fluorination. In some embodiments, the targeted delivery system is electrically charge neutral. In a further embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. In an additional embodiment, the present disclosure relates to a targeting platform that includes a fluorinated polymeric system including an agent. In another embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. Additionally, the method can include administering the fluorinated targeting compound to a subject.

Abstract: This application pertains to the technical field of LiDAR, and discloses a phased array emission apparatus, a LiDAR, and an automated driving device. The phased array emission apparatus includes an edge coupler, an optical combiner, and a phased array unit. An output end of the edge coupler is connected to an input end of the optical combiner, and an output end of the optical combiner is connected to an input end of the phased array unit. The edge coupler is configured to input and couple a first optical signal. The optical combiner is configured to transmit, to the phased array unit, the first optical signal coupled by the edge coupler. The phased array unit is configured to split the first optical signal into several first optical sub-signals and emit the first optical sub-signals. In the foregoing method, coupling efficiency can be improved, thereby meeting a low-loss requirement.

Abstract: A method includes injecting a probe signal into a power system; receiving a measurement of an operational parameter of the power system responsive to injecting the probe signal into the power system; generating a transfer function model of the power system based on the measurement of the operational parameter of the power system and the probe signal; and updating at least one control parameter of a Wide Area Damping Controller (WADC) communicatively coupled to the power system based on the transfer function model.